Clinical trials: Consciousness Disorder, open to volunteers
Vasovagal Syncope, AV Block-2Nd Degree-Type 1
Cardioneuroablation for Recurrent Vasovagal Syncope and Bradyarrhythmias: The CNA-FWRD Registry
The CNA-FWRD Registry is an international prospective observational multicenter registry of patients with symptomatic vasovagal syncope and bradyarrhythmias managed under routine care by medical therapy and radiofrequency…
- Conditions
- Vasovagal Syncope, AV Block-2Nd Degree-Type 1, Sinus Pause
- Trial name
- CNA-FWRD (NCT06166277)
- Testing
- Ablation procedure
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Rush University Medical Center
Acute Ischemic Stroke AIS, Impaired Consciousness
Bovis Calculus Stativus Treat Acute Cerebral Ischemic Stroke With Impaired Consciousness
Acute ischemic stroke (AIS) is a severe and life-threatening condition, with 35% of AIS patients experiencing impaired consciousness upon admission within 24 hours of onset.
- Trial name
- ASCENT-BC (NCT07240467)
- Testing
- Bovis Calculus Stativus (BCS)
- Volunteers
- 220 people
- Sponsor
- Xiang Luo
Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome
Paediatric Syncope in the Emergency Department
The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients.
- Conditions
- Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- DETECT-ED (NCT05555771)
- Testing
- Counterpressure Maneuvers, Usual Care
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Dr. Victoria Claydon
Cerebrovascular Event, Stent Stenosis
Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation
APICES trial is an investigator-initiated, multicenter, multicenter, randomized, double-blind, placebo-controlled clinical trial that plans to enroll 396 patients with a 1-year follow-up, including a neurovascular imaging…
- Conditions
- Cerebrovascular Event, Stent Stenosis, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT06308952
- Testing
- Atorvastatin 20mg
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Duan Chuanzhi
Traumatic Brain Injury
Sodium Lactate in Severe TBI
This is a safety phase 2 clinical trial of intravenous infusion of sodium lactate in patients with severe TBI. This study is intended for patients in the acute setting in an intensive care unit at centers that have been selected…
- Trial name
- NCT06701760
- Testing
- Sodium Lactate
- Volunteers
- 264 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury
This prospective observational study evaluates the safety profile and patient-reported outcomes associated with MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy in individuals aged 6 to 75 with chronic…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter
- Trial name
- MUSE-TBI-OBS (NCT07326059)
- Testing
- MUSE Stem Cell Therapy
- Where
- 2 sites in United States, Mexico
- Volunteers
- 10 people
- Sponsor
- Healing Hope International
Bodily Self-Consciousness, Interoception
Hyperventilation Effects on Bodily Self-Consciousness
This study examines how voluntary fast, deep breathing (hyperventilation) affects the way healthy adults perceive their own body.
- Conditions
- Bodily Self-Consciousness, Interoception, Healthy Volunteers
- Trial name
- HYPERSELF (NCT07769710)
- Testing
- Voluntary hyperventilation (guided paced breathing), Normal spontaneous breathing (within-subject control), Synchronous respiratory-visual VR feedback
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Unconscious State
The Effect of Auditory Stimulation and the "Love Glove" Technique
The aim of this study was to determine the effect of the "love glove" intervention, combined with the voices of family members and nurses, on vital signs in unconscious patients in the intensive care unit.
- Trial name
- NCT07602998
- Testing
- Voice of a patient's relative, Voice of nurse, Love glove
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Manisa Celal Bayar University
Tachycardia, Atrial Fibrillation
Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)
This registry is performed for the long-term assessment of outcome, performance and residual safety aspects of the BIOMONITOR III and possible successors in a real-life clinical set-up.
- Conditions
- Tachycardia, Atrial Fibrillation, Syncope, Bradycardia
- Trial name
- BIOSTREAM-ICM (NCT04075084)
- Where
- 31 sites in Australia, Czechia and 7 more
- Volunteers
- 1,400 people
- Sponsor
- Biotronik SE & Co. KG
Coma, Disorders of Consciousness
Recovery Trajectory for Coma and Disorders of Consciousness
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest…
- Conditions
- Coma, Disorders of Consciousness, Cardiac Arrest (CA), Traumatic Brain Injuries
- Trial name
- Coma Cohort (NCT07614074)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome
Postural Sway and Counterpressure Maneuvers for Pediatric Syncope
The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint.
- Conditions
- Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- NCT05633693
- Testing
- Counterpressure Maneuvers, Baseline Stand
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Simon Fraser University
Coma, Cardiac Arrest
Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest
To assess the performance of a predictive model resulting from the analysis of sMRI/fMRI/contrast-enhanced MRI-derived personalized connectomic data, as compared with standard predictors (clinical examination, electrophysiology…
- Conditions
- Coma, Cardiac Arrest, Disorder of Consciousness, Neurologic Disorder
- Trial name
- ARISE (NCT06617377)
- Testing
- advanced whole-brain sMRI/fMRI/contrast-enhanced MRI scan
- Where
- France
- Volunteers
- 263 people
- Sponsor
- University Hospital, Toulouse
Consciousness Disorder
Multimodal Neuroprognostication in Disorders of Consciousness
Disorders of consciousness frequently occur at the acute phase of brain injuries. For the most severe cases, consciousness impairment can be prolonged.
- Trial name
- M-Neuro-DoC (NCT04534777)
- Testing
- repeated neurological, behavioral assessments and conventional, quantitative and functional brain imagery
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
Assessment of Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Disorders of Consciousness
The main questions this study aims to answer are: Can low-intensity FUS neuromodulation be safely and feasibly administered to the bilateral central thalamus in patients with disorders of consciousness (DoC)? Does FUS…
- Trial name
- NCT07694258
- Testing
- Next Generation Dome Helmet (NGDH)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Healthy, Unconscious
External Nitric Oxide Measurement Through SNO Degradation
In this study, we aim to explore the feasibility of a novel, noninvasive SNO assay to acquire physiological SNO quantification from various parts of the human body and test this new method of analysis.
- Trial name
- NCT04903535
- Testing
- Alonefire SV003 10W 365nm UV Flashlight
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Indiana University
Disorder of Consciousness
Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined Approaches
Disorders of consciousness (DOC), such as the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS), represent severe clinical conditions arising from acquired brain injury (ABI)…
- Trial name
- NCT07385508
- Testing
- Multidisciplinary neurorehabilitation
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Coma, Traumatic
Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET
The neural correlates of consciousness have been studied at the macroscopic level. However, the neurochemical basis of these processes remains poorly understood.
- Trial name
- ComaDopa (NCT06930261)
- Testing
- LBT-999
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Seizures, Primary Motor Cortex
Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases
This is a randomized trial for patients with brain metastases in the primary motor cortex who have not had seizures to receive either the prophylactic anti-seizure medication levetiracetam (also known by its trade name Keppra) or…
- Conditions
- Seizures, Primary Motor Cortex, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases, Adult
- Trial name
- NCT07130786
- Testing
- Levetiracetam (Keppra)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Ayal A. Aizer, MD