Clinical trials: Congestive Heart Failure(CHF)
Heart Failure
Influence of Individualized Training on Cardiopulmonary Exercise Capacity in LVAD Patients
The aim of this study is to examine the influence of an individualized, spiroergometry- guided training on cardiopulmonary fitness in patients with a left ventricular assist device (LVAD).
- Trial name
- NCT03984162
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Cardio-Renal Syndrome
Contrast-induced Nephropathy: Incidence,Risk Factors,Effective Prevention and Management Method
This review article have included about ten thousand patients undergoing percutaneous coronary intervention (PCI), aim to identify the incidence of CIN in actual, find some new risk factors and the protecting methods for these…
- Trial name
- NCT02664246
- Testing
- percutaneous coronary intervention
- Volunteers
- 10,000 people
- Sponsor
- Chinese PLA General Hospital
Obstructive Sleep Apnoea, Central Sleep Apnoea
Leg Fluid Shift in Patients With Chronic Heart Failure and Obstructive or Central Sleep Apnea
This study aims to investigate the influence of a potential leg fluid shift (LFS) in patients with chronic heart failure (CHF) and obstructive sleep apnea (OSA) or central sleep apnea (CSA).
- Conditions
- Obstructive Sleep Apnoea, Central Sleep Apnoea, Cheyne Stokes Respiration
- Trial name
- NCT03092388
- Testing
- Multi Frequency Bioimpedance Analysis (mfBIA), Polysomnography/Polygraphy (PSG/PG), Capillary Blood Gas Analysis (CBGA)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Heart Failure
Anticipation and Detection of Heart Failure Decompensation With Automatic Treatment of Informations
Heart failure (HF) is a serious chronic disease with frequent readmissions, some of which can be prevented by early action. The management of HF is complex: long, often difficult and costly.
- Trial name
- e-INCA (NCT02411279)
- Testing
- Equiped group with telemedicine systems
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Right Ventricular Function, Prone Position
Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine
Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay.
- Conditions
- Right Ventricular Function, Prone Position, Atelectasis, Atelectases, Postoperative Pulmonary
- Trial name
- BAROLO (NCT07632027)
- Testing
- Prone position
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Atrioventricular Block
Ventricular Pacing Site Selection (V-PASS)
The purpose of this study is to determine whether there is a relationship between ventricular lead position and the incidence of heart failure and atrial fibrillation in patients with indication for permanent pacemaker…
- Trial name
- NCT00292383
- Testing
- Leads to be implanted according randomization on specified sites. Vitatron pacemakers to be implanted: T60 DR, T70 DR, T20 SR, C60 DR
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Medtronic BRC
Congestive Heart Failure, Medication Adherence
Assay to Measure Beta Blocker Adherence
This study will assess the feasibility and efficacy of using serum assay developed by Quest Diagnostics to detect the presence of beta blockers, specifically carvedilol and metoprolol succinate, in patients with heart failure.
- Trial name
- NCT05251974
- Testing
- Quest beta blocker assay
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Summa Health System
Pleural Effusions, Chronic, Congestive Heart Failure
Tunneled Pleural Catheters for Refractory Effusions Attributed to Congestive Heart Failure (TREAT-CHF) Trial
Congestive heart disease (CHF) can frequently cause transudative pleural effusions, some of which do not completely resolve with diuretics alone.
- Conditions
- Pleural Effusions, Chronic, Congestive Heart Failure, Shortness of Breath
- Trial name
- TREAT-CHF (NCT03696524)
- Testing
- tunneled pleural catheter
- Where
- United States
- Sponsor
- University of California, Los Angeles
Heart Failure
Primary Preventive Ventricular Tachycardia Ablation In High-Risk Patients Who Receive A Prophylactic Implantable Cardioverter Defibrillator
This prospective, multicenter, open-label, randomized-controlled trial compares two treatment strategies in high-risk ischemic cardiomyopathy (ICM) patients referred for primary ICD implantation.
- Trial name
- PREVENT-VT (NCT06543173)
- Testing
- Prophylactic Catheter-based VT Ablation
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 62 people
- Sponsor
- University of Rochester
Ischemic Heart Failure
Clinical Study of Lipoic Acid on Ischemic Heart Failure
The study will evaluate the efficacy of alpha-lipoic acid(α-LA) on mortality in patients with ischemic heart failure (NYHA Class II - IV and EF =< 50%).
