Clinical trials: Congestive Heart Failure Acute
Acute Heart Failure, Volume Overload
Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure
Acute heart failure is a condition where the heart suddenly cannot pump blood well enough for the body's needs. Many people admitted to the hospital with acute heart failure have too much fluid in the body.
- Trial name
- INFUSE-AHF (NCT07577596)
- Testing
- Intravenous furosemide continuous infusion, Intravenous furosemide bolus injections
- Where
- Denmark
- Volunteers
- 436 people
- Sponsor
- University of Aarhus
Heart Failure
Early Care After Discharge of HF Patients
After decompensated heart failure, a number of patients have high risk of early rehospitalization as well as death. Specialized medical management for a short period but very early after discharge could be critical for optimizing…
- Trial name
- ECAD-HF (NCT01820780)
- Testing
- Natriuretic peptides levels to J7 and J14, Consultations specialized to J7 and J14, Phone calls in 6 months and 12 months
- Where
- France
- Volunteers
- 507 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure
Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure
The purpose of this project will be to determine whether consumption of beet juice concentrate prior to exercise may acutely improve exercise tolerance in patients with heart failure.
- Trial name
- NCT01946542
- Testing
- beet juice concentrate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Jason Allen, Ph.D.
Acute Heart Failure
A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)
A placebo controlled, double-blind and randomized study to assess different doses of a new drug (BAY58-2667) given intravenously, to evaluate if it is safe and can help to improve the well-being of patients with acute…
- Trial name
- COMPOSE 2 (NCT01067859)
- Testing
- Cinaciguat (BAY58-2667)
- Where
- 30 sites in United States, Argentina and 7 more
- Volunteers
- 5 people
- Sponsor
- Bayer
Acute Heart Failure, Acute Coronary Syndrome
Heart Failure-USB: Prediction and Progression
This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical…
- Trial name
- HF-USB (NCT04000061)
- Testing
- medical chart review, data generated by direct IT export
- Where
- Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Heart Failure
Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study
The purpose of this study is to determine the benefits and safety of intravenous administration of low dose nesiritide or low dose dopamine in patients with congestive heart failure and kidney dysfunction.
- Trial name
- ROSE/RED ROSE (NCT01132846)
- Testing
- Nesiritide, Dopamine
- Where
- 8 sites in United States, Canada
- Volunteers
- 360 people
- Sponsor
- Duke University
Heart Failure, Obstructive Sleep Apnea
The Role of Sleep Apnea in the Acute Exacerbation of Heart Failure
This study will evaluate whether treating sleep apnea while in the hospital would help heart failure, and assist recovery from the worsening of the heart function more than the current clinical standard of waiting for treatment…
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Heart Failure, Congestive
- Trial name
- NCT00679549
- Testing
- CPAP Therapy
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Ohio State University
Heart Failure
Slow Continuous Ultrafiltration Using Central vs Peripheral Line: Feasibility of Implementation, Safety and Efficacy in Acute Heart Failure Syndromes.
Slow continuous ultrafiltration using central vs peripheral line: feasibility of implementation, safety and efficacy in acute heart failure syndromes.
- Trial name
- NCT01630317
- Testing
- Peripheral line, Central line vein
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Parc de Salut Mar
Heart Failure，Congestive, Atrial Fibrillation
The Cardio-share Telemedicine Cross-sector Collaboration Model for Managing Vulnerable Patients With Heart Failure
The goal of this observational study is to explore the potential of implementing a telemedicine-based cross-sector collaboration model to manage patients with frequent admissions with decompensated heart failure.
- Trial name
- ADHFQUAL-BFH (NCT06176131)
- Testing
- Telemedicine-based cross-sector collaboration for patient management
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Heart Failure
Pressure Wire Guided Cardiac Resynchronisation Therapy
Heart failure patients may benefit from having a special pacemaker implanted that can make the heart pump in a more coordinated and efficient way Cardiac Resynchronisation Therapy (CRT).
- Trial name
- NCT01464502
- Testing
- Standard CRT Implant, Pressure-wire guided CRT implant
- Where
- 10 sites in Italy, United Kingdom
- Volunteers
- 282 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Pulmonary Hypertension, Right Heart Failure
RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation
Exercise training in Pulmonary arterial hypertension in the setting of rehabilitation leads to an enormous improvement of functional state and haemodynamics. However the underlying mechanism is still unkown.
