Clinical trials: Consumption, Tobacco
Nicotine Dependence
Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes.
- Trial name
- NCT07698470
- Testing
- Oral Nicotine Pouch, Smoking Cue Reactivity Task
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Schizophrenia
Value of Voxel-Based Morphometry in Schizophrenia
This cross-sectional observational study investigates structural brain abnormalities in schizophrenia and nicotine use disorder (NUD), with a focus on understanding how these abnormalities correlate with behavioral traits such as…
- Trial name
- NCT07108673
- Testing
- MRI
- Volunteers
- 96 people
- Sponsor
- Assiut University
Smoking Cessation, Cigarette Smoking
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation
This pilot randomized controlled trial will test the feasibility of a smoking cessation intervention using mindful smoking practice and a smartphone-based sensor-band among adults who regularly smoke cigarettes.
- Conditions
- Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT07789496
- Testing
- Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Tobacco Use, Smoking
BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability
This will be a single-center, single-blind, four-cohort, 22-day ambulatory study during which up to 24 healthy adult subjects [6 smokers (SMK), 6 moist snuff consumers (MSC), 6 vapers (VAP), and 6 non-tobacco consumers (NTC)]…
- Conditions
- Tobacco Use, Smoking, Smoking, Tobacco
- Trial name
- NCT06105424
- Testing
- Lung Permeability Assessment
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Nicotine Use Disorder
Neural Basis of Eating Behavior in Abstinent Smokers
The purpose of this research study is to better understand why people gain weight when they quit smoking by examining food intake and changes in brain activity in smokers when they are smoking as usual compared to when they have…
- Trial name
- SIT (NCT03438188)
- Testing
- Practice Quit Attempt
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking, Smoking Cessation
Testing a Self-affirmation Intervention for Use in a Mobile Application
The aim of these studies is to adapt the self-affirmation kindness questionnaire for use in a mobile application. Two studies will be conducted to test hypotheses that simplifying and shortening the original questionnaire in…
- Conditions
- Smoking, Smoking Cessation, Smoking, Tobacco
- Trial name
- NCT03405220
- Testing
- Self affirmation, 10 items, written examples, Self affirmation, 10 items, no examples, Self affirmation, 10 items, imagined examples
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Kent State University
Gambling, Tobacco Use Disorder
N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers
The objective of this application is to examine whether, given its mechanism of action, the dietary supplement, N-acetyl cysteine (NAC) will reduce both tobacco use and pathological gamblers (PG) symptoms in nicotine dependent…
- Trial name
- NCT00967005
- Testing
- N Acetyl Cysteine, Sugar Pill
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Chicago
Alcohol Abuse, Tobacco Use Disorder
Computer Adaptation of Screening, Brief MET Intervention to Reduce Teen Drinking
The goal of this project is to evaluate the feasibility, acceptability, and effect size of a new computerized Motivational Enhancement Therapy (cMET) intervention for alcohol-involved adolescents in primary care.
- Conditions
- Alcohol Abuse, Tobacco Use Disorder, Substance Use
- Trial name
- NCT01881841
- Testing
- cMET
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Boston Children's Hospital
Cigarette Smoking
Brain Nicotine Receptor Density & Response to Nicotine Patch
Even though the health risks and societal costs of cigarette smoking are well-known, roughly 19.8% of American adults continue to smoke.
- Trial name
- NCT01526005
- Testing
- Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brentwood Biomedical Research Institute
Head and Neck Cancer, Lung Cancer
Alcohol and Tobacco Consumption in Patients With Head and Neck Cancer : Interest of an Addiction Support
This is a multicenter, interventional, randomized study for preventive and therapeutic strategies for patients with head and neck or Lung cancer; contribution of an addiction support
- Trial name
- NCT01652456
- Testing
- Addiction support
- Where
- 3 sites in France
- Sponsor
- Centre Oscar Lambret
Health Behavior, Risk Reduction Behavior
Multiple Risk Behavior Intervention in Health Care Settings
This study (aka Healthy Directions2 or HD2) builds on an earlier study titled Healthy Directions (aka Healthy Directions 1 or HD1).
- Trial name
- HD2 (NCT01415492)
- Testing
- HD2, HD2+
- Where
- United States
- Volunteers
- 2,440 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Nicotine Dependence
Nicotinic Modulation of the Default Network of Resting Brain Function
Background: A brain circuit called the default network is the brain circuit that is active when the brain is at rest; that is, when individuals are not concentrating on specific tasks.
- Trial name
- NCT01240616
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Use Disorder
Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity
The primary goal will be to identify the optimal pulse protocol by systematically measuring the efficacy of various theta burst stimulation and repetitive rTMS protocols to increase and decrease the reward positivity in dependent…
- Trial name
- NCT06695884
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence
Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence
The primary aim of this study is to conduct a 60-patient feasibility, acceptability, and preliminary efficacy study of mSMART (Mobile App based Personalized Solutions and Tools for Medication Adherence of Rx Pill), a smartphone…
- Trial name
- mSMART-Ib (NCT02635919)
- Testing
- mSMART
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Tobacco Use
Shrinking the Size of the Tobacco Power Wall
The overall aim of this research is to experimentally evaluate the extent to which reducing the size of the tobacco power wall and the number of tobacco product units displayed influences tobacco use risk in adolescents.
- Trial name
- NCT04632030
- Testing
- Tobacco power wall size and tobacco products displayed
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- RAND
Current Smoker, Tobacco Smoking
Strategies to Connect Patients at Federally Qualified Health Clinics With Evidence Based Tobacco Cessation Treatment
This trial aims to connect tobacco using patients of Community Health Centers (CHCs) and Federally Qualified Health Centers (FQHCs) with evidence-based treatment to help them quit.
- Conditions
- Current Smoker, Tobacco Smoking, Tobacco Use
- Trial name
- NCT03900767
- Testing
- Ask-Advise-Connect (AAC), Text Messaging (TM), Motivation And Problem-Solving (MAPS)
- Where
- United States
- Volunteers
- 12,009 people
- Sponsor
- University of Utah
Nicotine Dependence, Pregnancy
Biomarker Feedback to Motivate Cessation in Pregnancy
Phase 3 Pilot Clinical Trial.
- Trial name
- MAW Phase 3 (NCT02431611)
- Testing
- Biomarker feedback (phone based smoking cessation counseling), Control condition (phone based smoking cessation counseling)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nicotine Dependence, Other Tobacco Product
Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1
This study is to examine if inhaled doses of menthol that produce low and high cooling effects change the appeal of e-cigarettes containing low and high doses of nicotine in adolescent smokers.
- Trial name
- NCT02179034
- Testing
- Nicotine, Low Dose Menthol, High Dose Menthol
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking, Cigarette Smoking
e-Cigarette - DNA Adducts
This study will examine the level of toxicity of e-cigarette use compared to smokers and nonsmokers including inflammation markers, toxicant and carcinogen exposure.
- Conditions
- Smoking, Cigarette Smoking, Electronic Cigarettes
- Trial name
- NCT03284632
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Dependence
UW Withdraw From Tobacco Study
It is of considerable scientific and clinical importance to assess tobacco withdrawal accurately since withdrawal severity is highly determinant of smoking cessation success.
- Trial name
- NCT04969198
- Testing
- Combination nicotine replacement therapy (Nicotine patch + nicotine mini-lozenge)
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
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