Clinical trials: Conn Syndrome
Hypertension, Primary Aldosteronism
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy.
- Conditions
- Hypertension, Primary Aldosteronism, Hypokalemia
- Trial name
- SSTT (NCT06569589)
- Testing
- 23NaMRI Scan, Potassium Chloride (KCl)
- Where
- 4 sites in Singapore
- Volunteers
- 80 people
- Sponsor
- Jens Titze
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism
In this study, the investigators will perform endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) treatment of left-sided adrenal tumours in patients with primary aldosteronism (PA) and in patients with mild autonomous…
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Hypercortisolism
- Trial name
- NCT05368090
- Testing
- EUS-RFA of left adrenal tumour in PA with AVS-verified left lateralisation, EUS-RFA of left adrenal tumour in PA, "debulking group", EUS-RFA of left adrenal tumour in MACS with AVS-verified left lateralisation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Non Invasive Imaging Methods for Detecting PA：a Clinical PET Study of 18F-Pentixather
Primary aldosteronism (PA) is the most common endocrine cause of hypertension. 68Ga-pentixafor PET/CT possesses a relatively high sensitivity and specificity for Aldosterone producing adenoma (APA) detection.
- Trial name
- NCT06581744
- Testing
- [18F]AlF-NOTA-Pentixather
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fangfang Sun
Primary Aldosteronism
Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA
The primary objective of WAVE is to test the hypothesis that thermal ablation (microwave or RFA) is non-inferior to surgery in the biochemical (and if so, in the clinical) cure of unilateral PA, according to the international…
- Trial name
- WAVE (NCT05405101)
- Testing
- Thermal ablation of aldosterone producing adenoma., Unilateral adrenalectomy
- Where
- 6 sites in United Kingdom
- Volunteers
- 112 people
- Sponsor
- Queen Mary University of London
Adrenal Tumor, Pheochromocytoma
Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy
Laparoscopic adrenalectomy has become the gold standard operation for non-malignant adrenal tumors replacing open adrenalectomy.
- Conditions
- Adrenal Tumor, Pheochromocytoma, Conn's Syndrome, Cushing's Syndrome
- Trial name
- NCT01959711
- Testing
- Posterior RA, Lateral transperitoneal LA
- Where
- Poland
- Volunteers
- 65 people
- Sponsor
- Jagiellonian University
Hyperaldosteronism, Renal Insufficiency
The Water Intake Trail and Primary Aldosteronism Postoperation(WIT-PAP)
To investigate whether increasing water intake has renal protective effect on PA patients after surgical treatment.
- Trial name
- NCT04150666
- Testing
- Hydration
- Where
- China
- Sponsor
- Qifu Li
Hyperaldosteronism; Primary, Hypertension Secondary
Primary Aldosteronism In Hypertensive Patients in China
To investigate the prevalence of primary aldosteronism (PA) in Chinese patients with newly diagnosed hypertension.
- Trial name
- PA-China (NCT03155139)
- Testing
- Aldosterone/renin ratio (ARR) testing, Confirmatory tests
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Qifu Li
Primary Aldosteronism
Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism
1. Aim to investigate the pathological feature of UPA in Asians 2. To clarify the relationship between pathology, clinical phenotype, genetic mutation and surgical outcome of UPA in Asians. 3.
- Trial name
- NCT06597630
- Testing
- Tissue specimens were stained by histopathology of hematoxylin-eosin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qifu Li
Primary Aldosteronism, Hypertension
Effects of Adrenal Artery Ablation and Adrenalectomy in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is the main cause of secondary hypertension, affecting 5-15% of the general hypertensive population. Early diagnosis and treatment are of crucial importance as patients with PA are more susceptible to…
- Trial name
- NCT04269928
- Testing
- Endovascular chemical ablation of adrenal gland
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism
Prospective Evaluation of Confirmatory Testing for Primary Aldosteronism
This study is to evaluate the performance characteristics of the seated saline infusion test and the ultra low-dose ACTH stimulation test for the diagnosis of primary aldosteronism.
- Trial name
- NCT04422756
- Testing
- Seated intravenous saline infusion test, Ultra low-dose ACTH stimulation test
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- University of Calgary
Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Superselective Adrenal Arterial Embolization for Bilateral Idiopathic Hyperaldosteronism: A Prospective Cohort Study
The most common two subtypes of primary aldosteronism (PA ) are aldosterone producing adenoma (APA) and bilateral idiopathic hyperaldosteronism (IHA).
- Trial name
- SAAE-BIH (NCT05186675)
- Testing
- superselective adrenal arterial embolization
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
Accuracy of 68Ga-Pentixafor PET/CT for Subtypting Diagnosis in Patients With Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
To evaluate the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of primary aldosteronism concurrent with autonomous cortisol secretion patient, using AVS and/or postoperative remission as the reference standard…
- Trial name
- ABOARD (NCT06635993)
- Testing
- 68Ga-Pentixafor PET/CT
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Qifu Li
Primary Hyperaldosteronism
Primary Hyperaldosteronism and Ischemia-reperfusion Injury
Patients with primary hyperaldosteronism experience more cardiovascular events compared to patients with primary hypertension, independent of the blood pressure level.
- Trial name
- PHA-FMD (NCT01978132)
- Testing
- forearm ischemia and reperfusion
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Primary Aldosteronism
CETO First in Human Trial
The study is a Phase 1, single-centre, open label, micro-dosing study. The aim is to investigate an innovative new tracer, [18F]CETO, as a potential alternative to adrenal vein sampling for the lateralisation of primary…
- Trial name
- CETO (NCT04529018)
- Testing
- [18F]CETO
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia
First-in-human Evaluation of [18F]CETO
Purpose of this clinical phase 1 trial was to determine if para-chloro-2-[18F]fluoroethyletomidate positron emission computed tomography ([18F]CETO-positron emission computed tomography(PET)/computed tomography(CT)) can be used…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia, Adrenal Cushing Syndrome, Non-Secretory Adrenal Adenoma
- Trial name
- NCT05361083
- Testing
- F18CETO
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Primary Aldosteronism
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism
This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 (CXCR4) positron emission tomography (PET) imaging in patients with clinical suspected primary aldosteronism (PA), with postoperative…
- Trial name
- NCT06183554
- Testing
- CXCR4
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiao Chen
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Post Operative Pain, Acute
Comparison of Needlescopic vs. Conventional Laparoscopic Adrenalectomy for Tumor Less Than 4 cm
The investigator conduct a randomized clinical trial for the needlescopic and conventional laparoscopic adrenalectomy to assess whether mini laparoscopic adrenalectomy is better than conventional laparoscopic adrenalectomy in…
- Trial name
- NCT05675124
- Testing
- Needlescopic laparoscopic adrenalectomy, conventional laparoscopic adrenalectomy
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- National Taiwan University Hospital
Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Hypertension is known to be the major risk factor for stroke. The most common cause of secondary hypertension, primary aldosteronism (PA), is characterized by the excessive secretion of aldosterone and is related to hypertension…
- Trial name
- NCT03821571
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital