Clinical trials: Congestive Heart Failure(CHF)
Heart Failure, Myocardial Infarction
Impact of Intracoronary Injection of Autologous BMMC for LV Contractility and Remodeling in Patients With STEMI
This is multicentre, randomised open-label, controlled, parallel-group phase III study. Its aim is to demonstrate that a triple intracoronary infusion of autologous bone marrow-derived mononuclear cells in addition to state of…
- Trial name
- RACE-STEMI (NCT02323620)
- Testing
- Intracoronary infusion of BM-MC
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- American Heart of Poland
Congestive Heart Failure, Tricuspid Regurgitation
Hemodynamic Implications of Transcatheter Tricuspid Valve Repair in HFpEF Patients
The aim of the study is to investigate the pathophysiological implications of transcatheter tricuspid valve edge-to-edge repair in patient with heart failure and preserved ejection fraction and severe tricuspid regurgitation.
- Trial name
- HERACLES-HFpEF (NCT04782908)
- Testing
- Transcatheter tricuspid valve edge-to-edge repair
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Heart Center Leipzig - University Hospital
Heart Failure, Respiratory Failure
Microcirculation in Venoarterial Extracorporeal Membrane Oxygenation Life Support
Extra-corporeal membrane oxygenation (ECMO) life support system can provide both cardiac and respiratory support to patients with heart and respiratory failure.
- Trial name
- NCT02393274
- Testing
- Extra-corporeal membrane oxygenation life support
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Ventricular Tachycardia, Ventricular Fibrillation
DF4 Connector System Post-Approval Study
The purpose of this study is to evaluate long-term performance of the DF4 Connector System. This evaluation is based on the number of DF4 lead-related complications occurring during the study compared to the number of leads…
- Conditions
- Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death, Heart Failure
- Trial name
- NCT01638897
- Where
- 78 sites in United States, Canada and 1 more
- Volunteers
- 1,778 people
- Sponsor
- Medtronic
Heart Failure
Application of Nanotechnology and Chemical Sensors for Diagnosis of Decompensated Heart Failure by Respiratory Samples
Application of Nanotechnology and Chemical Sensors for Diagnosis of Decompensated Heart Failure by Respiratory Samples. Breath testing, which links specific volatile molecular biomarkers in exhaled breath to medical conditions…
- Trial name
- NCT03083717
- Testing
- Collection of breath samples, followed by analysis of exhaled breath using nanomaterial-based sensors (NaNose)
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Heart Failure
Benefits of Microcor in Ambulatory Decompensated Heart Failure
To assess investigator engagement of μCor system data in the context of heart failure management. The μCor system includes a sensor and wearable patch for fluid management.
- Trial name
- BMAD-TX (NCT04096040)
- Testing
- μCor
- Where
- 83 sites in United States, Austria and 2 more
- Volunteers
- 265 people
- Sponsor
- Zoll Medical Corporation
Heart Failure
Efficacy of Candesartan on Symptomatic Heart Failure in Treating Diabetic and Hypertensive Patients.
The purpose of this study is to determine the effects of candesartan, once daily (QD), on the N-terminal pro-B-type Natriuretic Peptide laboratory marker in subjects with symptomatic heart failure with diastolic dysfunction.
- Trial name
- NCT00775840
- Testing
- Candesartan
- Where
- 37 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Takeda
Heart Failure
Randomized Clinical Trial to Evaluate the Regenerative Capacity of CardioCell in Patients With Chronic Ischaemic Heart Failure (CIHF)
The main objective of the CIRCULATE project is to compare the clinical outcomes of CardioCell administration in treatment of ischemic damages of cardiovascular system with control group, who will receive the placebo.
- Trial name
- NCT03418233
- Testing
- CardioCell
- Where
- 5 sites in Poland
- Volunteers
- 115 people
- Sponsor
- John Paul II Hospital, Krakow
Obesity, Heart Failure, Diastolic
Improving Metabolic Health in Patients With Diastolic Dysfunction
The purpose of this study is to determine whether 1 year of supervised exercise training in obese individuals at high risk for developing HF, incorporating high intensity interval training (HIIT) two to three times per week in…
- Conditions
- Obesity, Heart Failure, Diastolic, Metabolic Syndrome
- Trial name
- MTG (NCT03448185)
- Testing
- High intensity exercise, Omega-3 fish oil, Yoga
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cardiogenic Shock
Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function.
Long term prognosis of cardiogenic shock is related to the resolution of haemodynamic failure, associated visceral failure and the recovery of an adequate myocardial function.
