Clinical trials: Congestion
Pain, Chronic Primary
Pain and Clinical Reflections in Pelvic Congestion Syndrome
Pelvic congestion syndrome (PKS) occurs as a result of dysfunction of the veins in the pelvic area. It is currently called pelvic venous disease.
- Trial name
- NCT06507267
- Testing
- Pain and Clinical Reflections in Pelvic Congestion Syndrome
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Cardiovascular Insufficiency, Venous Congestion
Fluid Challenge Impact in the Portal Vein Pulsatility Depending on the Fluid Responsivness Status
Portal vein pulsatility index is a marker of venous congestion evaluated by point of care ultrasound. It is associated with acute kidney injury, especially in critically ill patients. It may be considered as a dynamic marker.
- Trial name
- FLUID-REVENGE (NCT05828407)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Hospices Civils de Lyon
Heart Failure
A Phase 2 Study to Evaluate the Cardiac and Renal Effects of Short Term Treatment With Elamipretide in Patients Hospitalized With Congestion Due to Heart Failure
This is a phase 2 randomized, double-blind, placebo-controlled study to evaluate the cardiac and renal effects of short term treatment with elamipretide in patients hospitalized with congestion due to heart failure
- Trial name
- NCT02914665
- Testing
- elamipretide
- Where
- 46 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 308 people
- Sponsor
- Stealth BioTherapeutics Inc.
Acute Decompensated Heart Failure
Compression Therapy of the Lower Limbs in Patients With Decompensated Heart Failure
Randomized 1:1 multicenter double-blind clinical investigation evaluating the efficacy and safety of compression therapy of the lower limbs plus parenteral administration of diuretics vs.
- Trial name
- NCT06418932
- Testing
- UrgoK2 / UrgoK2 Lite, Controll
- Where
- 8 sites in Spain
- Volunteers
- 106 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Congestion, Venous
Hepatic Doppler to Assess Venous Congestion During Invasive Mechanical Ventilation (DOHECOV)
The purpose of the study is to investigate venous congestion using hepatic vein doppler for ICU patients with invasive mechanical ventilastion. The primary outcome is the systolic to diastolic hepatic vein velocity ratio S/D .
- Trial name
- DOHECOV (NCT06914336)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Pelvic Pain
Assessment of Pain of Pelvic Congestion Syndrome Treated by Coils Embolization
Summary: Main Objective: to evaluate the efficacy of pelvic gonadal vein embolization with coils in treatment of pelvic congestion syndrome Methods: retrospective study included 25 patients in the University hospital of Brest.
- Trial name
- SCVPC (NCT04461860)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Transcatheter Aortic Valve Replacement, Lung Ultrasound
LUS in Aortic Stenosis Patients Undergoing TAVR
1. Introduction and aims: Transcatheter aortic valve replacement (TAVR) is the gold standard for the treatment of elderly patients with severe aortic valve stenosis (AS).
- Conditions
- Transcatheter Aortic Valve Replacement, Lung Ultrasound, Severe Aortic Valve Stenosis, Pulmonary Congestion
- Trial name
- NCT05024942
- Testing
- Transfemoral TAVR (Transcatheter aortic valve replacement)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Catholic University of the Sacred Heart
Acute Heart Failure
Loop Diuretic Therapy in Acutely Decompensated Heart Failure
DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF.
- Trial name
- DIUR-AHF (NCT02638142)
- Testing
- Continuous Furosemide Infusion, Intermittent Furosemide Infusion
- Where
- 4 sites in Italy
- Volunteers
- 370 people
- Sponsor
- University of Siena
Sleep Disturbance
Sleep Disturbance in Chronic Rhinitis
The aim of this study is to evaluate the characteristic of sleep disturbance in allergic and non-allergic rhinitis in Dr. Cipto Mangunkusumo Hospital, Jakarta.
- Trial name
- NCT05312723
- Where
- Indonesia
- Volunteers
- 22 people
- Sponsor
- Universitas Indonesia
Pelvic Congestion Syndrome
Endovascular Management of Pelvic Congestion Syndrome
Pelvic congestion syndrome (PCS) is a common cause of chronic pelvic pain in women and is associated with pelvic venous insufficiency.
- Trial name
- PCSIR (NCT07735156)
- Testing
- Endovascular embolization
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Acute Heart Failure
Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation
The AHF-CODE preserved study is a prospective, non-randomized, monocenter study performed in patients with heart failure with preserved ejection fraction admitted for worsening heart failure.
- Trial name
- AHF-CODE-P (NCT04343430)
- Testing
- Clinical examination centered on congestion, Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography, Biological: Blood sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Central Hospital, Nancy, France
Post-Op Complication, Skin Flap Necrosis
Quantifying the Venous Congestion Curve of a Tissue Oximetry Device
The purpose of this research study is to measure rate of decline and pattern of tissue oxygenation using the device, ViOptix T.Ox. ViOptix probes will be secured to the arm and hand.
- Trial name
- NCT05592145
- Testing
- ViOptix
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Acute Heart Failure, Pulmonary Congestion
LUS in Acute Heart Failure Therapeutic Adaptation
Evaluate lung ultrasound aspect according to diuretics dosage evolution in patients hospitalized for acute heart failure.
- Trial name
- EPPICA (NCT04633629)
- Testing
- Lung ultrasound
- Volunteers
- 94 people
- Sponsor
- University Hospital, Grenoble
Chronic Rhinitis
Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion
Nasal glucocorticosteroids (GCS) are considered first-line therapy for both allergic and non-allergic rhinitis.1-3 Nasal congestion can persist despite maximum treatment with intranasal GCS.
- Trial name
- NCT00584662
- Testing
- Oxymetazoline Hydrochloride
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of South Florida
Systolic Chronic Heart Failure, Congestion, Venous
Ultrasound-assessed Internal Jugular Vein Distensibility in Advanced Chronic Heart Failure (US-IJVD in CHF)
Prospective validation of the ultrasound-assessed internal jugular vein distensibility (JVD) ratio to identify patients with systolic chronic heart failure and right atrial pressure (RAP) of 7 or less mmHg measured by the right…
- Conditions
- Systolic Chronic Heart Failure, Congestion, Venous, Advanced Heart Failure
- Trial name
- US-IJVD-CHF (NCT03874312)
- Testing
- Linear ultrasound (US) assessment of the internal jugular vein
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Niguarda Hospital
Nasal Congestion
Functional Magnetic Resonance Imaging (fMRI) Study of Nasal Strips in Nasal Congestion
The aim of the study is to evaluate the effect of the nasal strip (relative to the placebo strip) on the nasal passages using anatomical MRI scans and to demonstrate the effect of the strip on breathing correlated cortical…
- Trial name
- NCT02275364
- Testing
- Test strip, Nasal spray
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Heart Failure
Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure.
Intravenous (IV) loop diuretics have been a key component in treating pulmonary edema since the 1960s and has a Class 1 recommendation in the 2021 guidelines for acute heart failure.
- Trial name
- NCT06024889
- Testing
- Furosemide Injection
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Johannes Grand
Surgery--Complications, Congestive Heart Failure
The Clinical Significance of Portal Hypertension After Cardiac Surgery: a Multicenter Prospective Observational Study
Portal flow pulsatility detected by Doppler ultrasound is an echographic marker of cardiogenic portal hypertension from right ventricular failure and is associated with adverse outcomes based on previous studies performed at the…
- Conditions
- Surgery--Complications, Congestive Heart Failure, Right Heart Failure, Anesthesia
- Trial name
- TECHNO-MULTI (NCT03656263)
- Testing
- Doppler assessment of portal vein flow
- Where
- Canada
- Volunteers
- 360 people
- Sponsor
- Montreal Heart Institute
Sleep Disordered Breathing, Congestion, Nasal
To Characterize the Performance of the Nasal Dilator Strip in Lowering Nasal Resistance During Sleep, Promoting Nasal Route Breathing and Reducing the Signs and Symptoms of Sleep Disordered Breathing in a Group of Chronic Nocturnal Nasal Congestion Sufferers Who Report Trouble With Their Sleep.
To characterize the performance of the nasal dilator strip in lowering nasal resistance during sleep, promoting nasal route breathing and reducing the signs and symptoms of sleep disordered breathing in a group of chronic…
- Trial name
- NCT03105297
- Testing
- Prototype nasal dilator strip, No strip
- Where
- Australia
- Volunteers
- 91 people
- Sponsor
- GlaxoSmithKline
Congestive Heart Failure
BioImpedentiometry, Lung UltraSound and cONgestion in Heart Failure
The purpose of this study is to validate non-invasive and user-friendly methods to monitor systemic and pulmonary congestion in heart failure patients.
- Trial name
- BLUEMOON (NCT02394470)
- Testing
- Deuterium oxide dilution, Bioimpedentiometry, Lung and subcutaneous ultrasound
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Niguarda Hospital