Clinical trials: Connective Tissue
IgA Nephropathy (IgAN), Membranous Nephropathy
A Clinical Study Evaluating the Safety and Efficacy of GT719 Universal Cell Injection in the Treatment of Immune-mediated Kidney Diseases
This study is a single-arm, open-label, dose-escalation and dose-expansion clinical trial, divided into two phases: the first phase is the dose-escalation phase, and the second phase is the dose-expansion phase.
- Conditions
- IgA Nephropathy (IgAN), Membranous Nephropathy, ANCA-associated Vasculitis (AAV)/ANCA-associated Glomerulonephritis (AAGN), Refractory Podocytopathy
- Trial name
- NCT07389499
- Testing
- CD19-targeted iNKT Cell Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Grit Biotechnology
Fibrosis, Skin Scarring
Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention
Skin scarring (fibrosis) is a common complication in the wound healing process and remains a therapeutic challenge. Scar formation often occurs following injury to the skin such as surgery, trauma, and burns.
- Conditions
- Fibrosis, Skin Scarring, Skin Wound, Hypertrophic Scar
- Trial name
- NCT03795116
- Testing
- LED-RL phototherapy, Mock irradiation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Skin Diseases, Nail Diseases
Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery
The investigators conducted a controlled, prospective randomized study to examine the antiseptic efficacy of intraoperative irrigation methods during nail avulsion surgery.
- Conditions
- Skin Diseases, Nail Diseases, Nails, Ingrown
- Trial name
- ribebeva (NCT01330706)
- Testing
- Polihexanide
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad Complutense de Madrid
Skin Cancer
Engaging Moms on Teen Indoor Tanning Through Social Media
A sample of mothers in Tennessee are recruited to a group-randomized pretest-posttest controlled trial evaluating the effect of a social media campaign to decrease mothers' permissiveness for daughters to indoor tan.
- Trial name
- NCT02835807
- Testing
- Health Chat including Indoor Tanning, Health Chat excluding Indoor Tanning
- Where
- 4 sites in United States
- Volunteers
- 1,607 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Melanoma (Skin)
Cyclophosphamide and Fludarabine Followed By Interleukin-2 Gene-Modified Tumor Infiltrating Lymphocytes in Treating Patients With Metastatic Melanoma
RATIONALE: Drugs used in chemotherapy such as cyclophosphamide and fludarabine use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00062036
- Testing
- aldesleukin, filgrastim, incomplete Freund's adjuvant
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Vitiligo
T Central Memory Cells in Early Localized Non-Segmental Vitiligo
Assessing the level of circulating TCMs (cluster of differentiation (CD) 8+, CD3+,C- chemokine receptor (CCR)7, cluster of differentiation 45 receptor (CD45R) cells) in early localized vitiligo cases prior to treatment and after…
- Trial name
- NCT05706636
- Testing
- oral mini pulse, Topical cream, targeted phototherapy
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Triple Negative Breast Cancer
Adjuvant Platinum and Taxane in Triple-negative Breast Cancer (PATTERN)
Previous studies in Western country show that triple-negative breast cancer has aggressive clinical and pathological features compared with non-triple negative breast cancer, including onset at a young age, advanced clinical…
- Trial name
- NCT01216111
- Testing
- Paclitaxel Cisplatin, fluorouracil epirubicin cyclophosphamide and docetaxel (FEC-T)
- Volunteers
- 647 people
- Sponsor
- Fudan University
Rheumatoid Arthritis, Pregnancy
Preconceptional Counselling in Active Rheumatoid Arthritis
The first objective of the study is to evaluate a treat to target treatment strategy in women with moderate to high disease activity of RA and a pregnancy wish, from pre-pregnancy.
- Trial name
- PreCARA (NCT01345071)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- J.M.W. Hazes
Breast Cancer, Colon Cancer
The Efficacy of Health Partnership Program for Cancer Patients
The Objectives of this study is 1. To evaluate the efficacy for exercise, diet, and posttraumatic growth as a result of participating in tailored program (Health Partnership Program) for 24 weeks 2.
- Conditions
- Breast Cancer, Colon Cancer, Gastric Cancer, Lung Cancer
- Trial name
- NCT01527409
- Testing
- Tailored health partnership program, Usual care and health education workshop
- Where
- 10 sites in South Korea
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Breast Neoplasms
Shear Wave Elastography Assessment of Neoadjuvant Chemotherapy Response in Patients With Invasive Breast Cancer
The aim of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to neoadjuvant chemotherapy in patients with invasive breast cancer.
