Clinical trials: Conflict, open to volunteers
Bowel Cleansing for Colonoscopy, Inadequate Bowel Preparation
Comparing Three Rescue Bowel Preparation Regimens for Colonoscopy After Failed Cleansing
The goal of this clinical trial is to learn which rescue bowel preparation works best for adults who need a repeat colonoscopy after a previous bowel preparation did not clean the bowel well enough.
- Trial name
- NCT07557173
- Testing
- Drug
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Ospedale San Pio
Rhinosinusitis
Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis
The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS)…
- Trial name
- NCT02038166
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Hypercholesterolemia and Hyperlipidemia, Supplementation
Evaluation of the Effects of Two Dietary Supplement Formulations on the Lipid Profile in Mild Hypercholesterolemia
A single-center, randomized, parallel-group, double-blind, placebo-controlled clinical study followed by an open-label phase to evaluate the effects of a new formulation of a supplement on lipid profile in subjects with mild…
- Trial name
- NCT06810466
- Testing
- Test Product A, Test Product B
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- IBSA Farmaceutici Italia Srl
Active Rheumatoid Arthritis
A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)
This is a Phase 2 randomized, double-blind, placebo-controlled study with a total duration of 32 weeks from Screening to End-of-Study (EOS) Visit. Approximately 180 participants are planned to be enrolled.
- Trial name
- NCT07409103
- Testing
- ELV001 25 mg, ELV001 75 mg, ELV001 125 mg
- Where
- 34 sites in United States, Serbia and 1 more
- Volunteers
- 180 people
- Sponsor
- Elevara Medicines Limited
Schizophrenia
Sex Differences in NMDA-enhancing Treatment of Schizophrenia
Schizophrenia differs between sexes in clinical symptoms and functional outcome. Negative symptoms are the core pathology of this disease. NMDA receptor (NMDAR) dysfunction is a key factor in negative symptoms.
- Trial name
- NCT07122895
- Testing
- NMDAE
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Advanced Hepatocellular Carcinoma (HCC)
Different First-line Immunotherapy for Advancer Hepatocellular Carcinoma: A Prospective Observational Study on Efficacy and Immune Microenvironment
To evaluate the efficacy and immune microenvironment changes in advanced hepatocellular carcinoma (HCC) patients receiving different first-line immunotherapy.
- Trial name
- HCC-IM-1 (NCT07147101)
- Testing
- Sintilimab, Bevacizumab Biosimilar, Camrelizumab
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fudan University
COPD, COPD Chronic Obstructive Pulmonary Disease
The Effects of Different Vibration Exercises on COPD Patients
Pulmonary rehabilitation is effective in improving exercise tolerance, dyspnea, and fatigue in patients with COPD, and exercise training is an important component of pulmonary rehabilitation.
- Conditions
- COPD, COPD Chronic Obstructive Pulmonary Disease, Vibration Therapy
- Trial name
- NCT06413524
- Testing
- Whole-body Vibration Therapy, Local Vibration Therapy
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Taipei Medical University
Healthy Aging, Healthy
The Effect of Different Focus of Attention Instructions on Resistance Training and Its Transfer to Gait Parameters in Older Adults
The goal of this clinical trial is to investigate the effects of strength training with different focus of attention strategies on plantar flexor force and how this affects gait in apparently healthy older adults.
- Trial name
- NCT06538766
- Testing
- Strength training with an internal focus of attention, Strength training with a proprioceptive external focus of attention, Strength training with a visual external focus of attention
- Where
- Portugal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Arteriosclerosis Obliterans
Outcome and Improvement of Different Treatment in Arteriosclerosis Obliterans
This study is a prospective, single-center, observational study. In this study, we aim to evaluate the clinical outcome and cost-effectiveness of different treatments of lower extremity arterial occlusive disease.
- Trial name
- NCT06485622
- Testing
- open bypass group, bare metal stent group, plain old balloon angioplasty group
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Fever, Chest Tightness
Sulfamethoxazole Prophylaxis Duration After Renal Transplantation
Renal transplantation is the most ideal and effective treatment for end-stage renal disease. Pneumocystis jirovecii pneumonia (PJP) is one of the most common pulmonary infections after renal transplantation, with high morbidity…
- Trial name
- SPDART (NCT07231770)
- Testing
- Time-driven dosing
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Anhui Provincial Hospital
Sedentary Adults
Effects of Flexi-Bar Training in Different Postures on Core Muscle Activation, Trunk Muscle Strength, and Balance in Sedentary Adults
Trunk stability is a fundamental basis for achieving proximal stability and facilitating distal mobility, and is closely associated with balance control and neuromuscular coordination.
