Clinical trials: Consolidation Therapy
Healthy Subjects
Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects
The beneficial effect of daytime sleep on memory consolidation has been shown in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative…
- Trial name
- NCT01840865
- Testing
- brain stimulation, no stimulation
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Parkinson Disease
Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease
The study aims to assess the effects of cardiovascular (aerobic) training on memory formation and cognitive function in people with Parkinson's disease.
- Trial name
- EMCo (NCT06580977)
- Testing
- cardiovascular training, stretching
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Thymic Epithelial Tumor
neoadjuvant_thymic Epithelial Tumor
This is a Phase II single center, open-label, single arm study in patients with unresectable thymic epithelial tumors (Masaoka stage III, IVA).
- Trial name
- NCT03858582
- Testing
- pembrolizumab, Radiation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Neuroblastoma
A Study of the Effect of Hu3F8/GM-CSF Immunotherapy Plus Isotretinoin in Patients in First Remission of High-Risk Neuroblastoma
The purpose of this study is to test see the combined effects of the study drug called Humanized 3F8 (Hu3F8) when used with granulocyte-macrophage colony stimulating factor (GM-CSF).
- Trial name
- NCT03033303
- Testing
- Hu3F8, GM-CSF, Isotretinoin
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Non Small Cell Lung Cancer
Study of Docetaxel/Gemcitabine Followed by Chemo-radiotherapy (Chemo-RT), With or Without Consolidation Chemotherapy, in IIIA/IIIB Non Small Cell Lung Cancer (NSCLC)
The combination of chemotherapy with radiotherapy remains the standard of therapy for patients with stage III NSCLC. A recent phase II study has presented encouraging data regarding the administration of docetaxel as…
- Trial name
- NCT00431613
- Testing
- Docetaxel, Gemcitabine, Carboplatin
- Where
- 10 sites in Greece
- Volunteers
- 38 people
- Sponsor
- Hellenic Oncology Research Group
Dysphagia, Non-Small Cell Lung Cancer
Study to Evaluate Palifermin in the Reduction of Dysphagia in Patients With Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to determine if palifermin will reduce the incidence of dysphagia in patients receiving concurrent chemoradiotherapy followed by consolidation chemotherapy for treatment of unresectable stage III…
- Conditions
- Dysphagia, Non-Small Cell Lung Cancer, Lung Cancer
- Trial name
- NCT00094861
- Testing
- Palifermin, Radiotherapy, Paclitaxel
- Volunteers
- 100 people
- Sponsor
- Swedish Orphan Biovitrum
Lung Adenocarcinoma, Lung Non-Small Cell Carcinoma
Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer
This phase III trial studies how well nivolumab and ipilimumab works with or without local consolidation therapy in treating patients with stage IV non-small cell lung cancer.
- Conditions
- Lung Adenocarcinoma, Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT03391869
- Testing
- Ipilimumab, Local Consolidation Therapy, Nivolumab
- Where
- 5 sites in United States
- Volunteers
- 339 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Myeloma
Study Association of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab in Newly Diagnosed Standard Risk Multiple Myeloma
The main objective of this study is to evaluate the minimal residual disease-negativity rate after administration of the combination of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab as induction and consolidation therapy…
- Trial name
- IFM2018-01 (NCT03669445)
- Testing
- Ixazomib, Lenalidomide, Dexamethasone
- Where
- 12 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Toulouse
Brain and Nervous System, Eye and Orbit
Nivolumab Consolidation in Older (≥ 65) Patients With Primary CNS Lymphoma
The primary objective of Stage 1 is to evaluate the safety of nivolumab consolidation after completion of HD-MTX containing induction chemotherapy in older subjects with PCNSL in terms of a tolerated dose (based on dose-limiting…
- Trial name
- NCT04022980
- Testing
- Nivolumab
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Colon Adenocarcinoma, Microsatellite Stable Colon Carcinoma
Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer
This phase II/III trial compares the effect of the combination of encorafenib and cetuximab to usual care (patient observation) for reducing the chance of cancer recurrence after standard surgery and chemotherapy in patients with…
- Conditions
- Colon Adenocarcinoma, Microsatellite Stable Colon Carcinoma, Stage IIB Colon Cancer AJCC v8, Stage IIC Colon Cancer AJCC v8
- Trial name
- NCT05710406
- Testing
- Encorafenib, Cetuximab, Biospecimen Collection
- Where
- 202 sites in United States
- Volunteers
- 1 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Hodgkin Lymphoma
Tislelizumab, Gemcitabine and Cisplatin for R/R Hodgkin Lymphoma Followed by Tislelizumab Consolidation in Patients in Metabolic Complete Remission
This trial investigates the efficacy and safety of the drug tislelizumab in combination with chemotherapy as a treatment for patients with R/R HL.
- Trial name
- HOVON164HL (NCT05502250)
- Testing
- gemcitabine, cisplatin and tislelizumab
- Where
- 15 sites in Belgium, Denmark and 1 more
- Volunteers
- 75 people
- Sponsor
- Stichting Hemato-Oncologie voor Volwassenen Nederland
Multiple Myeloma, Newly Diagnosed
KPD Consolidation After ASCT in NDMM Patients
This study aims to evaluate the efficacy and safety of post-transplant consolidation therapy with the KPD regimen (carfilzomib, pomalidomide, and dexamethasone) versus no consolidation, followed by maintenance therapy, in…
- Trial name
- NCT06879379
- Testing
- KPD (carfilzomib, pomalidomide, and dexamethasone) consolidation
- Where
- 3 sites in China
- Volunteers
- 202 people
- Sponsor
- Peking University People's Hospital
Non-small Cell Lung Carcinoma
Randomised Study of Concomitant Radiochemotherapy in Non-small Cell Lung Cancer
The purpose of the present trial is to assess if induction concurrent chemoradiotherapy followed by consolidation chemotherapy will improve survival in comparison with the same chemotherapy given as induction followed by…
- Trial name
- NCT00633568
- Testing
- Concomitant Radiochemotherapy - Radiotherapy 66 Gy, Cisplatin, and Docetaxel, Concomitant Chemoradiotherapy - Radiotherapy 66 Gy, Cisplatin, and Docetaxel
- Where
- 19 sites in Belgium, France and 2 more
- Volunteers
- 125 people
- Sponsor
- European Lung Cancer Working Party
Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma
Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults
All patients are treated according to the same therapy regimen. Therapy duration (number of cycles) and radiotherapy vary according to age group, stage and response.
- Trial name
- NCT00797810
- Testing
- Rituximab
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Bologna
Non-Small-Cell Lung Carcinoma
Safety Study of Docetaxel/Cisplatin Induction Therapy Followed by Concurrent Chemoradiotherapy or Concurrent Chemoradiotherapy Followed by Consolidation Docetaxel/Cisplatin in NSCLC Patients
Primary : To determine the safety profile of each treatment group. Secondary : To determine efficacy in term of overall response, disease free survival and survival at 1 and 2 years.
- Trial name
- NCT00271323
- Testing
- docetaxel and cisplatin, radiotherapy
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Sanofi
Ovarian Cancer
Carboplatin Taxol Avastin in Ovarian Cancer (OVCA)
Study Design: This ia a Phase II study. Subjects: Patients with chemotherapy naive epithelial ovarian cancer; or fallopian, primary peritoneal and papillary serous mullerian tumors will be recruited.
- Trial name
- NCT00129727
- Testing
- Paclitaxel, Carboplatin, Bevacizumab
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Stereotactic Body Radiation for Consolidation After Standard Chemoradiation for Stage 3 Lung Cancer
The purpose of this study is to evaluate the efficacy and toxicity stereotactic body radiation (SBRT) as consolidation following standard chemoradiation for patients with stage III non-small cell lung cancer.
- Trial name
- NCT01656460
- Testing
- Stereotactic radiation Arm 1, Stereotactic radiation Arm 2, Stereotactic radiation Arm 3
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Dr Thomas DiPetrillo
Lung Cancer
Chemotherapy, Tirapazamine, and Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00033410
- Testing
- carboplatin, paclitaxel, tirapazamine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- California Cancer Consortium