Clinical trials: Congestive Heart Failure Acute
Acute Decompensated Heart Failure
The STIM-ADHF Study
The STIM-ADHF Study is a multi-center, observational study to assess the performance and safety of the CPNS System in patients with ADHF.
- Trial name
- NCT05313438
- Testing
- CPNS Therapy
- Where
- 6 sites in Hungary, Poland and 1 more
- Volunteers
- 13 people
- Sponsor
- Cardionomic Inc.
Heart Failure Acute, Point-of-care Ultrasound
Simulation-Based Cardiac Point-of-Care Ultrasound Program to Improve Clinical Outcomes in Acute Heart Failure Patients
The aim of this study is to co-design a cardiac POCUS simulation training intervention and implementation strategy for EM clinicians and evaluate the effectiveness of the cardiac point-of-care ultrasound (POCUS) simulation-based…
- Conditions
- Heart Failure Acute, Point-of-care Ultrasound, Simulation Training, Implementation Science
- Trial name
- NCT07592598
- Testing
- Simulation POCUS training, Clinical Practice Guidelines
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Duke University
Acute Decompensated Heart Failure
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve System to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure…
- Trial name
- FASTR-II (NCT06898515)
- Testing
- Reprieve System, furosemide infusion
- Where
- 50 sites in United States, Germany and 3 more
- Volunteers
- 400 people
- Sponsor
- Reprieve Cardiovascular, Inc
Heart Failure
Access Natriuretic Peptide Assay(s) Pivotal - Emergency Department Subject Enrollment and Specimen Collection
The purpose of the pivotal study is to collect blood specimens and clinical data from patients suspected of having Heart Failure (HF), which will be tested at a future date on Natriuretic Peptide assay(s) to validate diagnostic…
- Trial name
- NCT04169815
- Testing
- Access Immunodiagnostic Products
- Where
- 15 sites in United States
- Volunteers
- 2,370 people
- Sponsor
- Beckman Coulter, Inc.
Dyspnea; Cardiac
Bedside Lung Ultrasonography by Nurses in Acute Dyspnea.
This study assesses the potential of lung ultrasonography to diagnose heart failure.
- Trial name
- LUS (NCT05126940)
- Testing
- we perform a lung ultrasound to all the patients admitted for dyspnea independantly from the final diagnosis
- Where
- Tunisia
- Volunteers
- 216 people
- Sponsor
- University of Monastir
Acute Heart Failure
Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT)
The primary objective is to test the hypothesis that, compared with placebo, therapy with Subcutaneous (SQ) GLP-1 agonist in the post-Acute Heart Failure Syndrome (AHFS) discharge period will be associated with greater clinical…
- Trial name
- FIGHT (NCT01800968)
- Testing
- Liraglutide
- Where
- 25 sites in United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Heart Failure Acute
Prognostic Model Heart Failure
This study aims to determine the prognosis of heart failure in our population by using multiple validated risk scores and to evaluate the strengths of these scores in assessing prognosis with better discrimination.
- Trial name
- NCT06414928
- Testing
- Acute Heart Failure
- Where
- Pakistan
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Heart Decompensation, Heart Failure, Congestive
Pilot Study for the Evaluation of the Safety and Performance of the RenaSense System in Hospitalized Acute Decompensated Heart Failure Patients
The study is intended to verify the safety and assess the performance of up to 3-days treatment protocol with the RenaSense System in ADHF patients.
- Conditions
- Heart Decompensation, Heart Failure, Congestive, Renal Insufficiency
- Trial name
- NCT02324400
- Testing
- RenaSense Stimulation
- Where
- 3 sites in Israel
- Volunteers
- 36 people
- Sponsor
- Nephera Ltd.
Acute Myocardial Infarction, Chronic Heart Failure
Pilot Study of ILIADE : Exploring Health Literacy Within Patients Hospitalized for Acute Cardiovascular Events
Health literacy (HL) is the ability to access, understand, evaluate and apply information in order to communicate with health professionals and understand health instructions but also, promote, maintain and improve health…
- Trial name
- P-ILIADE (NCT03949309)
- Testing
- Exploring health literacy levels and patients' informal needs or individual relationship between caregivers and patients.
- Where
- France
- Volunteers
- 209 people
- Sponsor
- Hospices Civils de Lyon
Congestive Heart Failure
Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure
This study is being done to determine the effects of subcutaneous (under the skin) injection of human B-type natriuretic factor (BNP), Natrecor (nesiritide), a hormone produced by the heart, in combination with Tadalafil on: The…
- Trial name
- NCT01544998
- Testing
- Nesiritide, Tadalafil, Saline load
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Congestive Heart Failure
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
In congestive heart failure, cardiac output is low, blood pressure is high, and the body becomes congested with fluid. In normal people, when there is high blood pressure, the heart muscle cells secrete a hormone that excretes…
- Trial name
- PPG1 (NCT00387621)
- Testing
- Nesiritide, Saline
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Horng Chen
Kidney Failure, Acute, Myopathy; Drugs
The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)
The study aims to improve the safety of the electroporation ablation (PFA) procedure by using muscle relaxants to reduce skeletal muscle damage during the procedure.
- Conditions
- Kidney Failure, Acute, Myopathy; Drugs, Heart Arrhythmia, Succinylcholine Sensitivity
- Trial name
- NCT06707532
- Testing
- Propofol, Rocuronium
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Heart Failure
Feasibility Study of a Home Hospitalisation Strategy for Patients With Heart Failure
This feasibility study is part of a larger interregional European project (NWE-Chance) financially supported by the 'Interreg North West Europe' program to develop and validate promising integrated eHealth applications combined…
- Trial name
- NWECHANCE (NCT04084964)
- Testing
- Home-hospitalisation platform for heart failure
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- Hasselt University
Heart Failure, Cardiorenal Syndrome
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion despite usual medical therapy.
- Conditions
- Heart Failure, Cardiorenal Syndrome, Cardio-Renal Syndrome, ADHF
- Trial name
- DRAIN-HF (NCT05677100)
- Testing
- Aortix System
- Where
- 50 sites in United States, Hungary
- Volunteers
- 320 people
- Sponsor
- Procyrion
Acute Decompensated Heart Failure
A Study to Explore the Efficacy of TRV027 in Patients Hospitalized for Acute Decompensated Heart Failure
To evaluate the overall safety and efficacy of TRV027 when administered in addition to standard of care (SOC) on mortality, morbidity, dyspnea, and length of stay in patients hospitalized with Acute Decompensated Heart Failure…
- Trial name
- BLAST-AHF (NCT01966601)
- Testing
- TRV027 Dose #1, TRV027 Dose #2, TRV027 Dose #3
- Where
- 62 sites in United States, Argentina and 10 more
- Volunteers
- 620 people
- Sponsor
- Trevena Inc.
Heart Failure
HeartMed-HF Digital Therapeutics Improves Exercise Capacity in CHF Patients After AMI
Chronic heart failure (HF) is a severe manifestation and terminal stage of various cardiovascular diseases, with high incidence and mortality rates.
- Trial name
- NCT06478732
- Testing
- health services
- Volunteers
- 710 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Heart Decompensation
Short-term Efficacy of Furosemide, Isosorbide Dinitrate and Their Combination in ADHF
Background: Acute decompensated heart failure (ADHF) is a common and potentially fatal cause of acute respiratory distress that requires immediate treatment in emergency department.
- Trial name
- NCT02649998
- Testing
- Furosemide, Isosorbide Dinitrate
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
ST Segment Elevation Myocardial Infarction, Heart Failure
Doxycycline to Protect Heart Muscle After Heart Attacks
Current medical treatment allows more people to survive heart attacks than in the past. However, some of the survivors suffer heart disease and require hospitalization later on.
- Trial name
- NCT03508232
- Testing
- Doxycycline Hyclate
- Where
- Canada
- Volunteers
- 174 people
- Sponsor
- University of Alberta
Heart Failure, Acute Myocardial Infarction
Eplerenone in Heart Failure Treatment
Beta-blockers should be administered to all patients with heart failure stage II to IV according to NYHA.Beta-blockers reduce mortality and hospitalizations and improve the operational phase for all categories of patients with…
- Conditions
- Heart Failure, Acute Myocardial Infarction, Hypertension
- Trial name
- INOSET (NCT02344199)
- Where
- 3 sites in Greece
- Volunteers
- 450 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Acute Heart Failure
Estimated Plasma Volume in Patients With Acute Heart Failure
Congestion plays an essential role in acute heart failure (AHF) outcomes. Estimated plasma volume status (ePVS), derived from simple hematological parameters, may offer prognostic value.
- Trial name
- ePVS (NCT07085793)
- Where
- Tunisia
- Volunteers
- 2,500 people
- Sponsor
- University of Monastir