- Trial name
- NCT07872566
- Testing
- Flexi-Bar training with sitting posture, Flexi-Bar training with standing posture
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fooyin University
Presbyopia
Volumetric Visual Fields at Different Distances in Presbyopic Patients Using Occupational (PC-133 and PC-200) and General-Purpose Progressive Addition Lenses
This single-center, randomized, double-blind, crossover clinical trial aims to compare the volumetric visual fields provided by two occupational progressive addition lenses (OPLs) optimized for intermediate and near vision in…
- Trial name
- CIVIUS2026PAL (NCT07870785)
- Testing
- OPAL PC 133 assessment, OPAL PC 200 assessment, PAL assessment
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Seville
Insomnia
Intelligent Diagnosis and Treatment Model for Insomnia Disorder
To establish a multicenter, multi-dimensional cohort on insomnia disorder and to develop an intelligent model for the diagnosis and treatment of insomnia disorder.
- Trial name
- NCT06375447
- Testing
- Routine clinical treatment
- Where
- 5 sites in China
- Volunteers
- 16,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Hearing Loss
Randomised Study of Web-Based Auditory Training With Varying Perceptual and Cognitive Demands on Training Gains and Generalised Speech, Cognitive, and Communication Outcomes
WP1: PLUS-Auditory Training The goal of this experimental study is to better understand how task difficulty affects on-task learning thresholds and generalised benefits in two PLUS auditory training tasks involving perceptual and…
- Trial name
- PLUS-Optimal (NCT07506408)
- Testing
- Practice Listening and Understand Speech (PLUS)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Substance Use Disorders, Criminal Behavior
Improving Outcomes in Social Services Through Routine Outcome Monitoring and Systematic Client Feedback
In this project the investigators want to test whether a new method FIT (Feedback informed treatment) can improve the interventions people receive through social services.
- Conditions
- Substance Use Disorders, Criminal Behavior, Domestic Violence, Social Care
- Trial name
- NCT07303608
- Testing
- Feedback informed treatment (FIT), Treatment as usual (TAU)
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Accuracy of Different Scanning Techniques
Comparative Accuracy of Conventional Scan Bodies, Intra-oral Photogrammetry, and Calibrated Scan Flags in Full-Arch Implant Scanning
To assess and compare the accuracy of digital scans obtained using three different scanning protocols -conventional scan bodies, Intra-oral photogrammetry, and calibrated scan flags- on completely edentulous dental model with…
- Trial name
- NCT07200440
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Volunteers
- 24 people
- Sponsor
- Cairo University
Breast Masses, Breast Cancer
Photoacoustic/Ultrasound Imaging for Breast Nodule Diagnosis, Molecular Classification, and Neoadjuvant Chemotherapy Response Evaluation
Photoacoustic (PA) imaging (PAI) emergerd as a rapidly evolving biomedical imaging modality, which combines the merits of optical imaging and ultrasound (US) imaging, and has a capacity in morphological, functional and molecular…
- Conditions
- Breast Masses, Breast Cancer, Breast Cancer Treated with Neoadjuvant Chemotherapy
- Trial name
- NCT06908291
- Testing
- Multi-modal photoacoustic/ultrasonic (PA/US) imaging system
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Thrombocytopenia
The Study of Different Cycles of High-dose Dexamethasone in the Treatment of ITP
Primary immune thrombocytopenia is an autoimmune disorder characterised by decreased platelet counts and increased bleeding risk.
- Trial name
- NCT06913374
- Testing
- Dexamethasone
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Shandong University
Meningioma, Radiation Toxicity
Neurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma:
For the purpose of this research, investigator will constitute several cohorts of patients, treated either by intensity-modulated radiotherapy, stereotactic radiotherapy or proton-therapy.
- Trial name
- CANCER-COG (NCT06036706)
- Testing
- Normo-fractionated intensity-modulated brain irradiation with or without stereotactic positioning, Hypo-fractionated stereotactic brain irradiation, Normo-fractionated proton therapy brain irradiation
- Where
- 3 sites in France
- Volunteers
- 108 people
- Sponsor
- Centre Francois Baclesse
Alzheimer Disease
BnH-015B Clinical Trial in Moderate Alzheimer's Disease
BnH-015B is a small molecule compound that targets the GluN2B binding site on NMDA receptors and positively modulates. BnH-015B has shown, through nonclinical trials, to improve symptoms of cognitive decline by regulating the…
- Trial name
- NCT06535308
- Testing
- BnH-015B 5 mg, BnH-015B 10 mg, BnH-015B 20 mg
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- BnH Research
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