Clinical trials: Congenital Lung Malformation
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome in Premature Infant
Budesonide With Intratracheal Surfactants in Extremely Preterm Infants
This is a phase I/II trial in preterm infants aimed at identifying the optimal dose of budesonide with bovine lipid extract surfactant as vehicle for intratracheal administration.
- Trial name
- BITS (NCT04019106)
- Testing
- Budesonide in bovine lipid extract surfactant (BLES)
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Asthma, Allergic Rhinitis
Fractional Exhaled Nitric Oxide (FeNO) Result Prediction Factors in Children With Allergic Diseases
In about 800 children with allergic diseases (asthma, allergic rhinitis, atopic dermatitis) the investigators will retrospectively and cross-sectionally analyze the influence/correlation of diagnosis, treatment methods, allergy…
- Conditions
- Asthma, Allergic Rhinitis, Atopic Dermatitis
- Trial name
- NCT00815984
- Testing
- measurements of lung function tests
- Where
- Poland
- Volunteers
- 800 people
- Sponsor
- Medical University of Lodz
Bronchopulmonary Dysplasia, Thrombocytopenia
Thrombocytopoiesis and Platelet Homeostasis in Infants With Bronchoplumonary Dysplasia
To investigate the relationship between bronchopulmonary dysplasia and thrombocytopenia.
- Conditions
- Bronchopulmonary Dysplasia, Thrombocytopenia, Preterm Infant
- Trial name
- BPD (NCT04348799)
- Testing
- BPD
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- yangjie
Intrauterine Growth Restriction, Cardiopulmonary Disease
IUGR, Respiratory Muscle Function, and Exercise Capacity in Childhood
The study hypothesis is that intrauterine growth restriction (IUGR) may have long-term effects on respiratory muscle (RM) function, thus leading to reduced exercise capacity later in life.
- Trial name
- NCT03368755
- Testing
- Cardiopulmonary Exercise Testing, Respiratory Muscle Strength and Endurance
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University of Patras
Asthma, Cystic Fibrosis
Investigating Mucinase Activity in Airway Disease
The purpose of this study is to investigate how mucus (phlegm or spit) is broken down once it forms in the airways (bronchial tubes) of people with lung disease.
- Trial name
- Mucinase (NCT00596232)
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Cystic Fibrosis
Cystic Fibrosis and Endothelial Function: At Rest and During Exercise
Perhaps one of the most disturbing aspects of Cystic Fibrosis (CF) is the associated premature death. Oxidative stress has been observed in patients with CF and exercise intolerance has been shown to predict mortality in patients…
- Trial name
- NCT01772758
- Testing
- BH4 5mg, BH4 20mg, Antioxidant Cocktail
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Augusta University
Asthma, Diabetes Mellitus
Coordinated HEalthcare for Complex Kids
The University of Illinois Health and Health Sciences System (UI Health) developed an integrated care management quality improvement model designed to provide comprehensive care coordination for Medicaid insured minority children…
- Conditions
- Asthma, Diabetes Mellitus, Sickle Cell Disease, Premature Birth
- Trial name
- CHECK (NCT04057521)
- Testing
- Care Coordination
- Volunteers
- 6,259 people
- Sponsor
- University of Illinois Chicago
Hereditary Haemorrhagic Telangiectasia, Pulmonary Arteriovenous Malformation
Pulmonary Arteriovenous Malformations (PAVMs) in Hereditary Haemorrhagic Telangiectasia (HHT)
Computed tomography (CT) is the modality of choice to characterize pulmonary arteriovenous malformations (PAVMs) in patients with hereditary haemorrhagic telangiectasia (HHT).
- Conditions
- Hereditary Haemorrhagic Telangiectasia, Pulmonary Arteriovenous Malformation, Cerebral Disorder
- Trial name
- PAVM (NCT03940014)
- Testing
- Data collection from standard follow up
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Cystic Fibrosis
Trial to Evaluate Efficacy and Safety of Lenabasum in Cystic Fibrosis
This is a Phase 2 multicenter, double-blind, randomized, placebo-controlled study assessing the efficacy and safety of lenabasum for the treatment of cystic fibrosis in patients 12 years of age or older.
- Trial name
- NCT03451045
- Testing
- Lenabasum 20 mg, Lenabasum 5 mg
- Where
- 105 sites in United States, Austria and 19 more
- Volunteers
- 447 people
- Sponsor
- Corbus Pharmaceuticals Inc.
Tetralogy of Fallot
Pediatric REPlAcement of the PulmonaRy ValvE in Tetralogy of Fallot -
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect with the vast majority of survivors of corrective surgery left with some degree of right ventricular (RV) volume overload due to pulmonary…
- Trial name
- TOFandPVR (NCT03634072)
- Testing
- PVR
- Where
- 6 sites in United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital of Philadelphia
Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn
Milrinone in Congenital Diaphragmatic Hernia
Infants with congenital diaphragmatic hernia (CDH) usually have pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN) leading to hypoxemic respiratory failure (HRF).
- Conditions
- Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure, Pulmonary Hypoplasia
- Trial name
- NCT02951130
- Testing
- Milrinone
- Where
- 19 sites in United States
- Volunteers
- 66 people
- Sponsor
- NICHD Neonatal Research Network
Transient Tachypnea of the Newborn
High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation
The primary objective is to determine whether High Flow Nasal Cannula (HFNC) is a superior respiratory modality for neonates ≥36 weeks with transient tachypnea of the newborn (TTN) when compared to the standard of care modality…
- Trial name
- NCT01270581
- Testing
- High Flow Nasal Cannula, Bubble Nasal CPAP
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cystic Fibrosis
Efficacy of a New Sweat Collection Support: Impact on Neonatal Screening and Early Treatment of Cystic Fibrosis
In nearly 25% of children under 3 months, the sweat test produces a quantity of sweat that does not meet international recommendations and is insufficient to allow reliable and reproducible biological analyzes in the sweat…
- Trial name
- MACRODUCT-3710 (NCT03913507)
- Testing
- Macroduct® Advanced Model 3710 SYS, Wescor
- Where
- Belgium
- Volunteers
- 57 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cystic Fibrosis
Cystic Fibrosis (CF) Flow Rates Study
We wish to measure the inspiratory flow and volumes generated by the subjects inhaling from a spirometer with a high resistance dry powder inhaler in series in subjects with cystic fibrosis.
- Trial name
- NCT00779077
- Volunteers
- 25 people
- Sponsor
- Syntara
Cystic Fibrosis, Lung Diseases
Gene Modifiers of Cystic Fibrosis Lung Disease
The purpose of this study is to examine genetic modifiers of the severity of cystic fibrosis lung disease.
- Trial name
- NCT00037765
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of North Carolina, Chapel Hill
Cystic Fibrosis
Epidemiology and Clinical Characteristics of Non-Tuberculous Mycobacteria Infections in Cystic Fibrosis Patients.
An increase in the prevalence of infections due to non-tuberculous mycobacteria (NTM) is observed in many countries and recent data suggest the circulation of dominant clones with a possibility of human-to-human contamination.
- Trial name
- CIMENT (NCT03312075)
- Testing
- Sputum and blood samples
- Where
- 14 sites in France
- Volunteers
- 848 people
- Sponsor
- University Hospital, Brest
Advanced Malignant Solid Neoplasm, Recurrent Ependymoma
Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well larotrectinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with NTRK fusions that may have spread from where it first started to…
- Conditions
- Advanced Malignant Solid Neoplasm, Recurrent Ependymoma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Glioma
- Trial name
- NCT03213704
- Testing
- Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan
- Where
- 124 sites in United States, Puerto Rico
- Volunteers
- 9 people
- Sponsor
- National Cancer Institute (NCI)
Cystic Fibrosis, Physical Activity
Do More, B'More, Live Fit
Physical activity (PA) in individuals with cystic fibrosis (CF) improves exercise capacity, slows decline in lung function, increases mucus clearance and improves health-related quality of life (HRQoL).
- Trial name
- NCT03109912
- Testing
- Personalized-Coaching Interventions, Motivational Messages, Online Exercise Tutorials
- Volunteers
- 45 people
- Sponsor
- Johns Hopkins University
Alpha-1 Anti-trypsin Deficiency
AL1TER™: Alpha-1 Therapy, Evaluation, and Research Patient Registry
This is a longitudinal, observational, non-interventional registry study, designed to collect both retrospective and prospective real world data, on patients receiving Alpha-1 augmentation therapy in the home through Coram…
- Trial name
- AL1TER (NCT01974830)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Coram Clinical Trials
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