Clinical trials: Congenital Cataracts
Congenital Cataract
Comparison of Traditional Cataract Surgery and Traditional Surgery Combined Triamcinolone Staining
Previously, the investigators have developed a surgical technique to reduce inflammatory response after congenital cataract surgery.
- Trial name
- NCT04323982
- Testing
- new surgical procedure, traditional surgical procedure
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Eye Diseases
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases
This study will evaluate and treat children or adults with inherited or developmental eye conditions. It will allow specialists in pediatric ophthalmology, genetic ophthalmology, and ocular motility at the National Eye Institute…
- Trial name
- NCT00076271
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- National Eye Institute (NEI)
Congenital Cataract
Genetic Diagnosis in Congenital Cataracts
The prediction of genetic risk in congenital cataract patients has great clinical significance. In this trial, the investigators aim to screen the causative variants from 115 unrelated bilateral congenital cataract patients…
- Trial name
- NCT05782452
- Testing
- Ophthalmic examination, Whole-exome sequencing
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Congenital Cataract
Morphologic and Biometric Characteristics of Preexisting Posterior Capsule Defects in Congenital Cataracts During the First Year of Life
Few descriptive studies have focused on the anatomical parameters in patients with preexisting PCDs. The characteristics of cataract morphology and anatomical parameters in these patients remained unclear, when compared with CC…
- Trial name
- NCT03342794
- Testing
- cataract surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Cataract, Retinitis Pigmentosa (RP)
Impact of Capsular Tension Ring on Intraocular Lens Position in Retinitis Pigmentosa Cataract Patients
This is a self-controlled randomized clinical trial to investigate the effect of capsular tension ring (CTR) implantation on intraocular lens (IOL) position in cataract patients with retinitis pigmentosa(RP).
- Trial name
- NCT07126470
- Testing
- CTR implantation
- Where
- 3 sites in China
- Volunteers
- 88 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Cataract, Fuchs' Endothelial Dystrophy
Impact of Cataract Surgery on Keratoplasty Graft Survival
The follow up time after keratoplasty now routinely exceeds multiple decades. It is common for keratoplasty patients to also undergo cataract surgery at a later date in their lives.
- Conditions
- Cataract, Fuchs' Endothelial Dystrophy, Keratoconus
- Trial name
- IGREC (NCT02875145)
- Testing
- Cataract surgery
- Where
- France
- Volunteers
- 453 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Fuchs Endothelial Corneal Dystrophy, Cataract
The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal Dystrophy
The goal of this study is to learn if topical ROCK inhibitors protect endothelial corneal cells in patients with glaucoma and Fuchs endothelial corneal dystrophy after cataract surgery.
- Conditions
- Fuchs Endothelial Corneal Dystrophy, Cataract, Glaucoma
- Trial name
- NCT06969586
- Testing
- Netarsudil 0.02% Ophthalmic Solution, artificial tear substitute
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Dubrava
Microphthalmos With Congenital Cataracts
Long-term Postoperative Outcomes After Bilateral Congenital Cataract Surgery in Eyes With Microphthalmos
Cataract surgery in infantile eyes, which are microphthalmic, can be even more demanding. In addition, the frequent presence of other ocular and systemic anomalies such as nystagmus, glaucoma, amblyopia, and higher rate of…
- Trial name
- NCT01818037
- Testing
- Cataract surgery
- Where
- India
- Volunteers
- 36 people
- Sponsor
- Iladevi Cataract and IOL Research Center
Inclusion Body Myositis, Sporadic, Inclusion Body Myopathy, Autosomal-recessive
Natural History in CCFDN and IBM Syndromes
So far, only limited data is available regarding the natural course in Congenital Cataract Facial Dysmorphism Neuropathy Syndrome (CCFDN) and sporadic and hereditary inclusion body myopathies (IBM).
- Conditions
- Inclusion Body Myositis, Sporadic, Inclusion Body Myopathy, Autosomal-recessive, Inclusion Body Myopathy, Autosomal-dominant, Congenital Cataracts, Facial Dysmorphism, And Neuropathy
- Trial name
- NCT01902940
- Testing
- Natural History
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Fuchs' Endothelial Dystrophy, Cataract
Using the Optovue OCT to Select IOL Power
Many patients with endothelial dysfunction also present with cataracts. It is therefore common practice to perform cataract extraction and intraocular lens (IOL) implantation during the same operation and immediately prior to…
- Trial name
- NCT01361282
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Legacy Health System
Cataract
Comparison of Artificial Intelligent Clinic and Normal Clinic
In this study, the investigators provide participants≤14 years old the artificial intelligent clinic or normal clinic in the purpose of seeking out a better way to make a definite diagnosis with high efficiency and accuracy, and…
- Trial name
- NCT03240848
- Testing
- artificial intelligent clinic, normal clinic, experts diagnose
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Congenital Cataract
The Effect of Ophthalmic Solutions on Contact Lenses Used After Surgery for Congenital Cataract Investigated in Vivo
Patients with congenital cataract operated at St. Erik Eye Hospital are given the topical steroid dexamethasone (Isopto-Maxidex) according to a set treatment plan.
- Trial name
- NCT03125785
- Volunteers
- 80 people
- Sponsor
- St. Erik Eye Hospital
Pediatric Glaucoma
Combined Phacoaspiration and Angle Surgery Versus Phacoaspiration in Pediatric Cataract
The aim of this study is to report the effectiveness of phacoaspiration when combined with angle surgery in preventing postoperative glaucoma following pediatric cataract surgery
- Trial name
- NCT05401760
- Testing
- Group A :combined phacoaspiration and angle surgery, Group B : phacoaspiration only
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Multifocal Contact Lenses
Multifocal Contact Lenses vs Bifocal Spectacles for Congenital Cataracts
In this study, the investigators provide participants who had congenital cataract the multifocal contact lenses and bifocal spectacles in the purpose of seeking out a better way to make a definite diagnosis with high efficiency…
- Trial name
- NCT03260764
- Testing
- short term Multifocal Contact Lenses, short term Bifocal Spectacles, long term Multifocal Contact Lenses
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Unilateral Cataract Extraction, Congenital Cataract
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
The purpose of this study is to evaluate the effect of OMS302 compared to phenylephrine when administered in irrigation solution during cataract extraction on intraoperative pupil diameter, acute postoperative pain, and safety in…
- Trial name
- ILR7 (NCT02132312)
- Testing
- OMS302, Phenylephrine HCl
- Where
- 11 sites in United States
- Volunteers
- 78 people
- Sponsor
- Omeros Corporation
Congenital Cataract
Iridocorneal Angle and Anterior Segment Structure in Eyes of Children With Cataract
The aim of this study is to evaluate the morphology of iridocorneal angle and anterior segment structure in children with cataract, and to explore potential preoperative structural clues for postoperative glaucoma.
- Trial name
- ACA (NCT03778086)
- Testing
- gonioscopy
- Volunteers
- 100 people
- Sponsor
- Wenzhou Medical University
Congenital Cataract
Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy
In this prospective study , a cohort of 58 eyes with congenital cataract from Wenzhou medical university was erolled.33 eyes with congenital cataract was after lensectomy and anterior vitrectomy as post-surger group, 26 eyes…
- Trial name
- NCT04120818
- Testing
- secondary IOL implantation, primary IOL implantation
- Where
- 2 sites in China
- Volunteers
- 59 people
- Sponsor
- yin ying zhao
Cataract Congenital, Astigmatism
Toric Intraocular Lens Implantation in Pediatric Cataract
To evaluate the visual and refractive outcomes after an intraocular lens (IOL) implantation in pediatric eyes with cataract and preexisting corneal astigmatism
- Conditions
- Cataract Congenital, Astigmatism, IOL
- Trial name
- TILIPC (NCT06294795)
- Testing
- congenital/pediatric cataract surgery, Non-Toric IOLs, Toric IOLs
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Kazakh Eye Research Institute
Congenital Cataract
Analysis of Retinal Nerve Fiber Layer and Macular Thickness After Congenital Cataract Surgery
Congenital cataract is the main cause of form deprivation amblyopia in children. Current studies confirm that form deprivation amblyopia affects the retinal nerve fiber layer.
- Trial name
- NCT03621579
- Testing
- cataract surgery
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Fuchs Dystrophy, Cataract
The Evaluation of Balanced Salt Solution During Cataract Surgery
This study aims to identify if the use of BSS PLUS® Sterile Intraocular Irrigating Solution as an irrigation solution leads to improved corneal outcomes vs BSS® Sterile Irrigating Solution in more compromised corneas.
- Trial name
- NCT05853978
- Testing
- BSS Plus, BSS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Adam Fedyk, MD, FACS