Clinical trials: Congestive Heart Failure Acute
Acute Heart Failure
Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF
The purpose of the study was to evaluate the efficacy, safety and tolerability of intravenous infusion of serelaxin, when added to standard therapy, in acute heart failure (AHF) patients.
- Trial name
- RELAX-AHF-2 (NCT01870778)
- Testing
- RLX030
- Where
- 540 sites in United States, Argentina and 33 more
- Volunteers
- 6,600 people
- Sponsor
- Novartis Pharmaceuticals
Acute Decompensated Heart Failure
IC14 for Treatment of Acute Decompensated Heart Failure
The goal of this clinical trial is to learn if drug atibuclimab (IC14) works to treat adults hospitalized with acute decompensated heart failure (ADHF). It will also learn about the safety of IC14.
- Trial name
- NCT06556810
- Testing
- Atibuclimab (IC14)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Implicit Bioscience
Acute Coronary Syndromes, Heart Failure
Registry Of Acute meDical Emergencies in Brazil
Critical patients in emergency room are seriously situations that need quickly diagnosis and treatment. Different predictors of prognosis can be related with mortality and morbidity in-hospital and in long-term.
- Conditions
- Acute Coronary Syndromes, Heart Failure, Pulmonary Edema, Aortic Aneurysm, Familial Thoracic 1
- Trial name
- ROAD-Brazil (NCT02753023)
- Testing
- no intervention
- Where
- 6 sites in Brazil
- Volunteers
- 1,650 people
- Sponsor
- University of Sao Paulo General Hospital
Diastolic Heart Failure
Study of Nesiritide in Diastolic Heart Failure.
We hypothesize that nesiritide will have favorable effect in decreasing heart filling pressures and echocardiogram studies.
- Trial name
- NCT00309868
- Testing
- neseritide
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Acute Heart Failure
Effect of Short-Term Prednisone Therapy on C-Reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers ( CORTAHF )
Acute heart failure (AHF) is a common discharge diagnosis in the emergency department (ED), associated with 1-month mortality of 6%, and a 30% risk rate of 1-month rehospitalisation.
- Trial name
- CORTAHF (NCT05668676)
- Testing
- Prednisone arm, Usual care
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome, Right Heart Failure
Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection.
- Trial name
- IVOLIA (NCT07450846)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Bicetre Hospital
Acute Heart Failure, COPD Exacerbation
Valsalva Manœuvre in the Diagnosis of Left Ventricular Failure in Chronic Obstructive Pulmonary Disease Exacerbation
Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis .
- Trial name
- NCT01619540
- Testing
- Valsalva maneuver
- Where
- 4 sites in Tunisia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Heart Failure
A Study of Patients Hospitalized With Acute Heart Failure With Reduced Ejection Fraction (HFrEF)
A study of participants hospitalized with acute heart failure with reduced ejection fraction
- Trial name
- NCT03515655
- Where
- United States
- Volunteers
- 99,209 people
- Sponsor
- Bristol-Myers Squibb
Heart Failure Acute, Decompensated Heart Failure
Acetazolamide or Metolazone in Acute Heart Failure
Impact of Acute Heart Failure: According to the World Health Organization (WHO), approximately 26 million people suffer from Heart Failure (HF), with a mortality rate of up to 50% within five years of diagnosis.
- Trial name
- ACME-AHF (NCT06273397)
- Testing
- Acetazolamide 250 MG, Metolazone 2.5 MG, Furosemide Injection
- Volunteers
- 1,050 people
- Sponsor
- Clinica Alemana de Santiago
Acute Heart Failure
VExUS in Patients With Acute Heart Failure
The importance of assessing venous congestion in heart failure patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool.
- Trial name
- NCT06397404
- Testing
- Venous excess ultrasound score (VExUS) protocol
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Heart Failure
CVP-guided Aquapheresis for the Treatment of Acute Congestion in Heart Failure
The number of patients with acute congestion on chronic heart failure is increasing. Ultrafiltration has recently been proposed as an alternative approach for the stabilization of volume balance, especially in patients with…
- Trial name
- Aquadex (NCT02079259)
- Testing
- Ultrafiltration
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Dyspnea, Decompensated Heart Failure ; COPD Exacerbation
Diagnosis of Heart Failure in Chronic Obstructive Pulmonary Disease Using the Lung Ultrasound
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05352490
- Testing
- calculate LUS score
- Where
- Tunisia
- Volunteers
- 350 people
- Sponsor
- University of Monastir
Congestive Heart Failure
Pilot Study of the CoVa™ Monitoring of Patients With Congestive Heart Failure
The purpose of this study is to obtain observational data allowing for the preliminary assessment of the utility of a noninvasive physiologic monitor for monitoring of patients with congestive heart failure.
- Trial name
- CoVa (NCT02368184)
- Where
- United States
- Sponsor
- Scripps Translational Science Institute
Acute Decompensated Heart Failure, Heart Failure
The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart Failure
Purpose: To compare the hemodynamic effects of dobutamine and milrinone in hospitalized patients who are receiving Beta Blocker Participants: Patients who are admitted to the General Cardiology and Heart Failure Services at the…
- Trial name
- NCT01971944
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Heart Failure, Kidney Failure
New Biomarkers in Heart- and Renal Failure
In this study, prognostically relevant biomarkers for cardiovascular / renal insufficiencies will be clinically evaluated, to improve the course of assessment of such disease and to gain new insights into the typical course of…
- Trial name
- IM19 Register (NCT02830464)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- RWTH Aachen University
Acute Myocardial Infarction, Heart Failure
Safety and Efficacy on Cell-based Therapy in Patients With Recent Large Acute Myocardial Infarction
The purpose of this study is to test bone marrow mononuclear cells for patients with recent heart attack who are at high risk of experiencing heart failure. This study drug is made of you own cells.
- Trial name
- ReNeW (NCT00691834)
- Testing
- Intracoronary delivery of unfractionated bone marrow mononuclear cells
- Sponsor
- Duke University
Acute Heart Failure
An Observational Study of the Functional Capacity of Heart Failure
This is an observational study of the functional capacity of patients with Heart failure with Reduced Ejection Fraction (HFrEF) who are admitted to the hospital for routine medical treatment.
- Trial name
- NCT02350114
- Testing
- 6 Minute Walk Test
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Bristol-Myers Squibb
Severe Sepsis, Acute Heart Failure
Can the Venus 1000 Help Clinicians Treat Patients With Severe Sepsis or Acute Heart Failure? The CVP Trial
The purpose of this study is to evaluate the impact that the Venus 1000 non-invasive CVP system has on the management of emergency department (ED) patients with fluid sensitive conditions.
- Trial name
- NCT02258984
- Testing
- Mespere Venus 1000 Non-Invasive CVP System
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mespere Lifesciences Inc.
Dyspnea, Heart Failure
Registry of Patients With Acute Dyspnea in the Emergency Department
This is a prospective registry of patients presenting with acute dyspnea to the emergency department of the city hospital in Nuremberg.
- Conditions
- Dyspnea, Heart Failure, COPD
- Trial name
- NCT01910233
- Where
- Germany
- Volunteers
- 947 people
- Sponsor
- Klinikum Nürnberg
Acute Heart Failure (AHF), Congestive Heart Failure(CHF)
Evaluating Residual Congestion at Discharge in Acute Heart Failure Patients
Treatment of congestion is one of the main goals in patients hospitalized for acute heart failure. Nevertheless, current evidence shows that decongestion is often not achieved and that residual congestion at discharge is strongly…
- Trial name
- NCT06993220
- Testing
- Evaluation of residual congestion at discharge
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Consorci Sanitari Integral