Clinical trials: Contrast Agent
Contrast-induced Acute Kidney Injury (CI-AKI)
Hemodynamic Effects Of Impella On Renal Circulation And Risk Of CA-AKI Among Patients Undergoing Protected PCI
Patients undergoing Percutaneous Coronary Intervention (PCI) are exposed to the risk of suffering from a damage to the kidneys which goes under the name of Contrast-Associated Acute Kidney Injury (CA-AKI), which is more common if…
- Trial name
- NCT04928118
- Testing
- Evaluate the blood flow and pressure into kidneys
- Sponsor
- Virginia Commonwealth University
Brucella Spondylitis
Application of DCE-MRI in the Diagnosis of Brucellar Spondylitis
Brucellosis, also known as Mediterranean fever, undulant fever, or Malta fever is a zoonotic disease caused by Brucella infection.With the rapid development of animal husbandry and aquaculture and increasing consumption of dairy…
- Trial name
- NCT02809625
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Inner Mongolia Medical University
Ductal Carcinoma In Situ, Invasive Breast Cancer
Digital Breast Tomosynthesis Versus Contrast Enhanced Magnetic Resonance Imaging (MRI) for Breast Cancer Staging
The primary objective of this study is to compare the diagnostic accuracy of Digital Breast Tomosynthesis (DBT) versus that of Contrast Enhanced Magnetic Resonance Imaging (CEMRI) in determining the size of breast cancer…
- Trial name
- NCT01060085
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acute Ischemic Stroke, Tenecteplase
Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging
The benefit of intravenous tenecteplase for acute ischemic stroke with unknown time of onset, e.g. wake-up stroke, remains uncertain.
- Trial name
- UTOPIA (NCT07475949)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment
- Where
- 15 sites in China
- Volunteers
- 352 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Meningioma
MEningioma Detection Using Non Contrast MRI TecHniquEs
Meningioma, an extra-axial brain tumor developed at the expense of meninges, accounts for 35% of central nervous system tumors, and its incidence is estimated at 3% in large autopsy series.
- Trial name
- MENTHE (NCT04113408)
- Testing
- FABIR sequence
- Where
- France
- Volunteers
- 315 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Stable Angina, Unstable Angina
Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography
The purpose of this study is to evaluate the effect of vitamin E on preventing from incidence of contrast induced acute kidney injury (CI-AKI) in the patients who undergone coronary angiography.
- Conditions
- Stable Angina, Unstable Angina, Non ST Segment Elevation Myocardial Infarction, Post MI
- Trial name
- NCT02070679
- Testing
- Vitamin E
- Where
- 2 sites in Iran
- Volunteers
- 284 people
- Sponsor
- Urmia University of Medical Sciences
Contrast-induced Nephropathy, Acute Kidney Injury
Proenkephalin for Prediction of Contrast-Associated Kidney Events
Currently, contrast-induced kidney injury cannot be diagnosed on the day of cardiac catheterization. Recently, proenkephalin (penKid) was introduced as a new glomerular filtration marker.
- Conditions
- Contrast-induced Nephropathy, Acute Kidney Injury, Coronary Artery Disease
- Trial name
- PANCAKE (NCT03989505)
- Testing
- blood-draw for biomarker analyses
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Dr. med. Mahir Karakas
Age Related Macular Degeneration
Colour Contrast Sensitivity for the Early Detection of Wet Age-related Macular Degereration (CEDAR)
Neovascular or wet age-related macular degeneration (ARMD) is a retinal disease and is the leading cause of sight loss in the over 50s; it constitutes a major public health problem which will have an increasingly large impact as…
- Trial name
- CEDAR (NCT02173496)
- Testing
- Colour Contrast Sensitivity
- Where
- United Kingdom
- Volunteers
- 233 people
- Sponsor
- Aston University
Giant Cell Arteritis
Impact of the Spatial Resolution of Several Contrast-enhanced 3D T1-WI Sequences When Diagnosing Giant Cell Arteritis (GCA)
Giant cell arteritis (GCA) (or Horton's disease) is a segmental and focal inflammatory arteritis affecting large and medium-sized arteries.
- Trial name
- SPARTA (NCT05854927)
- Testing
- 3D T1 MRI sequences injected with fat saturation and black blood
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Allergic Rhinitis
Topical ASP-1001 (Contrast Media Formulation) and the Acute Response to Nasal Allergen Challenge (NAC)
The purpose of this study is to see whether ASP-1001 when given as a nasal spray is safe and can reduce the signs and symptoms of allergic rhinitis (hayfever) following nasal challenge with antigen.
- Trial name
- NCT00791102
- Testing
- ASP-1001 nasal spray
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Appendicitis
Impact of Oral Contrast in the Large Intestine on the Recognition of Appendix
Acute appendicitis is the most common cause of abdominal pain requiring surgical intervention. The gold standard test for the diagnosis of acute appendicitis is the CT scan.
- Trial name
- NCT02497183
- Testing
- ultrasound, iodine based solution of oral contrast material
- Where
- Israel
- Volunteers
- 1 people
- Sponsor
- HaEmek Medical Center, Israel
Gastrointestinal Motility
Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Transit
This clinical trial aims to characterize a novel method of imaging the gastrointestinal tract in healthy subjects. The method is using laser-light and soundwaves and it is performed in a similar manner as conventional ultrasound.
- Trial name
- NCT05933096
- Testing
- Contrast-enhanced multispectral optoacoustic tomography
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Contrast Induced Nephropathy
Statins for Prevention of Contrast Induced Nephropathy
In this randomized study the investigators wish to explore the role of pre-procedural statin therapy for the prevention of contrast induced nephropathy in patients with moderate-to-severe renal dysfunction, submitted to elective…
- Trial name
- NCT00770796
- Testing
- Atorvastatin
- Volunteers
- 304 people
- Sponsor
- Ospedale Misericordia e Dolce
Non-Small Cell Lung Cancer, Brain Metastases
Retrospective Multicenter Study of Patient-level T1CE/FLAIR MRI Deep Learning to Predict EGFR/ALK Driver Status in NSCLC Brain Metastases With External Validation and Survival Analysis
This retrospective multicenter observational study aims to develop and externally validate a noninvasive deep learning model based on routine brain MRI to identify actionable driver alterations in patients with non-small cell…
- Trial name
- DL-DriverBM (NCT07373951)
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Ming Yang
AKI - Acute Kidney Injury
Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients
Contrast-associated acute kidney injury (CA-AKI) is a common complication of procedures with intravascular contrast. Generally, CA-AKI is defined as serum creatinine (Scr) ≥ 25 to 50% or Scr rise around 0.3 to 0.5 mg/dl.
- Trial name
- NCT05540184
- Testing
- Trimetazidine 35 mg, Allopurinol 300 MG, Normal saline
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Enhancement of Aorta and Pulmonary Artery, Radiation Exposure
The Best Parameters for Imaging Agent Injection and Scanning Methods in Computed Tomography Angiography
Background: The contrast time-enhancement profiles of pulmonary artery (PA) and the aorta differ by using computed tomography (CT) angiography.
- Trial name
- NCT04832633
- Testing
- Different contrast media injection methods
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- Mackay Memorial Hospital
Colorectal Neoplasms, Neoplasm Metastasis
Health Economic Evaluation of Primovist-enhanced Liver MRI
Patients with a history of colorectal cancer and known or suspected liver metastases who are scheduled for contrast-enhanced tomographic imaging will be included in this study.
- Trial name
- NCT00764621
- Testing
- Primovist MRI, Extracellular contrast media (ECCM) MRI, Contrast-enhanced CT
- Where
- 44 sites in Austria, Germany and 7 more
- Volunteers
- 360 people
- Sponsor
- Bayer
Hepatocellular Carcinoma, Cholangiocarcinoma, Intrahepatic
Standardized CEUS Algorithms for Diagnosis of HCC - Prospective German Multicenter Study
Aim of this prospective national multicenter study is to improve standardization of contrast-enhanced ultrasound (CEUS) in the non-invasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients.
- Conditions
- Hepatocellular Carcinoma, Cholangiocarcinoma, Intrahepatic, Liver Cirrhosis, Liver Cancer
- Trial name
- ESCULAP (NCT03405909)
- Testing
- contrast enhanced ultrasound (CEUS), MRI, Histology
- Where
- Germany
- Volunteers
- 517 people
- Sponsor
- University Hospital Erlangen
Crohn Disease (CD)
WAter Preparation in Crohn's Disease's Imagery
The goal of this clinical trial is to compare distension quality and patient experience of water and polyethylene glycol preparation as oral contrast media in Magnetic Resonance Enterography (MRE) in patients with Crohn's…
- Trial name
- WAM (NCT06690632)
- Testing
- water preparation, polyethylene glycol preparation
- Where
- France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Toulouse
Atrial Fibrillation
Randomized Comparison Between 3 D CT Overlay and Conventional Fluoroscopy to Decrease Contrast and Radiation Exposure During Cryoballoon Ablation for Atrial Fibrillation
Cryoablation using a balloon is an effective therapy for paroxysmal atrial fibrillation (AF), however associated with significant amounts of radiation exposure and contrast medium use.
- Trial name
- CAFE (NCT06701383)
- Testing
- Cryoablation
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medisch Spectrum Twente
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