Clinical trials: Contrast Agent
Contrast Media Adverse Reaction
Effects of Contrast Media Temperature on Image Quality and Clinical Adverse Events in Coronary CTA
Extrinsic prewarming of iodinated CT contrast media (CM) to body temperature reduces viscosity and injection pressures. However, guideline recommendations on the necessity to prewarm iodinated CM are conflicting.
- Trial name
- NCT05489055
- Testing
- Iopamidol
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chongqing Emergency Medical Center
Loss of Visual Contrast Sensitivity, Near Vision
Visual Performance Following Implantation of Presbyopia Correcting IOLs
The purpose of the current study was to compare the visual performance after bilateral implantation of the Panoptix IOL , or the AT LISA IOL or Tecnis Symfony IOL .
- Conditions
- Loss of Visual Contrast Sensitivity, Near Vision, Visual Impairment
- Trial name
- NCT04907955
- Testing
- phacoemulsification with implantation of presbyopia correcting IOL
- Where
- Kuwait
- Volunteers
- 50 people
- Sponsor
- Dar Al Shifa Hospital
Pancreatic Cancer
Disposable Perfusion Phantom for Accurate DCE (Dynamic Contrast Enhanced)-MRI Measurement of Pancreatic Cancer Therapy Response
The goal of this study is to investigate whether the therapeutic response of pancreatic tumors can be accurately assessed using quantitative DCE-MRI, when the inter/intra-scanner variability is reduced using the Point-of-care…
- Trial name
- NCT04588025
- Testing
- Point-of-care Portable Perfusion Phantom, P4
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Ohio State University
Contrast Enhanced Mammography-guided Biopsy
Clinical Evaluation of CEM-guided Biopsy
CEM-guided biopsy is an optional accessory of Senographe Pristina intended to provide accurate location of lesions in the breast in three dimensions, using information obtained from Contrast Enhanced Mammography (CEM) images.
- Trial name
- NCT05250674
- Testing
- CEM-guided biopsy
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Extravasation of Contrast Media
Risk Prediction Model for Iodinated Contrast Medium Extravasation
This study aims to develop a risk prediction model for iodine contrast agent extravasation from peripheral veins and to implement this model clinically to establish a risk control management system for iodine contrast agent…
- Trial name
- RPMICME (NCT06859242)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhang Wenyan
Hepatocellular Carcinoma, Contrast-enhanced Ultrasound
Clinical Decision Biological Biomarker and Prognosis Prediction of Hepatocellular Carcinoma by Deep Learning
Developing a deep learning model based on contrast-enhanced ultrasound (CEUS) to predict the prognosis of hepatocellular carcinoma (HCC) and aid choose operation decisions
- Conditions
- Hepatocellular Carcinoma, Contrast-enhanced Ultrasound, Prognosis, Surgery
- Trial name
- NCT05257694
- Testing
- Surgery, Ablation (Microwave ablation or Radiofrequency ablation)
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Ping Liang
Adnexal Torsion
Contribution of Contrast Enhanced Ultrasound for Diagnosis of Adnexal Torsion
Adnexal torsion is the rotation of the ovary around its vascular axis resulting, in the absence of treatment, ischemia that can lead to peritonitis by necrosis or impaired fertility.
- Trial name
- COVARIAN (NCT06677554)
- Testing
- Addition of ultrasound with contrast injection (SonoVue®), Standard Care (in control arm)
- Where
- 6 sites in France
- Volunteers
- 256 people
- Sponsor
- Central Hospital, Nancy, France
Contrast Induced Nephropathy
Renoprotective Effects of Fluid Prophylaxis Strategies for Contrast Induced Nephropathy (CIN)
Contrast induced nephropathy (CIN) is a term applied to acute renal failure associated with intravascular injection of iodinated contrast agents typically used for cardiac angiography.
- Trial name
- CIN (NCT00749827)
- Testing
- Bicarbonate Hydration, Hypotonic hydration
- Where
- 2 sites in Canada
- Sponsor
- Memorial University of Newfoundland
Stenosis; Valve, Renal Failure
Transcatheter Implantation of Aortic Bioprosthesis Without the Use of Iodinated Contrast in Patients With Chronic Kidney Disease
Acute renal failure (ARF) after transcatheter aortic valve implantation (TAVI) is a frequent complication, with significant clinical consequences.
- Conditions
- Stenosis; Valve, Renal Failure, Renal Insufficiency
- Trial name
- NCT04581694
- Testing
- TAVI without contrast
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- University of Sao Paulo General Hospital
Renal Cancer, Kidney Cancer
Evaluating Renal Masses Using Ultrasound Intravenous Microbubble Contrast
The purpose of this study is to evaluate the blood flow in kidney masses by using ultrasound microbubble contrast material, and to see if results from ultrasound contrast studies can predict if a kidney mass is benign or…
- Trial name
- NCT00671411
- Testing
- Ultrasound with intravenous microbubble contrast injection
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
GI Carcinoma, GI Disorders
Phase 2 Study of NX9 for Delineation of Bowel Anatomy
This study will evaluate marking and distention of the bowel of the oral contrast agent, NX9, at CT of the abdomen and pelvis, VLDCT with no contrast will be followed by VLDCT with NX9 contrast followed by CT with NX9 and…
- Trial name
- NCT04789200
- Testing
- NX9 Oral Contrast Agent
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Nextrast, Inc.
AKI (Acute Kidney Injury) Due to Trauma
Single-Center Prospective Study to Investigate the Difference in the Incidence of Contrast-Induced Nephropathy in High-Risk Patients With the Use of the Dye-Vert Plus System
Coronary angiography (CAG) for diagnostic or therapeutic purposes such as percutaneous coronary intervention (PCI) is one of the common procedures which require the use of intravenous contrast media.
- Trial name
- Dye-Vert Plus (NCT04279457)
- Testing
- DyeVert Plus System, Standardized hydration protocol
- Where
- United States
- Volunteers
- 1,802 people
- Sponsor
- CAMC Health System
Orodental Injury
Quantitative Imaging Biomarker Prospective Validation of Dynamic Contrast-enhanced MRI as a Metric of Orodental Injury After Radiotherapy (QI-ProVE-MRI)
This research will focus on the prospective qualification and validation of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) candidate biomarkers (i.e., Ktrans and Ve) to assess the natural history of…
- Trial name
- (QI-ProVE-MRI) (NCT06586892)
- Testing
- Radiotherapy followed by chemotherapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- M.D. Anderson Cancer Center
Contrast Induced Nephropathy
The Use of Sodium Bicarbonate in the Prevention of Contrast Induced Nephropathy
Preliminary studies have shown a benefit of sodium bicarbonate infusion in decreasing the risk of contrast induced nephropathy with coronary angiography.
- Trial name
- NCT00494637
- Testing
- sodium bicarbonate
- Volunteers
- 468 people
- Sponsor
- Lenox Hill Hospital
Acute Cholecystitis, Colorectal Cancer
Safety and Feasibility of ActivSightTM in Human
ActivSightTM combines an innovative form factor and proprietary software to deliver precise, objective, real-time visualization of blood flow and tissue perfusion intraoperatively for laparoscope-based surgery.
- Conditions
- Acute Cholecystitis, Colorectal Cancer, Diverticulitis, Colonic, Obesity, Morbid
- Trial name
- NCT04633512
- Testing
- ActivSight
- Where
- 3 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Activ Surgical
Cholangitis
Effect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma
The purpose of this study is to determine the effect of normal temperature and 37℃ non-ionic contrast agent acting on ERCP-related cholangeitis after endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of hilar…
- Trial name
- NCT03104569
- Testing
- Injection of 37℃ contrast agent
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Age Related Macular Degeneration
Colour Contrast Sensitivity for the Early Detection of Wet Age-related Macular Degereration (CEDAR)
Neovascular or wet age-related macular degeneration (ARMD) is a retinal disease and is the leading cause of sight loss in the over 50s; it constitutes a major public health problem which will have an increasingly large impact as…
- Trial name
- CEDAR (NCT02173496)
- Testing
- Colour Contrast Sensitivity
- Where
- United Kingdom
- Volunteers
- 233 people
- Sponsor
- Aston University
Glioblastoma, High-grade Glioma
The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)
A greater extent of resection of the contrast-enhancing (CE) tumor part has been associated with improved outcomes in high-grade glioma patients.
- Conditions
- Glioblastoma, High-grade Glioma, Glioblastoma, IDH-wildtype, Glioblastoma, IDH-mutant
- Trial name
- SUPRAMAX (NCT06118723)
- Testing
- Supramaximal resection, Maximal safe resection
- Where
- 8 sites in United States, Belgium and 3 more
- Volunteers
- 784 people
- Sponsor
- Jasper Gerritsen
Contrast Media Induced Nephropathy (CIN)
Neutrophil Gelatinase-associated Lipocalin (NGAL) and Contrast Media Induced Nephropathy
Introduction: Patients with pre-existing impaired renal function are prone to develop acute contrast media induced nephropathy (CIN).
- Trial name
- NCT01292317
- Testing
- application of intravenous volume, oral fluid application
- Where
- Austria
- Volunteers
- 819 people
- Sponsor
- Medical University of Graz
Prostate Cancer
Biparametric MRI for Detection of Significant Prostate Cancer
Our aim is to develop a new diagnostic approach to improve the diagnosis of men suspicious of having significant prostate cancer (sPCa).
- Trial name
- BIDOC (NCT02584179)
- Testing
- Biparametric MRI before biopsy
- Where
- Denmark
- Volunteers
- 1,063 people
- Sponsor
- Herlev Hospital
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