Clinical trials: Congestive Heart Failure(CHF)
Dilated Cardiomyopathy
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants.
The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of AZD0233 following single and multiple ascending dose (SAD and MAD) administration in healthy participants.
- Trial name
- NCT06381466
- Testing
- AZD0233
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Heart Failure
The Inotrope Evaluation and Research Patient Registry
The INTERPRET Inotrope Evaluation and Research Patient Registry is a longitudinal, observational study designed to look at the demographics and outcomes of heart failure patients on inotropic therapy administered in the home or…
- Trial name
- INTERPRET (NCT03160846)
- Testing
- Inotrope
- Where
- 5 sites in United States
- Volunteers
- 129 people
- Sponsor
- Coram Clinical Trials
Heart Failure, Heart Failure Hospitalization
Non-Invasive Hemodynamic Monitoring in Hospitalized Heart Failure
Heart failure hospitalization is associated with a high risk of early readmission and mortality. There is an unmet clinical need for low-burden, non-invasive methods to better understand congestion and hemodynamic status during…
- Conditions
- Heart Failure, Heart Failure Hospitalization, Heart Failure (HF)
- Trial name
- NCT07671742
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Acorai AB
Coronary Artery Disease, Congestive Heart Failure
Cardiac Stem Cell Infusion in Patients With Ischemic CardiOmyopathy (SCIPIO)
The purpose of this study is to investigate the safety of intracoronary cardiac stem cells (CSCs) therapy in humans. Currently, there is no effective intervention to regenerate (regrow) dead heart muscle after a heart attack.
- Trial name
- SCIPIO (NCT00474461)
- Testing
- Treatment group
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Louisville
HCM, Noonan Syndrome and Other Rasopathy
Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT
This project seeks to perform a Phase 3 clinical trial to test whether an FDA-approved cancer drug called trametinib is effective in treating young infants with genetic conditions called RASopathies and a severe, life-threatening…
- Conditions
- HCM, Noonan Syndrome and Other Rasopathy, Heart Failure (Pediatric)
- Trial name
- Baby MERIT (NCT07817186)
- Testing
- Trametinib
- Volunteers
- 25 people
- Sponsor
- Carelon Research
Severe Cardiac Insufficiency
Determination of Risk Factors of Ventricular Arrhythmias (VAs) After Implantation of Continuous Flow Left Ventricular Assist Device With Continuous Flow Left Ventricular Assist Device (CF-LVAD)
Determination of risk factors of ventricular arrhythmias (VAs) after implantation of continuous flow left ventricular assist device in order to characterize which patient requires ICD implantation in primary prevention.
- Trial name
- ASSIST-ICD (NCT02873169)
- Testing
- Implantable cardioverter-defibrillator
- Where
- 20 sites in France
- Volunteers
- 681 people
- Sponsor
- Rennes University Hospital
Heart Failure With Reduced Ejection Fraction NYHA Class III-IV
Beta 3 Agonist Treatment in Heart Failure-2
Objective: The objective of the study is to assess the structural and functional cardiac effects of treatment with the beta 3 AR agonist Mirabegron in patients with moderate to severe chronic heart failure (LVEF<35%, NYHA…
- Trial name
- BEAT-HF II (NCT03926754)
- Testing
- Mirabegron
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Henning Bundgaard
Chronic Obstructive Pulmonary Disease, Heart Failure
Well Being and Rehabilitation in Chronically Ill Patients: Structured Patient Education and Physical Exercise
This study addresses self management and maintenance of health through evaluation of a program of patient education in combination with physical training and with a structured follow-up.
- Conditions
- Chronic Obstructive Pulmonary Disease, Heart Failure, Stroke
- Trial name
- NCT00989456
- Testing
- Self management education programme, exercise only
- Where
- 5 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Heart Failure
CareLink® Network Evaluation
The purpose of the study is to demonstrate the value of the Medtronic CareLink® Network in clinical practice in the country specific healthcare setting.
- Trial name
- NCT01023022
- Testing
- Medtronic CareLink® Network
- Where
- 10 sites in Poland
- Volunteers
- 176 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Transplant; Failure, Heart, Heart Failure, Congestive
Utilizing Technology for Optimization of Pain Management and Mobilization in High Risk Cardiac Surgical ICU Patients
The purpose of this project is to improve mobility in the perioperative period using activity trackers to augment current practice.
- Conditions
- Transplant; Failure, Heart, Heart Failure, Congestive, Lung Transplant Failure
- Trial name
- NCT04146727
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Cedars-Sinai Medical Center
Diastolic Heart Failure
Non-invasive Evaluation of Myocardial Stiffness by Elastography
SITUATION ON RESEARCH Diastolic heart failure (HF) or heart failure with preserved systolic function (SF) is the primary cause of heart failure in the elderly (over 2/3 of heart failure in patients over 60 years).
- Trial name
- Elasto-Cardio (NCT02537041)
- Testing
- elastography function ShearWave Imaging, MRI
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Heart Failure, Chronic Obstructive Airway Disease
A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure
This study looks at the effect of two drugs (carvedilol and metoprolol) which are used for patients with CHF (chronic heart failure).
- Trial name
- NCT00384566
- Testing
- Carvedilol, Metoprolol
- Where
- Australia
- Sponsor
- The Alfred
Heart Failure, Obesity
Safety of Body Composition Analysis in Heart Failure Patients With Implantable Cardioverter Defibrillators (ICDs)
The purpose of this study is to define the safety of using bioimpedance for analysis of body composition in heart failure patients with ICD devices.
- Trial name
- NCT01568606
- Testing
- Body Composition Analysis InBody Scale
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Heart Failure
Reverse HFpEF: Ketogenic Reversal of Heart Failure With Preserved Ejection Fraction Study
This protocol is a prospective pilot study utilizing the intervention of a medically supervised, registered nurse and registered diabetes educator coached low-carbohydrate, ketogenic diet to examine the impact it has as a…
- Trial name
- NCT04942548
- Testing
- Ketogenic Diet
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Jewish Health
Heart Failure
MPP Narrow QRS:Pilot Study on Multipoint Pacing in Patients With QRS Beetwen 100 and 130 Msec
The purpose of this study is to assess the impact of the Multi Point Pacing (MPP) feature in the treatment of patients with QRS beetwen 100 and 130 msec in patients candidate to ICD implant.
- Trial name
- NCT02402816
- Testing
- MultiPoint Pacing ON, Implantable cardioverter-defibrillator (ICD)
- Where
- 6 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Humanitas Hospital, Italy
Heart Failure, Systolic
Digital Remote Home Monitoring for Heart Failure
We will enroll 150 adult participants with systolic heart failure into the ADHERE-HF trial. The study will randomize participants in a 1:2 fashion to usual care or usual care plus the American Heart Association's Digital Solution…
- Trial name
- ADHERE-HF (NCT05988749)
- Testing
- Biofourmis Digital Platform
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Texas Southwestern Medical Center
COPD, CHF
Heart Failure Worsens Muscle Strength in COPD
The combination of heart failure (HF) and chronic obstructive pulmonary disease (COPD) is highly prevalent, but underdiagnosed and poorly recognized.
- Conditions
- COPD, CHF, Muscle Weakness
- Trial name
- NCT04261452
- Testing
- isokinetic dynamometer, Cardiopulmonary Exercise Test, Functional Capacity Tests
- Volunteers
- 50 people
- Sponsor
- Mayron Faria de Oliveira
Cardiac Transplant Disorder, Cardiac Death
HEart trAnsplantation Registry of piTie-Salpetriere University Hospital
Heart transplantation (HTx) is a procedure which is hindered by several complications. The HEARTS registry aims to allow the analysis of risk factors of all post-HTx complications.
- Conditions
- Cardiac Transplant Disorder, Cardiac Death, Heart Failure, Acute Cellular Graft Rejection
- Trial name
- HEARTS (NCT03393793)
- Volunteers
- 566 people
- Sponsor
- Lee S Nguyen
Heart Failure
Multiple Dose Study in Heart Failure of BAY 1067197
This is a study to investigate the safety, tolerability and early effects on cardiac function of the partial A1 agonist BAY1067197 in patients with chronic heart failure.
- Trial name
- PARSiFAL (NCT02040233)
- Testing
- BAY1067197 (10 mg), BAY1067197
- Where
- 6 sites in Germany, Italy and 2 more
- Volunteers
- 31 people
- Sponsor
- Bayer
Univentricular Heart, Microvascular Dysfunction
Cardiac Magnetic Resonance Stress-perfusion Study in Patinets with Fontan Circulation
Univentricular heart (UVH) is a severe congenital heart disease. Accurate advanced non-invasive diagnostic methods is limited. Cardiovascular magnetic resonance (CMR) imaging has evolved as a particularly useful tool for the…
- Conditions
- Univentricular Heart, Microvascular Dysfunction, Heart Failure, Magnetic Resonance
- Trial name
- CMR_TCPC (NCT06735521)
- Testing
- Cardiac magnetic resonance stress-perfusion
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
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