Clinical trials: Consumption, Tobacco
Nicotine Dependence
Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors
The proposed clinical studies will evaluate the acute effects of nicotine on the hypothalamic-pituitary-gonadal axis in women to test the hypothesis that nicotine alters gonadal steroid hormones, and/or disrupts feedback…
- Trial name
- NCT01636323
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Disorder, Nicotine Dependence
Treatment of Nicotine Dependence and Acute Depression
The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression.
- Trial name
- NCT00186446
- Testing
- bupropion and smoking cessation behavioral intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Health Risk Behaviors, Tobacco Smoking
Efficacy of the Proactive Automatized Lifestyle Intervention
Background: Individual brief behavior change interventions often do not sufficiently address the common co-occurrence of multiple health risk behaviors among people.
- Conditions
- Health Risk Behaviors, Tobacco Smoking, Alcohol Use, Unhealthy Diet, Exercise, Smoking, and Alcohol Use
- Trial name
- ePAL (NCT07441603)
- Testing
- Proactive Automatized Lifestyle intervention
- Where
- Germany
- Volunteers
- 788 people
- Sponsor
- University Medicine Greifswald
Nicotine Dependence
Cessation Screening Project
This project will use the Multiphase Optimization Strategy (MOST) to guide the development of optimized treatment strategies for the two most effective smoking cessation medications (Combination Nicotine Replacement [C-NRT] and…
- Trial name
- NCT04188873
- Testing
- Preparation Varenicline and Standard Duration Varenicline, Preparation Varenicline and Extended Duration Varenicline, Standard Duration Varenicline
- Where
- 2 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder
Neural Substrates in Nicotine Withdrawal
This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit.
- Trial name
- NCT01001520
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Pennsylvania
Smoking, Tobacco Use
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers.
- Conditions
- Smoking, Tobacco Use, Cigarette Smoking, E-Cig Use
- Trial name
- NCT06264154
- Testing
- E-cigarettes
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Healthy, Smoking, Cigarette
Investigation of Secreted Phosphoproteins and PiP3 (Phosphoinositolphospat 3) in Sputum
The aim of this study is to validate two new biomarkers in sputum samples. These are PiP3 (phosphoinositolphospat ) and phosphor proteins, representing important proteins within inflammatory situations of the lung.
- Trial name
- NCT03076086
- Testing
- Induced sputum procedure
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Tobacco Use
Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products
The purpose of the study is to evaluate changes in biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs) in adult smokers who completely switch to Ploom heated tobacco products (HTPs) compared to…
- Trial name
- NCT06179290
- Testing
- Ploom HTP Menthol HTS; MX3 (681), Ploom HTP Tobacco HTS; R8 (120), Smoking Abstinence (menthol)
- Where
- 8 sites in United States
- Volunteers
- 921 people
- Sponsor
- Altria Client Services LLC
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Tobacco Cessation
Tobacco Cessation Texting Intervention for People Living With HIV Who Smoke in Vietnam
The intersection of smoking and HIV/AIDS poses a serious public health threat in Vietnam. Vietnam is dealing with these two challenges with parallel rather than integrated plans.
- Trial name
- M2Q2-HIV (NCT05863923)
- Testing
- mHealth Messaging to Motivate Quitline use and Quitting among Persons Living With HIV (PLWH) in Vietnam (M2Q2-HIV), M2Q2-HIV Comparison
- Where
- 2 sites in United States, Vietnam
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Tobacco Dependence, Cardiovascular Diseases
Physical Activity as an Aid for Smoking Cessation
Including a tailored moderate-intensity physical activity intervention in a standard smoking cessation treatment program (pharmaceutical treatment and counseling) increases the chances of quitting and reduces nicotine withdrawal…
- Conditions
- Tobacco Dependence, Cardiovascular Diseases, Physical Activity
- Trial name
- PHASMO (NCT00521391)
- Testing
- Allez Hop
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Smoking, Nicotine Dependence
Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain
This study will test a combination of the drugs naltrexone and bupropion with weight-concerned smokers to investigate whether or not this combination of drugs improves smoking cessation quit rates and minimizes post quit weight…
- Trial name
- NCT00129246
- Testing
- Naltrexone, Bupropion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Tobacco Use, Substance Use
Tobacco-Concurrent Addictions in At-Risk Youth in Ottawa
According to the 2015 Ontario Student Drug Use and Health Survey (OSDUHS), there has been a significant increase in the number of secondary school youth who use poly-substances.
- Conditions
- Tobacco Use, Substance Use, Cannabis Use
- Trial name
- TCAY-Ottawa (NCT04812613)
- Where
- Canada
- Volunteers
- 520 people
- Sponsor
- Ottawa Hospital Research Institute
Smoking Cessation, Smoking, Cigarette
Pictorial Warning Labels & Memory for Relative & Absolute Cigarette Health-risk Information Over Time in Adult Smokers
Pictorial cigarette warning labels (PWLs) are thought to increase risk knowledge, but experimental research has not examined PWLs' longer term effects on memory for health risks.
- Trial name
- NCT03499340
- Testing
- text-only PWL, low arousal graphic PWL, high arousal graphic PWL
- Where
- United States
- Volunteers
- 3,213 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Smoking, Tobacco Dependence
Using a Teachable Moment Communication Process to Improve Outcomes of Quitline Referrals
This study will compare the effectiveness of two approaches for delivering smoking cessation advice in the primary care setting.
- Trial name
- NCT02764385
- Testing
- Teachable Moment Communication Process, AAC
- Volunteers
- 15,786 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Smoking
Testing Methylphenidate for Smoking Abstinence
Cigarette smoking continues to be a major public health problem. Tobacco dependence interventions, as recommended by the USPHS Clinical Practice Guideline are not effective for all smokers.
- Trial name
- NCT00549640
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Cancer, Tobacco Use
Lung Cancer Screening Navigation for Homeless People
The investigators will conduct a pragmatic clinical trial to test the effect of patient navigation on lung cancer screening (LCS) low-dose computed tomography (LDCT) completion among Boston Health Care for the Homeless Program…
- Conditions
- Lung Cancer, Tobacco Use, Homelessness
- Trial name
- NCT04308226
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Cigarette Smoking
Puff Biofeedback to Reduce Smoking Reinforcement
The purpose of the study is to examine the effects of a novel bio-behavioral paradigm, entitled, Puff Topography Biofeedback Training, compared to a control condition, in reducing stress-induced smoking reinforcement.
- Trial name
- NCT05644002
- Testing
- Puff Topography Biofeedback Training, Control
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Addiction
Pharmacogenetics of Nicotine Addiction Treatment
The purpose of this research program is to understand how a biomarker called the "nicotine metabolite ratio" (also referred to as NMR) may influence a smoker's ability to quit smoking.
- Trial name
- NCT01314001
- Testing
- Varenicline, Transdermal Nicotine
- Where
- 4 sites in United States, Canada
- Volunteers
- 1,246 people
- Sponsor
- University of Pennsylvania
Smoking, Cigarette
Switching to a Vaping Device: Evaluating Risk Reduction Among Quitline Treatment Failures
The overall aim of the study is to evaluate the provision of e-cigarette (EC) versus NRT on smoking behavior, product use patterns and continued use, and iCO, a biomarker of toxicant exposure, among a sample of recent QL…
- Trial name
- NCT03502200
- Testing
- JUUL, Treatment As Usual
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
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