Clinical trials: Confusion
Heart Failure, Delirium Confusional State
Delirium and Heart Failure
Biomarkers such as Systemic Immune-Inflammation Index (SII) and TG/Glucose Ratio (TyG) have shown promise in predicting delirium, reflecting the roles of inflammation and metabolic disturbances in its pathophysiology.
- Trial name
- NCT07302737
- Testing
- Comprehensive Geriatric Assessment, the Confusion Assessment Method (CAM test) or CAM-ICU, Delirium Rating Scale - Revised-98
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Critical Illness, Sepsis
Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial
This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical…
- Conditions
- Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure
- Trial name
- POC-AI-ICU (NCT07293078)
- Testing
- Point-of-care large language model decision support (ChatGPT-5)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- MetroWest Artificial Intelligence Research Workgroup
Delirium, Cognitive Dysfunction
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders
- Trial name
- CODEX (NCT04289142)
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- 8 sites in Canada
- Volunteers
- 2,400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Confusion, Delirium
Validation of a French Version of the Confusion Assessment Method (CAM)
To validate the French version of the CAM, a multicenter diagnostic study will be conducted. The principle of this study is identical to the study of Inouye which initially validated the CAM in 1990.
- Trial name
- NCT01775982
- Testing
- Psychiatric evaluation, Geriatric evaluation
- Where
- 8 sites in France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Alzheimer Dementia, Alzheimer Disease
Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy
The goal of this clinical trial is to determine if utilizing the Quest AD-Detect blood test, while patient's are hospitalized for a cognitive diagnosis (such as delirium or encephalopathy), will result in an earlier diagnosis of…
- Conditions
- Alzheimer Dementia, Alzheimer Disease, Delirium Confusional State, Encephalopathy
- Trial name
- NCT07222280
- Testing
- Quest AD-Detect blood test
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Covenant Health, US
Delirium
VoiceLove Digital Therapy for Delirium in the ICU
The study is a single-center, single-arm, prospective trial to evaluate the feasibility, safety, and acceptability of VoiceLOVE digital therapy for the management of delirium in surgical ICU patients.
- Trial name
- NCT07218484
- Testing
- VoiceLove therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Methodist Hospital Research Institute
Delirium Treatment, Delirium Confusional State
Management of Non-pharmacologic Delirium With the Use of a Nursing-led E-health Project: a Randonmized Controlled Trial
Application of an action protocol focused on the application of non-pharmacological interventions for managing delirium in the process of prevention, diagnosis and treatment, evaluated using an e-health intervention, with a…
- Conditions
- Delirium Treatment, Delirium Confusional State, Delirium in Old Age
- Trial name
- Delirium (NCT06809894)
- Testing
- Application of an action protocol for the management of delirium through the use of non-pharmacological interventions, Tradicional management of delirium
- Where
- Spain
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universitat de Lleida
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Disorientation, Cognitive Impairment
Evaluation of Safe Use of SECURIDRAP® SELFIA®
Interventional, multicenter, prospective and non-comparative clinical investigation carried out in 9 French establishments in order to assess the safety of the SÉCURIDRAP® SELFIA® bedding by mesasuring all the adverse events…
- Conditions
- Disorientation, Cognitive Impairment, Behavior Disorders
- Trial name
- SECURIDRAP (NCT05510401)
- Testing
- SECURIDRAP® SELFIA®
- Where
- 10 sites in France
- Volunteers
- 108 people
- Sponsor
- Groupe Mulliez-Flory
Confusion Postoperative, Delirium
Preoperative Prognostic Nutritional Index and Postoperative Delirium in Gastrointestinal Cancer Surgery
Aim: We aimed to show the relationship between preoperative prognostic nutritional index and postoperative delirium in patients who had undergone gastrointestinal cancer surgery.
- Conditions
- Confusion Postoperative, Delirium, Gastrointestinal Cancer, Nutritional Deficiency
- Trial name
- NCT06603129
- Testing
- prognostic nutritional index
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Post-Operative Confusion
High Spinal Anesthesia and the Incidence of Delirium After Cardiac Surgery
This is a feasibility study to determine if enough patients undergoing elective or urgent cardiac surgery, can be enrolled in a study where patients are randomized to receive high spinal anesthesia as an adjunct to general…
- Trial name
- NCT05374356
- Testing
- Intrathecal bupivacaine and morphine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Delirium
Occupational Therapy Intervention on the Prevention of Delirium and Occupational Performance Status in Elderly Patients
Delirium is an acute, fluctuating, transient, and usually reversible disorder of cognition and level of consciousness, with a high incidence in critical care units, especially in the elderly.
