Clinical trials: Congestive Heart Failure Acute
Dyspnea, Hypertension
Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF
The purpose of this study is to evaluate dyspnea improvement and other parameters of efficacy and safety in acute heart failure (AHF) patients receiving an intravenous (IV) infusion of clevidipine in comparison to standard of…
- Conditions
- Dyspnea, Hypertension, Acute Heart Failure
- Trial name
- PRONTO II (NCT04592380)
- Testing
- Stage 1: Clevidipine (double-blinded), Stage 2: Clevidipine (open-label), Stage 2: Standard of Care (open-label)
- Where
- 9 sites in United States
- Sponsor
- The Medicines Company
Chronic Heart Failure, Heart Diseases
Effect of Intravenous Ferrous Sucrose on Exercise Capacity in Chronic Heart Failure
This is a two-center, randomised, single-blind (physician), prospective, controlled study to assess the acute (8 weeks) and chronic (16 weeks) effects of intravenous (IV) iron sucrose supplementation in anaemic and non-anaemic…
- Conditions
- Chronic Heart Failure, Heart Diseases, Anemia, Iron-Deficiency
- Trial name
- NCT00125996
- Testing
- Venofer (intravenous iron sucrose)
- Where
- 2 sites in Poland, United Kingdom
- Volunteers
- 42 people
- Sponsor
- National Heart and Lung Institute
Disease
Chronic Obstructive Pulmonary Disease (COPD) in Patients Hospitalized for Acute Decompensated Heart Failure.
The presence of chronic obstructive pulmonary disease (COPD) would confer increased in-hospital mortality and length of hospital stay in patients with acute decompensated heart failure Assess the (1) prevalence of COPD in…
- Trial name
- COPD (NCT02340702)
- Testing
- COPD
- Sponsor
- Mayo Clinic
Heart Failure Acute, Heart Failure; With Decompensation
Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart Failure
This is a prospective, single-center, open-label and randomized trial for evaluation of the effect of a 5-day administration of high doses of spironolactone (≥100mg daily) on diuresis, natriuresis, weight loss and levels of…
- Trial name
- DANAUS-AHF (NCT04618601)
- Testing
- Spironolactone
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Laikο General Hospital, Athens
Cardiovascular Disease, Acute Rejection of Cardiac Transplant
Quantitative Detection of Circulating Donor-Specific DNA in Organ Transplant Recipients (DTRT-Multi-Center Study)
The primary goal of this Multicenter Study is to develop and to evaluate a method for measuring donor-specific cell free DNA in blood samples from transplant recipients as markers of rejection.
- Conditions
- Cardiovascular Disease, Acute Rejection of Cardiac Transplant, Cardiac Transplant Rejection, Heart Transplant Failure and Rejection
- Trial name
- DTRT (NCT02109575)
- Testing
- Blood Draw of up to 10 ml
- Where
- 8 sites in United States
- Volunteers
- 540 people
- Sponsor
- Medical College of Wisconsin
Cardiogenic Shock, Acute Myocardial Infarction of Inferior Wall
Routine Versus Provisional Distal Perfusion Catheter Placement in Patients Undergoing Mechanical Circulatory Support
A prospective, multi-center, open label, randomized controlled, superiority trial to compare clinical outcomes between routine distal perfusion catheter (DPC) insertion versus provisional distal perfusion catheter (DPC) insertion…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction of Inferior Wall, Congestive Heart Failure, Myocarditis
- Trial name
- PERFUSE-MCS (NCT07482865)
- Testing
- Distal perfusion catheter insertion
- Where
- 6 sites in South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Heart Decompensation, Mechanical Ventilation Pressure High
Comparison of PEEP in Acute Decompensated Heart Failure
Little is known about optimal level of positive end-expiratory pressure (PEEP) in patiens who recieved invasive mechanical ventilation for acute decompensated heart failure.
- Trial name
- NCT04853563
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Asan Medical Center
Acute Heart Failure (AHF), Heart Failure
Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure
The goal of this observational study is to learn how changes in urinary sodium and chloride levels relate to fluid overload and short-term outcomes in patients hospitalized with acute heart failure (AHF).
- Conditions
- Acute Heart Failure (AHF), Heart Failure, Congestion
- Trial name
- CLORINA-IC (NCT07597512)
- Where
- 4 sites in Spain
- Volunteers
- 223 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Heart Failure
Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure
The purpose of this project will be to determine whether consumption of beet juice concentrate prior to exercise may acutely improve exercise tolerance in patients with heart failure.
- Trial name
- NCT01946542
- Testing
- beet juice concentrate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Jason Allen, Ph.D.
Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI)
Preoperative Cardiology Consultation and the Incidence of Major Adverse Cardiac Events（MACE）
This cohort study aims to determine when preoperative cardiology consultation is needed to reduce the incidence of major adverse cardiac events (MACE) in elderly patients undergoing non-cardiac surgery.
- Conditions
- Major Adverse Cardiac Events, Acute Myocardial Infarction (AMI), Cardiac Death, Sudden, Cardiac Arrest (CA)
- Trial name
- MACE (NCT06884436)
- Where
- China
- Volunteers
- 22,000 people
- Sponsor
- Chinese PLA General Hospital
Chronic Heart Failure
Safety and Efficacy Study of YM087 (Conivaptan) in Patients With Acute Decompensated Heart Failure
This is a randomized, double-blind, placebo-controlled, dose ranging pilot study to examine the effects of conivaptan in patients with acute decompensated heart failure.
- Trial name
- NCT00057356
- Testing
- conivaptan
- Where
- 26 sites in United States
- Volunteers
- 170 people
- Sponsor
- Cumberland Pharmaceuticals
Acute Myocardial Infarction, Chronic Heart Failure
Pilot Study of ILIADE : Exploring Health Literacy Within Patients Hospitalized for Acute Cardiovascular Events
Health literacy (HL) is the ability to access, understand, evaluate and apply information in order to communicate with health professionals and understand health instructions but also, promote, maintain and improve health…
- Trial name
- P-ILIADE (NCT03949309)
- Testing
- Exploring health literacy levels and patients' informal needs or individual relationship between caregivers and patients.
- Where
- France
- Volunteers
- 209 people
- Sponsor
- Hospices Civils de Lyon
Acute Decompensated Heart Failure
Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF
The objective of this interventional study is to evaluate the safety and functional performance of the Nephronyx System in patients with ADHF, presenting clinical signs of volume overload and compromised response to diuretics.
- Trial name
- NCT05759806
- Testing
- Nephronyx system (Perfuser)
- Where
- 4 sites in Israel
- Volunteers
- 10 people
- Sponsor
- Nephronyx LTD
Cardiogenic Shock
Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock
The goal of this clinical trial is to learn if the drug istaroxime works to treat cardiogenic shock due to acute heart failure in adults. It will also learn about the safety of istaroxime.
- Trial name
- RESCUE HF-CS (NCT07583446)
- Testing
- istaroxime
- Where
- Armenia
- Volunteers
- 600 people
- Sponsor
- Seismic Pharmaceuticals Operations LLC
Acute ST-elevation Myocardial Infarction
Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction.
Heart imaging with magnetic resonance imaging (MRI) provides detailed insights into heart function and injury. The nature and significance of heart injury after a heart attack is incompletely understood.
- Trial name
- BHF MR-MI (NCT02072850)
- Testing
- Coronary pressure wire, Magnetic resonance imaging of the heart
- Where
- United Kingdom
- Volunteers
- 324 people
- Sponsor
- NHS National Waiting Times Centre Board
Heart Failure
Evaluation of Circulating Levels of Adult Stem Cells in the Peripheral Blood of Patients With Acute Decompensated Heart Failure and Following Stabilization, in Comparison With Healthy Volunteers
Despite advances in medical technology, heart failure remains a major cause of illness on a global scale. Medical research, over recent years, has shown that adult stem cells (as opposed to embryonic stem cells) are present in…
- Trial name
- CIRCSTEM-HF (NCT01027403)
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Monash University
Acute Heart Failure
Determining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE Study)
The purpose of this study is to determine if certain findings (blood tests, symptom improvement, etc.) after acute heart failure treatment can identify a group of patients who are safe for early hospital discharge.
- Trial name
- DECIDE (NCT00911703)
- Where
- 2 sites in United States
- Volunteers
- 835 people
- Sponsor
- Vanderbilt University
Shortness of Breath, Acute Exacerbation
NT-proBNP for Evaluation of the Dyspneic Patient in the Emergency Room and the Medical Ward
The proposed study intends to evaluate the impact of the NT-proBNP assay on the diagnosis of heart failure in patients with dyspnea of unknown etiology presenting to the emergency room and admitted to the medical wards.
- Trial name
- NCT00271128
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hillel Yaffe Medical Center
Heart Failure
Interleukin (IL)-1 Blockade in Acute Heart Failure (Anakinra ADHF)
Anakinra ADHF is a double-blind randomized clinical trial of anakinra, recombinant human interleukin-1 receptor blocker, or placebo in patients with acute decompensated heart failure with the aim to quench the acute inflammatory…
- Trial name
- NCT01936844
- Testing
- Anakinra (high dose), Anakinra (standard dose)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI
Metabolomics and Microbiomics in Cardiovascular Diseases
"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of…
- Conditions
- Acute Heart Failure, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction, Myocardial Infarction, Acute
- Trial name
- MEMORIA (NCT04146701)
- Testing
- Blood draw
- Where
- Germany
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim