Clinical trials: Contrast Agent
Breast Cancer
Supplemental Screening for Women With Extremely Dense Breast Tissue: the DENSE-2 Trial
Women with extremely dense breasts (nearly all glandular and connective tissue, little fatty tissue) have a 3-6 times higher risk of breast cancer than women with very low breast density.
- Trial name
- DENSE-2 (NCT06636370)
- Testing
- Contrast-enhanced mammography (CEM), Abbreviated MRI (AB-MRI)
- Where
- Netherlands
- Volunteers
- 36,000 people, healthy volunteers welcome
- Sponsor
- C.H. van Gils
Rheumatoid Arthritis
To Estimate the Efficacy of Treatment With TNFi as Monotherapy or Combination Therapy With MTX and Compare and Contrast Efficacy With Tofacitinib as Monotherapy and Combination Therapy in a Real World Setting.
To estimate the efficacy of treatment with TNFi as monotherapy or combination therapy with MTX and compare and contrast efficacy with Tofacitinib as monotherapy and combination therapy in a real world setting.
- Trial name
- NCT05576051
- Testing
- patterns of use of combination therapy and monotherapy
- Where
- United States
- Volunteers
- 9,159 people
- Sponsor
- Pfizer
Breast Neoplasms
CT-AI Breast Cancer Opportunistic Screening Health Examination Study
This study evaluates the clinical utility of a locked chest CT artificial intelligence model for opportunistic breast cancer screening among women undergoing health examinations.
- Trial name
- NCT07809698
- Testing
- CT-AI-assisted breast cancer screening
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Abdominal Diseases
Rapid Abdominal Diagnosis With AI & Radiology
This study aims to develop an AI-assisted diagnostic system for abdominal contrast-enhanced CT images using data from multiple inpatient centers.
- Trial name
- RADAR (NCT07040358)
- Where
- China
- Volunteers
- 2,000,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Exposure to Medical Diagnostic Radiation
Low Tube Voltage Computed Tomographic (CT) Urography Using Low Concentration Iodine Contrast Agent
Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing lesions of urinary tract such as urinary stone, tumor and inflammatory lesion.
- Trial name
- NCT01855204
- Testing
- Computed tomographic urography
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Percutaneous Coronary Intervention Patients
The Effect of Whole Blood Viscosity on Contrast-Induced Nephropathy Development in Patients Undergoing Percutaneous Coronary Intervention
In our study, we aimed to investigate how whole blood viscosity (WBV) affects the development of contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT04703049
- Testing
- Blood Viscosity Testing
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Bursa Postgraduate Hospital
Complications of Perfusion
Real-time Quantitative Optical Perfusion Imaging in Surgery
Surgeons are nowadays unable to visualize and quantitatively evaluate microvascularisation in real-time during surgery. Complications due to vascular compromise are a major problem, especially in reconstructive surgery.
- Trial name
- NCT02902549
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI), Contrast-induced Nephropathy Following Coronary Angiogram (CIN)
Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms.
The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used.
- Trial name
- RIP-CI-AKI (NCT05147831)
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Breast Neoplasms
Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging to Assess Tumor-Associated Vasculature in Patients With Metastatic Breast Cancer
This study will examine a non-invasive method to assess vasculature, that is, the development of a blood supply necessary to the growth of tumors.
- Trial name
- NCT00071357
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cardiorespiratory Arrest, Microcirculation
Enhanced-contrast Brain Ultrasound in Cardiorespiratory Arrest
Brain microcirculation alterations may be involved in comatose patients and non-survivors after cardiorespiratory arrest. For a three day-period, we investigate brain microcirculation using contrast-enhanced ultrasound with…
- Trial name
- NCT04294316
- Testing
- Sonovue
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Left Cardiac Catheterization, Percutaneous Coronary Intervention
Dapagliflozin to Prevent the Incidence of Contrast Induced Nephropathy After Heart Catheterization and Percutaneous Coronary Intervention
Left heart catheterization and percutaneous coronary intervention (PCI) has become a useful tool in interventional cardiology, in which iodinated contrast media is used.
- Conditions
- Left Cardiac Catheterization, Percutaneous Coronary Intervention, Acute Kidney Injury, Sodium-glucose Co-transporter 2 Inhibitors
- Trial name
- NCT04806633
- Testing
- Dapagliflozin 5mg
- Where
- 2 sites in Greece
- Volunteers
- 1,722 people
- Sponsor
- G.Gennimatas General Hospital
Coronary Artery Disease
High Frame Rate Ultrasound in Heart Disease Assessment
The study will compare standard ultrasound images to high frame rate ultrasound images in patients with heart disease or with a low risk of heart disease to see if a higher frame rate of ultrasound adds to the information…
- Trial name
- RUFUS-Heart (NCT03850015)
- Testing
- Standard echocardiography, High frame rate echocardiography
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- London North West Healthcare NHS Trust
Contrast-induced Nephropathy, Chronic Kidney Diseases
Continuing or Discontinuing ACE/ARBs in Patients With Chronic Kidney Disease Undergoing Coronary Angiography
Contrast induced nephropathy (CIN) is a well-known possible complication of percutaneous coronary intervention (PCI) with an incidence varies from 3.3% to 14.5% in patients undergoing PCI.
- Conditions
- Contrast-induced Nephropathy, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT05271448
- Testing
- Continue ACEI or ARBs ( Enalapril , Ramipril , Valsartan , Candesartan, Losartan ), Hold ACEI or ARBs
- Where
- Palestinian Territories
- Volunteers
- 600 people
- Sponsor
- An-Najah National University
Peripheral Venous Cannulation for Contrast-enhanced CT/MRI Examination, Peripheral Venous Access Establishment
Venipuncture Via Nurse-AI Collaboration
The goal of this clinical trial is to learn if AI-assisted site selection plus human-machine coordinated puncture improves the quality and safety of peripheral venous access for contrast-enhanced imaging in patients of all ages…
- Trial name
- NCT07854626
- Testing
- AI-assisted human-machine coordinated peripheral venipuncture, Conventional routine peripheral venipuncture
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Aortic Regurgitation, Transcatheter Aortic Valve Replacement
TAVR for Aortic Regurgitation Under TEE Guidance
Under contemporary practice, transcatheter aortic valve replacement (TAVR) is typically performed with fluoroscopic visualization and repeated injections of iodinated contrast.
- Trial name
- NCT07453849
- Testing
- TEE guided TAVR
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Meningioma
MEningioma Detection Using Non Contrast MRI TecHniquEs
Meningioma, an extra-axial brain tumor developed at the expense of meninges, accounts for 35% of central nervous system tumors, and its incidence is estimated at 3% in large autopsy series.
- Trial name
- MENTHE (NCT04113408)
- Testing
- FABIR sequence
- Where
- France
- Volunteers
- 315 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Primary Pterygium
The Effects of Primary Pterygium on Contrast Sensitivity Preoperatively and Postoperatively
Pterygium is the growth of conjunctival tissue onto the cornea, usually from the nasal quadrant of the cornea.Visual acuity may be reduced due to direct invasion of the visual axis or astigmatism induced by the pterygium.
- Trial name
- NCT03406390
- Testing
- Pterygium surgery
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Artificial Intelligence, Deep Learning
Feasibility of Gadolinium Contrast Reduced Brain MRI: the Potential of Deep Learning
MRI scans were performed using 3 different 1.5T scanners with an eight-channel head coils. Following a 3D pre-contrast T1w scan, a low-dose contrast-enhanced 3D T1w scan was obtained using 20% (0.02 mmol/kg) of the standard…
- Trial name
- NCT06462924
- Testing
- DeepGad
- Volunteers
- healthy volunteers welcome
- Sponsor
- DeepMeds
Dry Age-related Macular Degeneration
Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE II)
This LIGHTSITE II study is a double-masked, sham-controlled, parallel design, prospective multi-site study for the use of PBM as a treatment for visual impairment in subjects with dry AMD.
- Trial name
- NCT03878420
- Testing
- Valeda PBM treatment
- Where
- 8 sites in France, Germany and 3 more
- Volunteers
- 44 people
- Sponsor
- LumiThera, Inc.
Prostatic Hypertrophy, Benign
Assessing the Impact of the PVP With Greenlight Laser Using Prostatic MRI and Contrast-enhanced Ultrasound
The PVP by Greenlight laser 180W is becoming a potential therapeutic alternative in the treatment of benign prostatic hypertrophy (BPH) as recommended.
- Trial name
- PROPIL (NCT01732991)
- Testing
- prostatic photo-vaporization (PVP)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Tours
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