Clinical trials: Contrast-Induced Nephropathy
Radiocontrast-Induced Nephropathy, Chronic Kidney Disease
Efficacy of N-Acetylcysteine in Prevention of Post-Catheterization Contrast-Induced Nephropathy in Diabetic Patients With Chronic Kidney Disease
Contrast-induced nephropathy (CIN) is the third most common cause of hospital acquired acute kidney injury, accounting for 10% of all cases. The pathophysiology of CIN is unclear. Possible mechanisms involve 1.
- Conditions
- Radiocontrast-Induced Nephropathy, Chronic Kidney Disease, Diabetes Mellitus
- Trial name
- NCT00808795
- Testing
- N-acetylcysteine
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
ST Elevation Myocardial Infarction
Aggressive hydraTion in Patients With ST -Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention to prevenT Contrast-Induced Nephropathy
To compare the efficacy of 2 different hydration strategies, hydration according to clinical guideline and adequate hydration, on contrast-induced nephropathy in patients with STEMI undergoing primary PCI to investigate the…
- Trial name
- ATTEMPT (NCT02067195)
- Testing
- Receiving hydration with a 1 mL/kg bolus of intravenous isotonic saline (0.9% sodium chloride), 3 mL/kg.hour bolus of intravenous isotonic saline (0.9% sodium chloride)
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Guangdong Provincial People's Hospital
Contrast Induced Nephropathy
Safety Study Of N-Acetylcysteine For Prevention Of Contrast Induced Nephropathy In Patients w/Stage 3 Renal Failure
This will be a randomized prospective dose escalation clinical study of N-acetylcysteine (NAC) in patients with stage 3 or worse renal failure (Glomerular Filtration Rate 30-60 ml/min calculated with the Modification of Diet in…
- Trial name
- CIN-NAC (NCT00575419)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Acute Kidney Injury, IHD
The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography
an interventional study to measure the possible effects of spironolactone ( an aldosterone antagonist) on the incidence of acute kidney injury after coronary angiography
- Conditions
- Acute Kidney Injury, IHD, Contrast-induced Nephropathy
- Trial name
- NCT03329443
- Testing
- Spironolactone
- Where
- Iraq
- Volunteers
- 490 people
- Sponsor
- Alhasan Mujtaba Abdul-Wahid
Acute Myocardial Infarction, Acute Kidney Injury
Sodium Bicarbonate and N-Acetylcysteine for Nephroprotection in Acute Myocardial Infarction
Contrast-induced nephropathy (CIN) represents a potential complication of diagnostic and therapeutic procedures in interventional cardiology, especially in the acute setting of primary PCI.
- Trial name
- BINARIO (NCT01218178)
- Testing
- Sodium bicarbonate plus NAC, Saline hydration plus NAC
- Where
- Italy
- Volunteers
- 520 people
- Sponsor
- Catholic University of the Sacred Heart
Contrast Induced Nephropathy
Effects of Hydration to Prevent Contrast Induced Nephropathy in PCI for ST-elevation Myocardial Infarction.
The aim of the study is to test the efficacy of low versus high volume hydration and two different solutions (sodium chloride versus sodium bicarbonate) in preventing contrast induced nephropathy (CIN) in ST elevation myocardial…
- Trial name
- CINIMA (NCT00639912)
- Testing
- sodium chloride, sodium bicarbonate
- Where
- 5 sites in Italy
- Volunteers
- 599 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Kidney Diseases
Patients With Renal Impairment and Diabetes Undergoing Computed Tomography (CT)
The main purpose of this study is to compare the incidence of contrast induced nephrotoxicity following the administration of Isovue (iopamidol) or Visipaque in diabetic patients with moderate to severe chronic renal impairment…
- Trial name
- NCT00289614
- Testing
- Iopamidol 370 mgI/dL
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Bracco Diagnostics, Inc
Aortic Valve Stenosis, Renal Insufficiency
Remote Ischemic Preconditioning for Renal Protection in TAVI
Severe aortic stenosis remains a major cause of morbidity and mortality of the elderly affecting approximately 3% of elderly patients with an increasing number of patients undergoing transcatheter aortic valve interventions.
- Conditions
- Aortic Valve Stenosis, Renal Insufficiency, Contrast-induced Nephropathy
- Trial name
- NCT03347032
- Testing
- Remote ischemic preconditioning, Control
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Henry Ford Health System
Coronary Artery Disease
IVUS Guided PCI in Patients With Chronic Kidney Disease
The incidence of contrast-induced nephropathy (CIN) is high (> 25%) in patients with severe chronic renal disease (CKD) who undergo a percutaneous coronary procedure.
- Trial name
- SPEED (NCT06813534)
- Testing
- Intravascular Ultrasound guided PCI
- Where
- 2 sites in France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Radiographic Contrast Agent Nephropathy
Does Bicarbonate in Addition to Theophylline Reduce CIN?
Contrast-induced nephropathy (CIN) is the third most frequent cause of hospital-acquired acute renal failure. Different regimes in the prophylaxis of CIN have been investigated in the last years.
- Trial name
- NCT02643602
- Testing
- Hydration with bicarbonate in addition to theophylline, Hydration with sodium chloride in addition to theophylline
- Volunteers
- 152 people
- Sponsor
- Technical University of Munich
Contrast-Induced Nephropathy
High Dose Atorvastatin for Preventing Contrast-induced Nephropathy
The aim of this study is to determine the efficacy of atorvastatin in the prevention of contrast-induced nephropathy in patients undergoing computed tomography coronary angiography.
- Trial name
- NCT02114346
- Testing
- Atorvastatin, 0.9% sodium chloride
- Where
- Iran
- Volunteers
- 250 people
- Sponsor
- Isfahan University of Medical Sciences
Coronary Artery Disease, Chronic Kidney Disease
Hydration Guided by Remote Dielectric Sensing (ReDS) System for Preventing Acute Kidney Injury in Elderly Patients With Renal Insufficiency for Coronary Angiography and Intervention
Explore the effectiveness and safety of tailored hydration guided by lung water index monitor system for prevention of acute kidney injury after percutaneous coronary intervention for elderly patients with renal insufficiency.
- Conditions
- Coronary Artery Disease, Chronic Kidney Disease, Elderly
- Trial name
- HISTORY (NCT07394959)
- Testing
- Tailored hydration guided by ReDS system
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Chinese PLA General Hospital
Contrast-Induced Nephropathy, Acute Kidney Injury
Uric Acid to Albumin Ratio for Predicting Contrast Associated Acute Kidney Injury After Cardiac and Non Cardiac Procedures
Contrast-associated acute kidney injury (CA-AKI) is a potential complication that can occur following exposure to iodinated contrast media during diagnostic and interventional procedures, contributing to prolonged hospital stays…
- Trial name
- NCT07855653
- Volunteers
- 100 people
- Sponsor
- Assiut University
Contrast-Induced Nephropathy
Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy
Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans.
- Trial name
- NCT00606827
- Testing
- Sodium Bicarbonate, Isotonic Saline
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Ospedale Misericordia e Dolce
Contrast-induced Nephropathy
Contrast Induced Nephropathy Among Vascular Patients Undergoing Lower Limb Angioplasty
Contrast induced nephropathy (CIN) is an iatrogenic renal injury following intravascular administration of radio-opaque contrast media (CM) in susceptible individuals.
- Trial name
- NCT04879186
- Testing
- Peripheral endovascular angioplasty
- Where
- Singapore
- Volunteers
- 1,500 people
- Sponsor
- Singapore General Hospital
Contrast Induced Nephropathy, Acute Myocardial Infarction
Comparison Between Iso-Osmolar and Ipo-Osmolar Contrast Agents in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary Percutaneous Coronary Intervention (PCI)
The purpose of this study is to determine the incidence of contrast induced nephropathy and myocardial tissue reperfusion following iso-osmolar iodixanol or ipo-osmolar iopromide administration in patients with acute myocardial…
- Trial name
- CONTRAST-AMI (NCT00827788)
- Testing
- Iodixanol, Iopromide
- Where
- Italy
- Volunteers
- 432 people
- Sponsor
- Ospedale San Donato
Contrast Induced Acute Kidney Injury
Contrast-inDuced nephRotoxicity as Assessed by the KIdney Load-to-DAmage RElationship
We previously demonstrated that the slope of the relationship plotting individual iodine loads against contrast-induced serum creatinine changes ( the load-to-damage relationship, LDR) characterizes the intrinsic nephrotoxicity…
- Trial name
- DrKILDARE (NCT01908309)
- Testing
- Iobitridol 350, Iodixanol 320
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Sanitaria Locale 9, Grosseto
Kidney Diseases, Urologic Diseases
Folic Acid for Prevention of Contrast Induced Nephropathy
The purpose of this study is to determine whether periprocedural administration of folic acid is effective in the prevention of contrast induced nephropathy in patients undergoing coronary CTA/angiography/angioplasty.
- Trial name
- FAPCIN (NCT02444013)
- Testing
- Folic acid
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Atherosclerosis, Contrast Induced Nephropathy
The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases
The purpose of this research is to determine the relationship between novel blood tests for heart function (including hormones and heart enzymes measured in the blood), and assess for kidney damage before and after angiography…
- Conditions
- Atherosclerosis, Contrast Induced Nephropathy, Renal Impairment
- Trial name
- CASABLANCA (NCT00842868)
- Where
- United States
- Volunteers
- 1,298 people
- Sponsor
- Massachusetts General Hospital
Contrast Induced Nephropathy
PREdictive Value of COntrast voluMe to creatinINe Clearance Ratio
To determine a relatively safe contrast media volume to creatinine clearance cut-off value to avoid contrast-induced nephropathy in patients following coronary angiography
- Trial name
- PRECOMIN (NCT01400295)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital