Clinical trials: Contrast Media
Acute Kidney Injury, Renal Insufficiency
Novel Biomarkers for Risk Prediction of Contrast-Induced Acute Kidney Injury Post Coronary Angiography
Contrast-induced acute kidney injury (CI-AKI) has been recognized as the third most common cause of hospital acquired AKI, after hypotension-associated hypo-perfusion and post-operative AKI.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Kidney Diseases
- Trial name
- NORDICA (NCT02263820)
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Sapere Bio
Relapsing Remitting Multiple Sclerosis, Optic Neuropathy
Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis
The objective of this trial is to assess the efficacy and safety of CNM-Au8 as a remyelinating treatment for vision-impairing MS lesions in participants who have chronic vision impairment as a result of Relapsing-Remitting…
- Conditions
- Relapsing Remitting Multiple Sclerosis, Optic Neuropathy, Optic; Neuritis, With Demyelination
- Trial name
- VISIONARY-MS (NCT03536559)
- Testing
- CNM-Au8
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 73 people
- Sponsor
- Clene Nanomedicine
Contrast Enhancement in Magnetic Resonance Imaging, Healthy Volunteers
A Study to Learn More About the Safety and the Level of BAY 1747846 in Body Given as Injection Into the Vein at Increasing Single Doses in Japanese Healthy Male Participants
The goal of this clinical study was to learn more about BAY1747846 compared to placebo when given as an injection into the vein in Japanese healthy male participants: the safety of BAY1747846 when given at increasing single doses…
- Trial name
- NCT06125366
- Testing
- BAY1747846
- Where
- Japan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayer
Peripheral Vascular Disease
Crossover Study With MultiHance vs a Comparator for Peripheral MRA
This is a double blind crossover study designed to compare two different gadolinium products given at the same dose to patients undergoing MRA assessment of lower legs for the evaluation of peripheral steno-occlusive disease.
- Trial name
- NCT00408083
- Testing
- MultiHance, Magnevist
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Bracco Diagnostics, Inc
Brain Pathology
A Study Comparing Two Magnetic Resonance Imaging (MRI) Contrast Agents in MRI of the Brain
This study aims at a direct comparison between Multihance and a validated comparator like Omniscan in a cross-over individual design in patients with brain tumors to confirm the superior overall diagnostic performance of…
- Trial name
- ENHANCE (NCT00323102)
- Testing
- Multihance
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Bracco Diagnostics, Inc
Contrast Enhancement in Magnetic Resonance Imaging
An Observational Study to Collect Information on the Safety of Gadolinium-Based Contrast Agents in Patients in India
This is an observational study in which data from patients undergoing enhanced MRI using gadolinium based agents (GBCAs) are collected and studied.
- Trial name
- NCT06257277
- Testing
- GBCAs
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Bayer
Patients Undergoing Contrast Enhanced Multidetector Computed Tomography of the Chest, Abdomen, Liver or Aorta for Any Diagnostic Cause
Multidetector Computed Tomography (MDCT) Tailored Protocol
Collection of data from different sites regardless of whether they use standard or tailored protocols for the application of high concentration iodinated contrast agents to assess if the individually patient-adapted protocols…
- Trial name
- NCT01737333
- Where
- 2 sites in United States, Italy
- Volunteers
- 1,493 people
- Sponsor
- Bracco Diagnostics, Inc
Alzheimer Disease
Blood-Brain-Barrier Opening Using Focused Ultrasound With IV Contrast Agents in Patients With Early Alzheimer's Disease
This is a prospective, non-randomized, single-arm, feasibility study to evaluate the safety and initial effectiveness of opening of the Blood-Brain Barrier with intravenous contrast agents using the ExAblate Neuro System in…
- Trial name
- BBB-Alzheimers (NCT02986932)
- Testing
- BBB opening
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- InSightec
Coronary Artery Disease
Phase 3 Imaging and Safety Study of AI-700 in Patients With Suspected Coronary Artery Disease Undergoing SPECT Imaging
This study was designed to evaluate the ability of AI-700-enhanced rest-stress echocardiography to detect coronary artery disease (CAD) in patients with suspected ischemic heart disease who are indicated for single-photon…
- Trial name
- NCT00156793
- Testing
- AI-700 contrast-enhanced echocardiography
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Acusphere
Healthy, Coronary Artery Disease
Dose Finding Study of PB127 Ultrasound Contrast Agent in Healthy Volunteers and Patients With Coronary Artery Disease
The purpose of this study is to determine the dose of PB127 for detection and/or exclusion of coronary artery disease when used with cardiac ultrasound. This study also evaluates the safety of PB127.
- Trial name
- NCT00584818
- Testing
- PB127 for Injectable Suspension
- Where
- 16 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Point Biomedical
Renal Artery Stenosis
Renal Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF)
The study will evaluate the efficacy and safety of Dotarem enhanced MRA compared to TOF MRA in patients suffering from renal arterial disease.
- Trial name
- NCT00845702
- Testing
- Gadoterate meglumine (Dotarem), Time of Flight Magnetic Resonance Angiography
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Guerbet
Age-Related Macular Degeneration
OKKO Health Hyperacuity, Contrast and Colour Game Validation in Age-related Macular Degeneration
Smartphone apps have the potential to measure standard metrics of visual function. In addition, new tests may serve as digital biomarkers to detect early progression of disease, assess risk of developing disease or expand the…
- Trial name
- NCT05569226
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- OKKO Health
Artificial Intelligence, Deep Learning
Feasibility of Gadolinium Contrast Reduced Brain MRI: the Potential of Deep Learning
MRI scans were performed using 3 different 1.5T scanners with an eight-channel head coils. Following a 3D pre-contrast T1w scan, a low-dose contrast-enhanced 3D T1w scan was obtained using 20% (0.02 mmol/kg) of the standard…
- Trial name
- NCT06462924
- Testing
- DeepGad
- Volunteers
- healthy volunteers welcome
- Sponsor
- DeepMeds
CT Scanning Patients
Observational Study to Assess the Safety of Omnipure® Inj.(Iohexol) Contrast Media in CT Scanning Patients
The purpose of this study is to assess safety of Omnipure inj. (lohexol) contrast media in CT scanning patients
- Trial name
- NCT02946450
- Testing
- Other: Not applicable-observational study
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Myopia, Child Myopia Progression
Effect of MiYOSMART iQ Spectacle Lenses on Myopia Progression in Children
This prospective, single-center study aims to evaluate the efficacy and safety of MiYOSMART iQ spectacle lenses with DIMS (Defocus Incorporated Multiple Segments) and Triple Enhanced Design (TED) technology in slowing myopia…
- Trial name
- NCT07387159
- Testing
- MiYOSMART iQ spectacle lenses
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- Hoya Lens Rus LLC
Patient Participation
Safety and Performance of Optivantage Multi-use When Injecting Contrast Media for Contrast Enhanced CT Examination
The study is a prospective, single-arm observational multicenter clinical investigation. The primary objective is to confirm the safety and performance of the Optivantage® Injection System when injecting contrast media to…
- Trial name
- NCT05537779
- Testing
- CT examination
- Volunteers
- 100 people
- Sponsor
- Guerbet