- Trial name
- EMPASHOCK (NCT05879276)
- Testing
- Empagliflozin 10 MG
- Where
- 8 sites in France
- Volunteers
- 164 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure
MBSR on Physiological and Psychological Factors in Patients With HF
Objective The purpose of this study is to explore the relationship between mindfulness, resilience, depression and quality of life in patients with heart failure, and the effect of mindfulness-based stress reduction intervention…
- Trial name
- MBSR-PP-HF (NCT05967247)
- Testing
- The experimental group used App for MBSR intervention, the "Heart Care Life" app, APP
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- National Taiwan University Hospital
Heart Failure, Anemia
RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial
The purpose of the study is to determine the efficacy of treatment of anemia with darbepoetin alfa compared to placebo on the composite of time to death from any cause or first hospital admission for worsening heart failure in…
- Conditions
- Heart Failure, Anemia, Cardiovascular Disease, Ventricular Dysfunction
- Trial name
- NCT00358215
- Testing
- Darbepoetin alfa
- Where
- 754 sites in United States, Argentina and 34 more
- Volunteers
- 2,278 people
- Sponsor
- Amgen
Hypertrophic Cardiomyopathy
Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failure
A Study on the Efficacy, Safety, and Tolerability of Perhexiline maleate in Subjects with Hypertrophic Cardiomyopathy and Moderate-To-Severe Heart Failure
- Trial name
- NCT02431221
- Testing
- Perhexiline
- Sponsor
- Heart Metabolics Limited
Psychological Distress
Well-Being Therapy by Personalized Mobile Technology Program for Psychological Distress and Promote Healthy Behaviors
The WELL-ME study is a three-arm randomized controlled clinical trial (RCT). The aim of this RCT is to compare the effectiveness of the Well Being Web Based Therapy (WBT-Web) with the gold standard CBT (Cognitive Behavior…
- Trial name
- WELL-ME (NCT01543815)
- Testing
- Well-Being Therapy based on Web Mobile Technology, Cognitive Behavior Therapy, Standardized Care Management
- Volunteers
- 400 people
- Sponsor
- University of Bergamo
Congestive Heart Failure
Experimental Prospective Study on the Effectiveness and Efficiency of the Implementation of Clinical Pathways
The purpose of this study is to determine whether the use of clinical pathways improves the quality of the hospital care of decompensated heart failure patients.
- Trial name
- EPSEEIC2004 (NCT00519038)
- Testing
- Clinical Pathways, Usual Care
- Volunteers
- 424 people
- Sponsor
- Agenzia Regionale Sanitaria delle Marche
Heart Failure
Congestive Heart Failure Outreach Program
Heart failure is a very common condition and is one of the main reasons people are admitted to hospital. There are many things people with heart failure can do to manage their condition at home.
- Trial name
- COPE (NCT00371085)
- Testing
- education
- Where
- Canada
- Volunteers
- 539 people
- Sponsor
- University of Alberta
Congenital Heart Disease, Heart Failure
Gender Difference in NET Activation in Patients With Congenital Heart Disease and Heart Failure
Neutrophil hyperactivation has detrimental effects on cardiac tissue after injuries, leading to fibrosis lesions and cardiac dysfunction.
- Conditions
- Congenital Heart Disease, Heart Failure, Gender
- Trial name
- FIBRONETx (NCT05263843)
- Testing
- Biological markers of myocardial fibrosis
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases, Coronary Disease
Natural History of Coronary Heart Disease
To examine the natural history of mortality due to coronary heart disease in post-myocardial infarction patients from the Beta-Blocker Heart Attack Trial (BHAT) and the Aspirin Myocardial Infarction Study (AMIS).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005265
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Stable Heart Failure
A Study of CLR325 in Chronic Stable Heart Failure Patients.
The purpose of this study was to determine the safety and tolerability of CLR325 intravenous (i.v.) infusion in patients with stable heart failure to determine if further clinical development of the drug in this indication was…
- Trial name
- NCT02696967
- Testing
- CLR325
- Where
- 11 sites in United States, Belgium and 3 more
- Volunteers
- 26 people
- Sponsor
- Novartis Pharmaceuticals
Cardiomyopathies, Heart Failure
Follow-up of the Cardiomyopathy Cohort SFB/TR19
Follow-up of a cohort of inflammatory cardiomyopathy patients (suspected or validated inflammatory cardiomyopathy) recruited at baseline by the SFB-TR19 project.
- Trial name
- SFB/TR19plus (NCT02971267)
- Testing
- Observational
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Medicine Greifswald
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