Clinical trials: Congestive Heart Failure, completed
Periodic Breathing
Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing
Central sleep apnoea (CSA) is common in patients with chronic systolic heart failure (HFrEF). Various trials have shown a prevalence of 21 - 37% in this group of people.
- Trial name
- NCT03532412
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Sleep Apnea, Congestive Heart Failure
The Prevalence of Sleep Disordered Breathing in Hospitalized Patients With Acutely Decompensated Heart Failure Syndrome
OSA is associated with large negative swings in the intrathoracic pressure, significant increase in the sympathetic nerve activity and repetitive surges in blood pressure, along with episodic hypoxia and hypercapnea (8,9).
- Conditions
- Sleep Apnea, Congestive Heart Failure, Heart Failure
- Trial name
- NCT00701519
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- Ohio State University
Chronic Heart Failure
Safety of Repeat Doses of IV Serelaxin in Subjects With Chronic Heart Failure
The purpose of this study was to assess the safety of repeat doses of serelaxin in chronic heart failure.
- Trial name
- RELAX-REPEAT (NCT01982292)
- Testing
- RLX030 (serelaxin)
- Where
- 52 sites in United States, Australia and 11 more
- Volunteers
- 321 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Type 2
Effects of Rosiglitazone on Plasma BNP Levels and Left Ventricular Dysfunction
The present study aimed to evaluate the effect of rosiglitazone treatment on cardiac function compared with metformin
- Trial name
- NCT00300911
- Testing
- Rosiglitazone(drug), cardiac adverse effects
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Baskent University
Heart Failure
Discharge Education of Integrated Traditional and Western Medicine Reduces Re-hospitalization in Patients With Chronic Heart Failure
Although interventions combining patient education and postdischarge management have demonstrated benefits in patients with chronic heart failure, the benefit attributable to patient education alone is not known.
- Trial name
- NCT03447392
- Testing
- Discharge Education of Chinese Medicine
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Chronic Heart Failure
A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure
The primary objective of this study is to evaluate the safety and tolerability of single and multiple doses at escalating dose levels of mRNA-0184.
- Trial name
- NCT05659264
- Testing
- mRNA-0184
- Where
- 14 sites in United States, Poland and 1 more
- Volunteers
- 48 people
- Sponsor
- ModernaTX, Inc.
Influenza
T-cell Response-Flu Risk in Older Adults
The purpose of this study is to determine how the immune system changes with aging and makes influenza a more serious illness in older people.
- Trial name
- NCT00138398
- Testing
- Commercial TriValent Split Influenza Virus
- Where
- United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Heart Failure
Splanchnic Nerve Block for Therapy of Chronic Heart Failure (Splanchnic III)
Splanchnic vasoconstriction may contribute to decompensation of chronic heart failure (HF) via volume redistribution from the splanchnic vascular bed to the central compartment.
- Trial name
- NCT04575428
- Testing
- Splanchnic nerve block
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Heart Failure
Reveal LINQ™ Heart Failure
The purpose of the LINQ™ HF study is to characterize Reveal LINQ™ derived data from patients with heart failure by assessing the relationship between changes in LINQ™ derived data and other physiologic parameters with subsequent…
- Trial name
- LINQ HF (NCT02758301)
- Testing
- Reveal LINQ™ Insertable Cardiac Monitor (ICM)
- Where
- 19 sites in United States
- Volunteers
- 112 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Strategies for Aggressive Central Afterload Reduction in Patients With Heart Failure
Heart failure (HF) is the leading cause of hospitalization among Americans over the age of 65 years, affecting greater than 5 million in the U.S. alone.
- Trial name
- SACAR (NCT00588692)
- Testing
- SphygmoCor
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Heart Failure
Comparison of Lipophilic Versus Hydrophilic Statins on Patients With Heart Failure
There is a controversy whether statins are beneficial in patients with heart failure or not. Trials in which lipophilic statins have been used revealed positive results, unlike major studies where hydrophilic statins were…
- Trial name
- NCT03255044
- Testing
- Atorvastatin, Rosuvastatin, guideline directed therapy
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Ain Shams University
Heart Failure, Obstructive Sleep Apnea
Sleep Apnea in Heart Failure With Preserved Ejection Fraction
This is a prospective interventional study to better understand i) the prevalence of Obstructive Sleep Apnea (OSA) in Heart Failure with preserved Ejection Fraction (HFpEF), ii) its hemodynamic correlates, and iii) the impact of…
- Trial name
- NCT05008432
- Testing
- Home sleep apnea testing
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Healthy, Heart Failure
Pilot Study to Evaluate the Somnotouch Device to Quantify Spontaneous Baroreflex Sensitivity
To measure the spontaneous baroreflex sensitivity in ambulatory patient, a device made for measuring blood pressure beat by beat and continuously, the SOMNOtouch system, could be a useful tool.
- Trial name
- SOMNO-BRS (NCT02650232)
- Testing
- SOMNOtouch device (Somnomedics), Orthostatic test, Finapres Nova device (FMS system)
- Where
- 2 sites in France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Heart Failure, Myocardial Infarction
Teledi@Log - Tele-rehabilitation of Heart Patients
The idea behind the Teledi@log consortium is to develop tele-rehabilitation concepts and technologies so that all types of heart disease patients, regardless of degree of severity, can be offered individual, customized and…
- Conditions
- Heart Failure, Myocardial Infarction, Angina Pectoris, Coronary Stenosis
- Trial name
- Teledi@log (NCT01752192)
- Testing
- Telerehabilitation programme
- Where
- 2 sites in Denmark
- Volunteers
- 151 people
- Sponsor
- Aalborg University
Heart Failure, Cardiovascular Disease
Rhode Island Diastolic Dysfunction - Heart Failure
To study the hypothesis that treating patients with underlying diastolic dysfunction with oral Kuvan® (BH4, also known as tetrahydrobiopterin) in addition to current best practices will improve metabolic and echocardiographic…
- Trial name
- RIDD-HF (NCT02353312)
- Testing
- Kuvan
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Providence VA Medical Center
Myocardial Infarction, Heart Failure
Study of Oral PG-116800 Following a Heart Attack
The main purpose of the study is to test whether a possible new drug (called PG-116800) can prevent some of the damage to heart muscle in patients who have had a heart attack.
- Conditions
- Myocardial Infarction, Heart Failure, Heart Enlargement
- Trial name
- NCT00067236
- Testing
- PG-116800 (given as PG-530742)
- Where
- 52 sites in United States, Canada and 1 more
- Volunteers
- 253 people
- Sponsor
- Procter and Gamble
Peripheral Vascular Diseases, Heart Failure
Peripheral Artery Disease in Vastmanland
The main purposes of this study are: to describe the prevalence and degree of reduced left ventricular function and hypertrophy in patients with peripheral arterial disease in comparison to controls from the general population…
- Conditions
- Peripheral Vascular Diseases, Heart Failure, Ventricular Dysfunction
- Trial name
- PADVa (NCT01452165)
- Where
- Sweden
- Volunteers
- 457 people
- Sponsor
- Uppsala University
Heart Failure
Single Dose Escalation Study in Patients With Chronic Heart Failure
This study is to demonstrate the safety and tolerability of a single oral dose of BAY60-4552 in a single dose escalation design.
- Trial name
- NCT00565565
- Testing
- BAY60-4552
- Where
- 2 sites in Germany
- Volunteers
- 55 people
- Sponsor
- Bayer
Heart Failure
Goals of Care Communication
This study proposes to evaluate, among adults with advanced heart failure (HF) and their health care providers, the effects of a communication intervention designed to improve patient-provider communication about goals of care…
- Trial name
- GoC (NCT02466100)
- Testing
- goals of care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Congestive Heart Failure
Effect of Quality Improvement Tools in Congestive Heart Failure (CHF)
Hypothesis: Quality Improvement tools like "Heart Failure Discharge Checklist" which emphasizes on proper education to patients, ensure appropriate dose titration and counselling improve outcome in congestive heart failure (CHF).
- Trial name
- NCT01446536
- Testing
- Checklist cohort
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- St. Joseph Mercy Oakland Hospital
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