Clinical trials: Contact Lens Wear
Visual Correction
One Month Daily Wear Clinical Evaluation of New Prototype Contact Lenses in Habitual and Neophyte Contact Lens Wearers
There will be four study lenses tested; one marketed lens, and three prototype study lenses. Subjects will be randomized to one of the four study lenses which will be worn in a daily wear modality, with a two week replacement.
- Trial name
- NCT02081677
- Testing
- ACUVUE 2, Prototype E1, Prototype E2
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Contact Lens
Wear Experience With Daily Contact Lenses Over a Long Day
This study is evaluating the wear experience of a daily contact lens after 10, 12, 14, and 16 hours of lens wear.
- Trial name
- NCT04535310
- Testing
- Precision1® Daily Disposable Contact Lens
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Refractive Errors
Clinical Characterization of an Investigational Frequent Replacement Daily Wear Silicone Hydrogel Sphere Contact Lens
The primary objective of this study is to evaluate the overall clinical performance of an investigational silicone hydrogel contact lens over 7 days of daily wear.
- Trial name
- NCT04702984
- Testing
- LID021201 contact lenses, OPTI-FREE multipurpose solution
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- Alcon Research
Myopia
Refitting Somofilcon A Sphere Contact Lens Wearers Into Fanfilcon A Sphere Lenses for 4-Weeks of Wear
The aim of this subject-masked prospective study is to evaluate the clinical performance of habitual wearers of Clariti Elite sphere lenses after a refit with Avaira Vitality sphere lenses.
- Trial name
- NCT03974802
- Testing
- somofilcon A contact lens, fanfilcon A contact lens
- Where
- Mexico
- Volunteers
- 41 people
- Sponsor
- CooperVision, Inc.
Myopia
Evaluation of Wear Experience With One Week Reusable Contact Lenses in Habitual Two Week Reusable Lens Wearers
This open-label study is of current Acuvue® Oasys® wearers (2 - week replacement, reusable lenses) who are satisfied with their current lenses.
- Trial name
- NCT06382064
- Testing
- Biweekly replacement contact lenses, One week replacement contact lenses
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Astigmatism
Refitting Somofilcon A Toric Contact Lens Wearers Into Fanfilcon A Toric Lenses for 4-weeks of Wear
The aim of this prospective study is to evaluate the clinical performance of habitual wearers of Clariti Toric lenses after a refit with Avaira Vitality Toric lenses for 1-month of daily wear.
- Trial name
- NCT04050605
- Testing
- somofilcon A toric contact lens, fanfilcon A toric contact lens
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- CooperVision, Inc.
Refractive Errors
Clinical Evaluation of a Daily Wear Monthly Replacement Silicone Hydrogel Lens
The purpose of this clinical study is to evaluate the safety and effectiveness of an investigational soft contact lens compared to a commercially available soft contact lens when worn for daily wear and replaced monthly.
- Trial name
- NCT04178720
- Testing
- Lehfilcon A contact lenses, Comfilcon A contact lenses, CLEAR CARE
- Where
- 8 sites in United States
- Volunteers
- 119 people
- Sponsor
- Alcon Research
Contact Lens-induced Corneal Fluorescein Staining
Corneal Staining and Physiological Compromise After Eight Hours of Soft Contact Lens Wear
The purpose of this study is to assess corneal staining and to measure the relative corneal epithelial "barrier" function (the degree to which the cornea can prevent penetration of colored sodium fluorescein dye into the eye)…
- Trial name
- NCT01015768
- Testing
- ReNu Multiplus multipurpose disinfecting solution, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Ametropia
Endothelial Bleb Response With Toric Lenses
Evaluate the short-term corneal response of oxygen deprivation when using toric contact lenses. The response will be noted by endothelial bleb formation in both open eye and closed eye state.
- Trial name
- NCT00630305
- Testing
- alphafilcon A toric, lotrafilcon B toric, senofilcon A toric
- Where
- Australia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia
A Multi-Center Investigation of Patient Acceptability of OPTI-FREE RepleniSH® Multi-Purpose Disinfecting Solution (MPDS)
The purpose of this study was to demonstrate that current successful fulltime daily wear soft contact lens wearers using competitive multi-purpose solutions will note improved comfort when using OPTI-FREE RepleniSH®.
- Trial name
- NCT00772707
- Testing
- Multi-Purpose Disinfecting Solution (OPTI-FREE RepleniSH), Contact Lenses
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Alcon Research
Myopia
A Comparison of Two Color Contact Lenses in Habitual Clear Contact Lens Wearers
The purpose of this study is to evaluate the comfort of color contact lenses in a population of clear contact lens wearers who have an interest in wearing color contact lenses.
- Trial name
- NCT02175199
- Testing
- Lotrafilcon B contact lenses with color printing, Phemfilcon A contact lenses with color printing
- Volunteers
- 151 people
- Sponsor
- Alcon Research
Contact Lens Wear
Vistakon Investigational Multi-purpose Contact Lens Care Solution.
This study compares an investigational contact lens care multi-purpose solution to a currently marketed multi-purpose solution.
- Trial name
- NCT01055457
- Testing
- Vistakon Investigational Multi-Purpose Solution II, ReNu MultiPlus Multi-Purpose Solution
- Where
- 14 sites in United States
- Volunteers
- 315 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia, Refractive Error
Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface
The purpose of this study is to utilize in-vivo confocal microscopy to describe differences in corneal epithelial immune status across three lens care regimens in new contact lens wearers.
- Trial name
- NCT01250925
- Testing
- ReNu MultiPlus® MultiPurpose Solution, OPTI-FREE® RepleniSH®, Clear Care®
- Where
- 2 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Refractive Errors
Clinical Performance of a Silicone Hydrogel Contact Lens Following One Night of Extended Wear
The purpose of this clinical study is to evaluate the on-eye performance of an investigational soft contact lens compared to a commercially available soft contact lens following 1 night of extended wear.
- Trial name
- NCT03560141
- Testing
- LID011121 contact lens, Comfilcon A contact lens
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Alcon Research
Astigmatism
Performance of Two Toric Silicone Hydrogel Contact Lenses
Prospective study to evaluate the clinical performance of fanfilcon A toric contact lens and senofilcon A toric contact lens after two weeks of wear.
- Trial name
- NCT03578926
- Testing
- fanfilcon A toric lens, senofilcon A toric lens
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- CooperVision, Inc.
Myopia
A One-Week Crossover Dispensing Evaluation of New Daily Wear Soft Contact Lenses
The purpose of this study is to validate the clinical performance of a new contact lens design when worn over a period 1 week compared to nelfilcon A (control).
- Trial name
- NCT03306641
- Testing
- Test Contact Lens, Nelfilcon A
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- CooperVision, Inc.
Astigmatism
Evaluation of Delefilcon A and Senofilcon A Daily Disposable Toric Soft Contact Lenses Over One Week of Wear
This is a prospective, multi-site, 4-visit, bilateral, dispensing, randomized, controlled, double-masked, 2x2 crossover study to evaluate subjective comfort, overall opinion and end of day comfort following wear of two different…
- Trial name
- NCT06749496
- Testing
- Test Lens, Control Lens
- Where
- 12 sites in United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Refractive Error
DAILIES TOTAL1® Lubricity Post Wear
The primary objective of the study is to demonstrate that the lubricity of DAILIES TOTAL1® (DT1) lenses after 16 hours of wear is equivalent to the lubricity of unworn DT1 lenses.
- Trial name
- NCT02072980
- Testing
- Delefilcon A contact lenses
- Volunteers
- 15 people
- Sponsor
- Alcon Research
Myopia
Evaluation Of One Silicone Hydrogel Contact Lens and Two Hydrogel Lenses in Daily Wear
To evaluate the comparative clinical performance of the fanfilcon A silicone hydrogel lens used in daily wear and to compare this with competitive hydrogel lens products.
- Trial name
- NCT04050618
- Testing
- fanfilcon A test lens, ocufilcon D control lens, etafilcon A control lens
- Where
- 6 sites in United States
- Volunteers
- 114 people
- Sponsor
- CooperVision, Inc.