Clinical trials: Contrast Agent
Breast Cancer
Contrast Enhanced Spectral Mammography vs. MRI for Breast Cancer Screening
This research study is evaluating whether contrast enhanced mammography can be used as an alternative to breast Magnetic Resonance Imaging (MRI) for cancer screening
- Trial name
- NCT03482557
- Testing
- CESM, MRI
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Beth Israel Deaconess Medical Center
Intestinal Diseases
Efficacy of Buscopan® in Comparison With 654-II (Anisodamine) in Acute Gastric or Intestinal Pain
The aim of the study is to assess the efficacy of Buscopan® (hyoscine butylbromide) in comparison to 654-II (anisodamine)in acute gastric or intestinal spasm-like pain.
- Trial name
- NCT01929044
- Testing
- 654-II (anisodamine), Buscopan® (hyoscine butylbromide)
- Where
- 20 sites in China
- Volunteers
- 299 people
- Sponsor
- Boehringer Ingelheim
Patient Comfort and Safety
Iodixanol Versus Iopamidol in Patients Undergoing Contrast-Enhanced Computed Tomographic Imaging of Abdomen/Pelvis
The purpose of this study is to evaluate and compare overall patient comfort profile between the Iso-osmolar contrast media (IOCM), iodixanol 320 mg I/mL, and a Low-osmolar contrast media (LOCM), iopamidol 370 mg I/mL in patients…
- Trial name
- NCT01376089
- Testing
- Iodixanol, Iopamidol
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- GE Healthcare
Bleeding
Assessment of Limb Perfusion During Junctional Tourniquet
The goal of this study is to use contrast enhanced ultrasound to determine the degree to which flow is reduced during application of a junctional tourniquet (JT).
- Trial name
- NCT02092415
- Testing
- Application of a Junctional Tourniquet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Ventricular Tachycardia, Ischemic Cardiomyopathy
Contrast ICE for Myocardial Scar in VT Ablations
There is a high correlation between scar areas identified by contrast-enhanced ICE and scar areas identified by conventional electroanatomic mapping.
- Trial name
- NCT03212326
- Testing
- Perflutren Lipid Microsphere Intravenous Suspension [DEFINITY]
- Volunteers
- 24 people
- Sponsor
- Weill Medical College of Cornell University
Atrial Fibrillation
Efficacy of Optison Echo Contrast to Detect Thrombus in Left Atrial Appendage
The investigators intend to determine if using Optison echocardiography contrast increases sensitivity and specificity of detecting left atrial appendage thrombus in transesophageal echocardiography studies as opposed to standard…
- Trial name
- DOLOP (NCT01721447)
- Testing
- Optison echocardiography contrast agent
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Intrahepatic Cholangiocarcinoma
Contrast-Enhanced Ultrasound for the Prediction of Bile Duct Cancer Response to Radioembolization Treatment
This phase II trial tests whether contrast-enhanced ultrasound can predict the response of bile duct cancer to targeted radiotherapy (radioembolization treatment).
- Trial name
- NCT05328167
- Testing
- Perflutren Protein-Type A Microspheres, Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Thomas Jefferson University
Acute Kidney Injury, Pulmonary Embolism
Acute Kidney Injury in Patients Undergoing Contrast Exposure: VQ vs. CT
Both, CT scans and VQ scans, are used by doctors to look for pulmonary embolism. The most common reason to order a VQ scan is to avoid the IV dye.
- Conditions
- Acute Kidney Injury, Pulmonary Embolism, Contrast-induced Nephropathy
- Trial name
- VQ/CT (NCT03116139)
- Testing
- V/Q imaging, Computed tomography scan
- Where
- 5 sites in United States
- Volunteers
- 253 people
- Sponsor
- Indiana University
Renal Failure
Sodium Bicarbonate for Prevention of Contrast-Induced Nephropathy
The purpose of this study is to determine whether hydration with sodium bicarbonate is superior to hydration with saline to prevent contrast-induced nephropathy.
- Trial name
- NCT01172353
- Testing
- sodium bicarbonate, saline
- Where
- Brazil
- Volunteers
- 301 people
- Sponsor
- Hospital Sao Lucas da PUCRS
Acute Coronary Syndrome, Pulmonary Embolism
Assessment of Acute Disease to Reduce Imaging Costs
Overtesting for Acute Coronary Syndrome(ACS) and Pulmonary Embolism (PE) in low risk Emergency Department(ED) patients can increase exposure of nondiseased patients to radiation, intravenous contrast and anticoagulation.
- Trial name
- QUAADRICs (NCT01059500)
- Testing
- Webtool
- Where
- 4 sites in United States
- Volunteers
- 550 people
- Sponsor
- Wake Forest University Health Sciences
Hypoxic-Ischemic Encephalopathy, Brain Ischemia Hypoxia
CEUS Evaluation of Hypoxic Ischemic Injury
Neonates presenting with neurologic symptoms require rapid, non-invasive imaging with high spatial resolution and tissue contrast.
- Trial name
- NCT03549520
- Testing
- Sulfur hexafluoride lipid-type A microspheres
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital of Philadelphia
Breast Cancer
Study of Dual-energy (DE) Contrast-enhanced (CE) Digital Mammography
This is a feasibility study to evaluate dual-energy (DE) contrast-enhanced (CE) digital mammography to detect breast cancer in patients with increased breast density (BI-RADS category c or d).
- Trial name
- NCT02995980
- Testing
- Dual-Energy Contrast-Enhanced (DECE) mammography, digital mammography
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy
Open Label, Randomized Study of Low Concentration Ioforminol Injections for Use in Abdominal CECT in Healthy Volunteers
To optimize both the Ioforminol concentration and dosage(s) for CECT of the abdomen. To evaluate the safety and tolerability of low concentration Ioforminol Injections. Study recruits healthy volunteers.
- Trial name
- NCT01672996
- Testing
- Ioforminol 160 mgI/mL, Ioforminol 200 mgI/mL, Iopamidol 300 mgI/mL
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Breast Cancer
Performance of Contrast-Enhanced Spectral Mammography to Assess Neoadjuvant Chemotherapy Response (CEDM)
This study is designed to investigate the diagnostic accuracy of Contrast Enhanced Spectral Mammography (CEDM) in predicting early neoadjuvant therapy response and pathologic complete response (pCR) compared to mammography.
- Trial name
- NCT04625517
- Testing
- Digital Mammography, Low Osmolar Contrast Material, 300-399 Mg/Ml Iodine Concentration, Per Ml
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Texas Southwestern Medical Center
Renal Dysfunction
Evaluation of Gadoterate in Patients With Renal Dysfunction
This study is for individuals with decreased kidney function whose doctor has ordered Magnetic Resonance Imaging (MRI). Because kidney function is decreased, these patients usually do not receive the intravenous contrast material…
- Trial name
- NCT02382380
- Testing
- Gadoterate, No Gadoterate
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Loyola University
Glaucoma
Human Optokinetic Contrast Device (HOCD) to Measure Visual Function and Identify Patients With and Without Glaucoma
The purpose of this study is to determine if an optokinetic contrast detection device is sufficient to measure contrast sensitivity and to distinguish between patients with and without glaucoma.
- Trial name
- HOCD (NCT02014597)
- Testing
- HOCD
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Benjamin Frankfort, MD, PhD
Necrotizing Enterocolitis of Newborn, Bowel Ischemic
CEUS Evaluation of Bowel Perfusion in Necrotizing Enterocolitis
There is no bedside imaging technique that can quantify dynamic bowel perfusion with high soft tissue contrast and sensitivity in necrotizing enterocolitis (NEC).
- Trial name
- NCT03549507
- Testing
- Sulfur hexafluoride lipid-type A microspheres
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiovascular Disease
A Prospective, Phase IV, Surveillance Registry Study to Evaluate the Safety of DEFINITY® in Clinical Practice
The purpose of this registry study is to gather safety information on the current clinical use of and the safety of DEFINITY®
- Trial name
- NCT00625365
- Testing
- DEFINITY®
- Where
- 16 sites in United States
- Volunteers
- 1,060 people
- Sponsor
- Lantheus Medical Imaging
Visual Acuity
Evaluation of Electronic LogMar Visual Acuity and Contrast Sensitivity in a Population of Contact Lens Wearers
This is a bilateral, non-dispensing, randomized, cross-over, single-masked study. There are a total of 3 visits where all study endpoints will be measured in all subjects at baseline with habitual lenses and under the two testing…
- Trial name
- NCT03222037
- Testing
- senofilcon A, Control
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Coronary Artery Disease, Myocardial Perfusion Abnormalities
Regadenoson Real Time Perfusion Imaging Trial-Optison
The purpose if this study is to examine how effective Regadenoson is in detecting coronary artery disease during a stress echocardiogram when Optison is administered.
- Trial name
- NCT01489176
- Testing
- Regadenoson; Optison
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Nebraska