Clinical trials: Congenital Heart Defect
Congenital Heart Disease
Pharmacokinetics of Acetaminophen in Pediatric Patients With Congenital Heart Disease
This is a prospective study of pediatric patients with congenital heart disease, in which acetaminophen serum concentrations will be measured following a single intraoperative intravenous dose of acetaminophen.
- Trial name
- NCT04278625
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Peter Winch
Congenital Heart Disease
Critical Congenital Heart Defect (CHD) Outcomes in Children
Congenital heart disease in infants and children often challenges healthcare providers both in regards to diagnosis and in the management of these conditions.
- Trial name
- NCT00208689
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Emory University
Congenital Heart Disease
Sophrology and Congenital Heart Disease
The SOPHRO-CARE trial aims to measure the impact of sophrology on exercise capacity of adolescents and young adults with congenital heart disease.
- Trial name
- SOPHRO CARE (NCT03999320)
- Testing
- Sophrology sessions, usual care
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Ventricular Septal Defect
Longterm Outcome After Ventricular Septal Defect Closure
Isolated ventricular septal defect (VSD) is a well know congenital heart anomaly. If discovered in infancy or early childhood surgical intervention can be of necessity depending on the size of the defect, to assure a healthy…
- Trial name
- NCT02138435
- Testing
- MRI exercise test, Gas-exchange exercise test
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Congenital Heart Disease
Imaging by 4 DFlow in Patients With Tetralogy of Fallot
Conventionnal cadiac magnetic resonance (CMR) is the reference to assess changes in right heart flow and pulmonary artery hemodynamics in patients with repaired Tetralogy of Fallot.
- Trial name
- 4DFlowFallot (NCT03542968)
- Testing
- magnetic resonance imaging
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Congenital Heart Disease, Congenital Heart Defect
Comparison of Home and Standard Clinic Monitoring of INR in Patients With CHD
Summary: Congenital heart disease (CHD) is the most prevalent form of birth defect with a global rate of 1.35 million newborns born with CHD annually.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Adult Congenital Heart Disease
- Trial name
- NCT04136379
- Testing
- INR monitoring using a CoaguChek POC device
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Ulster
Congenital Heart Disease (CHD), Structural Heart Disease
Artificial Intelligence-assisted Diagnosis
This study aims to investigate whether an AI-assisted decision support can improve the diagnosis of congenital heart diseases on Chest X-ray.
- Trial name
- AID (NCT06783933)
- Testing
- surgical or interventional validation
- Where
- China
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Congenital Heart Disease
Brain Function in Children With Congenital Heart Disease (CHD)
The purpose of the study is to determine whether the neurodevelopmental outcome and in particular executive functions in 9 to 14 year old school children with congenital heart disease who underwent cardiopulmonary bypass surgery…
- Trial name
- NCT02814539
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bea Latal
Cardiovascular Diseases, Heart Failure
Development of CIRC Technologies
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization.
- Conditions
- Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy
- Trial name
- CIRC (NCT05654272)
- Testing
- MRI
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Congenital Heart Disease, Smartphone Application
The Effects of a CONCOR Smartphone Application
Life expectancy of children with congenital heart disease (CHD) has increased dramatically during the past years, due to the successes of cardiac surgery.
- Conditions
- Congenital Heart Disease, Smartphone Application, Arrhythmia, Heart Failure
- Trial name
- NCT02599857
- Testing
- CONCOR smartphone application
- Where
- Netherlands
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Congenital Heart Disease, Health Related Physical Fitness
Web-based Motor Intervention to Increase Health Related Physical Fitness in Children With Congenital Heart Disease
Children with congenital heart diseases (CHD) often show reduced health related physical fitness as well as limitations in gross and fine motor skills/development.
- Conditions
- Congenital Heart Disease, Health Related Physical Fitness, Motor Skills, Cardiovascular Prevention
- Trial name
- NCT03488797
- Testing
- Supervised web- and home-based exercise intervention
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Heart Disease, Cystic Fibrosis
Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung Disease
The primary objective of this study is to determine if quantitative Dynamic contrast-enhanced magnetic resonance (DCE MR) perfusion imaging accurately quantifies right and left pulmonary artery blood flow as compared with phase…
- Conditions
- Heart Disease, Cystic Fibrosis, Asthma
- Trial name
- NCT01192360
- Testing
- Phase contrast flow velocity mapping (PC), Dynamic contrast-enhanced magnetic resonance imaging
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- The Hospital for Sick Children
Pulmonary Arterial Hypertension of Congenital Heart Disease
Observatory of Pulmonary Arterial Hypertension of Congenital Heart Disease
The complex congenital cardiac malformations are a significant number of different diseases, each having specific natural histories.
- Trial name
- ItinerAir (NCT02260362)
- Where
- France
- Volunteers
- 349 people
- Sponsor
- French Cardiology Society
Congenital Heart Disease
Health Literacy in Adults With Congenital Heart Disease
Currently, both oral and written health education make certain assumptions about the health literacy of patients and their parents.
- Trial name
- NCT03170024
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Stanford University
Congenital Heart Disease
Pulmonary Capillary Recruitment in Fontan Patients
This study evaluates the effects of pulmonary vasodilator therapy on pulmonary capillary blood flow by measuring the functional capillary surface area (FCSA) at baseline and post nitric oxide inhalation, through the injection of…
- Trial name
- NCT04292483
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Jewish General Hospital
Congenital Heart Disease in Children
How to Report Postoperative Outcomes After a Paediatric Cardiac Surgery ?
Congenital heart disease is a common abnormality in newborns. The marked improvement in the surgical management of congenital heart disease has led to a reduction in postoperative mortality, historically a quality criterion for…
- Trial name
- Pedia-Card (NCT05546983)
- Where
- France
- Volunteers
- 189 people
- Sponsor
- University Hospital, Strasbourg, France
Vocal Fold Palsy, Dysphagia
Universal Screening for Vocal Fold Motion Impairment in Children Undergoing Congenital Cardiac Surgery
The purpose of this study is to determine how often heart or chest surgery in children leads to problems with the movement of the vocal folds.
- Conditions
- Vocal Fold Palsy, Dysphagia, Congenital Heart Disease in Children
- Trial name
- NCT03882450
- Testing
- Flexible fiberoptic laryngoscopy, Laryngeal ultrasonography
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Emory University
Heart Failure, Cardiac Imaging Techniques
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients
Overall Research Strategy of this protocol is to refine and validate noninvasive CMR imaging sequences with invasive hemodynamic and pathology results to create a comprehensive, noninvasive, radiation-reduced regimen for…
- Conditions
- Heart Failure, Cardiac Imaging Techniques, Congenital Heart Defects
- Trial name
- NCT03822442
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Children's National Research Institute
Congenital Heart Disease
Does Modified Ultrafiltration Affect Thromboelastography Results?
The study is to evaluate the effect of modified ultrafiltration on different components of Thromboelastography (TEG) in neonates undergoing cardiac surgery using cardiopulmonary bypass.
- Trial name
- NCT03214120
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Patent Ductus Arteriosus, Congenital Heart Disease
PDA for Kidneys Study
The goal of this observational study is to gather more information on kidney oxygen levels in babies with a patent ductus arteriosus (PDA), and evaluate the relationships between kidney oxygen levels, PDA status and kidney…
- Trial name
- PDA4K (NCT06658496)
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Wisconsin, Madison