- Trial name
- NCT05068999
- Testing
- shear wave elastography
- Volunteers
- 35 people
- Sponsor
- Assiut University
Stage IV Breast Cancer
Oxaliplatin in Treating Patients With Metastatic Breast Cancer
This phase 0/II trial studies the effect of carbon C 14 oxaliplatin in tumor tissue and blood and the side effects and how well oxaliplatin works in treating patients with metastatic breast cancer.
- Trial name
- NCT02077998
- Testing
- carbon C 14 oxaliplatin, oxaliplatin, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, Davis
Rheumatoid Arthritis
A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDs
The objective of this study was to verify the superiority of ASP015K alone or in combination with disease-modifying antirheumatic drugs (DMARDs) over placebo in terms of efficacy in participants with rheumatoid arthritis (RA) who…
- Trial name
- NCT02308163
- Testing
- Peficitinib, Etanercept
- Where
- 153 sites in Japan, South Korea and 1 more
- Volunteers
- 509 people
- Sponsor
- Astellas Pharma Inc
Breast Cancer
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are…
- Trial name
- FLEX (NCT03053193)
- Testing
- MammaPrint, BluePrint, and Full-Genome Testing
- Where
- 134 sites in United States, Canada and 2 more
- Volunteers
- 30,000 people
- Sponsor
- Agendia
Breast Neoplasms
PemVin vs Vin in Previously Treated Metastatic Breast Cancer
Pemetrexed is a multi-targeted anti-folate, that is used for non-small cell lung cancer and mesothelioma. There are several clinical studies of pemetrexed in breast cancer, but these are largely done before the wide use of…
- Trial name
- NCT03242616
- Testing
- Pemetrexed + Vinorelbine, Vinorelbine
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Seoul National University Hospital
Diabetic Foot Ulcer, Diabetic Foot
Effect of Self-foot Exercise on the Incidence of Plantar Foot Diabetic Ulcer Recurrence
The incidence of diabetic foot ulcer recurrence in one year can reach 35%. Plantar foot diabetic foot ulcer is the most frequently diabetic foot ulcer recurrence.
- Trial name
- NCT04624516
- Testing
- self-structured foot exercise
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Maria Suryani
Netherton Syndrome
Clinical Trial Using Humira in Netherton Syndrome
The main objective of this studies therapeutic : to determine the effect of Adalimumab (HumiraR) on clinical inflammatory manifestations of patients with Netherton syndrome after 3 months of treatment , with a post treatment…
- Trial name
- AntiTNF-SN (NCT02113904)
- Testing
- Adalimumab
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Prostate Cancer
Stereotactic Body Radiation Therapy for Spinal Metastases in Favorite Tumors
Stereotactic Body Radiation Therapy(SBRT) for spinal metastases has been proved a good results in pain relieve and local control, However,the longterm of efficacy and safety of this regimen is unclear.The purpose of the study is…
- Conditions
- Breast Cancer, Prostate Cancer, Non Small Cell Lung Cancer
- Trial name
- NCT03392233
- Testing
- Stereotactic Body Radiation Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Interstitial Lung Disease, Scleroderma
Open-label Study With Bosentan in Interstitial Lung Disease
This study will asses the long term safety and efficacy of oral bosentan to patients suffering from Interstitial Lung Disease.
- Trial name
- BUILD 2 OL (NCT00319033)
- Testing
- bosentan
- Volunteers
- 132 people
- Sponsor
- Actelion
Breast Cancer, Cancer Survivor
Hypnosis in Treating Hot Flashes in Breast Cancer Survivors
RATIONALE: Hypnosis may be effective in decreasing hot flashes in breast cancer survivors. PURPOSE: This randomized clinical trial is studying how well hypnosis works in treating hot flashes in breast cancer survivors.
- Conditions
- Breast Cancer, Cancer Survivor, Hot Flashes
- Trial name
- NCT00094133
- Testing
- hot flashes attenuation, hypnotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Scott and White Hospital & Clinic
Neoplasms
Study Evaluating MST-997 in Advanced Malignant Solid Tumors
The primary objective of this clinical research study is to evaluate the safety, tolerability, and maximum tolerated dose (MTD) of intravenous (IV) MST-997 formulated in Intralipid 20% administered on a weekly schedule to…
- Trial name
- NCT00088647
- Testing
- MST-997
- Where
- 3 sites in United States
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer