Clinical trials: Congestive Heart Failure, completed
Tachycardia, Congestive Heart Failure
MADIT-CRT: Multicenter Automatic Defibrillator Implantation With Cardiac Resynchronization Therapy
The MADIT-CRT trial is designed to determine if combined implantable cardiac defibrillator (ICD)-cardiac resynchronization therapy (CRT-D) will reduce the risk of mortality and heart failure (HF) events by approximately 25%, in…
- Trial name
- MADIT-CRT (NCT00180271)
- Testing
- Cardiac resynchronization therapy with defibrillation, Implantable Cardioverter Defibrillator (ICD)
- Where
- United States
- Volunteers
- 1,820 people
- Sponsor
- Boston Scientific Corporation
Ventricular Arrythmia, Lead
Safety and Performance of INVICTA Ventricular DF4 LEADS With Active Fixation-(APOLLO)
The primary objective of this study is to assess the safety and key electrical performance of the INVICTA leads equipped with DF4 connector: ACTIVE fixation type models (single and dual coil: INVICTA 1CR, INVICTA 2CR)
- Conditions
- Ventricular Arrythmia, Lead, ICD, Heart Failure
- Trial name
- APOLLO (NCT04590144)
- Testing
- INVICTA lead
- Where
- 45 sites in Austria, France and 6 more
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- MicroPort CRM
Congestive Heart Failure
Hemodynamic Assessment in Acute Decompensated Heart Failure
This study will assess the ability of a novel optical measurement system to determine changes in the hemodynamic status of heart failure patients admitted to the hospital with a primary diagnosis of acute decompensated heart…
- Trial name
- NCT03535909
- Testing
- Noninvasive Hemodynamic Measurement System
- Where
- 2 sites in United States, Croatia
- Volunteers
- 5 people
- Sponsor
- Rodin Scientific LLC
Diastolic Dysfunction, Heart Failure
Aerobic Versus Combined Exercise and Diastolic Dysfunction
Thirty-two stable patients with chronic heart failure participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM).
- Trial name
- NCT04916184
- Testing
- aerobic exercise, combined exercise
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Evangelismos Hospital
Heart Failure With Left Ventricular Ejection Fraction Greater Than or Equal to 40 Per Cent, Healthy Volunteers
A Study to Compare How Much of the Study Treatment Finerenone Gets Into the Blood When the Same Amount is Taken in One and in Two Tablets of Different Strengths in Healthy Male Participants
In this bioequivalence study, healthy male participants took the study treatment finerenone in the form of one and two tablets of different strengths by mouth.
- Trial name
- NCT07116512
- Testing
- Finerenone (BAY94-8862): intervention A, Finerenone (BAY94-8862): intervention B
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bayer
Shortness of Breath, Acute Respiratory Failure
Enhanced FoCUS in Patients With Shortness of Breath
Retrospective observational study performed in a internal medicine ward of a French university hospital. Included patients were hospitalized for acute shortness of breath who have benefited from a eFOCUS which was defined as a…
- Trial name
- eFOCUS (NCT05403619)
- Testing
- Diagnostic test
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Nantes University Hospital
Congestive Heart Failure, Ischemic Cardiomyopathy
AutoLogous Human CArdiac-Derived Stem Cell to Treat Ischemic cArdiomyopathy (ALCADIA)
The aim of this study is to evaluate the safety and efficacy on the transplantation of autologous human cardiac-derived stem cells (hCSCs) with the controlled release of basic fibroblast growth factor (bFGF) to severe refractory…
- Conditions
- Congestive Heart Failure, Ischemic Cardiomyopathy, Ventricular Dysfunction
- Trial name
- ALCADIA (NCT00981006)
- Testing
- human cardiac stem cells
- Where
- 2 sites in Japan
- Volunteers
- 6 people
- Sponsor
- Naofumi Takehara
Heart Failure, Cognitive Impairment
HeartMapp: Assessment and Treatment for Heart Failure
In the current application, the investigators propose to elaborate upon, reconstruct and advance to pivotal trial readiness a recently validated mobile application (HeartMapp), designed for the ecological momentary assessment and…
- Trial name
- HeartMapp (NCT03827954)
- Testing
- HeartMapp+CT
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Posit Science Corporation
Heart Failure With Normal Ejection Fraction
Left Ventricular Stiffness vs. Fibrosis Quantification by T1 Mapping in Heart Failure With Preserved Ejection Fraction
StiffMAP-HFpEF trial is an investigator initiated, observational, single-center study that will evaluate whether fibrosis quantification by cardiac MRI correlates with left and right ventricular stiffness derived from…
- Trial name
- STIFFMAP (NCT02459626)
- Testing
- Diagnostic P-V-loops and MRI
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Heart Center Leipzig - University Hospital
Coronary Artery Disease, Congestive Heart Failure
Enhanced External Counterpulsation
Enhanced external counterpulsation (EECP) is a noninvasive circulatory assist device that has been as a treatment option for refractory angina in left ventricular (LV) dysfunction.
- Trial name
- NCT01355315
- Volunteers
- 19 people
- Sponsor
- Far Eastern Memorial Hospital
Heart Failure, Cardiomyopathy
Nebulized Inhaled Milrinone in a Hospitalized Advanced Heart Failure Population
Patients with end stage heart failure have significant symptoms (including fatigue and shortness of breath) which prevent them from being able to perform most activities of daily living.
- Trial name
- iMilrinone (NCT02077010)
- Testing
- Inhaled nebulized milrinone
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Heart Failure
Utility of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Predicting Renal Impairment, Further Decompensation and Rehospitalization in Acutely Decompensated and Chronic Heart Failure Patients
Acute decompensated heart failure (ADHF) is the leading cause of admission to hospital in the US, and is associated with high mortality, morbidity, and major cost to the health care system.
- Trial name
- ANGLE-HF (NCT00874289)
- Testing
- NGAL kit
- Where
- Australia
- Volunteers
- 106 people
- Sponsor
- The Alfred
Congestive Heart Failure, Renal Insufficiency
Nesiritide Infusion for the Treatment of Decompensated Heart Failure and Renal Dysfunction
The researchers hypothesize that the addition of nesiritide to standard therapy will prevent worsening of renal function in patients admitted to the hospital with decompensated heart failure and renal dysfunction relative to…
- Trial name
- NCT00119691
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Brigham and Women's Hospital
Chronic Heart Failure With Preserved Systolic Function
Dapagliflozin in PRESERVED Ejection Fraction Heart Failure
The primary purpose of this study is to evaluate the impact of dapagliflozin, as compared with placebo, on heart failure, disease specific biomarkers, symptoms, health status and quality of life in patients with chronic heart…
- Trial name
- PRESERVED-HF (NCT03030235)
- Testing
- Dapagliflozin 10Mg Oral Tablet
- Where
- 26 sites in United States
- Volunteers
- 324 people
- Sponsor
- Saint Luke's Health System
Diabetes, Hypertension
Care Guides in the Primary Care Office (Phase II)
Trained lay persons ("care guides") working with chronic disease patients and their providers can help outpatients with diabetes, hypertension, and congestive heart failure achieve standard clinical care goals
- Conditions
- Diabetes, Hypertension, Congestive Heart Failure
- Trial name
- NCT01156974
- Testing
- education and care guide, education only
- Where
- United States
- Volunteers
- 2,135 people
- Sponsor
- Allina Health System
Heart Failure, Wide QRS Complex
Effect of Rate-responsive Compared to VDD Pacing in Cardiac Resynchronization Therapy Recipients
This study aims to understand the best programming pacing mode for cardiac resynchronization therapy devices used to treat chronic heart failure.
- Trial name
- NCT06592690
- Testing
- Atrial pacing support, Atrial tracking pacing mode
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Ospedale Centrale Bolzano
Heart Failure
Advanced Telemonitoring of Patients With Heart Failure in Home Environment
Heart failure is currently not only a major medical but also a socio-economic problem. Its prevalence is estimated at 1-2% of the population with an exponential increase in older age groups.
- Trial name
- NCT05268978
- Testing
- Medimonitor
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- University Hospital Olomouc
Cardiovascular Diseases, Inflammation
Evaluation of Volume Status in Peritoneal Dialysis Patients
Patients with kidney failure on dialysis have a much higher risk of developing cardiovascular disease as compared to the general population.
- Conditions
- Cardiovascular Diseases, Inflammation, Peritoneal Dialysis
- Trial name
- NCT00182338
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McMaster University
Heart Failure, Acute Kidney Injury
Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury
The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus…
- Trial name
- MyDAKI-01 (NCT01924663)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Saskatchewan
Heart Failure and Reduced Ejection Fraction
The Effect of Ozone Treatment on Coronary Flow Reserve in Patients With Heart Failure Having Reduced Ejection Fraction
The goal of this clinical trial is to determine the effect of ozone treatment in heart failurte with reduced ejection fraction. The main questions it aims to answer are: Does ozone treatment have beneficial effects in heart…
- Trial name
- NCT07134972
- Testing
- Ozone treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ekrem Bilal Karaayvaz
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