Clinical trials: Congestive Heart Failure, completed
Palliative Care, Heart Failure
Advanced Heart Care at Home
End-of-life (EOL) care for heart failure (HF) patients includes high healthcare utilization and costs, in part due to the lack of integration of optimal HF management and home-based palliative care.
- Conditions
- Palliative Care, Heart Failure, Health Care Utilization, Quality Improvement
- Trial name
- AHCAH (NCT03724695)
- Testing
- Clinician nudge or opt out approach for AHCAH liaison visit
- Where
- United States
- Volunteers
- 709 people
- Sponsor
- University of Pennsylvania
Arterial Stiffness
Arterial Stiffness in Heart Failure and Chronic Kidney Disease
This observational study is assessing the effects that arterial stiffness may have on patients with heart failure (HF) and chronic kidney disease (CKD). Arterial stiffness will be measured by assessing pulse wave velocity (PWV).
- Trial name
- ASHFCKD (NCT05012722)
- Testing
- Sphygmocor CVMS (Atocr Medical, Sydney Australia) PWV measurement
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Congestive Heart Failure
Assess Measurements of Wireless Cardiac Output Device
Heart failure is a common cardiovascular problem which is increasing in both prevalence and incidence and associated with substantial morbidity and mortality.
- Trial name
- Remote-CO-1 (NCT02252757)
- Testing
- CoVa
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Aventyn, Inc.
Heart-Assist Devices, Heart Failure NYHA Class IV
Exergaming in Advanced HF With Multiple Chronic Conditions Prior to LVAD Implantation or Heart Transplant
The purpose of this study is to test a home-based exergaming intervention designed to decrease frailty and fatigue and improve affective well-being, functional capacity, and immune function in individuals with advanced heart…
- Conditions
- Heart-Assist Devices, Heart Failure NYHA Class IV, Exercise Training
- Trial name
- PREHAB-HF (NCT03580759)
- Testing
- PREHAB
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Nebraska
Heart Failure
REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Trial name
- NCT00271154
- Testing
- Cardiac Resynchronization Therapy (CRT) Device or Implantable Cardioverter Defibrillator (ICD) with CRT
- Where
- 65 sites in United States, Austria and 13 more
- Volunteers
- 684 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Pilot Study on Withdrawal of Spironolactone Among Heart Failure With Improved Ejection Fraction
The study is a randomized controlled pilot trial to evaluate whether withdrawal of spironolactone is safe and associated with re-deterioration of left ventricular function in patients with heart failure with improved ejection…
- Trial name
- NCT04367051
- Testing
- Withdrawal of Spironolactone, Continuation of spironolactone
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Asan Medical Center
Heart Failure
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3
This is a double-blind, randomized, two x two crossover (aprepitant vs placebo) during both initiation of Entresto, LCZ696, (50 mg dose) and at steady-state of Entresto (200 mg bid dose or the highest tolerated dose).
- Trial name
- NCT04649229
- Testing
- LCZ 696, Para-aminohippurate, Iohexol
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Yale University
Heart Failure, Cardiovascular Diseases
Activity-Aware Prompting to Improve Medication Adherence in Heart Failure Patients
The long-term objective of this project is to improve human health and impact health care delivery by developing intelligent technologies that aid with health monitoring and intervention.
- Trial name
- NCT04152031
- Testing
- Prompting
- Volunteers
- 40 people
- Sponsor
- Washington State University
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Heart Failure, Systolic, Ketonemia
Ketones in Heart Failure - Effects on Cardiac Efficiency
Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized…
- Trial name
- NCT03073356
- Testing
- Infusion of 3-OHB
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Heart Failure
Quartet Lead and Resynchronization Therapy Options III (QUARTO_III)
The purpose of the study is to assess prospectively at 6 months the percentage of responder patients implanted with a Cardiac Resynchronization Therapy (CRT-D) device and a Quartet Left Ventricular (LV) quadripolar lead and with…
- Trial name
- QUARTO_III (NCT02476201)
- Testing
- MPP ON
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Abbott Medical Devices
Heart Failure
Strategic Management to Optimize Response To Cardiac Resynchronization Therapy
The primary objective is to evaluate the benefit of the SmartDelay™ algorithm in patients with a prolonged RV-LV interval.
- Trial name
- SMART CRT (NCT03089281)
- Testing
- CRT-D
- Where
- 72 sites in United States, Canada and 9 more
- Volunteers
- 699 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Heart Attack, Cardiac Arrest
Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys
Based on limited published epidemiological data, up to an alarming 1 in 50 surgical inpatients die within 30 postoperative days.
- Conditions
- Heart Attack, Cardiac Arrest, Congestive Heart Failure, Atrial Fibrillation
- Trial name
- SATISFY-SOS (NCT02032030)
- Where
- United States
- Volunteers
- 73,952 people
- Sponsor
- Washington University School of Medicine
Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF)
Clinical Trials for Elderly Patients With Multiple Disease
The CHROMED project focuses its investigation on the applicability of an integrated solution for a pathological condition which: a) is very prevalent in ageing patients and b) severely impairs quality of life: COPD with other…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF), Sleep Disordered Breathing (SDB)
- Trial name
- CHROMED (NCT01960907)
- Testing
- CHROMED monitoring system
- Where
- 6 sites in Estonia, Slovenia and 3 more
- Volunteers
- 312 people
- Sponsor
- Restech Srl
ST Elevation Myocardial Infarction (STEMI), Coronary Artery Disease
Metformin to Reduce Heart Failure After Myocardial Infarction
The investigators will evaluate the effect of metformin therapy during 4 months in non-diabetic patients following ST-elevation myocardial infarction on left ventricular ejection fraction as measured with cardiac magnetic…
- Conditions
- ST Elevation Myocardial Infarction (STEMI), Coronary Artery Disease, Heart Failure, Diabetes
- Trial name
- GIPS-III (NCT01217307)
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- University Medical Center Groningen
Heart Failure, Myocardial Infarction
Teledi@Log - Tele-rehabilitation of Heart Patients
The idea behind the Teledi@log consortium is to develop tele-rehabilitation concepts and technologies so that all types of heart disease patients, regardless of degree of severity, can be offered individual, customized and…
- Conditions
- Heart Failure, Myocardial Infarction, Angina Pectoris, Coronary Stenosis
- Trial name
- Teledi@log (NCT01752192)
- Testing
- Telerehabilitation programme
- Where
- 2 sites in Denmark
- Volunteers
- 151 people
- Sponsor
- Aalborg University
Heart Failure With Preserved Ejection Fraction
Circulating NEP and NEP Inhibition Study in Heart Failure With Preserved Ejection Fraction
To determine biomarker responses to Entresto™in patients with Heart Failure with preserved Ejection Fraction (HFpEF) and who have high or low serum neprilysin (NEP) levels.
- Trial name
- CNEPi (NCT03506412)
- Testing
- Entresto™ 49Mg-51 mg tablet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Congestive Heart Failure
Evaluation of the BodyGuardian End-to-end Remote Monitoring Platform in an Outpatient Heart Failure Population
We will evaluate the end to end remote monitoring system in a less controlled environment and concurrently develop the infrastructure to support the back end of the system
- Trial name
- R01-Aim2 (NCT01975402)
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Mayo Clinic
Chronic Heart Failure
Safety of Repeat Doses of IV Serelaxin in Subjects With Chronic Heart Failure
The purpose of this study was to assess the safety of repeat doses of serelaxin in chronic heart failure.
- Trial name
- RELAX-REPEAT (NCT01982292)
- Testing
- RLX030 (serelaxin)
- Where
- 52 sites in United States, Australia and 11 more
- Volunteers
- 321 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Left Ventricular Synchronous Versus Sequential MultiSpot Pacing for Cardiac Resynchronization Therapy (CRT)
The SYNSEQ study intends to assess the positive left ventricular dP/dt max achieved by MultiSpot LV pacing (either simultaneously or sequentially) in comparison to the response achieved by the current (standard) BiV pacing…
- Trial name
- SYNSEQ (NCT02914457)
- Testing
- Electrophysiological Study
- Where
- 7 sites in Poland, Slovakia and 3 more
- Volunteers
- 31 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
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