Clinical trials: Congestion, active
Acute Heart Failure
Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation
The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure.
- Trial name
- AHF-CODE-R (NCT04343443)
- Testing
- Clinical examination centered on congestion, Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography, Biological: Blood sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Allergic Rhinitis, Chronic Rhinitis
Laser Posterior Nasal Nerve Neurolysis
This clinical trial aims to learn if laser posterior nasal nerve neurolysis can treat chronic rhinitis in adults. It will also learn about the safety of laser posterior nasal nerve neurolysis.
- Conditions
- Allergic Rhinitis, Chronic Rhinitis, Rhinorrhea, Sneezing
- Trial name
- LPN3 (NCT07050992)
- Testing
- Laser posterior nasal nerve neurolysis
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chiayi Christian Hospital
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
VExUS in Ards Patients and Association with AKI
A single-center prospective observational study will be conducted with the aim of determining the prevalence of venous congestion during ARDS using venous Doppler and the VExUS score.
- Trial name
- VEXAKI (NCT06805409)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury After Open Heart Surgery, Venous Congestion After Open Heart Surgery
Evaluation of the Association Between the VEXUS Score and Hemodynamic Status and the Occurrence of Acute Kidney Injury After Open-Heart Surgery
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass and is associated with prolonged intensive care unit stay, increased morbidity, and mortality.
- Trial name
- NCT07805564
- Where
- Vietnam
- Volunteers
- 135 people
- Sponsor
- Hanoi Medical University
Chronic Heart Failure, Reduced Ventricular Ejection Fraction
CHF-COV Reduced (Chronic Heart Failure With Reduced Ejection Fraction - COngestion eValuation)
Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of hospitalization for HF.
- Trial name
- CHF-COVReduced (NCT05089162)
- Testing
- Clinical examination centered on congestion, Cardiac, pulmonary, peritoneal, jugular and renal Doppler ultrasounds, Blood sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Pr. Nicolas GIRERD
Acute Dyspnea, Dyspnea
Proof-of-concept Study on Dyspnea Analysis Via GapCO2
Patients presenting to the emergency department with acute dyspnea undergo arterial blood gas measurement and monitoring of transcutaneous capnography using the TCM5 monitor.
- Trial name
- MicroDys (NCT06556797)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure Acute, Discharge Follow-up Phone Calls
Congestion and LActate at diScHarge in Acute Heart Failure
Acute heart failure (AHF) is a leading cause of hospitalization and is associated with high short-term morbidity and mortality, with 20-30% of patients experiencing rehospitalization or death within 30 days.
- Conditions
- Heart Failure Acute, Discharge Follow-up Phone Calls, Mortality Prediction
- Trial name
- CLASH-HF (NCT07345156)
- Testing
- Lung Ultrasound Score, Lactate Blood Test
- Where
- Tunisia
- Volunteers
- 350 people
- Sponsor
- University of Monastir
Heart Failure With Reduced Ejection Fraction (HFrEF), Congestive Heart Failure(CHF)
BIOmarker Based Diagnostic TOOLkit to Personalize Pharmacological Approaches in Congestive Heart Failure
This retrospective study will take advantage of an existing EU-funded dataset, the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF), which was designed to identify biomarkers related to the response to…
- Trial name
- NCT07470554
- Where
- Italy
- Volunteers
- 4,254 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Congestion, RRT
Optimization of Fluid Balance Guided by Bioelectrical Impedance Analysis in Patients Undergoing Continuous Renal Replacement Therapy in Critical Care
In critical care, hemodynamic instability often requires volume expansion to restore tissue perfusion, increasing fluid balance and TBW, factors associated with higher mortality.
- Conditions
- Congestion, RRT, UF, Bio-impendance Analysis
- Trial name
- OBHIMER (NCT06799910)
- Testing
- continuous renal replacement therapy (CRRT), Free UF Prescription
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bronchial Congestion, Airway Clearance Impairment
Bronchial Clearance Carried Out With a Mechanical In-exsufflator vs. a Manual Respiratory Physiotherapy Technique in Hospitalized Elderly People
Everywhere in the world, life expectancy is increasing. Currently, most individuals can expect to live up to 60 years and beyond. In all countries, the number and proportion of older adult in the population are rising.
