Clinical trials: Consciousness, Level Depressed
Down Syndrome, Polyendocrinopathies, Autoimmune
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome
This study plans to learn more about Down syndrome. The investigators think there is a different level of the AIRE gene in individuals with Down syndrome.
- Conditions
- Down Syndrome, Polyendocrinopathies, Autoimmune, Respiratory Tract Infections, Autoimmunity
- Trial name
- NCT02421276
- Testing
- Phlebotomy
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Major Depressive Disorder, Dysthymic Disorder
Cognitive Behavioral Therapy for Early-Onset Depression
Depression is a debilitating illness affecting large numbers of young people. In this study, children and adolescents ages 10 to 17 meeting criteria for clinical depression will participate in a 15-session group therapy…
- Trial name
- NCT00096642
- Testing
- Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
Suicide and Depression
Accelerated Theta Burst Stimulation for Treatment of Suicidality in Depressed Patients
The objective of this study is to investigate efficacy of accelerated theta burst stimulation (TBS) in suicidal reduction in patients with unipolar and bipolar depression
- Trial name
- NCT06289842
- Testing
- Transcranial Magnetic Stimulation MagPro R30 with the MCF-B70 figure-of-eight coil (MagVenture, Denmark)
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Zagazig University
MDD
Effect of Bupropion on Seizure Threshold in Depressed Patients
The purpose of the study is to examine the effect of bupropion on seizure threshold and duration in depressed patients receiving right unilateral ultra-brief electroconvulsive therapy (ECT).
- Trial name
- NCT03126682
- Testing
- Wellbutrin SR 300Mg Extended-Release Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Heart Failure, Systolic Dysfunction
A Pilot Study of Spinal Cord Stimulation in Heart Failure Patients With Depressed Left Ventricular Function
A randomized pilot study of spinal cord stimulation in patients with chronic heart failure aiming to show whether this therapy impacts central haemodynamic and autonomic regulations.
- Trial name
- RAPID-HELP (NCT02450110)
- Testing
- Spinal cord stimulation
- Where
- Russia
- Volunteers
- 3 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Major Depressive Disorder, Bipolar Disorder
The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients
This study evaluates the efficacy of sleep deprivation treatment in accelerating antidepressant responses when administered during the first week of medications and augmenting a sustained response with chronobiological…
- Trial name
- NCT00581009
- Testing
- chronobiological augmentation, sertraline, lithium, one night of sleep deprivation and two FDG PET scans
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Healthy Volunteers
Performance and Safety of Restylane Lidocaine for Treatment of Depressed Facial Acne Scars
The purpose of this study is to evaluate performance and safety of Restylane Lidocaine for treatment of depressed facial acne scars
- Trial name
- NCT03127384
- Testing
- Restylane Lidocaine, No-treatment control
- Where
- 2 sites in Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Depression
Effectiveness of a Relaxation-Response Based Cognitive Behavioral Therapy Group for Depressed Chinese Patients
The goal of this research is to evaluate whether group therapy combining Relaxation Response (RR) training and Cognitive Behavioral Therapy (CBT) in a group format merits further investigation in the treatment of Major Depressive…
- Trial name
- NCT01359839
- Testing
- Relaxation Response and Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Anxiety Disorders
Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression
Psychological therapies for depression have demonstrated efficacy, but outcomes are still unsatisfactory, especially in cases with high comorbidity.
- Trial name
- NCT01829100
- Testing
- Group Behavioral Activation Therapy (GBAT)
- Where
- United States
- Volunteers
- 895 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Depression
Treatment of Depressed Women Who Have Been Sexually Abused
The purpose of this study is to compare Schema-Focused Therapy plus antidepressant medication and antidepressant medication alone for the treatment of major depression in women with a history of childhood sexual abuse.
- Trial name
- NCT00042237
- Testing
- Schema Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Butler Hospital
Depression
Evaluating a Behavioral Activities Treatment Program for Depressed Nursing Home Residents
This study will evaluate whether a behavioral activities treatment program improves symptoms of depression in nursing home residents.
- Trial name
- BE-ACTIV (NCT00536406)
- Testing
- BE-ACTIV, Treatment as usual (TAU)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Smoking, Bipolar Disorder
Varenicline in Bipolar Depressed Patients
Patients with bipolar disorder have one of the highest rates of nicotine dependence and one of the lowest quit rates. Varenicline has been shown in previous trials to be effective for smoking cessation, but has not been studied…
- Conditions
- Smoking, Bipolar Disorder, Depression
- Trial name
- Varenicline (NCT00813800)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mark Frye
Depression
Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
This study aims to determine whether a keto-like supplement relative to placebo results in functional brain changes during fMRI tasks evaluating positive and negative valence in individuals with moderate to severe depression.
- Trial name
- NCT06263660
- Testing
- Keto-like supplement
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Major Depressive Disorder, Bipolar Depression
Chronotherapy Randomized Controlled Trial
Chronotherapy is a term that describes therapeutic alterations of sleep wake cycles. Different variations of sleep deprivation, set sleep wake schedules, and types of light therapy have demonstrated efficacy in rapidly treating…
- Conditions
- Major Depressive Disorder, Bipolar Depression, Suicidal Ideation
- Trial name
- NCT02176824
- Testing
- Total Sleep deprivation, Sleep Phase Advance, and Bright Light Therapy, Partial Sleep deprivation, Sleep Phase Delay, and Low amber light., Treatment as usual
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medical University of South Carolina
Bipolar Depression Depressed Phase, Obesity & Overweight
The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
This research study examines how a medication called lumateperone may affect mood symptoms, and inflammation in adults with bipolar disorder over approximately 6 weeks.
- Trial name
- NCT07699445
- Testing
- Lumateperone 42 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Depression, Spinal Cord Injuries
Acceptance and Commitment Therapy for Depressed Individuals Living With Spinal Cord Injury Sustained Within 5 Years
This randomized controlled trial aims to assess effects of videoconferencing acceptance and commitment therapy (ACT) on mental health outcomes in individuals living with spinal cord injuries (SCI).
- Trial name
- NCT05725161
- Testing
- Acceptance and commitment therapy (ACT), Wait-list control group with psychoeducation materials provided
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Alabama at Birmingham
Heart Failure
Efficacy of Candesartan on Brain Natriuretic Peptide Levels in Subjects With Chronic Heart Failure
The purpose of this study is to determine the effects of Candesartan, once daily (QD), added to ongoing chronic heart disease therapy in measuring brain natriuretic peptide in patients with chronic heart failure.
- Trial name
- CANDHEART (NCT00843154)
- Testing
- Candesartan and standard chronic heart disease therapy, Standard chronic heart disease therapy
- Volunteers
- 571 people
- Sponsor
- Takeda
Depression, Anxiety
Supportive Expressive Therapy for Depressed and Anxious Adolescents
The purpose of the study is to investigate the effectiveness of providing Supportive Expressive Therapy to adolescents who are depressed and/or anxious.
- Trial name
- NCT00381979
- Testing
- Supportive Expressive Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Infertility, Female, Depression
Educational and Supportive Care to Depressed Infertile Females
Infertility affects married adults, and In Vitro Fertilization (IVF) is an Assisted Reproductive Technology (ART) that can be treated. Women undergoing IVF are more likely to experience depression.
- Conditions
- Infertility, Female, Depression, IVF
- Trial name
- NCT06022640
- Testing
- Educational and supportive care
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- Al-Rasheed University College
Major Depressive Disorder
Psychophysiological Study of Pain Perception in Depressed Patients With Suicidal Risk
Joiner's interpersonal theory of suicide postulates that the wish of death comes from feelings of perceived burdensomeness and thwarted belongingness.
- Trial name
- R2D2 (NCT04461327)
- Testing
- Painful stimulations of major depressive patients, Blood sample, Clinical assessment
- Where
- 2 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Montpellier