Clinical trials: Congestive Heart Failure Acute
Shock, Cardiogenic, Heart Failure
Effects of Pyruvate in Patients With Cardiogenic Shock and Intra-aortic Balloon Counterpulsation
Pyruvate is an intermediate of energy metabolism and was shown to possess pronounced positive inotropic effects in vitro and in vivo without altering myocardial oxygen consumption.
- Conditions
- Shock, Cardiogenic, Heart Failure, Acute Myocardial Infarction
- Trial name
- NCT00604331
- Testing
- Pyruvate
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Herzzentrum Goettingen
Acute Decompensated Heart Failure
Evaluate the Efficacy and Safety of Short-term Administration of SIMDAX
A randomized, double-blind, Multicenter, parallel, placebo-controlled study
- Trial name
- NCT03555123
- Testing
- Simdax
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Cardiogenic Shock
Empagliflozin's Microcirculatory Effects in Cardiogenic Shock: an Ancillary Pilot Study of the EMPASHOCK Trial
Despite advancements in treatment, the mortality rate for cardiogenic shock (CS) remains high at around 50%. The EMPULSE-HF trial showed that early introduction of empagliflozin in stabilized patients with acute heart failure led…
- Trial name
- EMPAmicroSHOCK (NCT07141355)
- Testing
- microcirculation using the video microscopy tool.
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Heart Failure, Diuretics Drug Reactions
Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment
This is a pragmatic, multicenter, interventional, parallel-arm, randomized, open-label trial to investigate whether a diuretic regimen, based on serial assessment of sodium concentration (UNa) on spot urine samples after diuretic…
- Trial name
- DECONGEST (NCT05411991)
- Testing
- UNa measurement after intravenous loop diuretic bolus, Intravenous acetazolamide 500 mg OD, Intravenous bumetanide TID
- Where
- 2 sites in Belgium
- Volunteers
- 107 people
- Sponsor
- Vrije Universiteit Brussel
Kidney Injury, Acute, Cardiac Function Failed
Effect of Vasopressin on Kidney and Cardiac Function in Septic Shock
Septic shock is a syndrome characterized by tissue hypoperfusion and hypotension secondary to an uncontrolled infection. It is a frequent cause of admission to the intensive care unit (ICU) and has an associated mortality around…
- Trial name
- NCT06125184
- Testing
- Vasopressor test
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Dyspnea,, Acute Heart Failure Syndrome
Fluid Status of Outpatients With Dyspnea
The purpose of this study is to determine the distribution of lung fluid status as reported by the IMED-4 system in patients presenting to the emergency department or urgent care facility with shortness of breath.
- Conditions
- Dyspnea,, Acute Heart Failure Syndrome, Pulmonary Congestion
- Trial name
- FLOOD (NCT02111525)
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Intersection Medical, Inc.
Heart Failure
FRENCH OBSERVATORY OF ACUTE HEART FAILURE-2
In 2009, OFICA 1 provided a snapshot of the management of acute heart failure in France. Over the past 10 years, practitioners have observed a change in the profiles of hospitalized patients and it is necessary to specify the…
- Trial name
- OFICA2 (NCT05232058)
- Where
- France
- Volunteers
- 1,593 people
- Sponsor
- French Cardiology Society
Heart Failure
Effects of Acute and Chronic Empagliflozin Heart Failure
This is a 60-patient randomized, double-blind, placebo-controlled mechanistic study to understand the utility of empagliflozin in worsening heart failure (HF) patients with or without diabetes.
- Trial name
- EMPA HF (NCT05553938)
- Testing
- Empagliflozin 10 mg
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Yale University
ACS (Acute Coronary Syndrome), HF - Heart Failure
A Clinical Study on the Effect of Cardiopulmonary Function and Quality of Life in Patients With Acute Coronary Syndrome Complicated by Heart Failure by "Lying-Sitting-Standing" Sequential Baduanjin
This study investigates the effects of a sequential "lying-sitting-standing" Baduanjin intervention on patients with acute coronary syndrome complicated by heart failure.
- Trial name
- NCT07486791
- Testing
- standard treatment and routine rehabilitation nursing guidance, "Lying-Sitting-Standing" Sequential Baduanjin
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xiling Qi
Acute Decompensated Heart Failure, Volume Overload
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
This study aims to compare two medications, acetazolamide and metolazone, along with loop diuretics, to see which one works better and is safer for patients with ADHF who have volume overload.
- Conditions
- Acute Decompensated Heart Failure, Volume Overload, Edema
- Trial name
- NCT06414759
- Testing
- Acetazolamide, Metolazone, IV Loop Diuretics
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Cairo University
Heart Failure, Sleep Apnea Syndromes
Treatment of Sleep Disordered Breathing In Acute Decompensated Heart Failure Patients
Heart Failure affects 5-6 million Americans and there are about 550 thousand new cases of heart failure every year. There are approximately 3 million hospital admission for acute decompensated heart failure with hospital…
- Trial name
- ARIA-II (NCT00804349)
- Testing
- Autotitrating Positive Airway Pressure
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Albert Einstein Healthcare Network
Acute Decompensated Heart Failure
Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure
The primary objective of the study is to determine efficacy of metolazone as synergistic therapy with Lasix in patients with acute decompensated heart failure.
- Trial name
- MELT-HF (NCT05633758)
- Testing
- Metolazone
- Where
- United States
- Sponsor
- Scripps Health
Acute Myocardial Infarction, Heart Failure
Inflammation-mediated Coronary Plaque Vulnerability, Myocardial Viability and Ventricular Remodeling
VIABILITY study aims to investigate the link between systemic inflammation, pancoronary plaque vulnerability (referring to the plaque vulnerability within the entire coronary tree), myocardial viability and ventricular remodeling…
- Trial name
- VIABILITY (NCT03830944)
- Testing
- Blood sampling, transthoracic echocardiography, Late Gadolinium-Enhancement Cardiac Magnetic Resonance
- Where
- Romania
- Volunteers
- 150 people
- Sponsor
- Cardio Med Medical Center
Chronic Heart Failure
Evaluation of Functionnal ElectromyoStimulation on Leg In Advanced Chronic Heart Failure After Hospitalisation for Acute Decompensation
The purpose of the study is to test the efficacy of the Functionnal ElectromyoStimulation (FES) of lower limbs in advanced chronic heart failure. The hypothesis is that FES treatment could improve functional exercise capacity.
- Trial name
- EMSICA (NCT01548508)
- Testing
- Functionnal ElectroStimulation (FES)
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Cardiorenal Syndrome
Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study
The long-term objective of this study is to test whether the addition of SGLT2 inhibitors to usual care during acute heart failure management in patients who develop kidney injury shortens the time to achieving symptomatic…
- Trial name
- SGLT2i in CRS (NCT06111768)
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Heart Failure, Acute Kidney Injury
Treatment According to Venous Excess Ultrasound Score in Patients With Heart Failure
Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1).
- Trial name
- NCT06341816
- Testing
- VEXUS score, NGAL
- Volunteers
- 100 people
- Sponsor
- Inonu University
Acute Heart Failure, Diabetes Mellitus
Short Term Outcome of Acute Heart Failure in Diabetic and Non Diabetic Patients
Around 26 million people suffer from heart failure (HF) globally, and the prevalence is increasing with an increasing longevity, prevalence of risk factors, and improved survival in patients with cardiovascular diseases In Egypt…
- Trial name
- NCT06447467
- Testing
- pro BNP
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Heart Failure; With Decompensation
Compression Wraps as Adjuvant Therapy in Management of Acute Systolic Heart Failure
There will be two populations in this study: control group, and intervention group. These groups will undergo propensity matching to account for confounders and minimize selection bias.
- Trial name
- CATAS-HF (NCT04095416)
- Testing
- ACE compression wrap
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Henry Ford Health System
Pulmonary Hypertension, Right Heart Failure
RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation
Exercise training in Pulmonary arterial hypertension in the setting of rehabilitation leads to an enormous improvement of functional state and haemodynamics. However the underlying mechanism is still unkown.
- Conditions
- Pulmonary Hypertension, Right Heart Failure, Heart Failure, Contractility
- Trial name
- Reserve (NCT04188756)
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- University of Giessen
Acute Decompensated Heart Failure
Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients
The goal of this clinical trial is to compare the effectiveness of acetazolamide versus dapagliflozin as an add-on in treating acute decompensated heart failure (ADHF) in adult patients with clinical signs of volume overload…
- Trial name
- NCT06535529
- Testing
- Acetazolamide, Dapagliflozin 10mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Helwan University