Clinical trials: Congestive Heart Failure, completed
Diabete Mellitus, Heart Failure
Effect of Empagliflozin 10 vs 25 mg on LV Remodeling in Diabetic Patients With Anterior STEMI With Reduced LVEF
This study is investigating how the medication Empagliflozin affects the heart's structure and function in patients with heart disease.
- Conditions
- Diabete Mellitus, Heart Failure, Remodeling, Left Ventricle
- Trial name
- EMPA-DMMI (NCT07169981)
- Testing
- Empagliflozin 10 MG [Jardiance], empagliflozin (Jardiance) 25 mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Heart; Dysfunction Postoperative, Cardiac Surgery, Right Heart Failure
Femoral Venous Pulsatility and Right Heart Dysfunction in Heart Surgery: An Observational Study
Right heart failure during cardiac surgery is associated with increased perioperative morbidity and mortality. In this context, it is imperative to develop simple diagnostic tools to detect right heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- FemousTechno6 (NCT05038267)
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Montreal Heart Institute
Heart Failure, Systolic
ECG Belt vs. Echocardiographic Optimization of CRT
Cardiac resynchronization therapy (CRT) has been a valuable intervention for patients with systolic heart failure for over 15 years.
- Trial name
- NCT03305692
- Testing
- Optimization of CRT Device
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Alan J. Bank, MD
Inpatients and Outpatients With Routine 12-lead ECG
Personalized Risk Identification and Management for Arrhythmias and Heart Failure by ECG and MRI
Prevention of myocardial functional deterioration and sudden cardiac death among individuals of intermediate risk remains one of the most elusive frontiers of contemporary medicine.
- Trial name
- PRIMERI (NCT01353131)
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Johns Hopkins University
Chronic Heart Failure
Left Bundle Branch Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy
The present study will recruit 40 symptomatic heart failure patients with left ventricular ejection fraction (LVEF) below 35% and complete left bundle branch block(QRSd≥130 ms).
- Trial name
- LBBP-RESYNC (NCT04110431)
- Testing
- Left bundle branch pacing, Biventricular pacing
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cardiovascular Disease, Acute Rejection of Cardiac Transplant
Quantitative Detection of Circulating Donor-Specific DNA in Organ Transplant Recipients (DTRT-Multi-Center Study)
The primary goal of this Multicenter Study is to develop and to evaluate a method for measuring donor-specific cell free DNA in blood samples from transplant recipients as markers of rejection.
- Conditions
- Cardiovascular Disease, Acute Rejection of Cardiac Transplant, Cardiac Transplant Rejection, Heart Transplant Failure and Rejection
- Trial name
- DTRT (NCT02109575)
- Testing
- Blood Draw of up to 10 ml
- Where
- 8 sites in United States
- Volunteers
- 540 people
- Sponsor
- Medical College of Wisconsin
Cardiovascular Diseases, Heart Diseases
Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH)
To conduct a randomized, unblinded clinical trial comparing the left ventricular assist device (LVAD) with maximum medical management in patients with end-stage heart failure who were not candidates for heart transplantation.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Heart Failure, Congestive
- Trial name
- NCT00000607
- Testing
- Left ventricular assist device, Optimal medical therapy
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Columbia University
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Diuretic Response in Advanced Heart Failure: Bolus Intermittent vs Continuous INfusion
Loop diuretics are the main therapy for decongestion of patients with advanced acute heart failure. However, these patients often develop diuretic-resistance or even diuretic-refractoriness.
- Trial name
- DRAIN (NCT03592836)
- Testing
- Loop Diuretics
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Turin, Italy
Heart Failure
Brain Volume and Cardiac Function in Heart Failure
Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population.
- Trial name
- NCT06623344
- Testing
- Magnetic Resonance Imaging with or without Contrast
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Heart Failure
Home-based Disease Management Program to Improve Clinical Outcomes in Patients With Heart Failure
Although many studies have demonstrated the efficacy of disease management programs on mortality, morbidity, quality of life (Qol), and medical cost in patients with heart failure (HF), no study has focused on psychological…
- Trial name
- NCT01284400
- Testing
- Home-based disease management
- Volunteers
- 156 people
- Sponsor
- Japanese Heart Failure Outpatient Disease Management Evaluation Investigators
Heart Failure, Family Caregivers
Web-based Support to Caregivers in Heart Failure
Caregivers of people with heart failure experience a lack of support from health care in their caring role. They often want to become more involved in care, receive education and have the opportunity to share experiences with…
- Trial name
- NCT04885465
- Testing
- web-based psychoeducational support
- Where
- Sweden
- Volunteers
- 202 people
- Sponsor
- Linkoeping University
Pulmonary Hypertension, Heart Failure
Study for Evaluation of Safety and Efficacy of PADN to Treat Combined Post- and Pre- Capillary Pulmonary Hypertension Associated With Chronic Heart Failure（PADN-CpcPH-PILOT）
The goal of this pilot study is to evaluate the safety and efficacy of pulmonary artery denervation (PADN) in Combined Post- and Pre- Capillary Pulmonary Hypertension Associated with Chronic Heart Failure.
- Trial name
- NCT05996562
- Testing
- Pulmonary Artery Denervation
- Where
- 7 sites in Georgia, Italy and 3 more
- Volunteers
- 30 people
- Sponsor
- Pulnovo Medical (Wuxi) Co., Ltd.
Heart Failure
Jardiance® Post Marketing Surveillance (PMS) in Korean Patients With Chronic Heart Failure
The primary objective of this study is to monitor the safety profile of Jardiance® in Korean patient with chronic heart failure (New York Heart Association (NYHA) class II-IV) in a routine clinical setting.
- Trial name
- NCT05236673
- Testing
- JARDIANCE®
- Where
- 21 sites in South Korea
- Volunteers
- 676 people
- Sponsor
- Boehringer Ingelheim
Anemia, Chronic Heart Failure
Hepcidin in Anemic Chronic Heart Failure (CHF) Patients
Background: Anemia in chronic heart failure (CHF) is directly linked to increased mortality and reduced exercise capacity. The pathomechanism for the development of anemia in CHF is not well understood.
- Trial name
- NCT00437866
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Heart Failure, Depression
Depression and Congestive Heart Failure in Outpatients.
Patients with a diagnosis of CHF, NYHA class II, III or IV will be recruited for a study comparing a nursing intervention addressing CHF (SIM group) or CHF and depression (CIM group).
- Trial name
- NCT00321269
- Testing
- Single Illness Management, Comorbid Illness Management
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- VA Office of Research and Development
Heart Failure
Noninvasive Pulse Contour Analysis for Hemodynamic Assessment in Patients With Chronic Heart Failure
Determination of hemodynamics plays an important role in the diagnosis of chronic heart failure. The gold standard is intermittent thermodilution via pulmonary artery catheter (PAC).
- Trial name
- NCT02977546
- Testing
- Noninvasive pulse contour analysis, Pulmonary artery catheterization
- Where
- Germany
- Volunteers
- 107 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Heart Failure
Deutsches Device Qualitätsregister
It is the aim of this register to document the development of therapies by implantation of Cardioverter/Defibrillators (ICDs) and/or Cardiac Resynchronization therapy (CRT)-Systems.
- Trial name
- NCT01173783
- Where
- 7 sites in Germany
- Volunteers
- 4,008 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Pleural Effusion, Heart Failure
Noninvasive Ventilation Therapy for the Treatment of Pleural Effusion in Patients With Heart Failure
There are no investigations so far whether an application of positive pressure during non-invasive ventilation might be a therapeutic option for transudative pleural effusion in patients with heart failure.
- Trial name
- NCT03189654
- Testing
- Non-invasive ventilation
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Chronic Renal Insufficiency, Diabete Mellitus
Safety Study of GE-145 320 mg I/mL Injection vs. Iopamidol 370 mg I/mL in Elderly Subjects Undergoing Coronary Procedure
To evaluate cardio-renal and overall safety profile of GE 145 320 mg I/ml Injection when compared to iopamidol 370 mg I/mL. The study will focus on elderly subjects with either chronic renal insufficiency, or diabetes mellitus…
- Conditions
- Chronic Renal Insufficiency, Diabete Mellitus, Congestive Heart Failure
- Trial name
- NCT01252810
- Testing
- GE-145
- Where
- United States
- Volunteers
- 284 people
- Sponsor
- GE Healthcare
Hypertension
Study of Preoperative Management of Angiotensin Converting Enzyme Inhibitor (ACEi) and Angiotensin Receptor Blocker (ARB) Medications
Patients on a stable dose of ACE inhibitor or ARB medication who are scheduled for elective surgery will be randomized to take their ACE inhibitor or ARB up to and including the morning of surgery, or to hold them a day prior to…
- Trial name
- PASS (NCT01091961)
- Testing
- Preoperative ACEi/ARB management
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
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