Clinical trials: Conduction Block
Aortic Stenosis, Conduction Disturbances
Systematic Ambulatory ECG Monitoring Following TAVI
This multicenter, prospective, randomized superiority trial will evaluate whether systematic 14-day ambulatory ECG monitoring following hospital discharge after transcatheter aortic valve implantation (TAVI) reduces the risk of…
- Trial name
- RECORDII (NCT07739316)
- Testing
- Ambulatory ECG monitoring
- Where
- Canada
- Volunteers
- 754 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Ranolazine Implantable Cardioverter-Defibrillator Trial
The purpose of the study is to see how effective a drug called ranolazine is in reducing the risk of ventricular arrhythmia and death in people with implantable cardioverter-defibrillators (ICDs).
- Conditions
- Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy, Heart Failure
- Trial name
- RAID (NCT01215253)
- Testing
- Ranolazine
- Where
- 90 sites in United States, Canada
- Volunteers
- 1,012 people
- Sponsor
- University of Rochester
Atrioventricular Conduction Block
Micra Atrial TRacking Using A Ventricular AccELerometer 2
The purpose of the Micra Atrial TRacking Using A Ventricular AccELerometer 2 (MARVEL 2) study is to demonstrate safe and effective operation of the MARVEL 2 features for providing AV synchronous pacing in patients with normal…
- Trial name
- MARVEL2 (NCT03752151)
- Testing
- MARVEL 2 Algorithm Monitor Mode then Adaptive Mode
- Where
- 12 sites in United States, Austria and 6 more
- Volunteers
- 77 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Appendectomy, Laparoscopy
TAP Block or Wound Infiltration for Laparoscopic Pediatric Appendectomy: a Pilot Study
Effectiveness of the TAP block compared to wound infiltration in controlling pain after laparoscopic appendectomy in children
- Conditions
- Appendectomy, Laparoscopy, Anesthesia, Conduction, Child, Preschool
- Trial name
- NCT04294537
- Testing
- TAP Block, LIA local infiltration, General anesthesia
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Heart Failure, Left Bundle Branch Block
Clinical Efficacy and Safety of Left Bundle Branch Area Pacing Using Quantitative Guidance of Multimodal Data in the Treatment of Heart Failure
Heart failure is a common chronic cardiovascular disease that seriously impairs patients' quality of life and long-term prognosis.
- Conditions
- Heart Failure, Left Bundle Branch Block, Non-ischemic Cardiomyopathy
- Trial name
- NCT07814612
- Testing
- Apply multimodal data fusion for quantitative guidance of left bundle branch region pacing, Conventional Biventricular Pacing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Cardiac Resynchronization Therapy, Chronic Heart Failure
Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment
The objective of this prospective, multicenter controlled study is to assess the feasibility of a patient-tailored implantation by creating a cloud-based pre-procedural multimodality CRT-roadmap by integration of 3D images from…
- Conditions
- Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block
- Trial name
- CRT-DRIVE (NCT05327062)
- Testing
- CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
- Where
- 13 sites in United States, Austria and 5 more
- Volunteers
- 150 people
- Sponsor
- XSpline S.p.A.
Aortic Valve Stenosis
Impact of Local Tissue Inflammation on Intramyocardial Conduction Pathways Post Percutaneous Valve : Evaluation by Positron Emission Tomography on Exploratory Cohort
Aortic valve stenosis is the most common valve disease leading to surgical or percutaneous intervention in Europe and North America.
- Trial name
- IMPACT (NCT05308888)
- Testing
- 18F-FDG PET-CT
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Aortic Stenosis, Heart Block
Conduction Disease After Transcatheter Aortic Valve Replacement
This is a prospective single center Cardiology department observational study. The study aim is to better understand the predictors of high grade conduction abnormalities associated with TAVR such that a more robust…
- Conditions
- Aortic Stenosis, Heart Block, Aortic Insufficiency
- Trial name
- NCT04489095
- Testing
- Electrophysiology Study
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Henry Ford Health System
Right Bundle-Branch Block, Heart Failure With Reduced Ejection Fraction
Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction. The Study Tests the Superiority of Right Ventricular Bifocal Stimulation Over VVI Implantable Defibrillator in Right Bundle Branch Block and Heart Failure.
RATIONALE: Cardiac resynchronization therapy (CRT) is known to improve cardiac performance and to reduce morbidity and mortality in reduced-ejection fraction heart failure (HFrEF) despite optimal medical therapy (OMT).
- Conditions
- Right Bundle-Branch Block, Heart Failure With Reduced Ejection Fraction, Bifocal Stimulation
- Trial name
- BiPARK-HF (NCT03524001)
- Testing
- Compare VVi mode versus DDD bifocal stimulation through crossover randomization
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Cardiovascular Surgical Procedures, Pain, Postoperative
Fascial Plane Blocks and Quality of Recovery in Cardiac Surgery
In this randomized trial, the investigators will test the hypothesis that combining regional analgesia techniques-which have the potential to improve the quality of postoperative recovery following median sternotomy-with PIFB…
- Conditions
- Cardiovascular Surgical Procedures, Pain, Postoperative, Cardiovascular Diseases
- Trial name
- NCT07557108
- Testing
- Ultrasound-Guided Pectointercostal Fascial Plane Block, Ultrasound-Guided Rectus Sheath Block, Ultrasound-Guided Recto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Ordu University
Bradycardia, Sinus Node Dysfunction
ImageReady(TM) MR Conditional Pacing System Clinical Study
The objective of the SAMURAI Clinical Study is to collect data to confirm the safety, performance and effectiveness of the ImageReady System for use in the Magnetic Resonance Imaging (MRI) environment when used in accordance with…
- Trial name
- SAMURAI (NCT01781078)
- Testing
- MRI, ImageReady System implant
- Where
- 41 sites in United States, Australia and 5 more
- Volunteers
- 363 people
- Sponsor
- Boston Scientific Corporation
Atrioventricular Block, Pacing-Induced Cardiomyopathy
Conduction System Pacing to Prevent Pacing-Induced Cardiomyopathy
The purpose of this randomized, open-label trial was to determine whether permanent conduction system pacing preserves left ventricular function and reduces the incidence of pacing-induced cardiomyopathy compared with…
- Conditions
- Atrioventricular Block, Pacing-Induced Cardiomyopathy, Cardiac Pacing, Artificial
- Trial name
- PRESERVE-CSP (NCT07831655)
- Testing
- Conduction System Pacing, Right Ventricular Apical Pacing
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Germans Trias i Pujol Hospital
Anesthesia, Local, Nerve Block
Lateral Sagittal vs Costoclavicular Approach for Ultrasound-Guided Infraclavicular Block
An ultrasound-guided infraclavicular block performed with the costoclavicular (CC) approach and the lateral sagittal (LS) approach will be compared in patients scheduled for forearm and hand surgery.
- Conditions
- Anesthesia, Local, Nerve Block, Brachial Plexus Block
- Trial name
- NCT04356521
- Testing
- Lateral Sagittal Approach, Costoclavicular Approach
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Skeletal Muscle Changes After Crt
Effect of Cardiac Resynchronization Therapy (CRT) on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response
Heart failure patients with left bundle branch block have a poor prognosis. Biventricular pacing which synchronize the heart pump action is associated with improved functional capacity.
- Trial name
- NCT01019915
- Testing
- CRT
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Helse Stavanger HF
Breast Neoplasm Female, Postoperative Pain Management
PECS II vs. MTP for Analgesia After MRM
This randomized controlled study aims to compare the analgesic efficacy of the ultrasound-guided modified pectoral nerve block (PECS II) and the midpoint transverse process to pleura (MTP) block in female patients undergoing…
- Trial name
- NCT06187909
- Testing
- PECS II BLOCK, MTP BLOCK
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Hypertension Resistant to Conventional Therapy, Bradycardia
Safety and Performance Study of the Moderato System
The purpose of the study is to evaluate the safety and performance of the Moderato System by implanting the Moderato pacemaker in patients who require a dual chamber pacemaker, and who also have hypertension, in order to reduce…
- Conditions
- Hypertension Resistant to Conventional Therapy, Bradycardia, Atrioventricular Block
- Trial name
- NCT02282033
- Testing
- The Moderato System
- Where
- 10 sites in Austria, Chile and 5 more
- Volunteers
- 57 people
- Sponsor
- BackBeat Medical Inc
Arrhythmias, Cardiac, Atrioventricular Block
ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing
The goal of this observational study is to evaluate the clinical characteristics of patients undergoing permanent cardiac pacing and to compare procedural efficacy and safety of different implantation approaches in the clinical…
- Conditions
- Arrhythmias, Cardiac, Atrioventricular Block, Reduced Systolic Function, Atrial Fibrillation
- Trial name
- TREEBEARD (NCT06324682)
- Testing
- Cardiac pacing - Conventional RV pacing, Cardiac pacing - Conduction System Pacing, Cardiac pacing - Cardiac resynchronization therapy (pacing - CRTP - or defibrillation - CRTD)
- Where
- 31 sites in Italy
- Volunteers
- 8,400 people
- Sponsor
- University Hospital of Ferrara
Left Ventricular Ejection Fraction, Heart Failure (HF)
REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)
Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide…
- Conditions
- Left Ventricular Ejection Fraction, Heart Failure (HF), Left Bundle-Branch Block
- Trial name
- REINVENT (NCT05652218)
- Testing
- LB-CRT, BIV-CRT
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Inova Health Care Services
Pain, Postoperative, Anesthesia, Conduction
Effect of a Lateral Nerve of the Thigh Block on Postoperative Pain After Total Hip Replacement Surgery
The purpose of this study was to evaluate the analgesic efficacy of the nervus cutaneous femoral lateralis (NCFL) blockade on postoperative pain after total hip replacement surgery. The NCFL-block is a pure sensory block.
- Conditions
- Pain, Postoperative, Anesthesia, Conduction, Arthroplasty, Replacement, Hip
- Trial name
- NCT02289937
- Testing
- Ropivacaine, An ultrasound-guided Nervus cutaneous femoral lateralis blockade will be given postoperatively
- Volunteers
- 100 people
- Sponsor
- Daniel Hägi-Pedersen
Pacemaker DDD, Atrioventricular Block
Risk of Pacing-induced Cardiomyopathy
This study will evaluate the association between right ventricular pacing and the risk of pacing-induced cardiomyopathy.
- Conditions
- Pacemaker DDD, Atrioventricular Block, Pacing-Induced Cardiomyopathy
- Trial name
- NCT04269733
- Testing
- Right ventricular pacing
- Where
- Denmark
- Volunteers
- 153 people
- Sponsor
- Aalborg University Hospital