Clinical trials: Congestive Heart Failure, completed
Heart Failure
A Study on Impact of Canagliflozin on Health Status, Quality of Life, and Functional Status in Heart Failure
The purpose of this study is to determine the superiority of the effectiveness of canagliflozin 100 milligram (mg) daily versus placebo in participants with symptomatic heart failure (HF) in improving the overall Kansas City…
- Trial name
- CHIEF-HF (NCT04252287)
- Testing
- Canagliflozin 100 mg
- Where
- 18 sites in United States
- Volunteers
- 476 people
- Sponsor
- Janssen Research & Development, LLC
Heart Failure
Crossover Study to Compare the Pharmacokinetics and Bioavailability of a Novel Furosemide Regimen Administered Subcutaneously vs. the Same Dose Administered Intravenously in Subjects With Chronic Heart Failure
The proposed study aims to compare the pharmacokinetics and bioavailability of intravenous and subcutaneous Furosemide. Although these regimens are not intended to be bioequivalent, they are both expected to achieve therapeutic…
- Trial name
- NCT02329834
- Testing
- Fursemide Injection Solution for subcutaneous administration (80 mg), Furosemide Injection, USP
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- scPharmaceuticals, Inc.
Heart Failure, Diastolic, Diabetes Mellitus, Type 2
Effects of Empagliflozin on Exercise Capacity and Left Ventricular Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction and Type-2 Diabetes Mellitus
Patients enrolled into the study will be randomly allocated either to Empagliflozin group or control group. In the Empagliflozin group patients will be receiving standard care + Empagliflozin 10 mg o.d., in the control group…
- Trial name
- NCT03753087
- Testing
- Empagliflozin, Standard care
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Heart Failure
Home Telemonitoring System for Patients With Heart Failure
This randomized controlled trial compares a home telemonitoring system (HTS) versus usual care during a 90 days follow-up of Heart Failure (HF) ambulatory patients, in order to evaluate if the use of the HTS improves self-care…
- Trial name
- NCT04071093
- Testing
- Home Telemonitoring System (HTS)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Universidad Nacional de Tucuman
Heart Failure
Coping in Heart Failure Partnership Intervention
The purpose of this study is to examine the feasibility and preliminary effectiveness of a 12-week support and problem-solving telephone-based intervention (COPE-HF) on heart failure self-care, depression, and healthcare…
- Trial name
- COPE-HF (NCT05337293)
- Testing
- COPE-HF Partnership Intervention, Attention
- Where
- 2 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Florida State University
Post Myocardial Infarction
Daily REmote Ischaemic Conditioning Following Acute Myocardial Infarction
Remote ischaemic conditioning (RIC) is known to reduce infarct size post MI when used in the peri/immediate post infarct period.
- Trial name
- DREAM (NCT01664611)
- Testing
- Remote Ischaemic Conditioning administered via the inflation of a blood pressure cuff on the upper arm
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Leicester
Heart Failure
The Application of Negative Atrioventricular Hysteresis in Cardiac Resynchronization Therapy With MultiPoint Pacing
The purpose of this study is to evaluate the application of Negative AV Hysteresis (NAVH) to improve electrical synchrony in MultiPoint Pacing (MPP) Cardiac Resynchronization Therapy (CRT) patients.
- Trial name
- NCT02782598
- Testing
- CRT+NAVH
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Abbott Medical Devices
Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
This was a retrospective observational cohort study using patient data from the Get With The Guideline-Heart Failure (GWTG-HF) registry linked to Medicare Fee-for-Service (FFS) claims.
- Trial name
- NCT06671314
- Where
- United States
- Volunteers
- 42,494 people
- Sponsor
- Novartis
Heart Failure
Sacubitril-valsartan in Patients With Heart Failure.
The aim of this study is to evaluate the safety and efficacy of Sacubitril -Valsartan in patients with heart failure.
- Trial name
- NCT07341893
- Testing
- Sacubitril-valsartan, standard treatment of heart failure
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour University
Cardiorenal Syndrome
Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study
The long-term objective of this study is to test whether the addition of SGLT2 inhibitors to usual care during acute heart failure management in patients who develop kidney injury shortens the time to achieving symptomatic…
- Trial name
- SGLT2i in CRS (NCT06111768)
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Central Venous Pressure
Correlation of Physical Exam Versus Non-invasive Assessment Versus Invasive Assessment of Central Venous Pressure
The purpose of this study is to establish the accuracy of a non-invasive device that uses near infrared spectroscopy (NIRS) to estimate central venous pressure (CVP) comparing it to physical exam and invasive hemodynamic…
- Trial name
- NCT01574690
- Testing
- Mespere Venus System, Right heart catheterization (RHC), Physical examination of jugular vein
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mespere Lifesciences Inc.
Ischemic Heart Disease, Unstable Angina
Technology-Based Intervention to Promote Heart Health After Cardiac Rehab (Mobile4Heart)
The purpose of this study is to determine whether using a mobile app increases adherence to a heart healthy prescription after discharge from a cardiac rehab program.
- Conditions
- Ischemic Heart Disease, Unstable Angina, Systolic Heart Failure, Cardiovascular Diseases
- Trial name
- Mobile4Heart (NCT03446313)
- Testing
- Movn Mobile App
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Heart Failure
Evaluate the Safety and Efficacy of 48-Hour Infusions of HNO (Nitroxyl) Donor in Hospitalized Patients With Heart Failure
A Study to Evaluate Safety and Efficacy of Continuous 48-Hour Intravenous Infusions of HNO Donor in Hospitalized Patients with Heart Failure and Impaired Systolic Function
- Trial name
- STANDUP AHF (NCT03016325)
- Testing
- HNO Donor
- Where
- 116 sites in United States, Argentina and 11 more
- Volunteers
- 329 people
- Sponsor
- Bristol-Myers Squibb
Congestive Heart Failure, Cardiac Resynchronization Therapy
Quartet™ Bad Oeynhausen Trial
Primary objective of this study is to evaluate whether the use of a quadripolar left ventricular (LV) electrode compared to a standard bipolar LV electrode leads to lower non-responder rates in patients undergoing cardiac…
- Trial name
- QUOTA (NCT01850264)
- Testing
- Application of quadripolar / bipolar LV electrodes
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Heart Failure, Congestive
SUrvey of Guideline Adherence for Treatment of Systolic Heart Failure in Real World
The purpose of this study is to survey the guideline compliance of the cardiologists in the treatment of systolic heart failure in Korea
- Trial name
- SUGAR (NCT01390935)
- Testing
- guideline adherence
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Heart Failure，Congestive
Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)
The investigators sought to evaluate the effectiveness of treatment with furosemide + HSS in terms of reduction of serum levels of some chosen markers of heart failure and the response in terms of these markers at a compensated…
- Trial name
- NCT04628325
- Testing
- Furosemide
- Where
- 2 sites in Italy
- Volunteers
- 136 people
- Sponsor
- University of Palermo
Heart Failure, Left Ventricular Systolic Dysfunction
Cardiac Magnetic Resonance GUIDEd Management of Mild-moderate Left Ventricular Systolic Dysfunction.
Contemporary heart failure (HF) guidelines recommend insertion of a primary prevention implantable defibrillator (ICD) in patients with left ventricular ejection fraction less than 35% (LVEF < 35%) on maximally tolerated medical…
- Trial name
- CMR_GUIDE (NCT01918215)
- Testing
- ICD, ILR
- Where
- 18 sites in Australia, Germany and 1 more
- Volunteers
- 453 people
- Sponsor
- Flinders University
Heart Failure
Heart Failure Re-admission Risk Estimation Using NICaS System With Comparison to Serum BNP Levels
HF represents a major burden in the developed world. Mortality and rehospitalization rates post-discharge in patients admitted with HF may be as high as 15%-30% within 60-90 days, respectively.
- Trial name
- NCT01765335
- Testing
- NICaS system
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Heart Failure
CLUSTER-HF: Lung Ultrasound Guided Therapy in Heart Failure
Introduction: Heart failure is the leading cause of hospitalization among adults >65 years of age. Discharge from a heart failure hospitalization is followed by a 30 day readmission rate of ≈24%.
- Trial name
- CLUSTER-HF (NCT03613779)
- Testing
- LUS-guided therapy, Standard of Care
- Where
- Mexico
- Volunteers
- 130 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Chronic Heart Failure, Fragility
Effectiveness of Combined Aerobic and Strength Training in Acute and Chronic Adaptations in Patients With Heart Failure
Patients with chronic heart failure (CHF) underwent to a hospital-based cardiac rehabilitation (CR) program in the Lisbon district Hospitals will be recruited.
- Trial name
- NCT03320655
- Testing
- Combined Aerobic Training, Combined Strength Training
- Where
- Portugal
- Volunteers
- 28 people
- Sponsor
- University of Lisbon
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