Clinical trials: Consciousness Assessment
Consciousness Disorders, Severe Acquired Brain Injury
Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC)
Patients with severe acquired brain injury may evolve from coma into prolonged disorders of consciousness. In these patients, residual language comprehension and swallowing abilities are difficult to evaluate because standard…
- Trial name
- NCT07711119
- Testing
- Italian SWallowing Assessment in Disorders of Consciousness (SWADOC), Italian Brief Evaluation of Receptive Aphasia (BERA)
- Where
- 4 sites in Italy
- Volunteers
- 79 people
- Sponsor
- Alfonso Magliacano
Disorders of Consciousness
Resting State fMRI in Disorders of Consciousness
Disorders of consciousness (DoC) remain a major clinical challenge in which high rates of misdiagnosis and difficult prognostication stem from limitations in the ability to access the disordered physiological processes mechanisms…
- Trial name
- NCT05463029
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabetes (DM), Diabete Mellitus
Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track Subgroups
Mental conditions and disorders (e.g. distress, depressive, anxiety, and eating disorders) are more prevalent in people with diabetes (PWD) and associated with reduced quality of life and impaired glycaemic outcomes.
- Conditions
- Diabetes (DM), Diabete Mellitus, Diabete Type 1, Diabete Type 2
- Trial name
- TwinPeaks (NCT07212075)
- Where
- 3 sites in Germany
- Volunteers
- 1,809 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Acquired Brain Injury, Consciousness, Level Altered
Physical Activity on Heart Rate Variability in Patients With Severe Acquired Brain Injury
This study aims to explore autonomic cardiovascular regulation, through measures of heart rate variability (HRV), during different passive and active activities in patients with severe acquired brain injury and a low conscious…
- Trial name
- NCT03328221
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute and Chronic Hepatic Failure With Developing Coma
Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure
The purpose of this study is to understand mechanisms associated with the development of coma during hepatic failure. As of today, those mechanisms are not understood and it is difficult to intervene and prevent coma development…
- Trial name
- NCT01582087
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Disorder of Consciousness
Study of Brain Function Evaluation System for Acute and Prolonged Disorders of Consciousness
The research focuses on establishing a system for detecting loss of consciousness, developing clinical prognostic and awakening-related brain function testing criteria.
- Trial name
- NCT06097013
- Testing
- Routine clinical rehabilitation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Low Mood, Depressive Symptoms
The Effects of Bifidobacterium Longum 1714® in a Population With Low Mood
A randomised, double-blind, placebo-controlled clinical trial to evaluate the effect of 8 weeks of supplementation with Bifidobacterium longum 1714® strain on Beck's Depression Inventory-II Score in adults who experience low mood.
- Trial name
- NCT04925440
- Testing
- Bifidobacterium longum 1714® strain
- Where
- Ireland
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- PrecisionBiotics Group Ltd.
Orthostatic Intolerance, Syncope
Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension
This study is aimed primarily at providing a simple and effective form of treatment to reduce the symptoms of Initial Orthostatic Hypotension (IOH) and prevent syncope.
- Conditions
- Orthostatic Intolerance, Syncope, Fainting, Presyncope
- Trial name
- IOH (NCT03970551)
- Testing
- Physical Counter-maneuver, Stress Test, Functional Electrical Stimulation
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Brain Death, Coma
Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared Spectroscopy
This study aims to assess brain death and deep coma with the self-made near infrared spectroscopy (NIRS) instrument. The investigators used the noninvasive method to monitor the Δ[HbO2] (the concentration changes in…
- Trial name
- NCT04623294
- Testing
- Oxygen supply of high-low-high procedure, Oxygen supply of low-high-low procedure
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Supratentorial Brain Tumor
Influence of Intracranial Lesions on Bispectral Index
The purpose of this study is to assess whether BIS values at return of consciousness are different in patients with or without brain tumors.
- Trial name
- NCT01060631
- Testing
- BIS values at return of consciousness in patients + predicted and measured propofol plasma concentrations
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Depression Chronic, Depressed
Evaluation of Dalia Solution For Depressed Patient
The goal of this superiority clinical investigation, prospective, multicenter, controlled, randomized, open-label is to evaluate the clinical impact of the Dalia medical telemonitoring device on the management of depressive…
- Conditions
- Depression Chronic, Depressed, Depressed Mood, Depression and Quality of Life
- Trial name
- DaliaMonitorin (NCT07211984)
- Testing
- Dalia Monitoring, Conventional healthcare
- Where
- France
- Volunteers
- 644 people
- Sponsor
- Dalia Care
Cardiovascular Diseases, Cardiovascular Diseases Risk
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk assessment beyond conventional single-purpose ambulatory rhythm…
- Conditions
- Cardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular Abnormalities
- Trial name
- Cor360 (NCT07775976)
- Testing
- COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Sleep
Assessment of Consciousness States with NextSense Ear Bud Devices
The goal of this study is to determine the feasibility in continuing to explore NextSense's ear-EEG device (EEGBud) and Ellcie Healthy glasses as wireless, wearable alternatives to the expense, discomfort, and burden in…
- Trial name
- NCT05114616
- Testing
- NextSense EEG-enabled earbuds, Ellcie Healthy Glasses
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Emory University
Comatose, Neurophysiologic Abnormality
EXPRE-SON-REA : Expressive Own Names in Neurophysiologic Assessment of Comatose Patients
Evaluating the neurologic prognosis in disorders of consciousness (DOC) patients is still a crucial issue in intensive care units.
- Trial name
- EXPRESONREA (NCT04798508)
- Testing
- Evoked related potential - P3 paradigm
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Centre Hospitalier St Anne
Anesthesia; Functional
Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?.
Using very slow or fast propofol intravenous injection, monitored using standard American Society of Anesthesiology (ASA) standard and SEDLine EEG (Med Tech), the patient was evaluate by a neurologist every 30 sec using the FOUR…
- Trial name
- Top&Bottom (NCT03140982)
- Testing
- FOUR coma scale and frontal espectrograpy evaluation
- Where
- Chile
- Volunteers
- 16 people
- Sponsor
- Universidad del Desarrollo
Syncope
Evaluation of Syncope,Its Diagnosis, Treatment, Outcome and Prognosis
The investigators want to look at how patients admitted after passing out (syncope) or nearly passing out (pre-syncope) do after going home and how many of them remain free of symptoms of syncope or pre-syncope.
- Trial name
- E-STOP (NCT00764985)
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Infectious Pneumonia, Coma
Key to Improve DiagNosis in Aspiration Pneumonia
To evaluate the diagnostic performance of amylase assay performed from bronchial alveolar fluid to differentiate aseptic chemical inhalation pneumonitis from an infectious inhalation pneumonitis in comatose patients with…
- Trial name
- KIDNAP (NCT03182387)
- Where
- France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Bordeaux
Child Behavior, Dental Caries in Children
Sedation Versus Protective Stabilization for Pediatric Dental Treatment
There is a lack of evidence on the effectiveness of moderate sedation in pediatric dentistry, compared to protective stabilization, which remains routinely used in the Brazilian context despite moral questions.
- Trial name
- NCT04119180
- Testing
- Ketamine 50 MG/ML, Midazolam Hcl 2Mg/Ml Syrup, Protective stabilization
- Where
- 2 sites in Brazil
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Lung Collapse
The Effect of Lateral Tilt on Ventilation Distribution in Lungs Assessed by Electrical Impedance Tomography
Prevention of lung inhomogeneity is an essential part of preventive strategy in neurocritical care, reducing the risks of secondary brain damage from hypoxemia, hypo/hypercapnia or pneumonia.
- Trial name
- N-LAT-EIT (NCT04235231)
- Testing
- Bed tilting, Body positioning
- Where
- Czechia
- Volunteers
- 250 people
- Sponsor
- Regional Hospital Liberec
Epilepsy, Absence
Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy
In this project EEG recordings between healthy participants and those with a diagnosed Absence-epilepsy will be compared. The investigators suggest differences in EEG microstate analysis and neuropsychological parameters related…
- Trial name
- NCT04799795
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein