Clinical trials: Contrast Agent
Peripheral Artery Disease
Contrast Ultrasound Assessment of Perfusion Changes After Peripheral Artery Revascularization
This study represents an important step to validate the use of contrast-enhanced ultrasound (CEU) as a clinical research tool that can be used as a biologic readout of new therapies for Peripheral Artery Disease (PAD), and as a…
- Trial name
- NCT02877563
- Testing
- Contrast ultrasound perfusion imaging of the limb
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Type1diabetes, Insulitis
Pancreas Ultrasound Imaging in type1 Diabetes
The overall goal of this study is to develop and test a novel method involving ultrasound imaging, in order to detect the development of type 1 diabetes.
- Conditions
- Type1diabetes, Insulitis, Pancreas Inflamed
- Trial name
- NCT05482321
- Testing
- Definity Suspension for Injection
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Stroke, Acute
Thrombolysis in stRoke With Unknown onSet Based on noncontrasT CT
Multicentric, observational, registry-based study of 0.9 mg/kg i.v. thrombolysis in wake-up stroke or stroke with unknown onset based on non-contrast CT appearance only
- Trial name
- TRUST CT (NCT03634748)
- Where
- 5 sites in Austria, Germany and 2 more
- Volunteers
- 117 people
- Sponsor
- University Hospital Tuebingen
Hypertension, Chronic Kidney Disease
Renal Sympathetic Denervation in Moderate to Severe Chronic Kidney Disease
A pilot, single-center, prospective, interventional study. The objective is to demonstrate that catheter-based renal denervation using carbon dioxide renal angiography in patients with moderate to severe chronic kidney disease…
- Trial name
- NCT02863510
- Testing
- Renal Sympathetic Denervation
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Heart of England NHS Trust
Cardio-Renal Syndrome
Adequate Hydration Therapy Combined With Intravenous Infusion of Isosorbide Dinitrate Prevention for CIN
Patients at moderate and high risk for contrast induced nephropathy (CIN) should receive sufficient hydration before application of contrast to prevent CIN, but hydration could obviously increase the preload for congestive heart…
- Trial name
- NCT02718521
- Testing
- Hydration Combined With Intravenous Infusion of Isosorbide Dinitrate, Visipaque, 0.9% sodium chloride fluid administration
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Nodule
Utility of Contrast-Enhanced Sonography and Shear Wave Elastography
Our overall hypothesis is that Contrast-enhanced ultrasound (CEUS) and Shear Wave Elastography (SWE) will allow for high diagnostic accuracy of benign and malignant thyroid nodules, which will correlate with and complement the…
- Trial name
- NCT04614389
- Testing
- Contrast-enhanced ultrasound, Shear Wave Elastography, Sequoia System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Breast Cancer
Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)
Consecutive patients with a first diagnosis of breast cancer will be identified at the Tom Baker Cancer Centre (TBCC) and included into the study, if they are going to receive chemotherapy with anthracyclines and / or Trastuzumab…
- Trial name
- Cardiotox (NCT00679874)
- Testing
- Cardio-vascular MRI
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Non Small Cell Lung Cancer
Feasibility Study of Enhanced MRI for Early Stage Non Small Cell Lung Cancer (NSCLC)
This is a pilot study. A pilot study is done with a small number of participants to see if a technique works before using it in a larger research study.
- Trial name
- NCT01799135
- Testing
- DCE-MRI scan, Stereotactic Body Radiation Therapy, 4D-CT scan
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Dana-Farber Cancer Institute
Contrast-induced Nephropathy
Contrast-Induced Nephropathy After Revision of the Prophylaxis Threshold
After administration of intravascular iodinated contrast media Contrast-Induced Nephropathy (CIN), also known as Contrast-Induced Acute Kidney Injury (CIAKI), may occur.
- Trial name
- CINART (NCT03227835)
- Testing
- intravascular iodinated contrast material administration
- Where
- Netherlands
- Volunteers
- 1,372 people
- Sponsor
- Maastricht University Medical Center
Colorectal Cancer
Feasibility of Reduction in Right Sided Bowel Cancer Through Contrast Enhanced Colonoscopy
The Bowel Cancer Screening program was implemented to address the important issue of prevention and early detection of bowel cancer.
- Trial name
- CONSCOP (NCT01972451)
- Testing
- Colonoscopy with enhanced dye
- Where
- United Kingdom
- Volunteers
- 1,320 people
- Sponsor
- Lisette Nixon
Breast Cancer
Contrast-enhanced Mammography in Women With a Personal History of Breast Cancer and Dense Breast Tissue: Benefit?
This study aims to assess the effectiveness of Contrast-Enhanced Mammography (CEM)as an alternative to traditional ultrasound for breast cancer screening in women with dense breasts and a personal history of breast cancer.
- Trial name
- CEM (NCT06993246)
- Testing
- Contrast-Enhanced Mammography (CEM)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Jean Seely
Breast Cancer
Added Value of Contrast Enhanced Spectral Mammography, CESM. A Pilot Study.
Introduction: To avoid unnecessary mastectomies and reoperations a correct size assessment of malignant lesions in breast is required. Sometimes a supplementary MRI is therefore recommended.
- Trial name
- NCT03402529
- Testing
- Contrast Enhanced Spectral Mammography
- Where
- Sweden
- Volunteers
- 47 people
- Sponsor
- Region Skane
Hepatocellular Carcinoma
Fusion Imaging Contrast-enhanced Ultrasound LI-RADS
CEUS LI-RASD apply to lesion visible at precontrast ultrasound but not the lesion invisible. Fusion imaging can use to invisible lesions at precontrast ultrasound in clinical practice.
- Trial name
- NCT04955119
- Testing
- Fusion imaging contrast-enhanced ultrasound
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Tianjin Third Central Hospital
Central Nervous System Pathology
Study to Find the Appropriate Dose of a New Gadolinium-based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Brain and/or Spinal Cord Conditions
Researchers in this study want to find the appropriate dose of drug BAY1747846 for adults undergoing MRI for known or highly suspected brain and/or spinal cord conditions so that the image quality is similar to that of drug…
- Trial name
- NCT04307186
- Testing
- Gadoquatrane (BAY1747846), Gadobutrol (Gadovist/Gadavist)
- Where
- 17 sites in United States, Bulgaria and 2 more
- Volunteers
- 57 people
- Sponsor
- Bayer
Head and Neck Cancer
Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body
This trial studies how well dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) works in diagnosing osteoradionecrosis in patients with head and neck cancer that is primary, has come back, or has spread to other places…
- Trial name
- NCT03145077
- Testing
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Questionnaire Administration
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- M.D. Anderson Cancer Center
Magnetic Resonance Imaging, Central Nervous System
Contrast-enhanced 3D T1-weighted Gradient-echo Versus Spin-echo 3 Tesla MR Sequences in the Detection of Active Multiple Sclerosis Lesions
Gadolinium-enhanced magnetic resonance imaging (MRI) is currently the imaging gold standard to detect active inflammatory lesions in multiple sclerosis (MS) patients.
- Conditions
- Magnetic Resonance Imaging, Central Nervous System, Brain, Multiple Sclerosis
- Trial name
- COGITE (NCT03268239)
- Testing
- Additional MRI sequences
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Hypertrophic Cardiomyopathy
Perfusion Imaging With Myocardial Contrast Echocardiography in HCM
The objective of this study is to determine whether myocardial contrast echocardiography in patients with cardiomyopathy (HCM) can detect resting hypo-perfusion due to fibrosis or stress induced perfusion defects due to…
- Trial name
- NCT02560467
- Testing
- Echo and myocardial contrast echocardiography perfusion imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Schizophrenia
A Study to Assess Learning Performance in Patients With Schizophrenia and Young and Elderly Healthy Volunteers
The purpose of this study is to measure and contrast implicit and explicit learning performance in patients with schizophrenia relative to young and elderly healthy volunteers.
- Trial name
- NCT01788436
- Testing
- Cognitive Test Battery 1, Cognitive Test Battery 2
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Brain Metastases
Response of Brain Metastases After Gamma-Knife Radiosurgery Using Dynamic Susceptibility-weighted Contrast-enhanced Perfusion Magnetic Resonance Imaging
This study is designed to evaluate whether advanced magnetic resonance imaging (MRI) techniques such as dynamic susceptibility-weighted contrast-enhanced perfusion MRI may be used to predict treatment response of brain metastasis…
- Trial name
- NCT02311556
- Testing
- dynamic susceptibility-weighted contrast-enhanced perfusion magnetic resonance imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis, Optic Neuritis
Ampyra for Optic Neuritis in Multiple Sclerosis
Fifty subjects will be enrolled in this Phase II, investigator-initiated, randomized and blinded cross-over trial of dalfampridine of 8 weeks duration The study will test the hypothesis that dalfampridine, when administered to…
- Trial name
- NCT01337986
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Washington University School of Medicine
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