Clinical trials: Constipation, open to volunteers
Constipation
Effect of Abdominal Massage Training Provided to Caregivers on Constipation Management
Constipation is a common and uncomfortable problem among patients receiving palliative care. Alongside usual treatment and nursing care, abdominal massage may help manage constipation.
- Trial name
- NCT07886125
- Testing
- Caregiver Training in Abdominal Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- HAMİYET KIZIL
Infantile Colics, Constipation
Randomized, Blinded, Placebo-Controlled Evaluation of BioAmicus Complete
This is a randomized, single-blind, placebo-controlled study to evaluate the efficacy of the dietary supplement BioAmicus Complete (oral drops; a mixture of 10 strains of lacto- and bifidobacteria) in managing functional…
- Conditions
- Infantile Colics, Constipation, Infantile Diarrhea, Atopic Dermatitis
- Trial name
- NCT07444008
- Testing
- BioAmicus Complete
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- NovoNatum Ltd
Functional Constipation (FC)
Implementation of Physical Therapy Protocol for Functional Constipation
The goal of this randomized controlled trial is to investigate the effects of standard medical treatment alone and the effects of adding different physiotherapy protocols to standard medical treatment on constipation severity…
- Trial name
- NCT07719504
- Testing
- Standard medical treatment, Maitland orthopedic manual therapy (MOMT), Russian current stimulation (ERS)
- Volunteers
- 60 people
- Sponsor
- Cairo University
Constipation - Functional, Fecal Microbiota Transplantation (FMT)
The Safety and Efficacy of Fecal Microbiota Transplantation Combined With Nutritional Intervention in the Treatment of Functional Constipation：a Pilot Study
Chronic constipation is a common gastrointestinal disease with a global prevalence of about 15%, significantly affecting daily life and quality of life.
- Conditions
- Constipation - Functional, Fecal Microbiota Transplantation (FMT), Chronic Constipation
- Trial name
- NCT07387952
- Testing
- FMT
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Peking Union Medical College Hospital
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea
Effect of Consuming a Nutraceutical Composition on Signs and Symptoms in Adult Patients With Irritable Bowel Syndrome
Irritable bowel syndrome is characterized by the presence of chronic, recurrent abdominal pain, alterations in bowel habits, and abdominal distension. The medical diagnosis is made using the Rome IV criteria.
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea, Irritable Bowel Syndrome With Constipation, Irritable Bowel Syndrome Mixed
- Trial name
- NCT07103772
- Testing
- Ananá
- Where
- Mexico
- Volunteers
- 94 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Dyssynergic Defecation
Effects of Connective Tissue Massage Plus Biofeedback for Dyssynergic Defecation
The goal of this randomized controlled clinical trial is to evaluate the effects of connective tissue massage (CTM) added to electromyographic biofeedback (EMG-BF) in adults with dyssynergic defecation (DD).
- Trial name
- NCT07890727
- Testing
- Electromyographic Biofeedback (EMG-BF), Connective Tissue Massage (CTM)
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Selcuk University
Irritable Bowel Syndrome, Constipation
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)
The purpose of this study is to evaluate how well brenipatide (LY3537031) is tolerated what side effects may occur, and the safety and efficacy in participants with Irritable Bowel Syndrome-Constipation (IBS-C).
- Trial name
- RENEW-IBS-C (NCT07545772)
- Testing
- LY3537031
- Where
- 70 sites in United States, Belgium and 6 more
- Volunteers
- 342 people
- Sponsor
- Eli Lilly and Company
Constipation
Spinal Stabilization Exercise Training in Women With Chronic Constipation
This study was planned to investigate the effects of spinal stabilization exercise training on constipation symptom severity, quality of life, perception of recovery, and spinal stability in women with chronic constipation.
- Trial name
- Exercise (NCT06941103)
- Testing
- Spinal stabilization exercise training and recommendation, Recommendation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Özel Artı Disleksi Özel Eğitim ve Rehabilitasyon Merkezi
Irritable Bowel Syndrome
Fecal Microbiota Transplantation to Relieve Symptoms of Irritable Bowel Syndrome Without Constipation
Irritable bowel syndrome (IBS) is a complex multifactorial functional disorder, whose pathophysiology is largely associated to an impairment of the intestinal microbiota composition, namely dysbiosis.
- Trial name
- TRAMIR (NCT05803980)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Constipation - Functional
Chronic Ingestion of Fructooligosaccharide and Psyllium on Intestinal Transit in Women With Functional Constipation: A Randomized Crossover Trial
The goal of this clinical trial is to evaluate the effect of dietary fibers in the treatment of functional constipation in women. It will also assess the potential side effects associated with fiber consumption.
- Trial name
- NCT07202481
- Testing
- Psyllium powder, Fructooligosaccharide
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Federal University of Minas Gerais
Constipation
Usefulness of High Resolution Manometry in Constipation
Constipation is a frequent symptom that is reported by more than 10% of the general population. In a few case, constipation is resistant to medical standard care, including osmotic and stimulant laxatives.
- Trial name
- MANOCOHR (NCT04623359)
- Testing
- High resolution manometry
- Where
- 3 sites in France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Constipation, Orthopedic Disorder
Effect of Pre-Surgery Constipation Podcast: A RCT
In this study, the investigators will evaluate the effect of a podcast on constipation on the number of patients with constipation.
- Trial name
- NCT06877078
- Testing
- Constipation information via Podcast
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Central Jutland Regional Hospital
Constipation - Functional, Refractory Constipation
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients.
- Conditions
- Constipation - Functional, Refractory Constipation, Fluoxetine, fMRI
- Trial name
- NCT06221722
- Testing
- BOLD-fMRI, Regular treatment of functional constipation, fluoxetine
- Where
- 3 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Cardiovascular Side Effects of Clozapine, Neutropenia Due to Clozapine
Nor)Clozapine Kinetics and Side Effects in Therapy Resistant Schizophrenia and the Optimal Sampling Time for Therapeutic Drug Monitoring
The goal of this observational study is to better understand how clozapine treatment can be tailored as regards minimizing side effects and optimizing efficacy and monitoring.
- Conditions
- Cardiovascular Side Effects of Clozapine, Neutropenia Due to Clozapine, General Side Effects of Clozapine, Constipation Due to Clozapine
- Trial name
- COTTONS (NCT06749041)
- Volunteers
- 60 people
- Sponsor
- GGZ Noord-Holland-Noord
Irritable Bowel Syndrome, Irritable Bowel Syndrome - Constipation
Efficacy of Chatbot for Irritable Bowel Syndrome (IBS) Patients
The goal of this clinical trial is to evaluate the efficacy of an automated chatbot system in improving quality of life, reducing depression and anxiety, and decreasing visceral sensitivity in patients with Irritable Bowel…
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome - Constipation, Irritable Bowel Syndrome - Diarrhoea, Irritable Bowel Syndrome - Mixed
- Trial name
- IrBiS (NCT06837064)
- Testing
- Chatbot supporting system
- Where
- Russia
- Volunteers
- 54 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Lower Urinary Tract Symptoms (LUTS), Transition Care
Study of Transition in Real-life Experiences Affecting Micturition and Well-being in Adolescent Years
With this study, we would like to interview 16-25-year-olds who have experienced urinary problems since childhood and who are still experiencing symptoms in young adulthood.
- Conditions
- Lower Urinary Tract Symptoms (LUTS), Transition Care, Enuresis Nocturnal, Adverse Childhood Experiences
- Trial name
- STREAMWAY (NCT07339865)
- Testing
- Semi-structured in-depth interviews with standardized validated questionnaires, Completion of a urological time-line
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Chronic Idiopathic Constipation (CIC)
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
This is a 26-week, multi-center, randomized, double-blind, placebo-controlled study with a 4-week treatment-free Safety Follow-up period to assess the safety and efficacy of tenapanor (5 mg, 25mg, and 50 mg) in adult patients…
- Trial name
- NCT07382167
- Testing
- Tenapanor 5 mg BID, Tenapanor 25 mg BID, Tenapanor 50 mg BID
- Where
- 109 sites in United States
- Volunteers
- 692 people
- Sponsor
- Ardelyx
Fecal Incontinence, Outlet Dysfunction Constipation
Treatment of Fecal Incontinence and Functional Evacuation Disorders Using Non-instrumental Biofeedback
Background. Rehabilitation and re-education using instrumental anorectal biofeedback are the main treatment of anorectal functional disorders producing incontinence and outlet obstructed defecation.
- Trial name
- NCT06273046
- Testing
- Biofeedback
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Multiple Sclerosis, Pelvic Floor Disorder
RedCord in Neurogenic Bowel Dysfunction in Multiple Sclerosis
The study aims to evaluate the effectiveness of Redcord treatment for neurogenic bowel dysfunction in patients with multiple sclerosis.
- Trial name
- NCT06838624
- Testing
- Redcord, Control (Standard treatment)
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- University of Castilla-La Mancha
Dyssynergia, Constipation
Fecobionics in Biofeedback Therapy in Dyssynergia Patients
Constipation affects 12-19% of Americans. Pelvic floor dyssynergia is considered to play an important role in constipation but the underlying mechanisms are not well understood in individual patients.
- Trial name
- NCT05807321
- Testing
- Fecobionics
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- The California Medical Innovations Institute, Inc.