- Trial name
- NCT06479031
- Testing
- Occupational Therapy
- Volunteers
- 114 people
- Sponsor
- Hospital Sirio-Libanes
Diabetes Mellitus, Type 2, Cognitive Functions Confusion
Effects of SGLT2i on the Cognitive Function in T2DM Patient (ESCDP)
Type 2 diabetes is associated with diabetic cognopathy, the prevalence of Alzheimer's Disease(AD) in T2DM patients is 1.5 to 2.5 times higher than the general population.
- Trial name
- ESCDP (NCT04304261)
- Testing
- Canagliflozin, Sitagliptin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Third Military Medical University
Postoperative Confusion
Cognitive Functions After TIVA With Dexmedetomidine
It is important to wake up without any problem and comfortably from the general anesthesia. The aim of this study is to investigate the effects of addition dexmedetomidine to the balanced intravenous anesthesia with propofol over…
- Trial name
- NCT02631135
- Testing
- Remifentanil, Propofol, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uludag University
Delirium in Old Age, Delirium of Mixed Origin
Music Therapy as a Treatment for Delirium in Acutely Hospitalized Older Patients
The purpose of this study is to assess feasibility and potential effectiveness of two different music interventions for managing delirium symptoms in acute geriatric patients.
- Conditions
- Delirium in Old Age, Delirium of Mixed Origin, Delirium Superimposed on Dementia, Delirium Confusional State
- Trial name
- NCT05398211
- Testing
- Preferred Recorded Music (PRM), Preferred Live Music (PLM)
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Delirium
Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR)
This is a pilot randomized controlled trial that will test whether a multicomponent decision support system will improve the postoperative environment for neurocognitive and clinical recovery in older, high-risk surgical…
- Trial name
- NCT04007523
- Testing
- Family Support System, HELP Support System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Neurologic Manifestations, Psychiatric Disorders
Cohort of Patients With Covid-19 Presenting Neurological or Psychiatric Disorders (CoCo-Neurosciences)
Covid-19 pandemic now affects more than two million people worldwide. The neurotropism of the virus is assumed by its frequent association with neurological symptoms (anosmia, ageusia, headaches) but the extent of the central or…
- Conditions
- Neurologic Manifestations, Psychiatric Disorders, COVID-19
- Trial name
- CoCo-Neuro (NCT04362930)
- Where
- France
- Volunteers
- 730 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium
Neuronal Damage In Delirium Study
The purpose of this study is to evaluate associations between neuronal damage biomarkers (S100 calcium-binding protein beta [S-100β], neuron-specific enolase [NSE], ubiquitin carboxy-terminal hydrolase L1 [UCHL1], and…
- Trial name
- NDID (NCT03724201)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Hypnotic; Withdrawal State With Delirium, Neurological Disorder
Efficacy of BIS Monitoring in Deep Hypnotic State
Determining the efficacy of the BIS monitor in monitoring deep hypnotic states as well as intra- and post-operative outcomes in neurosurgery patients
- Conditions
- Hypnotic; Withdrawal State With Delirium, Neurological Disorder, Postoperative Delirium, Postoperative Confusion
- Trial name
- NCT06177847
- Testing
- BIS
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Surgery, Old Age; Debility
Pre-surgical Protocol for Frail Elderly People in Order to Reduce Hospitalization Days (APOPM).
Elderly people (EP) have increased, as well as life expectancy at birth. In Chile there are more than 2 million 800 thousand EP, which corresponds to 1/6 of the Chilean population.
- Conditions
- Surgery, Old Age; Debility, Frail Elderly Syndrome, Post-Operative Confusion
- Trial name
- APOPM (NCT04770259)
- Testing
- Timely pre-surgical conditioning
- Where
- 2 sites in Chile
- Volunteers
- 87 people
- Sponsor
- Pontificia Universidad Catolica de Chile