Clinical trials: Contractures
Palmar Fibromatosis
Effect Of Extracorporeal Shock Wave Therapy On Ultrasonography Changes In Patients With Palmar Fibromatosis: A Randomized Controlled Trial
this study will be conducted to investigate the effect of extracorporeal shock wave therapy on ultrasonography chnges In patients with palmar fibromatosis
- Trial name
- ESWT (NCT06248866)
- Testing
- Extracorporeal Shock Wave Therapy, traditional treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Dupuytren Disease
Skin Involvement in Dupuytren Surgical Treatment Outcome
Palmar skin is often retracted in Dupuytren disease (DD), making surgical management challenging and skin-preserving surgery difficult.
- Trial name
- Skin in DD (NCT07470684)
- Testing
- Suction cutometry, Ultrasound measurement, Microbiopsy for histological analysis
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Contracture
Collagenase Injection for Contracture Management
The overall goal is to investigate the effectiveness of a novel intervention - Collagenase injection, for contracture management in patients with neurological impairments, such as stroke, brain injury, and spinal cord injury.
- Trial name
- NCT07693556
- Testing
- Active XIAFLEX Collagenase injection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Finger Proximal Interphalangeal Joint Contracture
A Novel Shape Memory Alloy-Based Orthosis for Proximal Interphalangeal Joint Stiffness
The goal of this clinical trial is to evaluate the applicability, effectiveness, and usability of a shape memory alloy-based orthosis for patients with finger proximal interphalangeal joint stiffness.
- Trial name
- NCT06716086
- Testing
- shape memory alloy-based orthosis, conventional stretching program
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Cheng-Kung University Hospital
Dupuytren Contracture, Dupuytren Disease of Finger
Safety and Efficacy Study of Collagenase CNT201 Injection for Treatment of Dupuytren's Contracture
This trial is a multicenter, Phase 1/2, study to assess the safety, tolerability, efficacy, PK, and immunogenicity of CNT201 in adult participants with DC (Dupuytren's Contracture).
- Trial name
- NCT07640425
- Testing
- [Step1] CNT201 First-dose, [Step1] CNT201 Low-dose, [Step1] CNT201 Intermediate-dose
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- CONNEXT
Stroke, DVT
Soft Robotic Sock Intervention for Robot-assisted Ankle-foot Mobility in Post-stroke Patients
Stroke is closely associated with high mortality among patients in hospitals and immobility leading development of deep vein thrombosis (DVT) leading to pulmonary embolism (PE) and Venous thromboembolism (VTE) and/or ankle joint…
- Conditions
- Stroke, DVT, Ankle Contracture
- Trial name
- NCT05491109
- Testing
- Venous Assistance and Contracture Management System (VACOM)
- Where
- Singapore
- Volunteers
- 19 people
- Sponsor
- National University Hospital, Singapore
Hamstring Contractures
Cyclops Syndrome After Anterior Cruciate Ligament Reconstruction
Monocentric, prospective, randomised, double-blind study of two parallel groups of 66 patients with post-reconstruction ACL hamstring contracture treated with an ultrasound-guided injection at two points on the body of the…
- Trial name
- SCALA (NCT05008731)
- Testing
- Botulinum toxin
- Where
- France
- Volunteers
- 13 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Knee Flexion Contracture, Total Knee Arthroplasty (TKA)
Anterior Heel Wedge to Treat Flexion Contracture After Total Knee Arthroplasty
Total knee arthroplasty (TKA) remains the only treatment for end-stage knee osteoarthritis, whereby the diseased ends of the bones comprising the knee joint are removed and replaced with prosthetic joint components.
- Trial name
- NCT07620145
- Testing
- Anterior heel wedge
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Charlotte
Dupuytren's Disease
Nodular Shrinking in Dupuytren Disease
Dupuytren disease (DD) is a common hand disorder with disabling finger contractures that may require surgery to restore function.
- Trial name
- Echo (NCT06321991)
- Testing
- Ultrasound measurement
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Burn, Burn Contracture of Skin
Development and Clinical Study of Burn Wound Nursing Dressing Based on Sodium Hyaluronate Carbomer Composite Hydrogel
Development and clinical study of burn wound nursing dressing based on sodium hyaluronate carbomer composite hydrogel
- Conditions
- Burn, Burn Contracture of Skin, Burn Degree Second
- Trial name
- NCT07568600
- Testing
- sodium hyaluronate carbomer composite hydrogel
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Dupuytren Contracture
Trial Comparing Treatment Strategies in Dupuytren's Contracture
Trial is a prospective, randomized, controlled, outcome assessor-blinded, three armed parallel 1:1:1, multicenter trial. The research objective is to determine, which treatment strategy 1) primary percutaneous needle fasciotomy…
- Trial name
- DETECT (NCT03192020)
- Testing
- Percutaneous needle fasciotomy (PNF), Collagenase Clostridium Histolyticum (CCH) 2.9 MG/ML [Xiaflex], Limited fasciectomy (LF)
- Where
- 6 sites in Finland
- Volunteers
- 302 people
- Sponsor
- Tampere University
Dupuytren's Disease
Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease
Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand.
- Trial name
- REMEDY (NCT05067764)
- Testing
- Aponeurectomy with grafting, Aponeurectomy alone
- Where
- 2 sites in France
- Volunteers
- 172 people
- Sponsor
- Elsan
Hamstring Contractures, Muscle Relaxation
Dynamic Stretching vs. Foam Rolling: Effects on Hamstring Flexibility and Muscle Oxygenation in Tight Hamstrings
Hamstring muscle flexibility plays a vital role in functional movement and in the prevention of injuries. Reduced flexibility of the hamstring muscles is common and can lead to biomechanical dysfunctions, a limited range of…
- Conditions
- Hamstring Contractures, Muscle Relaxation, Muscle Tightness
- Trial name
- NCT07024017
- Testing
- Foam roller, dynamic stretch
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pelin Pişirici
Breast Cancer, Capsular Contracture Associated With Breast Implant
Predictive Toxicity Test Linked to Radiotherapy After Mastectomy and Immediate Implant Reconstruction
This study evaluates the capacity of the NovaGray RILA Breast® test to predict the toxicity linked to radiotherapy and the impact of implant breast reconstruction.
- Trial name
- PRETORIA (NCT04342546)
- Testing
- NovaGray RILA Breast® test
- Where
- 9 sites in France
- Volunteers
- 250 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Dupuytren's Disease
MiniFlo for Advanced Dupuytren's Disease
The aim of this study is to investigate the potential use of the MiniFlo (CitiEffe) progressive distraction external fixator in the treatment of advanced Dupuytren's disease.
- Trial name
- NCT07505563
- Testing
- MiniFlo
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Burn Contracture of Skin
Serial Casting for Upper Extremity Burn Contractures
The use of a splint, serial casting and passive stretching have been described in the literature as conservative interventions to manage joint contractures after burn injury.
- Trial name
- NCT05425433
- Testing
- Tailored serial casting intercention
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Dupuytren's Disease, Dupuytren Contracture
Post-contracture Release Radiation for Dupuytren's Disease
To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.
- Conditions
- Dupuytren's Disease, Dupuytren Contracture, Dupuytren Disease of Palm and Finger, Dupuytren Disease of Finger
- Trial name
- NCT04122313
- Testing
- Evaluation of Dupuytren's Disease Treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Dupuytren Contracture
The Effects of Prophylactic Limited Palmar Fasciectomy on Surgical Outcomes and Scarring
Research is instrumental for improving medical care and the patient experience. Finding new surgical techniques can create better outcomes and minimize recovery time and complications for patients.
- Trial name
- NCT03155854
- Testing
- Pretendinous cord excision, Division/manipulation of the cord
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Dupuytren's Disease
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
Dupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions.
- Trial name
- Micronerves (NCT06142929)
- Testing
- Microfasciectomy
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Disease
Ultrasound Features of Dupuytren's Disease
Dupuytren's disease (DD) is a benign and progressive condition that affects the palmar aponeurosis with a very high global incidence.
- Trial name
- Micro in DD (NCT06956027)
- Testing
- Ultrasound assesment, ROM measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven