Clinical trials: Congestive Heart Failure(CHF)
Heart Failure, Readmissions
Factors Contributing to Readmission of Heart Failure Patients to Emergency Departments and Prospects for Improvement
Heart failure (HF) represents a major public health challenge due to its increasing prevalence and significant impact on healthcare systems.
- Trial name
- CARDIO-REA (NCT07385404)
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Heart Failure, Growth Hormone Deficiency
Treatment of GHD Associated With CHF
Aim of the current study is to assess the cardiovascular effects of GH replacement therapy in patients with coexisting GHD and CHF
- Trial name
- NCT03775993
- Testing
- Human growth hormone
- Volunteers
- 64 people
- Sponsor
- Federico II University
Heart Failure
Heart Failure Study: The Atlanta Cardiomyopathy Consortium
Heart failure is a very common cause of hospital admission and there are half a million new cases diagnosed each year in the United States.
- Trial name
- TACC (NCT00599014)
- Where
- 2 sites in United States
- Volunteers
- 335 people
- Sponsor
- Emory University
Heart Failure, Renal Insufficiency
Safety Study of Cenderitide in Chronic Stable Heart Failure With Moderate Renal Impairment
CNDP-578-02 is a randomized, double-blind, placebo-controlled, dose-escalation, crossover design trial. Eight evaluable subjects (n=8) with chronic stable heart failure and moderate renal impairment will be randomized (1:1) to…
- Trial name
- NCT02603614
- Testing
- Cenderitide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Capricor Inc.
Heart Failure
Efficacy and Safety of Sacubitril/Valsartan in African American Patients With Heart Failure With Reduced Ejection Fraction
There is limited long-term evidence specific to AAs with HFrEF on sacubitril/valsartan therapy. Plasma NT-proBNP levels are lower in AA individuals as compared to Caucasian individuals in general.
- Trial name
- NCT05168787
- Testing
- sacubitril/valsartan
- Where
- United States
- Volunteers
- 6,558 people
- Sponsor
- Methodist Health System
Heart Failure, Myocardial Infarction
A Multinational Trial To Evaluate The Parachute Implant System
The primary objective is to assess the safety of the CardioKinetix Parachute Implant and Delivery System in the partitioning of the left ventricle in patients with heart failure due to ischemic heart disease.
- Trial name
- PARACHUTE (NCT01286116)
- Testing
- Parachute Implant
- Where
- 13 sites in France, Germany and 6 more
- Volunteers
- 59 people
- Sponsor
- CardioKinetix, Inc
Heart Failure, Left Bundle-Branch Block
Tailor-CRT: Better Application of Cardiac Resynchronization Therapy
Approximately one third of patients treated with cardiac resynchronization therapy (CRT) do not derive any clinical benefit. CRT response can be improved by tailoring LV lead placement and programming of atrio-ventricular (AV)…
- Trial name
- NCT02326493
- Testing
- Cardiac Resynchronization Therapy
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Maastricht University Medical Center
Diabetes, Heart Failure
Avoidable Hospitalizations/ Emergency Department Visits- Systematic Review and Meta-synthesis of Qualitative Research
The aim of the study is to synthesize qualitative evidence related to preventable hospitalizations/ emergency department visits from the perspectives of patients, their families/caregivers, health care providers, and…
- Conditions
- Diabetes, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05456906
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Kaohsiung Medical University
Heart Failure With Preserved Ejection Fraction, Hypomagnesemia
Intracellular Magnesium and Heart Failure
Low magnesium levels are surprisingly common in those with a heart condition known as HFpEF, where the heart pumps well but is too rigid to fill properly with blood.
- Trial name
- NCT06353750
- Testing
- Magnesium supplement
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Heart Failure
Cardiac Resynchronization Therapy Modular Registry
The purpose of the study is to collect some parameters (clinical, electrical, radiographic, echocardiographic and ECG) able to predict response to cardiac resynchronization therapy.
- Trial name
- CRT-MORE (NCT01573091)
- Testing
- Cardiac Resynchronization Therapy
- Where
- 12 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Giuseppe Ricciardi
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Congestive Heart Failure, Heart Disease
Efficiency Study of Triple-Site Cardiac Resynchronization in Patients With Heart Failure
The purpose of this study is to assess the efficiency of permanent biventricular pacing using three ventricular leads in terms of reduction in adverse cardiac events rates, improvement in cardiac capacity and patients' functional…
- Trial name
- TRUST CRT (NCT00814840)
- Testing
- Cardiac resynchronization pacemaker (InSync Sentry or Concerto, Medtronic, Minneapolis, MN,USA) with two intracardiac leads, Triple-site cardiac resynchronization
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Silesian Centre for Heart Diseases
Mitral Regurgitation
Structural Mitral Valve Project
This is a prospective Quality Improvement (QI) study using the Model for Improvement framework. The objective of this study is to implement a structured, comprehensive, innovative, and sustainable approach to the management of…
- Trial name
- NCT05678868
- Testing
- MitraClip procedure
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Queen's University
Mitral Valve Insufficiency, Heart Failure
Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure
Mitral regurgitation (MR), also known as mitral insufficiency, is a condition in which the heart's mitral valve, located between two of the heart's main chambers, does not firmly shut, allowing blood to leak backwards within the…
- Trial name
- SMMART-HF (NCT00608140)
- Testing
- Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
- Where
- 9 sites in United States, Canada
- Volunteers
- 2 people
- Sponsor
- Duke University
Heart Failure, Primary Prevention of Sudden Cardiac Death
Cardioverter DefIbriIlator PlacEMent for priMary Prevention of Sudden cArdiac Death in Patients Older Than 70 Years
The primary objective of DILEMMA study is to assess whether the "heart failure optimal therapy alone (HFOT)" strategy is non inferior to the "HFOT+ICD" strategy in terms of overall survival 48 months after randomization, in…
- Conditions
- Heart Failure, Primary Prevention of Sudden Cardiac Death, Implantable Cardioverter Defibrillator
- Trial name
- DILEMMA (NCT05373940)
- Testing
- ICD implantation, No ICD implantation
- Where
- 19 sites in France
- Volunteers
- 730 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcopenia in Elderly, Chronic Heart Failure
Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure
The goal of study is to evaluate the effects of an eight-week machine-based resistance training program on managing sarcopenia in older outpatients with chronic heart failure (HF) at Military Hospital 175.
- Trial name
- NCT06785168
- Testing
- Machine-based Resistance Training
- Where
- 2 sites in Vietnam
- Volunteers
- 146 people
- Sponsor
- Kieu Dang Phuong Nguyen
Heart Failure, Congestive
Educational Program for Various Health Literacy Levels to Improve the Health of Individuals With Heart Failure
Heart failure (HF) affects 5 million people in the United States. Health literacy, which is the ability to read and comprehend important medical information, plays an important role in the health of individuals with HF.
- Trial name
- NCT00378950
- Testing
- Teach to Goal (TTG), Brief Educational Intervention (BEI)
- Where
- 4 sites in United States
- Volunteers
- 605 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypertrophic Cardiomyopathy
Role of Perhexiline in Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy (HCM) is the most common inherited heart muscle condition affecting up to 1 in 200 of the general population.
- Trial name
- RESOLVE-HCM (NCT04426578)
- Testing
- Perhexiline
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Flinders University
Heart Failure，Congestive
Implementing a Digitally-enabled Community Health Worker Intervention for Patients With Heart Failure
The purpose of this study is to assess the acceptability, feasibility, and preliminary effectiveness of implementing a 30-day digitally-enabled community health worker intervention compared to usual care with a community health…
- Trial name
- NCT05130008
- Testing
- Digitally-enabled CHW Care, Usual CHW Care
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Failure
BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction
The purpose of this registry (NCT02880618) is to evaluate the effect of BAROSTIM THERAPY with the BAROSTIM NEO System in the commercial setting in subjects recently implanted under the CE-Marked indication for heart failure with…
- Trial name
- HFrEF (NCT02880618)
- Testing
- Barostim Neo™ System
- Where
- 30 sites in Germany, Italy
- Volunteers
- 500 people
- Sponsor
- CVRx, Inc.
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