Clinical trials: Congenital Ichthyosis
Partial-thickness Burn Wounds
Evaluating Whether Intact Fish Skin Graft Can Decrease the Need for Autograft in the Treatment of Deep Partial-Thickness Burns
The goal of this randomized controlled clinical trial is to determine whether use of Kericis Intact Fish Skin Graft (IFSG) can decrease the amount of autograft tissue needed for treatment of deep partial-thickness burns in…
- Trial name
- LOGI (NCT07326657)
- Testing
- Intact fish skin graft, autograft
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Kerecis Ltd.
Irritable Bowel Syndrome
Neuroimaging and Biomarkers in Chronic Visceral Pain
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to evaluate brain resting state networks, responses to abdominal stimuli and the effect of MBSR Training on these measures.
- Trial name
- NCT01602575
- Testing
- Mindfulness based Stress Reduction Training (MBSR)
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of California, Los Angeles
TGM-1 Related Autosomal Recessive Congenital Ichthyosis
Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)
This study is an intra-patient comparison of KB105 and placebo-administered Target Areas. The primary objectives of this study are to evaluate safety and Investigator Global Assessment (IGA) scale improvement of topically…
- Trial name
- NCT04047732
- Testing
- KB105
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Krystal Biotech, Inc.
Ichthyosis
Efficacy of Injectable Gentamicin in Hereditary Ichthyosis
This study will evaluate the efficacy and safety of intravenous gentamicin in congenital ichthyosis due to a non-sens mutation. The primary objective is the severity of scales and erythema at the third month, compared to…
- Trial name
- GENTIC (NCT06362447)
- Testing
- Gentamicin Injectable Solution
- Where
- 2 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Toulouse
IBS - Irritable Bowel Syndrome, General Population
International Psychometric Validation Study of the Intestinal Gas Questionnaire (IGQ)
Objective: To confirm the psychometrics properties of the Intestinal Gas Questionnaire (IGQ) in subjects with Irritable Bowel Syndrome (IBS) diagnosis and General population both complaining of Gas-Related Symptoms (GRS).
- Trial name
- PRoVING (NCT03002584)
- Testing
- completion of self-reported questionnaires
- Where
- 5 sites in France, Spain and 1 more
- Volunteers
- 300 people
- Sponsor
- University Paris 7 - Denis Diderot
Irritable Bowel Syndrome With Diarrhea
Efficacy Study of Rezular (Arverapamil) in the Treatment of Irritable Bowel Syndrome With Diarrhea (IBS-D)
The purpose of the study is to determine the efficacy and safety of Rezular (arverapamil) in the treatment of IBS-D.
- Trial name
- ARDIS-1 (NCT00552565)
- Testing
- Rezular 15mg, Rezular
- Where
- United States
- Volunteers
- 711 people
- Sponsor
- AGI Therapeutics, Inc.
Autosomal Recessive Congenital Ichthyosis, Skin Barrier Dysfunction
Cholesterol Cream vs Urea Cream for Skin Barrier and Quality of Life in Ichthyosis
This study looks at whether a cream containing 10% cholesterol works better than a cream containing 10% urea for people with autosomal recessive congenital ichthyosis (ARCI), a rare inherited skin condition that causes dry…
- Conditions
- Autosomal Recessive Congenital Ichthyosis, Skin Barrier Dysfunction, Ichthyosis Inherited
- Trial name
- CURE-ARCI (NCT07689435)
- Testing
- 10% Cholesterol Cream, 10% Urea cream
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Institute of Dermatology, Thailand
Ichthyosis
An Open-Label and Long-Term Extension Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Patients With Ichthyoses
The ichthyoses are a group of lifelong genetic disorders that share characteristics of generalized skin thickening, scaling and underlying cutaneous inflammation.
- Trial name
- NCT04549792
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Northwestern University
Soft Tissue Sarcoma, Sts
Neoadjuvant ADI-PEG 20 + Ifosfamide + Radiotherapy in Soft Tissue Sarcoma
In this study, patients with soft tissue sarcoma (STS) will receive ADI-PEG 20 and ifosfamide in combination with radiation as neoadjuvant therapy.
- Conditions
- Soft Tissue Sarcoma, Sts, Sarcoma,Soft Tissue
- Trial name
- NCT05813327
- Testing
- ADI PEG20, Ifosfamide, Radiotherapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Washington University School of Medicine
Congenital Ichthyosis
A Safety and Tolerability Study of Topical PAT-001 in Congenital Ichthyosis
Congenital ichthyosis (CI) is a large, heterogeneous family of inherited skin disorders of cornification resulting from an abnormality of skin keratinization, such as scaling and thickening of the skin.
- Trial name
- NCT02864082
- Testing
- PAT-001, 0.1%, PAT-001, 0.2%, Vehicle for PAT-001 0.1%
- Where
- 5 sites in United States
- Volunteers
- 19 people
- Sponsor
- Patagonia Pharmaceuticals, LLC