Clinical trials: Congenital Diseases
Colorectal Neoplasms, Colorectal Neoplasms Malignant
Smart Measurement of Circulating Tumor DNA
The goal of this study is to develop a blood-test which can detect colorectal cancer in early stages. Participants will be asked to take an extra blood test, which will be analyzed further in the lab.
- Conditions
- Colorectal Neoplasms, Colorectal Neoplasms Malignant, Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Nonpolyposis Colon Cancer
- Trial name
- SMART (NCT06989814)
- Testing
- Blood Product
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Atopic Dermatitis
A Single-center, Randomized, Double-blinded, Placebo-controlled, Phase 1 Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of NCP112
To evaluate safety, tolerability and pharmacokinetics of NCP 112 after single and multiple applications on the skin of healthy male volunteers.
- Trial name
- NCT05638165
- Testing
- NCP112
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- NovaCell Technology Inc.
Gastroschisis, Intestinal Occlusion
Prospective Study of Antenatal Diagnostic Criteria for Digestive Complications of Gastroschisis
Gastroschisis is a rare congenital malformation consisting in a right para-umbilical defect of the abdominal wall leading to an evisceration of the abdominal content.
- Trial name
- LaparoDAN (NCT04174807)
- Where
- 36 sites in France, Martinique
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Danon Disease
Danon Disease Natural History Study
The goal of this international observational study is to learn about the natural history of Danon disease in male patients (≥8 years of age) and female patients (8 to 50 years of age).
- Trial name
- NCT06214507
- Testing
- No intervention
- Where
- 16 sites in United States, Australia and 5 more
- Volunteers
- 60 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Osteoarthritis, Hip, Femur Head Necrosis
Efficiency and Safety of Navigation Aids in Total Hip Arthroplasty With Direct Anterior Approach
This retrospective cohort study aimed to evaluate the effectiveness of an imageless navigation system in total hip arthroplasty (THA) via the direct anterior approach (DAA) on a traction table for reducing functional limb length…
- Conditions
- Osteoarthritis, Hip, Femur Head Necrosis, Developmental Dysplasia of the Hip
- Trial name
- NCT07134036
- Testing
- Navigation system, Conventional total hip arthroplasty
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- China Medical University Hospital
Cyanotic Congenital Heart Disease, Right Ventricular Outflow Tract Obstruction
RVOT Stenting Versus Surgical RV-PA Conduit in Cyanotic Adults
This prospective observational cohort study aims to compare clinical and hemodynamic outcomes of percutaneous right ventricular outflow tract stenting versus surgical right ventricle-to-pulmonary artery conduit placement in…
- Trial name
- NCT07866911
- Volunteers
- 30 people
- Sponsor
- Assiut University
Biliary Atresia
Survival With Own Liver of Conventional Versus Laparoscopic Kasai for Biliary Atresia
This study evaluated laparoscopic (videosurgery) versus conventional (open surgery) Kasai portoenterostomy (anastomosis of small intestine to the liver hilus) in children with biliary atresia.
- Trial name
- NCT01063699
- Testing
- Laparoscopic Kasai operation
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Hannover Medical School
Fetal Growth Restriction
Prostaglandins Versus Trans-cervical Balloon for Induction of Labor in Fetal Growth Restriction (PROBIN)
The goal of this randomized trial is to compare two methods of induction in a fetal growth restriction population. The main question it aims to answer is: Is trans-cervical balloon superior to prostaglandins in reducing the…
- Trial name
- PROBIN (NCT05674487)
- Testing
- Trans-cervical balloon, Misoprostol
- Where
- France
- Volunteers
- 774 people
- Sponsor
- University Hospital, Bordeaux
Primary Immunodeficiency Diseases (PIDD)
Expanded Access to TAK-881 for People With Primary Immunodeficiency Diseases in the USA and Czech Republic
The expanded access program allows people to gain access to an unlicensed treatment on compassionate grounds. This study will provide access to TAK-881 for participants with PIDD who have completed study TAK-881-3002…
- Trial name
- NCT06955793
- Testing
- TAK-881, SC Investigational Needle Sets
- Sponsor
- Takeda
Transcutaneous Vagal Nerve Stimulation (tVNS), Prader-Willi Syndrome
Proof of Concept Study of Vagus Nerve Stimulation
The investigator's recent pilot study of vagus nerve stimulation (VNS) from a surgically implanted medical device to control the excess eating behaviour characteristic of Prader-Willi Syndrome (PWS) found that it was safe and…
- Trial name
- NCT03689621
- Testing
- Transcutaneous vagus nerve stimulation (tVNS)
- Volunteers
- 9 people
- Sponsor
- Jessica Beresford-Webb
Brain Injury, Central Nervous System Degenerative Disorder
Using Ferumoxytol-Enhanced MRI to Measure Inflammation in Patients With Brain Tumors or Other Conditions of the CNS
This pilot clinical trial study will assess the inflammatory response of brain tumors or other central nervous system conditions in pediatric and adult patients using ferumoxytol-enhanced MRI.
- Conditions
- Brain Injury, Central Nervous System Degenerative Disorder, Central Nervous System Infectious Disorder, Central Nervous System Vascular Malformation
- Trial name
- NCT02452216
- Testing
- Ferumoxytol, Tissue Analysis, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Michael Iv
Septal Defect
Deep Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block in Pediatric Cardiac Patients Undergoing Primary Repair of Septal Defects Via Median Sternotomy
In this study we are aiming to compare the Erector Spinae Plane Block and the Deep Parasternal intercostal plane block as regard to their technique, application and outcome in order to describe the most suitable method for…
- Trial name
- NCT06873906
- Testing
- Deep Parasternal intercostal plane block, Erector Spinae Plane Block, conventional analgesic regimen
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Autosomal Dominant Polycystic Kidney Disease, Chronic Kidney Diseases
Atorvastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease
Polycystic Kidney Disease (PKD) is the most common genetic disease leading to End Stage Kidney Disease (ESKD), affecting between 1 in 500-1000 individuals from every ethnic group.
- Trial name
- NCT05870007
- Testing
- Atorvastatin 20 Mg Oral Tablet, Sodium Bicarbonate 600 Mg Oral Tablet
- Where
- 3 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Retinitis Pigmentosa
New Enrollment Post-Approval Study of the Argus® II Retinal Prosthesis System
This post-approval study is being implemented to monitor the use of Argus II System in a larger US population than available within pre-approval studies.
- Trial name
- NCT01860092
- Where
- 17 sites in United States
- Volunteers
- 53 people
- Sponsor
- Second Sight Medical Products
Sickle Cell Disease, COVID-19
COVID-19 Vaccine Response in Sickle Cell Disease
The purpose of this study is to assess the antibody response to COVID-19 vaccination in a cohort of patients with sickle cell disease (SCD) and to assess vaccine and SCD related complications around the time of vaccination.
- Trial name
- NCT05139992
- Testing
- COVID-19 Vaccine
- Where
- 8 sites in United States
- Volunteers
- 59 people
- Sponsor
- ASH Research Collaborative
Sickle Cell Disease
Is the Preoperative Preparation of Sickle Cell Patients Optimal: Assessment of Practices and Post-operative Complications
Children with sickle cell disease systematically receive a transfusion 2 to 5 days before scheduled surgery (with the exception of minor surgeries) in order to avoid post-operative complications of which the vaso-occlusive crisis…
- Trial name
- NCT04264871
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Queen Fabiola Children's University Hospital
Rhinitis, Allergic, Asthma, Allergic
Food-specific IgG4-guided Elimination Diets Improve Allergy Symptoms in Children
Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of…
- Conditions
- Rhinitis, Allergic, Asthma, Allergic, Conjunctivitis, Allergic, Atopic Dermatitis
- Trial name
- NCT06063044
- Where
- China
- Volunteers
- 407 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stage I Kidney Wilms Tumor, Stage II Kidney Wilms Tumor
Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor
This phase III trial is studying vincristine, dactinomycin, and doxorubicin with or without radiation therapy or observation only to see how well they work in treating patients undergoing surgery for newly diagnosed stage I…
- Conditions
- Stage I Kidney Wilms Tumor, Stage II Kidney Wilms Tumor, Stage III Kidney Wilms Tumor
- Trial name
- NCT00352534
- Testing
- 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection, Chest Radiography
- Where
- 240 sites in United States, Australia and 5 more
- Volunteers
- 808 people
- Sponsor
- Children's Oncology Group
Cytomegalovirus Retinitis, HIV Infections
The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes and Disease of the Stomach and Intestines in Patients With HIV
To evaluate the safety and efficacy of oral ganciclovir for prophylaxis against cytomegalovirus (CMV) retinal and gastrointestinal mucosal disease in HIV-infected patients with severe immunosuppression.
- Conditions
- Cytomegalovirus Retinitis, HIV Infections, Gastrointestinal Diseases
- Trial name
- NCT00001034
- Testing
- Ganciclovir
- Where
- 17 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atopic Dermatitis, House Dust Mite Allergy
Skin Responses and T Cell Immunology After House Dust Mite Exposure in Sensitized Atopic Dermatitis Patients
The present study investigates the reaction of the skin upon exposure to house dust mite (HDM) in patients with atopic dermatitis who have antibodies against HDM in the blood.
- Trial name
- CODES (NCT05019209)
- Testing
- House Dust Mite Allergen, Allergen-free air
- Where
- 2 sites in Germany
- Volunteers
- 23 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
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