Clinical trials: Contrast Agent
Liver Neoplasm
Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy
This observational study will investigate the properties of image files standardly collected during radiation therapy treatment in a cross-section of liver cancer patients who received stereotactic ablative body radiation therapy…
- Trial name
- ROCK-RT (NCT05169177)
- Where
- 5 sites in Australia
- Volunteers
- 50 people
- Sponsor
- University of Sydney
Kidney Disease
Comparative Investigation of Intravenously Administered Omnipaque and Isovue: Effects on Serum Creatinine Concentration in Outpatients
The purpose of this study is to determine if one CT contrast agent (medication injected into a vein; used in CT examinations to help produce clearer images) is safer to use than another.
- Trial name
- NCT00734357
- Testing
- Blood work
- Where
- United States
- Volunteers
- 413 people
- Sponsor
- University of Michigan
Contrast Enhancement in Magnetic Resonance Imaging, Healthy Volunteers
A Study to Learn More About the Safety and the Level of BAY 1747846 in Body Given as Injection Into the Vein at Increasing Single Doses in Japanese Healthy Male Participants
The goal of this clinical study was to learn more about BAY1747846 compared to placebo when given as an injection into the vein in Japanese healthy male participants: the safety of BAY1747846 when given at increasing single doses…
- Trial name
- NCT06125366
- Testing
- BAY1747846
- Where
- Japan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayer
Acute Kidney Failure
Ioxaglate Versus Iodixanol for the Prevention of Contrast-induced Nephropathy in High-risk Patients (IDPC Trial)
Contrast media-induced nephropathy following diagnostic and therapeutic cardiac catheterization.
- Trial name
- IDPC (NCT02991742)
- Testing
- contrast media
- Volunteers
- 2,262 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Acute Kidney Failure
The Acetylcysteine for Contrast-Induced Nephropathy Trial
The purpose of this study is to evaluate the efficacy of acetylcysteine compared to placebo for the contrast-induced nephropathy prevention, between 48 and 96 hours after procedures that use contrast.
- Trial name
- ACT (NCT00736866)
- Testing
- Acetylcysteine
- Where
- Brazil
- Volunteers
- 2,300 people
- Sponsor
- Hospital do Coracao
Contrast-induced Nephropathy, Contrast-induced Acute Kidney Injury
Effect of Allopurinol or Febuxostat to Prevent Contrast Induced Acute Kidney Injury (CI-AKI)
A randomized, placebo-controlled, double-blind clinical trial of effect of allopurinol or febuxostat to prevent contrast induced acute kidney injury (CI-AKI)
- Trial name
- CI-AKI (NCT03767322)
- Testing
- Allopurinol, Febuxostat
- Where
- Mexico
- Volunteers
- 558 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Hepatocellular Cancer, Liver Cirrhoses
Diagnostic Efficacies of Sonazoid-CEUS and EOB-MRI in Patients With High Risk of HCC
Hepatocellular carcinoma (HCC) is the fifth most common cancer. Patients with HCCs usually have a poor prognosis. Hepatocarcinogenesis is an intricate and multistep process.
- Conditions
- Hepatocellular Cancer, Liver Cirrhoses, Diagnoses Disease
- Trial name
- NCT04212273
- Testing
- Diagnostic Sonazoid-CEUS and EOB-MRI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tianjin Third Central Hospital
Parotid Neoplasm, Parotid Cancer
Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology for Parotid Gland Neoplasms
Parotid gland tumors are mostly treated surgically, but the extent of parotidectomy is decided upon preoperative work-up information.
- Trial name
- NCT03849482
- Testing
- Multiparametric Magnetic Resonance Imaging, Fine Needle Aspiration Cytology, Clinical Evaluation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Davide Di Santo
Kidney Transplantation, Pancreas Transplantation
CEUS in Kidney and Pancreas Transplantation
This study is to investigate whether it is possible to use a special type of ultrasound scan (CEUS, Contrast Enhanced Ultrasound Scan) to view the shape, assess blood supply and calculate the amount of oxygen being carried to a…
- Trial name
- NCT02104024
- Testing
- Contrast Enhanced Ultrasound Scanning
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- University of Manchester
Head and Neck Cancer
Contrast Between Traditional Regression Model and AI in Predicting Prolonged Stay Stay After Head and Neck Tumors
This experiment is an observational study of cohort. By establishing a cohort of patients with head and neck tumors transferred to ICU after surgery, investigators compared the prediction effect of AI and the traditional…
- Trial name
- NCT06570486
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Pulmonary Disease
Improved Chest CT Diagnostic and Contrast Medium Administration
Investigation of impact of using different CM approaches on contrast enhancement in chest Ct examinations - A prospective study
- Trial name
- NCT05645796
- Testing
- Adopted contrast media amount by using different approaches
- Where
- Norway
- Volunteers
- 360 people
- Sponsor
- Oslo Metropolitan University
Contrast Enhancement in Magnetic Resonance Imaging
A Study to Evaluate the Pharmacokinetics (How it Moves Into, Through and Out From the Body) of a New Gadolinium-based Contrast Agent (GBCA) After Injection and How Safe it is in Participants With Normal and Impaired Renal Function
Researchers in this study want to learn how a new contrast agent for magnetic resonance imaging (MRI) called BAY1747846 moves into, through and out of the body (pharmacokinetics) after injection in participants with normal and…
- Trial name
- NCT05061979
- Testing
- BAY1747846
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Brain Metastases
MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
The purpose of this study is to test whether an additional magnetic resonance image (MRI) sequence can improve the ability to distinguish radiation damage from tumor recurrence in participants with brain metastasis who have…
- Trial name
- NCT04246879
- Testing
- MRI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas
Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With Metastases to the Liver or Lung
This phase I trial studies the side effects of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in patients with advanced breast or pancreatic cancer with metastases to the liver or lung.
- Conditions
- Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas, Liver Metastases, Lung Metastases
- Trial name
- NCT01741597
- Testing
- dynamic contrast-enhanced magnetic resonance imaging, pharmacological study, tumor-homing peptide iRGD
- Where
- United States
- Sponsor
- City of Hope Medical Center
Aortic Valve Stenosis, Chronic Kidney Diseases
Impact of Trans-catheter Aortic Valve Implantation on Renal Function
Both contrast-induced acute kidney injury (AKI) and pre-existing chronic kidney disease are associated with an increased mortality risk in patients requiring aortic valve replacement.
- Conditions
- Aortic Valve Stenosis, Chronic Kidney Diseases, Renal Failure Acute Chronic
- Trial name
- TAVIKOD (NCT07626710)
- Testing
- Trans-catheter aortic valve implantation (TAVI)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Prostate Cancer, Prostatic Neoplasms
CEUS Targeted Biopsies Compared to mpMRI Targeted and Systematic Biopsies for the Detection of Prostate Cancer
The current standard for Prostate Cancer (PCa) detection remains taking 10-12 systematic biopsies of the prostate. This approach leads to overdiagnosis of insignificant PCa on the one hand and underdiagnosis and undergrading of…
- Trial name
- NCT02831920
- Testing
- CEUS and targeted biopsies, MRI and targeted biopsies
- Where
- Netherlands
- Volunteers
- 299 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Disease, Heart Diseases
Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle
Coronary artery disease (CAD) can cause poor blood flow and supply to the heart muscle. It can result in irreversible damage to the heart muscle and poor function.
- Trial name
- NCT00001891
- Testing
- Myocardial contrast echocardiography, Dobutamine echocardiography
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy
First in Human Study of RVP-001, a New Manganese Based MRI Contrast Agent
The objectives of this trial are: 1. To evaluate the safety and tolerability of single ascending doses of RVP-001 in healthy adult volunteers 2.
- Trial name
- NCT05413668
- Testing
- RVP-001
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Reveal Pharmaceuticals Inc.
Renal Disease
A Study on the Verification of Kidney CT Non-inferiority Using Low Concentration Contrast Agent
This prospective study aims to evaluate clinical usefulness of low-voltage renal CT using low-concentration contrast agent and to compare with existing imaging techniques.
- Trial name
- NCT05831943
- Testing
- Contrast enhanced Kidney CT
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cataract, Signs and Symptoms
Spherical Aberration and Contrast Sensitivity in IOLs
Purpose: To determine whether implantation of an intraocular lens (IOL) with a modified anterior aspheric surface results in reduced spherical aberration and improved contrast sensitivity after cataract surgery.
- Conditions
- Cataract, Signs and Symptoms, Pseudophakia, Lens Diseases
- Trial name
- IOLs (NCT00576485)
- Testing
- Cataract surgery and intraocular lens implantation
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
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