Clinical trials: Congestive Heart Failure(CHF)
Kidney Diseases, End-Stage Kidney Disease
Major Outcomes With Personalized Dialysate TEMPerature
People with failed kidneys need an artificial kidney machine (called dialysis) to remove toxins and extra fluid from the body. Most patients receive dialysis treatments at a hospital three times a week.
- Conditions
- Kidney Diseases, End-Stage Kidney Disease, Hemodialysis
- Trial name
- MyTEMP (NCT02628366)
- Testing
- Personalized Dialysate Temperature
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Heart Failure
Electronic Medical Records and Genomics
The purpose of this study is to develop a biobank containing samples of 2,000 patients treated in a tertiary cardiology hospital containing electronic medical records and genetic data in genome-wide scale for performing genetic…
- Trial name
- NCT02043431
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- University of Sao Paulo General Hospital
Heart Failure
Inspiratory Muscle Training in HFpEF
This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.
- Trial name
- NCT06510231
- Testing
- Inspiratory Muscle Training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mayo Clinic
Diastolic Dysfunction, Systolic Dysfunction
Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES
Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions.
- Conditions
- Diastolic Dysfunction, Systolic Dysfunction, Diastolic Heart Failure
- Trial name
- CardiacAging (NCT05408559)
- Testing
- Sulforaphane
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
AV Block
Left Septal Pacing or Left Bundle Branch Pacing to Avoid Left Ventricle Systolic Dysfunction
Right ventricular apical pacing (RVAP) can produce left ventricular dysfunction (LVD). Conduction system pacing (CSP) has been used successfully to reverse LVD in patients with left bundle branch block.
- Trial name
- STAY II (NCT06707662)
- Testing
- Pacemaker and defibrillator
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Parc de Salut Mar
Atrial Fibrillation (AF), Heart Failure (HF)
Diagnostic Electrical Cardioversion for Explaining Patient's AF and HF Symptoms
Rationale: The co-existence of Atrial Fibrillation (AF) and Heart Failure (HF) is associated with increased morbidity, mortality, and hospital admissions, significantly contributing to healthcare burden.
- Conditions
- Atrial Fibrillation (AF), Heart Failure (HF), Electrical Cardioversion
- Trial name
- DEEP-AF-HF (NCT07000942)
- Testing
- Electrical cardioversion (ECV)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- M. Rienstra
Heart Failure
Effects of Aliskiren, Ramipril, and the Combination on Levels of Angiotensin II in Patients With Decompensated Systolic Heart Failure
In addition to the blood pressure lowering effects of aliskiren, it may have beneficial effects on blocking the so called RAAS (renin-angiotensin-aldosterone system) at the tissue level.
- Trial name
- ESCAPE-SHF (NCT00923156)
- Testing
- aliskiren, ramipril
- Where
- 16 sites in Germany, Poland and 1 more
- Volunteers
- 123 people
- Sponsor
- Novartis Pharmaceuticals
Atrial Fibrillation (AF), Pacemaker Therapy
Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate…
- Conditions
- Atrial Fibrillation (AF), Pacemaker Therapy, Atrioventricular Block, Preserved Ejection Fraction
- Trial name
- LBBP-AHRE (NCT07250529)
- Testing
- Right Ventricular Pacing, Left Bundle Branch Pacing
- Where
- Greece
- Volunteers
- 244 people
- Sponsor
- University Hospital of Patras
Heart Failure，Congestive
Evaluation of Post-operative, Nurse-based Heart Failure Care in Non-cardiac Surgery
Patients with heart failure NYHA >= II receiving non-emergent non-cardiac in-patient surgery will be randomized to receive either standard post-operative care (surgeon has to ask actively for specialist cardiological support) or…
- Trial name
- NCT03202329
- Testing
- standard care, Nurse-based care
- Where
- 2 sites in Germany
- Volunteers
- 525 people
- Sponsor
- Birgit Assmus
NYHA Class III Heart Failure
Correlation of SOZO BIS Measures With CardioMEMS PA Pressure
This study aims to establish the degree to which change in the ratio of ECF to TBW measured using the SOZO BIS device correlates with change in end-expiratory end-diastolic PAP measured using the CardioMEMS HF System (St.
- Trial name
- NCT02939053
- Testing
- SOZO
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- ImpediMed Limited
Heart Failure
The Value of a Simple Tool for the Early Detection of Decompensated Heart Failure in People Over 55 on Réunion Island: A Preliminary Study in Hospitals (DEPIST'IC-RUN)
The goal of this study is to assess the discriminatory power of a previously developed tool for detecting decompensated heart failure-which includes, in particular, clinical signs-in a population of patients hospitalized in…
- Trial name
- DEPIST'IC-RUN (NCT07673562)
- Testing
- Early Detection Questionnaire
- Where
- 3 sites in Reunion
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Acute Myocardial Infarction
Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction
This study is planned to investigate the impact of Empagliflozin on biomarkers of heart failure in patients with myocardial infarction with and without type 2 diabetes mellitus within 6 months after the event.
- Trial name
- EMMY (NCT03087773)
- Testing
- Empagliflozin 10 mg
- Where
- 11 sites in Austria
- Volunteers
- 476 people
- Sponsor
- Medical University of Graz
Heart Failure, Depression
Online Psychological Support Group for Patients With Heart Failure and Depression
Heart failure is a chronic disease, being the second cause of death in Brazil. Currently, it is estimated that 6.4 million Brazilians suffer from this disease.
- Trial name
- NCT05948241
- Testing
- Online psychological support group, Standard multidisciplinary care
- Where
- Brazil
- Volunteers
- 132 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Obstructive Sleep Apnea, Hypertension
Antihypertensive and PAP Treatment in Obstructive Sleep Apnea Patients With Hypertension (AHPAP)
The investigators will perform a long term registry based prospective analysis on incidence of major cardiovascular events or death in hypertensive patients with obstructive sleep apnea .
- Conditions
- Obstructive Sleep Apnea, Hypertension, Death, Cardiac, Treatment Compliance
- Trial name
- AHPAP (NCT05115994)
- Testing
- Continous positive airway pressure
- Where
- Sweden
- Volunteers
- 10,000 people
- Sponsor
- Vastra Gotaland Region
Kidney Transplant Recipient, Kidney Transplant; Complications
Vascular Complications After Kidney Transplantation
To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients…
- Conditions
- Kidney Transplant Recipient, Kidney Transplant; Complications, Transplant Renal Artery Stenosis, Renovascular Disease
- Trial name
- DAN-PTRAIII (NCT07531966)
- Testing
- Catheter-based angiography, Measurement of translesional pressure gradients, Intravascular ultrasound (IVUS)
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Cardiovascular Diseases
CAB Versus Medical Therapy in Patients With AF and HF With Different EF Categories
This study is to assess the effectiveness and safety of cryoballoon ablation comparing with medical therapy in patients with atrial fibrillation and heart failure with different ejection fraction categories.
- Trial name
- NCT05364866
- Testing
- Antiarrhythmic drug Therapy, cryoballoon ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Affiliated Hospital of Nantong University
Heart Failure
Study of Organ Perfusion With Custodiol-N Solution Compared With Custodiol Solution in Heart Transplantation
The objective of this investigation is to demonstrate non-inferiority in outcome of Custodiol-N against Custodiol in heart transplantation.
- Trial name
- NCT02869022
- Testing
- Custodiol-N, Custodiol, organ perfusion for heart transplantation
- Where
- 9 sites in Austria, Germany
- Volunteers
- 105 people
- Sponsor
- Dr. F. Köhler Chemie GmbH
Acute Heart Failure (AHF), Congestive Heart Failure Acute
POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure
Acute decompensated heart failure (ADHF) is a frequent cause of hospitalization and is associated with high morbidity and mortality.
- Conditions
- Acute Heart Failure (AHF), Congestive Heart Failure Acute, Diuretic Effect, Lung Ultrasonography Score
- Trial name
- POINTER-HF (NCT07469722)
- Testing
- Furosemide 40 Milligrams., Hydrochlorothiazide (HCTZ) 25 milligrams., Acetazolamide 250 milligrams.
- Where
- Brazil
- Volunteers
- 128 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure
Physiological Response to Exercise: Sensor Evaluation at Specified Exertions
Assessment of sensor parameter in patients with heart failure.
- Trial name
- PRE-SENSE (NCT01229137)
- Testing
- SRD-1 conversion
- Where
- 14 sites in United States
- Volunteers
- 71 people
- Sponsor
- Boston Scientific Corporation
Myocardial Ischemia, Congestive Heart Failure
Stem Cell Study for Patients With Heart Failure
The purpose of this study is to determine if cell therapy with your own cells (autologous cells) delivered with a catheter to regions of the heart with poor blood flow will be safe and if it will improve your ejection fraction…
- Conditions
- Myocardial Ischemia, Congestive Heart Failure, Cardiovascular Disease
- Trial name
- NCT00346177
- Testing
- Autologous Stem Cells
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Losordo, Douglas, M.D.
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