Clinical trials: Contrast Agent
Contrast Induced Nephropathy
Effects of Hydration to Prevent Contrast Induced Nephropathy in PCI for ST-elevation Myocardial Infarction.
The aim of the study is to test the efficacy of low versus high volume hydration and two different solutions (sodium chloride versus sodium bicarbonate) in preventing contrast induced nephropathy (CIN) in ST elevation myocardial…
- Trial name
- CINIMA (NCT00639912)
- Testing
- sodium chloride, sodium bicarbonate
- Where
- 5 sites in Italy
- Volunteers
- 599 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Hepatocellular Carcinoma (HCC), Transarterial Chemoembolization
CECT Features of MVI Predict Response to TACE Plus TKI in Intermediate-stage HCC
This retrospective multicenter study aims to evaluate whether radiographic microvascular invasion (MVI) status can predict treatment response in patients with intermediate-stage hepatocellular carcinoma (HCC) receiving…
- Conditions
- Hepatocellular Carcinoma (HCC), Transarterial Chemoembolization, Microvascular Invasion (MVI), Tyrosine Kinase Inhibitors
- Trial name
- NCT07449065
- Testing
- TKI, TACE
- Where
- China
- Volunteers
- 324 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Renal Insufficiency, Acute Kidney Injury
Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast
Point-of-care (POC) creatinine devices allow rapid measurement of creatinine levels and calculation of estimated glomerular filtration rate (eGFR) which give an indication of renal function.
- Conditions
- Renal Insufficiency, Acute Kidney Injury, Contrast-induced Nephropathy
- Trial name
- EPIC (NCT04597892)
- Testing
- serum creatinine assay
- Where
- Netherlands
- Sponsor
- Maastricht University Medical Center
Solid Pancreatic Masses
Clinical Research on a Novel Deep-learning Based System in Pancreatic Mass Diagnosis
In this study, a single-center, prospective, self-control, and blind design was adopted.
- Trial name
- NCT04607720
- Testing
- artificial-EUS-FNA, AI-EUS-FNA
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Liver Metastases From Colorectal Cancer
Sonoporation and Tumor Microenvironment Response in Colorectal Liver Metastases
This study is an investigator-initiated, randomized controlled trial enrolling patients with colorectal liver metastases. The objectives are to evaluate the safety and efficacy of contrast-enhanced ultrasound (CEUS)-mediated…
- Trial name
- CEUSON (NCT07365527)
- Testing
- Low-intensity contrast enhanced ultrasound, High-intensity contrast enhanced ultrasound
- Where
- 2 sites in Denmark
- Volunteers
- 48 people
- Sponsor
- Zealand University Hospital
Multiple Sclerosis
Evaluation of Sloan-Charts for Assessment of Disease Progress in Multiple Sclerosis
Impairment of visual deficits, in particular contrast acuity and contrast impairment are frequent symptoms in MS. However, visual function is not appropriately covered by the standard tools for clinical assessment, namely, the…
- Trial name
- NCT01272596
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Acute Renal Failure
Intravenous High Dose NAC and Sodium Bicarbonate for the Prevention of Contrast-induced Acute Injury
Contrast-induced acute kidney injury is a common cause of acquired in-hospital renal insufficiency and is associated with prolonged hospitalization and unfavorable early and late outcomes.
- Trial name
- NCT01612013
- Testing
- Sodium bicarbonate plus saline, Intravenous NAC plus saline, NAC plus sodium bicarbonate plus saline
- Where
- Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Optic Nerve Sheath Diameter
Effect of Contrast Medium on Optic Nerve Sheath Diameter
One method of indirect measurement of intracranial pressure is using optic nerve sheath diameter. There is no study whether equal volume of contrast medium injection has any increasing effect of optic nerve sheath diameter.
- Trial name
- NCT04826042
- Testing
- thoracic epidural catheterization
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Keimyung University Dongsan Medical Center
Central Nervous System (CNS) Lesions, Brain Metastases
Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent
This Phase 2 clinical trial will study RVP-001, a new manganese-based MRI contrast agent, in people who are known to have gadolinium-enhancing central nervous system (CNS) lesions, for example brain tumors or multiple sclerosis.
- Conditions
- Central Nervous System (CNS) Lesions, Brain Metastases, Brain Neoplasms, Brain Neoplasms, Benign
- Trial name
- NCT06322342
- Testing
- RVP-001
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- Reveal Pharmaceuticals Inc.
Multiple Pulmonary Emboli
Efficacy of Low (30ml) Versus Full Dose (100ml) Contrast CT Pulmonary Angiography in Detecting Emboli
With the improvement in CT scanners and injectors, diagnostic chest CT can now be performed in less than 10 seconds. It was hypothesized that diagnostic CT pulmonary angiograms could be done with less than the usual 80-120 ml of…
- Trial name
- NCT01935141
- Testing
- Low-Dose IV Contrast, Siemens Sensation 64-MDCT scanner., Visipaque 320 non-ionic isoosmolar contrast agent
- Where
- United States
- Sponsor
- VA Greater Los Angeles Healthcare System
Breast Cancer
Accuracy Of Contrast Enhanced Mamography in Predicting Response of Breast Cancer Post Neoadjuvant Chemotherapy
The aim of this work to evaluate the accuracy of contrast enhanced spectral mamography in predicting the response to NAC and assessment of residual disease in breast cancer patients
- Trial name
- NCT05141279
- Volunteers
- 50 people
- Sponsor
- Assiut University
Transplantation, Kidney
IRB 14-009240, Does CEUS Positively Influence Selection of Biopsy Sites When Evaluating Transplant Kidneys?
This is a pilot study to investigate whether contrast-enhanced ultrasound (CEUS) may help evaluate segmental differences in renal perfusion better than Doppler Ultrasound and thus help direct the biopsy to the most abnormal part…
- Trial name
- NCT02625428
- Testing
- Optison, Ultrasound (US), Contrast-enhanced ultrasound (CEUS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Cardio-Renal Syndrome
Central Venous Pressure Guided Hydration Prevention for Contrast-Induced Nephropathy
Patients at moderate and high risk for contrast induced nephropathy (CIN) should receive sufficient hydration before application of contrast to prevent CIN, but hydration could obviously increase the preload for congestive heart…
- Trial name
- NCT02405377
- Testing
- hydration, Visipaque, 0.9% sodium chloride fluid administration
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Chinese PLA General Hospital
Infertility, Female
RCT of Ethiodized Poppyseed Oil VS the Second-generation Non-ionic Monomer Contrast in Hysterosalpingography of Infertile Patients.
This study evaluates the difference of imaging diagnostic quality and fertility promoting effect in the diagnosis and treatment of infertility by hysterosalpingography between using ethiodized poppyseed oil and the…
- Trial name
- NCT03370575
- Testing
- ethiodized poppyseed oil, the second-generation non-ionic monomer contrast
- Where
- 13 sites in China
- Volunteers
- 900 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Prostate Cancer
TULIP ReTrain Study
This prospective clinical study aims to retrain and validate the PCaVision AI algorithm for the detection and localization of clinically significant prostate cancer (csPCa) using multiparametric ultrasound (mpUS) with two…
- Trial name
- TULIP ReTrain (NCT06974539)
- Testing
- Multiparametric ultrasound with contrast (Sonovue and Optison)
- Where
- Netherlands
- Volunteers
- 212 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Physical Performance
Contrast Training and Volleyball Players' Jumping Ability
The aim of the study was to compare the effects of three 10-week training interventions on vertical jump performance in volleyball players.
- Trial name
- NCT07799701
- Testing
- Elastic Band-Assisted Contrast Training (G_CNT), Contrast Training (CNT), Complex Training (CTRL)
- Where
- Poland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Aortic Regurgitation, Transcatheter Aortic Valve Replacement (TAVR)
TAVR for Aortic Regurgitation Under TTE Guidance
Transcatheter aortic valve replacement (TAVR) is an established therapy for severe aortic valve disease, yet conventional workflows rely on fluoroscopy and iodinated contrast, exposing patients and operators to ionizing radiation…
- Trial name
- NCT07458672
- Testing
- TTE guided TAVR
- Volunteers
- 30 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Contrast Induced Nephropathy
PREdictive Value of COntrast voluMe to creatinINe Clearance Ratio
To determine a relatively safe contrast media volume to creatinine clearance cut-off value to avoid contrast-induced nephropathy in patients following coronary angiography
- Trial name
- PRECOMIN (NCT01400295)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Coronary Artery Disease
Contrast- Enhanced Whole-Heart Coronary MRA at 3.0T (Tesla)
Investigators at the Biomedical Imaging Research Institute (BIRI) at Cedars-Sinai Medical Center have developed a Magnetic Resonance Imaging (MRI) method for imaging coronary arteries using slow-infusion, contrast-enhanced data…
- Trial name
- NCT02092428
- Testing
- Image Quality, Diagnostic Accuracy
- Where
- United States
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Old Age (Focus; Not a Recognized Condition)
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance With Age; the Role of Amino Acids in Modulating Muscle Metabolism
The investigators plan to measure changes in muscle protein metabolism in response to feeding, comparing between a single large essential amino acid (EAA) feed (the normal building blocks of protein) and the provision of the same…
- Trial name
- Ajinomoto1A (NCT01735539)
- Testing
- 15g EAA bolus, 4 x 3.75g Mixed EAA Pulses, 15g EAA Bolus supplemented with 3g Arginine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
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