Clinical trials: Contraceptives, Oral, open to volunteers
Endometriotic Cyst of Ovary
Letrozole in Preventing Recurrence of Endometrioma Following Laparoscopic Ovarian Cystectomy
Endometriosis is a chronic inflammatory disease that affects approximately 10-15% of women of reproductive age. Symptoms include dysmenorrhoea, chronic pelvic pain, dyspareunia and infertility.
- Trial name
- NCT05487092
- Testing
- Letrozole
- Where
- 5 sites in Hong Kong
- Volunteers
- 194 people
- Sponsor
- The University of Hong Kong
Menstrual Cycle, Resistance Training
Impact of Menstrual Cycle-Based Resistance Training on Neuromuscular Performance in Female Athletes
The goal of this clinical trial is to assess the impact of menstrual cycle-based resistance training on neuromuscular function in female athletes.
- Conditions
- Menstrual Cycle, Resistance Training, Neuromuscular Function, Female Athlete
- Trial name
- MENSES (NCT06679491)
- Testing
- Resistance periodized training program (N-PF), Resistance peioridized training program (N-PL), Continuous resistance training program (C)
- Where
- Reunion
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universite de La Reunion
Healthy Volunteers
A Study to Assess Potential Drug-Drug Interactions of E2086 in Healthy Participants
The primary purpose of this study is to assess potential drug-drug interactions of E2086 when coadministered orally with Itraconazole, Carbamazepine, Midazolam, Dextromethorphan, Bupropion, or Combined Oral Contraceptives in…
- Trial name
- NCT07766369
- Testing
- E2086
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Contraception
Arterial Vascular Effects of Estetrol-drospirenone Combined Oral Contraceptive Pill
The goals of this clinical trial are to investigate the effect of the estetrol (E4)-drospirenone combined oral contraceptive (COC) pill on flow-mediated dilatation (FMD) of the brachial artery and pulse wave velocity (PWV), in…
- Trial name
- NCT07536763
- Testing
- Estetrol-drospirenone, Ethinylestradiol-levonorgestrel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Dr. Hang Wun Raymond Li
Obesity, Overweight
A Study of Eloralintide (LY3841136) in Female Participants With Obesity or Overweight
The main purpose of this study is to evaluate how eloralintide (LY3841136) effects the way the body processes oral contraceptive in female participants with obesity or overweight.
- Trial name
- NCT07808060
- Testing
- Eloralintide, Combined oral contraceptive
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Fertility Preservation
Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or…
- Trial name
- HOLIDAY (NCT07225660)
- Testing
- OCP pause
- Where
- 3 sites in United States
- Volunteers
- 394 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Contraception, Pharmacogenomic Drug Interaction
Oral Contraceptive Pill (OCP) Pharmacogenomics
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these…
- Trial name
- NCT06334315
- Testing
- Desogestrel / Ethinyl Estradiol Pill
- Where
- 2 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Yale University
Glucose Homeostasis
Postprandial Glucose Handing in Contraceptive and IUD Users
Goals: The long-term use of hormonal birth control has been shown to effect glucose handling, or blood sugar regulation, and potentially lead to insulin resistance which increases a person's risk for metabolic diseases such as…
- Trial name
- HCPG (NCT07169591)
- Testing
- Oral Glucose Tolerance test (75g 2-hour)
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 1 Diabetes
Exercise and the Menstrual Cycle in Type 1 Diabetes
Female participants with type 1 diabetes using oral contraceptives will be asked to wear a continuous glucose monitor for at least three days on two separate occasions (once during the last week of active pills and once during…
- Trial name
- NCT05188014
- Testing
- Luteal Phase Aerobic Exercise, Follicular Phase Aerobic Exercise
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Alberta
Menstrual Cycle, Oral Contraceptive Use
Effects of the Menstrual Cycle and Oral Contraceptive Use on Health and Performance in Athletes
A review of the sports medicine literature reveals a clear underrepresentation of female athletes in research. In the current era of precision medicine, increasing attention has been directed toward the regulatory roles of…
- Conditions
- Menstrual Cycle, Oral Contraceptive Use, Athlete
- Trial name
- Flow2Perform (NCT07591818)
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Contraception Use
Sildosin as a Male Contraceptive Non Hormonal
In all, 200 healthy, sexually active, fertile male candidates will be assigned 100 in silodosin group and 100 in placebo group. Males using other contraceptive methods will be excluded.
- Trial name
- NCT07195097
- Testing
- Oral intake of sildosin
- Volunteers
- 200 people
- Sponsor
- Benha University
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Effects of VX-407 on the Pharmacokinetics of Combined Oral Contraceptives
The purpose of the study is to evaluate the pharmacokinetic effects and safety and tolerability of VX-407 when coadministered with oral contraceptives.
- Trial name
- NCT07792408
- Testing
- VX-407, LNG/EE, NGM/EE
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
The Focus of the Study is to Investigate Reversible Effects of Combined Oral Contraceptive Use on Serotonergic Neurotransmission, Healthy Adult Females
Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission
The goal of this study is to learn about potential reversible effects of combined oral contraceptive (COC) use on the serotonergic brain system.
- Trial name
- REVERSE (NCT07511439)
- Testing
- Discontinuation of 2nd generation combined oral contraceptive use, Continuation of 2nd generation combined oral contraceptive use
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Polycystic Ovary Syndrome (PCOS)
Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS
This cross-sectional study aims to compare the effectiveness of oral contraceptives, oral progesterone (didrogesterone), and inositol in regulating menstrual cycles among women diagnosed with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07242131
- Testing
- Combined Oral Contraceptive (Ethinylestradiol 0.03 mg + Drospirenone 3 mg), Inositol mid-level volume, Dydrogesterone Pill
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ege University
Advanced Malignancies
A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies
This drug-drug interaction (DDI) study aims to evaluate the impact of pelabresib at steady-state plasma concentrations on the pharmacokinetic (PK) profile of A) a single dose of repaglinide and a single dose of midazolam, and B)…
- Trial name
- NCT07340190
- Testing
- pelabresib, repaglinide, midazolam
- Where
- 6 sites in France, Italy and 1 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Oral Hormonal Contraceptive Use, Neural Activity
Contraceptive Hormone and Reward Measurement (CHARM Study)
Purpose of this study: The purpose of this study is to learn more about how hormonal oral contraceptives affect brain processes and emotional wellbeing.
- Conditions
- Oral Hormonal Contraceptive Use, Neural Activity, Mood, Hedonic Function
- Trial name
- CHARM (NCT05058872)
- Testing
- Levonorgestrel/ethinyl estradiol
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Overweight, Obesity
A Research Study Looking Into How UBT251 Works With Birth Control Tablets and Emptying of the Stomach in Women With Excess Body Weight Not Able to Become Pregnant
The purpose of this clinical study is to find out if UBT251 is safe and effective to be taken together with medicines, like birth control tablets, and emptying of the stomach in women not able to become pregnant living with…
- Trial name
- NCT07710729
- Testing
- UBT251, Oral contraceptive, Acetaminophen
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Tuberculosis
A Study to Investigate the Repeat-dose Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With Ganfeborole in Female Participants of Non-childbearing Potential
This study is designed to assess the pharmacokinetics (PK), safety, and tolerability of Ganfeborole and Microgynon, an oral contraceptive containing ethinylestradiol (EE) and levonorgestrel (LNG), when Microgynon is administered…
- Trial name
- NCT07784894
- Testing
- Ganfeborole, Microgynon
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Female Sex Hormones, Menstrual Cycle
Menstrual Cycle vs. Oral Contraceptives: Effects on Muscle Protein Metabolism After Resistance Exercise
The muscles of the body are constantly breaking down old proteins and building new ones. These two processes, protein breakdown and protein synthesis, together are known as protein turnover.
- Conditions
- Female Sex Hormones, Menstrual Cycle, Oral Contraceptives, Protein Metabolism
- Trial name
- MCOC (NCT07258576)
- Testing
- Protein Beverage, Stable Isotope Tracer [D5]phenylalanine, Stable Isotope Tracer [13C]phenylalanine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto