Clinical trials: Contrast Agent
Breast Cancer Prevention, Breast Cancer Diagnosis
Supine Photon-Counting CT and Contrast-Enhanced Mammography Versus Breast MRI for Pretreatment Tumor Size in Breast Cancer Candidates for Neoadjuvant Chemotherapy
Retrospective single-centre agreement study in women with biopsy-proven invasive breast cancer who underwent CEM, supine PC-CT and prone breast MRI before neoadjuvant chemotherapy. Prone MRI is the clinical reference.
- Trial name
- PC CEM MRI (NCT06843083)
- Testing
- Supine photon-counting CT (PC-CT), CEM, Prone dynamic contrast-enhanced breast MRI
- Where
- Italy
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Graziella di Grezia
Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma
An Investigational Scan (89Zr-DFO-GmAb PET/CT) Compared to Contrast-Enhanced CT for the Detection of Recurrent Clear Cell Renal Cell Cancer After Surgery Comparing Carbonic Anhydrase IX (CAIX) PET CT to Conventional PET CT for Post-Op Staging in Kidney Cancer
This phase II trial compares the safety and effectiveness of 89Zr-DFO-GmAb positron emission tomography (PET)/computed tomography (CT) compared to contrast-enhanced CT after surgery in detecting clear cell renal cell cancer that…
- Conditions
- Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage II Renal Cell Cancer, Stage III Renal Cell Cancer
- Trial name
- NCT06447103
- Testing
- Biospecimen Collection, Bone Scan, Computed Tomography
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Cancer
Digital Mammography for the Detection and Preoperative Staging of Breast Cancer
Breast tumors are normally seen with mammography or ultrasound without the use of a dye but the size and extent of the tumor may be hard to see.
- Trial name
- NCT01086514
- Testing
- Dual Energy Contrast Enhanced Digital Mammography (DE CEDM)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Screening Contrast-enhanced Mammography
The main objective of this study is to compare the diagnostic performance of two diagnostic methods, namely CESM and MRI, in the evaluation of a lesion suspicious of breast cancer in 300 Quebec women referred for the…
- Trial name
- NCT05390229
- Where
- Canada
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Acute Kidney Injury, Renal Insufficiency
Timing of Coronary Angiography, Cardiac Surgery, and Adverse Renal and Cardiac Events (MARCE)
1. To examine two main predictor variables independently and then jointly in stratified and multivariate analyses for the outcomes of CSA-AKI, MARCE, need for RRT, and inpatient mortality, and the composite, as well as the…
- Trial name
- MARCE (NCT02332070)
- Testing
- cardiac surgery
- Where
- United States
- Volunteers
- 965 people
- Sponsor
- Baylor Research Institute
Lung Cancer
SLN Detection With Tc-MSA-ICG in Lung Cancer Patients
It is necessary to develop a technique of sentinel lymph node detection using radioactive fluorescent dual contrast agent consisting targetable albumin for specific marker to accurately determine whether or not the sentinel lymph…
- Trial name
- NCT05039905
- Testing
- 99mTc-MSA-ICG
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Korea University Guro Hospital
Hydrotherapy
Effects of Various Modalities Water Immersion on Veins
Objectives In this study the investigators examined the changes in common femoral vein (CFV) and great saphenous vein (GSV) calibre during thermo neutral water immersion (TNI), cold water immersion (CWI) and contrast water…
- Trial name
- NCT02677402
- Testing
- immersion
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Franche-Comté
Contrast-induced Nephropathy, Acute Renal Failure
Prevention of Contrast-Induced Nephropathy
Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.
- Conditions
- Contrast-induced Nephropathy, Acute Renal Failure, Chronic Renal Failure
- Trial name
- NCT00175227
- Testing
- intravenous saline hydration + mannitol + furosemide, intravenous saline hydration
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
Brain Tumor
Intraoperative Optical Imaging of Brain Function
The goal of this proposal is to test the performance of a novel optical imaging system for real-time quantitative imaging of brain function through multiple hemodynamic measures during neurosurgery.
- Trial name
- NCT00632437
- Testing
- Speckle-Contrast Imaging
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Contrast Enhancement in Magnetic Resonance Imaging
An Observational Study to Collect Information on the Safety of Gadolinium-Based Contrast Agents in Patients in India
This is an observational study in which data from patients undergoing enhanced MRI using gadolinium based agents (GBCAs) are collected and studied.
- Trial name
- NCT06257277
- Testing
- GBCAs
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Bayer
Chronic Kidney Failure
Improved Estimation of GFR by Cystatin C in Preventing Contrast Induced Nephropathy by NAC or Zn
Background Prevention of contrast media (CM) induced nephropathy (CIN) by pharmacological prophylaxis (e.g. N-acetylcysteine; NAC) is controversially discussed.
- Trial name
- NCT00399256
- Testing
- Acetylcysteine, Zinc
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Obesity, Dyslipidemias
Evaluation of Systemic Microvascular Endothelial Function in Metabolically Healthy Obesity
Obesity is known to be a risk factor for cardiovascular disease (CVD), type 2 diabetes mellitus, gastrointestinal tract disease, respiratory problems (such as obstructive sleep apnea), joint and muscle problems, reproductive…
- Trial name
- NCT04233528
- Testing
- Evaluation of systemic skin microvascular endothelial function
- Where
- Brazil
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Glioma (Any Grade) in the Brain, Glioma
Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation
This study plans to learn more about using contrast enhanced ultrasound (CEUS) in brain tumor surgery. The goal of glioma brain tumor surgery is to remove as much of the glioma as possible.
- Trial name
- NCT07050836
- Testing
- Definity contrast during ultrasound
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
Abdominal Aortic Aneurysm Without Rupture
Efficacy of Biomarkers and CEUS Versus CTA in AAA Follow-up Post-EVAR
This prospective observational study evaluates the efficacy of contrast-enhanced ultrasound and biomarker determination in the follow-up of patients with abdominal aortic aneurysm (AAA) treated with Endovascular Aneurysm Repair…
- Trial name
- EVAR-markers (NCT06866769)
- Testing
- CTA
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Myocardial Infarction
Safety and Efficacy of SeeMore (TM) in Heart Patients
This study will examine the safety and effectiveness of a manganese-based agent called SeeMore (EVP 1001-1 Injection) for enhancing magnetic resonance imaging (MRI) in patients who have previously had a heart attack.
- Trial name
- NCT00881075
- Testing
- SeeMore(TM)
- Volunteers
- 24 people
- Sponsor
- Eagle Vision Pharmaceutical Corp.
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (ICC)
An Exploratory Study on Developing an Integrated Approach Combining Multimodal Imaging and Multi-omics Characterization of Tumor Heterogeneity for Precision Diagnosis and Treatment Optimization in Liver Cancer.
Primary liver cancer, mainly including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), represents the third leading cause of cancer-related mortality.
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (ICC), Primary Liver Cancer
- Trial name
- NCT07101237
- Testing
- Multi-modal ultrasonic imaging system for liver cancer
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Peking Union Medical College Hospital
Stroke, Ischemic, Stroke Hemorrhagic
Study on the Performance of a Machine Learning Algorithm Recognizing and Triaging Large Vessel Occlusions Using Non-contrast CT Scans
The goal of this prospective observational study is to assess the effectiveness and performance of Methinks AI stroke imaging software platform in acute Code Stroke patients, and as a comparator to study sites utilizing existing…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Acute, Brain Ischemia
- Trial name
- SMART-LVO (NCT06216457)
- Testing
- AI software for Stroke
- Volunteers
- 5,000 people
- Sponsor
- Methinks Software SL
Liver Tumors
Contrast Enhanced (CE) Ultrasound and CE Computed Tomography or CE Magnetic Resonance Imaging in Liver Masses
This comparison study is performed to show equivalence of CEUS with CECT or CEMR to diagnose noninvasively focal liver masses. This is a multi-center prospective cohort study of 250 subjects, which will be performed at four…
- Trial name
- NCT00828607
- Where
- 4 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Foothills Medical Centre
Acute Kidney Injury
Double-Blind Placebo-Controlled CIN Trial
This double-blinded placebo-controlled study will examine the incidence and significance of contrast-induced acute kidney injury following IV iodine-based contrast material administration in subjects with stage IIIB or stage IV…
- Trial name
- NCT02467075
- Testing
- Iopamidol 300 (Contrast)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Michigan
Contrast Enhancement on Cardiac CT
Comparison of Contrast Agents During CT Angiography
The purpose of this study is to compare the effects of a certain contrast agent (iodixanol) to two other commonly used contrast agents called Iopamidol (Isovue) and iohexol (Omnipaque), on heart and kidney safety in patients…
- Trial name
- Visipaque (NCT01534975)
- Testing
- contrast agent
- Where
- United States
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
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