- Trial name
- INEXPA2 (NCT06730217)
- Testing
- Intervention : mechanical insufflator, Control : standard care
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Nasal Congestion, Common Cold
Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers
The goal of this observational post-market clinical follow-up study is to evaluate the safety and performance of the CE-marked nasal spray for the relief of nasal congestion in infants and toddlers aged 6 to 48 months at day 5…
- Conditions
- Nasal Congestion, Common Cold, Allergic Rhinitis, Rhinosinusitis
- Trial name
- NASBY (NCT07257224)
- Testing
- Quinton Medical Nasal Health Baby®
- Where
- 2 sites in Spain
- Volunteers
- 83 people
- Sponsor
- Laboratoires Quinton International S.L.
Heart Failure, NYHA Class III Heart Failure
NORM-HF Pivotal Study
This is an international, multi-center, prospective, randomized, open-label blinded endpoint study designed to demonstrate that use of the FIRE1 NORM™ System in the management of New York Heart Association Class II/III HF…
- Conditions
- Heart Failure, NYHA Class III Heart Failure, NYHA Class II Heart Failure
- Trial name
- NORM-HF (NCT07574593)
- Testing
- IVC Sensor
- Where
- 25 sites in United States
- Volunteers
- 800 people
- Sponsor
- Foundry Innovation & Research 1, Limited (FIRE1)
Heart Failure
Evaluation of the Effects of Sauna Therapy on Congestion and Loop Diuretic Use in Patients With Heart Failure With Reduced or Moderately Reduced Ejection Fraction
This study aims to evaluate the effect of sauna therapy on congestion levels during cardiac rehabilitation in patients with heart failure who have an impaired or moderately impaired ejection fraction, compared to standard cardiac…
- Trial name
- SAUNA-HF RCT (NCT07468344)
- Testing
- Sauna
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Weaning Failure, Pulmonary Edema - Acute
Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation
Mechanical ventilation is an essential, life-saving therapy in the ICU, allowing critically ill patients to rest and recover. Transitioning patients back to spontaneous breathing-known as weaning-is clinically challenging.
- Conditions
- Weaning Failure, Pulmonary Edema - Acute, Mechanical Ventilation, POCUS
- Trial name
- SCOUT (NCT07343882)
- Testing
- point of care ultrasound
- Volunteers
- 350 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Heart Failure
Patient-Reported Health Status Assessment Using the KCCQ for Early Detection of Heart Failure Worsening
This observational feasibility study aims to assess (i) how practical and acceptable repeated KCCQ assessments are; (ii) the connection between changes over time in KCCQ scores and signs of congestion; and (iii) clinical…
- Trial name
- KCCQ-WHF (NCT07552142)
- Testing
- Serial KCCQ assessments delivered via chatbot
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Heart Failure With Preserved Ejection Fraction
Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction
The heart is a pump that must both fill and empty effectively to move blood; if it cannot move enough, heart failure may ensue. Approximately half of all adults living with heart failure have a form where the heart stiffens…
- Trial name
- NCT05582044
- Testing
- Lower-body Negative Pressure (-25 mmHg), Lower-body Negative Pressure (-15 mmHg), Lower-body Neutral Pressure (0 mmHg)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after surgery and anesthesia. Its primary clinical manifestations include a significant decline in cognitive abilities after surgery and…
- Trial name
- NCT07483151
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POCD assessments
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhuan Zhang
Acute Heart Failure
a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure
The goal of this observational is to study the prevalence of distinct congestion phenotypes and study their association with response to therapy and outcomes in acute heart failure patients.
- Trial name
- PROFILE-AHF (NCT06587854)
- Where
- Netherlands
- Volunteers
- 270 people
- Sponsor
- University Medical Center Groningen
Congestive Heart Failure(CHF)
BIOmarker Based Diagnostic TOOLkit to Personalise Pharmacological Approaches in Congestive Heart Failure: the BIOTOOL-CHF Validation Trial
By the re-analysis, in the BIOTOOL-CHF DISCO study, of a previously enrolled cohort of patients, a Biological Congestion Score (BCS) was newly developed.
- Trial name
- NCT07635810
- Testing
- Intervention: diuretic therapy guided by the Biological Congestion Score (BCS) using a predefined treatment nomogram
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pelvic Congestion Syndrome
Embolization of Ovarian Vein and Pelvic Venous Reservoir for Treatment of Secondary Pelvic Congestion Syndrome
Transcatheter Embolization of Ovarian Vein and Pelvic Venous Reservoir for Treatment of Pelvic Congestion Syndrome Secondary to May-Thurner Syndrome.
- Trial name
- NCT07472504
- Testing
- embolization therapy
- Volunteers
- 100 people
- Sponsor
- Mark Magdy Zekry