Clinical trials: Congestive Heart Failure(CHF)
Heart Failure With Preserved Ejection Fraction
A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
This is a study to evaluate whether macitentan is an effective and safe treatment for patients with heart failure with preserved ejection fraction (HFpEF) and pulmonary vascular disease.
- Trial name
- SERENADE (NCT03153111)
- Testing
- Macitentan
- Where
- 95 sites in United States, Argentina and 15 more
- Volunteers
- 143 people
- Sponsor
- Actelion
Chronic Heart Failure, Oxygen Deficiency
Oxygen Therapy in Patients With Chronic Heart Failure With Reduced Ejection Fraction
The purpose of this study is to assess patients with chronic heart failure and moderate-severe ventricular dysfunction (left ventricular ejection fraction (FEVE) <40%) with nocturnal desaturation (mean Oxygen saturation (SatO2)…
- Trial name
- ROXIC (NCT05913739)
- Testing
- Oxygen Therapy
- Where
- Spain
- Volunteers
- 1 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Heart Failure
Heart Transplantation Using Normothermic Regional Perfusion Donation After Circulatory Death
Normothermic regional perfusion (NRP) utilizes Extracorporeal Membrane Oxygenation (ECMO) or cardiopulmonary bypass to reperfuse the heart and other organs in situ after isolation and ligation of the cerebral vessels.
- Trial name
- NCT04284319
- Testing
- DCD Heart Transplantation Using NRP
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Heart Failure, Diastolic, Heart Failure, Systolic
Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Methylation and Point-of-carE Risk calculaTors (PRESMET)
Heart failure (HF) is a syndrome, resulting from structural or functional impairment of ventricular filling or ejection of blood.
- Conditions
- Heart Failure, Diastolic, Heart Failure, Systolic, Pulmonary Hypertension, Atrial Fibrillation
- Trial name
- PRESMET (NCT05475028)
- Testing
- RRBS
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Heart Failure With Reduced Ejection Fraction
Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Failure
Randomized trial of adult patients to study the effects of preferential left ventricular pacing on ventriculoarterial coupling of both systemic and pulmonary circulation, indices of systolic and diastolic function of both…
- Trial name
- READAPT (NCT04420065)
- Testing
- Preferential left ventricular pacing, Biventricular pacing
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- National and Kapodistrian University of Athens
Heart Diseases, Heart Failure, Congestive
Ventricular Matrix Remodeling: Correlates and Prognosis
To assess the diagnostic and prognostic usefulness of serum markers of left ventricular remodeling for predicting congestive heart failure.
- Conditions
- Heart Diseases, Heart Failure, Congestive, Cardiovascular Diseases, Heart Failure
- Trial name
- NCT00021892
- Sponsor
- Boston University
Cardiovascular Diseases, Heart Diseases
Prevalence of Asymptomatic Ventricular Dysfunction
To conduct a population-based study of the prevalence of asymptomatic ventricular dysfunction.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Congestive, Heart Failure
- Trial name
- NCT00005534
- Sponsor
- Mayo Clinic
Chronic Heart Failure
Omega-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Severe Chronic Heart Failure
To investigate whether n3-fatty acids have beneficial effects in chronic heart failure as regards circulatory function.
- Trial name
- NCT00149409
- Testing
- Omacor
- Where
- Austria
- Sponsor
- Medical University of Vienna
Heart Failure
Use of mHealth to Increase Physical Activity for Patients Recently Hospitalized With Acute Heart Failure
The aim of this trial is to determine if a mobile application that promotes physical exercise in the follow-up of patients recently hospitalized with acute heart failure can improve exercise capacity after 6 months and physical…
- Trial name
- mRehab (NCT04848298)
- Testing
- mHealth Intervention
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hypertension, Heart Failure
Finding Early Predictors of Myocardial Dysfunction
The study objective is to clarify the grounds of heart exertional dyspnoea stenocardia in patients with well-controlled stage I or II hypertension according to European Society of Hypertension, without changes in epicardial…
- Trial name
- NCT02026154
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Heart Failure
Hemodynamic Effects of Rolofylline in the Treatment of Patients With Heart Failure (7418-503)
The study will estimate the effects of rolofylline, alone and in addition to loop diuretic therapy on pulmonary capillary wedge pressure and other hemodynamic parameters, in patients with heart failure and renal impairment.
- Trial name
- NCT00729222
- Testing
- rolofylline
- Volunteers
- 60 people
- Sponsor
- Merck Sharp & Dohme LLC
Vitamin D Deficiency, Chronic Heart Failure
The Role of Vitamin D in the Pathophysiology of Chronic Failure
Patients will undergo at baseline and regular intervals: clinically indicated bloodwork/urine and echocardiogram testing biomarker studies Upon enrolment in the study patients will be divided into 4 groups normal, mildly…
- Trial name
- NCT01993537
- Testing
- Vitamin D
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ischemic Heart Failure, Ischemic Heart Disease
Study to Examine the Safety and Effectiveness of Implanted Skeletal Muscle Cells (Cells Removed From the Thigh Muscle) Into Scarred Areas of Heart Muscle After Heart Attack.
Study to examine the safety and effectiveness of implanted skeletal muscle cells (cells removed from the thigh muscle) into scarred areas of heart muscle after heart attack.
- Conditions
- Ischemic Heart Failure, Ischemic Heart Disease, Ischemic Cardiomyopathy
- Trial name
- NCT00102128
- Testing
- Cellular Therapy (Cultured Autologous Skeletal Myoblast Transplantation)
- Where
- 28 sites in Belgium, France and 4 more
- Sponsor
- Genzyme, a Sanofi Company
Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Mechanical Alternans Study
The purpose of this study is to determine whether mechanical alternans (alternating strong and weak heart beats with a constant beat-to-beat interval), can be used to predict malignant ventricular arrhythmias, requiring…
- Conditions
- Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy, Heart Failure
- Trial name
- MAS (NCT01557465)
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Johns Hopkins University
Heart Failure With Reduced Ejection Fraction
Changes in Intrathoracic Impedance During Sacubitril/Valsartan Treatment
The CHILISALT Study aimed to explore the effect of angiotensin-neprilysin inhibition on intrathoracic impedance and -derived fluid index in HFrEF patients who had a device for cardiac resynchronization therapy and/or an…
- Trial name
- CHILISALT (NCT03359967)
- Testing
- Entresto tablet
- Volunteers
- 24 people
- Sponsor
- Central Hospital, Izmir
Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia
Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-Defibrillators
This prospective observational study evaluates whether circulating small non-coding RNAs, particularly microRNAs, are associated with ventricular arrhythmias in patients with post-myocardial infarction heart failure who have an…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia, Ischemic Cardiomyopathy
- Trial name
- NCT07795892
- Testing
- Circulating Small RNA Profiling
- Where
- Poland
- Volunteers
- 57 people
- Sponsor
- University of Rzeszow
Cardiac Failure
Assessment of Exercise Intensity in Cardiac Rehabilitation Programmes for Patients With Chronic Heart Failure
Cardiac rehabilitation is the ideal comprehensive intervention for patients with chronic heart failure (CHF), since it addresses the complex interplay of medical, psychological and behavioural factors facing these individuals.
- Trial name
- NCT01545102
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy Lloyd
Atrial Fibrillation, Biomarker
The Application of Biomarkers in the Care of Patients With Atrial Fibrillation
From 2020 to 2023, we established a longitudinal AF patient cohort with comprehensive clinical data collection. In our previous work, we utilized the Milliplex platform to screen 52 circulating biomarkers and identified several…
- Trial name
- NCT07565337
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Heart Failure
Cardiac Rehabilitation and Metabolomics in Heart Failure
This is a randomized controlled trial of participants with heart failure randomized into usual care plus integrated cardiac rehabilitation or usual care only.
- Trial name
- CROMe (NCT03743012)
- Testing
- Integrated cardiac rehabilitation, Usual Care
- Where
- Kenya
- Volunteers
- 91 people
- Sponsor
- Duke University
Heart Failure, Congestive
Validation of a Mortality Prediction Model for Acutely Decompensated Heart Failure Patients
The purpose of this protocol is to determine if the 3 variable mortality prediction model established using data from a retrospective, multi-center patient registry (The ADHERE Acute Decompensated HEart FailuRE National Registry)…
- Trial name
- NCT00536367
- Testing
- No intervention - observational study only
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Brian Hiestand MD
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