- Trial name
- NCT03491969
- Testing
- Alpha-Lipoic Acid(α-LA)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Valvulopathy
Stent Implantation of Polyurethane Expandable Valve, by Catheter, in Patients With Pulmonary Valve Dysfunction
Prospective Study, Single Arm to evaluate the safety and efficacy of polyurethane expandable valve implantation in the pulmonary position, in 5 patients over 18 years of age, with pulmonary valve dysfunction and moderate to…
- Trial name
- NCT05289622
- Testing
- Polyurethane expandable valve stent implant
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Dr. Miguel Angel Maluf
Hypotension
Norepinephrine in the Management of General Anesthesia-Induced Arterial Hypotension in Chronic Heart Failure Patients
Arterial hypotension is a frequent complication of general anesthesia and a significant contributor to postoperative complications.
- Trial name
- NORAFLOW (NCT06350929)
- Testing
- Cardiac output monitoring by the Starling™ SV Sebac®
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Non-ischemic Dilated Cardiomyopathy, Heart Failure With Reduced Ejection Fraction
High Fat Diet for Cardiac Metabolic Reprogramming
Heart failure (HF) continues to be a leading cause of morbidity and mortality worldwide, despite advances in treatment. HF is often characterized by an altered metabolism in the heart, where glucose is favored over fatty acids as…
- Trial name
- HF4HF (NCT06747429)
- Testing
- High fat diet, Standard diet
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 80 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Cardiovascular Disease, Pulmonary Arterial Hypertension
Effect of BIA 5 1058 on Cardiac Repolarization
The purpose is to evaluate the effect of single therapeutic (400 mg) and supratherapeutic (1200 mg) doses of BIA 5-1058 on the time-matched change from baseline in placebo-adjusted interval corrected (QT) for heart rate (HR)
- Conditions
- Cardiovascular Disease, Pulmonary Arterial Hypertension, Heart Failure
- Trial name
- NCT03489005
- Testing
- BIA 5-1058, Moxifloxacin 400 mg
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Type 2 Diabetes Mellitus, Obesity
Macrovascular and Microvascular Morbidity and Mortality After Metabolic Surgery Versus Medicines
The goal of this study is to compare the impact of metabolic surgery and a class of anti-diabetes medications (Glucagon-like peptide-1 receptor agonists,GLP-1 RAs) on occurrence of diseases involving small and large vessels such…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Microvascular Disease, Macrovascular Disease
- Trial name
- M6 (NCT06355219)
- Volunteers
- 3,932 people
- Sponsor
- Ali Aminian
Dilated Cardiomyopathy, Ventricular Remodeling
The Impact of Ivabradine on Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy (NIDCM) on Current Medical Therapy Era
In non-ischemic dilated cardiomyopathy (NIDCM), left ventricular reverse remodeling (LVRR) can be achieved through guideline-directed medical therapy (GDMT).
- Conditions
- Dilated Cardiomyopathy, Ventricular Remodeling, Heart Failure, Reduced Ejection Fraction
- Trial name
- NCT05973591
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Yonsei University
Heart Transplant Failure and Rejection, Heart Failure
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
Heart transplantation is a life saving therapy for people with end stage heart failure. Acute rejection, a process where the immune system recognizes the transplanted heart as foreign and mounts a response against it, remains a…
- Conditions
- Heart Transplant Failure and Rejection, Heart Failure, Heart Diseases, Heart Failure，Congestive
- Trial name
- HEARTBiT (NCT03575910)
- Where
- 4 sites in United States, Canada
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Telehealth Services, Telehealth
Impact of Telehealth Care
Heart failure is associated with high incidence and mortality rates, limited physical activity, decreased quality of life, and increased healthcare expenses.
- Trial name
- NCT06656520
- Sponsor
- Pei-Hung Liao
Heart Failure, Heart Failure With Reduced Ejection Fraction
Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction.
The goal of this clinical trial is to evaluate guideline-directed medical therapy (GDMT) up-titration in patients with heart failure with reduced ejection fraction.The main question it aims to answer is the improvement in…
- Trial name
- ReQUAD-HF (NCT06273280)
- Testing
- SOC, Protocolized up-titration
- Where
- Belgium
- Volunteers
- 345 people
- Sponsor
- Ziekenhuis Oost-Limburg
Heart Failure, Arrhythmia
Upregulating the Nitric Oxide Pathway To Restore Autonomic Phenotype (UNTRAP).
Autonomic nervous system dysfunction is known to be associated with an increased risk of heart rhythm abnormalities and sudden cardiac death (SCD) in patients with chronic heart failure - a condition affecting millions of people…
- Trial name
- UNTRAP (NCT03658174)
- Testing
- Nitrate-rich beetroot juice, Nitrate-free beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Leicester
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