- Conditions
- Pulmonary Hypertension, Right Heart Failure, Heart Failure, Contractility
- Trial name
- Reserve (NCT04188756)
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- University of Giessen
Acute Heart Failure
French Observatory of Acute Heart Failure
During the last decade, progress has been made in the management of heart failure. However, the changing characteristics of patients and practices in the "real world" and their impact on the prognosis of patients admitted for…
- Trial name
- OFICA (NCT01080937)
- Where
- France
- Volunteers
- 1,818 people
- Sponsor
- French Cardiology Society
Dyspnea, Heart Failure
The Triple A Initiative Study ("Aktionsbündnis Akute Atemnot")
Acute dyspnea is a common chief complaint of patients presenting to the emergency department. Patients with acute dyspnea display a high mortality rate.
- Trial name
- NCT02049853
- Testing
- NTproBNP measurement with point of care device "Cobash232" in the POCT group
- Where
- 6 sites in Germany
- Volunteers
- 67 people
- Sponsor
- Prof. Dr. Michael Christ
Heart Diseases, Cardiovascular Diseases
Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes
Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well…
- Conditions
- Heart Diseases, Cardiovascular Diseases, Acute Myocardial Infarction, Unstable Angina
- Trial name
- NCT01804439
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Heart Failure
A Health Economic Evaluation of Using N-Terminal Pro Brain Natriuretic Peptide (NT-Pro BNP) in Acute Heart Failure
Cardiac biomarkers have dramatically impacted the way HF patients are evaluated and managed. In fact, the role of biomarkers has developed to better differentiate HF against other diseases and, to timely initiate and influence…
- Trial name
- NCT03669198
- Testing
- NT-Pro BNP
- Where
- Indonesia
- Volunteers
- 56 people
- Sponsor
- Heart Failure Biomarker Group
Acute Dyspnea, Acute Heart Failure
Multimarker Approach for Acute Dyspnea in Elderly Patients Admitted in the Emergency Department
Elderly people constitute the largest proportion of emergency department (ED) patients, representing 12% of all ED admissions. The need for diagnostic tests or therapeutic interventions is much greater in this patient population.
- Trial name
- READ-MA (NCT04240067)
- Testing
- READ-MA Multimarker Approach
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Heart Failure, Congestion
SUbCONgestion in Heart Failure Registry
The goal of this observational study is to learn about the decongestion process in heart failure patients. The main question it aims to answer is: What is the behavior of congestion during hospitalization in adult patients with…
- Trial name
- SUCONIC (NCT06244693)
- Testing
- No intervention
- Where
- Chile
- Volunteers
- 49 people
- Sponsor
- University of Chile
Heart Failure, Systolic
Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure
The study evaluates the pharmacokinetics of metformin in heart failure patients in acute and chronic state in relation to metformin transporter genotypes.
- Trial name
- MetKin (NCT02797340)
- Testing
- Blood draws and urine samples for metformin concentration measurements, Metformin
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Aarhus University Hospital
Heart Failure, Sleep Apnea, Obstructive
Adaptive Servo-Ventilation In Acute Heart Failure Patients Protecting the Heart and Kidneys
The primary hypothesis of this study is: the use of minute ventilation-adaptive servo-ventilation (MV-ASV) during hospitalization will mitigate deterioration in renal function and prevent kidney injury in patients admitted with…
- Trial name
- ASLEEP PK (NCT02796638)
- Testing
- Adaptive Servo-Ventilation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Veterans Medical Research Foundation
Acute Heart Failure With Reduced Left Ventricular Ejection Fraction
Telemonitoring to Optimize Medication Titration for Heart Failure: a Feasibility Study
Problem: Aggressive titration of guideline-directed medical therapy is the cornerstone of heart failure management to reduce heart failure related hospitalization and mortality.
- Trial name
- TOM-HF (NCT07016815)
- Testing
- Wearable wrist heart rate and activity monitor, Bluetooth enabled body weight scale with bioimpedance analysis, Bluetooth enabled electronic blood pressure device
- Where
- 2 sites in Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong