Clinical trials: Constriction
Low Back Pain, Leg Pain
Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis
The purpose of this multi-center, randomized, clinical study is to establish the safety and effectiveness of the TOPS™ System, used following decompression, in the treatment of lower back and leg pain with, or without spinal…
- Conditions
- Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- NCT00405691
- Testing
- "TOPS System" - Total Posterior Arthroplasty Implant
- Where
- 16 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Impliant, Ltd.
Coronary Artery Stenosis
Optimal Predilatation Technique for BVS Implantation
The purpose of this study is to determine the optimal way of predilatation for BVS implantation.
- Trial name
- OPTI-BVS (NCT02946320)
- Testing
- Predilatation with non-compliant balloon, Predilatation with scoring balloon (Scoroflex), Predilatation with cutting balloon (Flextome)
- Volunteers
- 45 people
- Sponsor
- Cardiology Center Agel
Coronary Artery Stenosis
Prospective Multicenter Study to Characterize the REAL-WORLD EVIDENCE Regarding Safety and Performance of the PTCA NC Catheters Family
The purpose of this post market study is to collect clinical data of the Arthesys PTCA NC catheters family during angioplasty intervention of coronary vessels or coronary bypass graft stenosis to support MDR submission.
- Trial name
- NCT05536180
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Arthesys
Severe Aortic Valve Disease
Five-year Outcomes of Rapid-deployment Aortic Valve Replacement With the Edwards Intuity TM Valve
Objectives: This report presents 5-year outcomes of the rapid-deployment Edwards Intuity TM valve in a single-center prospective study.
- Trial name
- NCT04696926
- Testing
- Edwards Intuity TM Valve implantation
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Coronary Artery Stenosis, Fractional Flow Reserve
A Study to Evaluate Direct Wire Pacing (DWP) for Measuring Fractional Flow Reserve (FFR)
This is a randomized, non-inferiority, crossover investigation comparing the Direct Wire Pacing (DWP) versus standard method to measure Fractional Flow Reserve (FFR) in subjects with FFR indications.
- Trial name
- NCT04970082
- Testing
- FFR DWP, FFR
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Recherche Cardio Vasculaire Alpes
Percutaneous Coronary Intervention, Intravenous Ultrasound
IVUS-FFR Accuracy for Coronary Stenosis
IVUS-FFR Online Accuracy for Coronary Stenosis What is this study testing? This study is testing a new technology called IVUS-FFR , which uses ultrasound imaging inside heart arteries (IVUS) to quickly measure whether a narrowed…
- Conditions
- Percutaneous Coronary Intervention, Intravenous Ultrasound, Coronary Physiology
- Trial name
- IVUS-FFR (NCT07446023)
- Testing
- Ultrasound-Derived Fractional Flow Reserve Computational System
- Where
- China
- Volunteers
- 292 people
- Sponsor
- China National Center for Cardiovascular Diseases
Intervertebral Disc Degeneration, Stenosis, Spinal
Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure
This study is designed to evaluate the clinical utility of a known intraoperative neuromonitoring modality (SSEP) using saphenous nerve as the site of stimulation to identify changes to the lumbar nerves which may be at risk…
- Conditions
- Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity
- Trial name
- NCT05648474
- Testing
- Somatosensory evoked potential [SSEP] intraoperative monitoring
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Alphatec Spine, Inc.
Carotid Artery Disease, Carotid Artery Stenosis
Neurological Outcome With Carotid Artery Stenting
The purpose of this study is to determine how well patients undergoing carotid artery angioplasty and/or stent-supported angioplasty for the treatment of carotid artery stenosis will perform on a battery of tests to assess brain…
- Conditions
- Carotid Artery Disease, Carotid Artery Stenosis, Stroke, Transient Ischemic Attack
- Trial name
- CAS (NCT00597974)
- Testing
- Angioplasty, Stent, Neurological and neuropsychological evaluations
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Columbia University
Left Main Coronary Artery Disease
Functional Diagnostic Accuracy of Ultrasonic Flow Ratio in Assessment of Left Main Coronary Artery Stenosis
This is a prospective, observational, single-center study. The main purpose of this study is to evaluate the diagnostic accuracy of offline computational ultrasonic flow ratio (UFR) in predicting functionally significant left…
- Trial name
- FUNCTION II (NCT06053944)
- Testing
- fractional flow reserve (FFR); ultrasonic flow ratio (UFR); intravascular ultrasound (IVUS)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China National Center for Cardiovascular Diseases
Lumbar Spinal Stenosis
Feasibility Study of NL-Prow Interspinous Spacer to Treat Lumbar Spinal Stenosis
The purpose of the study is to evaluate the clinical safety and feasibility of the NL-Prow™ Interspinous Spacer implant and insertion procedure in the treatment of lumbar spinal stenosis
- Trial name
- NCT01053364
- Testing
- NL-Prow interspinous spacer implant
- Where
- Czechia
- Volunteers
- 6 people
- Sponsor
- Non-Linear Technologies
Inflammatory Bowel Diseases, Stricture; Bowel
Endoscopically Placed Lumen-Apposing Metal Stents for the Treatment of Symptomatic Intestinal Strictures in Individuals With Inflammatory Bowel Disease
This is a single-center prospective pilot study in patients with symptomatic partially obstructing intestinal strictures without severe active inflammation or penetrating complications, evaluating the use of LAMS with respect to…
- Trial name
- NCT06725563
- Testing
- Endoscopically placed lumen-apposing metal stents for the treatment of IBD-strictures
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Coronary Artery Disease
MCG Algorithm Optimization Study in Patients With Coronary Artery Stenosis
This prospective, multicenter study aims to optimize the Magnetocardiography (MCG) algorithm for detecting myocardial ischemia in patients with coronary artery stenosis.
- Trial name
- NCT07888465
- Volunteers
- 165 people
- Sponsor
- AMCG
Hypertension, Aortic Stenosis, Calcific
Pressure Assessment to Improve Outcomes After TAVR: a Registry
At the Malcom Randall Veterans Affairs Medical Center (MRVAMC), invasive cardiac pressures are routinely recorded after transcatheter aortic valve replacement (TAVR) procedures.
- Conditions
- Hypertension, Aortic Stenosis, Calcific, Quality of Life, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT03923530
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- North Florida Foundation for Research and Education
Acute Myocarditis, Dilated Cardiomyopathies
German Centre for Cardiovascular Research Cardiomyopathy Register
This is a joint project by Heidelberg University and Greifswald University. Our objective is to establish an unique national multi-center registry and biobank of well phenotyped patients with non-ischemic cardiomyopathies (CMP)…
- Conditions
- Acute Myocarditis, Dilated Cardiomyopathies, Hypertrophic Cardiomyopathies, Left Ventricular Myocardial Noncompaction Cardiomyopathy
- Trial name
- TORCH (NCT02187263)
- Where
- Germany
- Volunteers
- 2,300 people
- Sponsor
- Heidelberg University
Pyloric Stenosis, Intubation, Pediatric
Conventional Direct Laryngoscopy Vs. Video Laryngoscopy With The C-MAC For Pyloromyotomy
The purpose of this study is to compare two different ways of placing breathing tubes for surgery. Both ways are used currently to place breathing tubes and are safe and effective.
- Trial name
- NCT02775214
- Testing
- Video Laryngoscopy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Indiana University
Coronary Artery Disease
Diastolic Hyperemia Free Index for Assessment of Moderate Coronary Stenoses
A total of 106 subjects will be enrolled at up to 3 sites. Initial enrollment will occur at Washington University only. After 15 subjects have been enrolled at the primary site and no serious adverse events or protocol events…
- Trial name
- DFRiFR (NCT04019535)
- Testing
- physiological assessment with Volcano Verrata pressure wire (iFR)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Washington University School of Medicine
Esophageal Stent Fixation
Comparison of Stent Suturing Versus OTSC Stentfix
The purpose of this study is to investigate whether OTSC stentfix is a feasible, safe, and efficient device that can be used for esophageal stent fixation (to prevent stent migration) in patients with benign, non-stricture…
- Trial name
- NCT04936425
- Testing
- OTSC Stentfix
- Where
- United States
- Sponsor
- NYU Langone Health
Carotid Artery Stenosis
Evaluation of the Ton-bridge Carotid Stent for Carotid Artery Stenosis
The purpose of this trial is to evaluate effectiveness and safety of the Ton-bridge carotid stent for the treatment of carotid artery stenosis.
- Trial name
- NCT06365697
- Testing
- Ton-bridge carotid stent, WALLSTENT carotid stent
- Where
- 7 sites in China
- Volunteers
- 188 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Renal Artery Obstruction, Hypertension, Renal
The HERCULES Trial - A Safety and Effectiveness Study of the Herculink Elite Renal Stent to Treat Renal Artery Stenosis
The purpose of this study is to determine whether the Herculink Elite Renal Stent System is safe and effective in the treatment of renal artery stenosis in patients with less than optimal angioplasty results and uncontrolled…
- Trial name
- HERCULES (NCT00490841)
- Testing
- Herculink Elite Renal Stent System
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Abbott Medical Devices
Lumbar Spine Disease, Lumbar Disc Herniation
Perioperative Local Anesthesia Block in Spine Surgery
The purpose of the this study to evaluate the feasibility, safety, and efficacy of a fluoroscopically-guided dorsal ramus block placed by the operative neurosurgeon prior to lumbosacral surgery.
- Conditions
- Lumbar Spine Disease, Lumbar Disc Herniation, Lumbar Spinal Stenosis
- Trial name
- NCT05094427
- Testing
- Preoperative fluoroscopically-guided dorsal ramus block placed by the operative neurosurgeon
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- Columbia University