Clinical trials: Controlled Diabetes
Type 1 Diabetes Mellitus
Pramlintide Combined With Model Predictive Control Algorithm
This is a scientific research study that will look at how a "closed-loop" system and the drug Pramlintide may work together to improve blood sugar control in people with type 1 diabetes mellitus.
- Trial name
- ALM002 (NCT01434862)
- Testing
- Closed loop with pramlintide, Closed loop without pramlintide, Open loop with pramlintide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Virginia
Diabetes, Diabetes Mellitus, Type 2
Safety of NovoMix® 30 or Levemir® for Treatment of Type 2 Diabetics in Macedonia
This study is conducted in Europe. The aim of this observational study is to investigate the incidence of serious adverse drug reactions when using NovoMix® 30 (biphasic insulin aspart 30) or Levemir® (insulin detemir) for…
- Trial name
- NCT00842894
- Testing
- insulin detemir, biphasic insulin aspart 30
- Where
- North Macedonia
- Volunteers
- 3,421 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 1
An Observational Study in Patients Using NovoMix® 30 or Levemir® for Treatment of Type 1 or Type 2 Diabetes Mellitus
This trial is conducted in Europe. The aim of this trial is to investigate efficacy and safety of NovoMix® 30 (biphasic insulin aspart 30) or Levemir® (insulin detemir) in subjects with type 1 or 2 diabetes mellitus.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01542424
- Testing
- biphasic insulin aspart 30, insulin detemir
- Where
- North Macedonia
- Volunteers
- 1,889 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Healthy
Safety, Tolerability, and Profile of Action of Drug in the Body of NN9535 in Healthy Male Japanese and Caucasian Subjects
This trial is conducted in Europe. The aim of this clinical trial is to assess and compare the safety and tolerability, as assessed by adverse events after multiple subcutaneous doses of NN9535 in healthy male Japanese and…
- Trial name
- NCT00851773
- Testing
- semaglutide
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
Supervised Walking Groups as a Model to Increase Physical Activity in Type 2 Diabetes
The purpose of the study is to evaluate the impact of an exercise programme organized into supervised walking groups on metabolic control, functional capacity and overall quantity of physical activity in subjects with type 2…
- Trial name
- NCT01115205
- Testing
- Supervised walking, Standard counselling procedure
- Volunteers
- 59 people
- Sponsor
- Universita di Verona
Type 2 Diabetes (T2DM), Cardiovascular Disease
The Effectiveness of Resistance Training on Glycemic Control for Patients With Type 2 Diabetes in Cardiac Rehabilitation
This study is designed to investigate the effect of a structured resistance training program on glycemic control, measured by hemoglobin A1c (glycated hemoglobin), in patients with type 2 diabetes (T2DM) who are enrolled in…
- Trial name
- NCT02707380
- Testing
- Resistance Training, Standard of Care
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- NYU Langone Health
Type1 Diabetes Mellitus
Chinese Smartphone App for 6-18 Years With T1DM - RCT
Moving into the era of electronic communication, it changes the way we shall engage our children and adolescents. According to data of the Census and Statistics Department of Hong Kong releases in 2019, more than 80% and up to…
- Trial name
- NCT05418569
- Testing
- Intervention arm - A new smartphone application for pediatric type 1 DM, Standard diabetic eduction
- Where
- Hong Kong
- Volunteers
- 114 people
- Sponsor
- Chinese University of Hong Kong
Diabetes Mellitus, Insulin Resistance
Insulin Infusion Diabetes Ulcer
Normoglycemia is important for the outcome of surgical and medical conditions. Insulin infusions have been studied to achieve normoglycemia during these circumstances and have proved to be useful.
- Conditions
- Diabetes Mellitus, Insulin Resistance, Hyperglycemia, Surgery
- Trial name
- IINDU (NCT00700154)
- Testing
- Insulin infusion
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Pre Diabetes, Overweight and Obesity
A Digital Therapy for Diabetes Prevention Among Overweight Adults in Terengganu, Malaysia
The modern world revolves around technology; unsurprisingly companies are leveraging the expertise of the digital tech industry to aid in the prevention of chronic diseases.
- Trial name
- NCT03997656
- Testing
- MyDiPP (Malaysia Diabetes Prevention Program), usual care
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sultan Zainal Abidin
Type 1 Diabetes
The International Diabetes Closed Loop (iDCL) Trial: Protocol 4
The investigators aim to compare the efficacy and safety of an AID system using an adaptive MPC algorithm versus SAP (which may or may not include PLGS; to be referred to as SAP) in people with type 1 diabetes.
- Trial name
- DCLP4 (NCT04436796)
- Testing
- interoperable Artificial Pancreas System (iAPS), Sensor-Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS)
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes, Diabetes Mellitus, Type 2
Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes
This trial is conducted globally. The aim of the trial is to evaluate cardiovascular and other long-term outcomes with semaglutide in subjects with type 2 diabetes. The trial is event-driven, i.e.
- Trial name
- SUSTAIN™ 6 (NCT01720446)
- Testing
- semaglutide
- Where
- 253 sites in United States, Algeria and 19 more
- Volunteers
- 3,297 people
- Sponsor
- Novo Nordisk A/S
MASH - Metabolic Dysfunction-Associated Steatohepatitis, T2DM (Type 2 Diabetes Mellitus)
A Study of Chiglitazar in Patients With Metabolic Dysfunction-associated Steatohepatitis and Type 2 Diabetes Mellitus
This trial aims to evaluate the efficacy and safety of chiglitazar as a combination therapy for patients with MASH and T2DM.
- Trial name
- CHIG-MASH (NCT07303803)
- Testing
- Chiglitazar, vitamin E, Polyene Phosphatidyl choline
- Where
- 17 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetic Foot, Diabetes Type 2 With Diabetic Ulcer of Toe, Skin Breakdown
CGM and DFU Healing Post-discharge
The purpose of this study is to look at the benefits of using a Continuous Glucose Monitoring (CGM) system compared with standard-of-care testing for patients with type 2 diabetes and diabetic foot ulcers (DFU) and how this will…
- Trial name
- NCT06054659
- Testing
- Real Time Continuous Glucose Monitoring (rt-CGM), Fingerstick blood glucose (FBG) monitoring, Diabetes Education
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- Emory University
Diabetes Mellitus, Type 1
Omnipod® 5 With Libre 2 vs. MDI for Type 1 Diabetes in Children and Adults
This study is a randomized, controlled trial to evaluate the efficacy and safety of the Omnipod® 5 System with the FreeStyle Libre 2 continuous glucose monitor compared to Multiple Daily Injections (MDI) along with the FreeStyle…
- Trial name
- RADIANT (NCT05923827)
- Testing
- Omnipod 5 System
- Where
- 19 sites in Belgium, France and 1 more
- Volunteers
- 189 people
- Sponsor
- Insulet Corporation
Type 2 Diabetes
Electrical Vestibular Nerve Stimulation (VeNS) Compared to Sham Control As a Means of Improving Glycemic Control in Adults with Type 2 Diabetes Mellitus
Trial Title A randomized, double blind sham controlled clinical trial to evaluate the efficacy of vestibular nerve stimulation (VeNS), together with a lifestyle modification program, compared to a sham control with a lifestyle…
- Trial name
- NCT04595968
- Testing
- Vestal DM Active device, Lifestyle modification
- Where
- 16 sites in United States, Ireland
- Volunteers
- 267 people
- Sponsor
- Neurovalens Ltd.
Type 2 Diabetes
A Single Supplement of a Standardised Bilberry Extract Modifies Glycaemic Response
Dietary strategies for alleviating health complications associated with type 2 diabetes (T2D) are being pursued as alternatives to pharmaceutical interventions.
- Trial name
- NCT01245270
- Testing
- Bilberry capsule first, then control cap, Control capsule first then bilberry cap
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Aberdeen
Dose Administration Aids, Medication Adherence
Testing a Smart Medication Dispenser (Mobili®) to Help People With Chronic Conditions Take Their Medicine
Medication adherence is one of the biggest challenges faced by healthcare systems, especially among people with multiple chronic diseases who take several medications daily.
- Conditions
- Dose Administration Aids, Medication Adherence, Polypharmacy, Technology in Health
- Trial name
- MobiMAd@PT RCT (NCT07175545)
- Testing
- Independent use of the Mobili® Device by patients, overseen by pharmacists
- Where
- Portugal
- Volunteers
- 96 people
- Sponsor
- Lusofona University
Type 2 Diabetes
Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Saxagliptin as Monotherapy in Pediatric Patients With Type 2 Diabetes
The purpose of this study is to evaluate the efficacy, safety, tolerability, of Saxagliptin in pediatric patients with type 2 diabetes.
- Trial name
- NCT01204775
- Testing
- Saxagliptin, Metformin IR, Metformin (Active Rescue)
- Where
- 16 sites in United States, Russia and 2 more
- Volunteers
- 26 people
- Sponsor
- AstraZeneca
Diabetic Foot Ulcer
A Study to Evaluate the Efficacy of a Purified Native Type 1 Collagen Extracellular Matrix With Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers
This prospective, multi-center, randomized, controlled modified platform Trial compares Purified Native Type 1 Collagen Extracellular Matrix with Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care versus…
- Trial name
- PREPARE (NCT06618612)
- Testing
- Standard of Care, PuraPly AM, PuraPly XT
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Organogenesis
Diabetes Mellitus, Type 2
Efficacy and Safety of Linagliptin (BI 1356) in Black/African Americans With Type 2 Diabetes With a MTT Sub-study
Study of linagliptin vs. placebo in Black/African American patients with T2DM with a MTT sub-study
- Trial name
- NCT01194830
- Testing
- Linagliptin
- Where
- 93 sites in United States
- Volunteers
- 234 people
- Sponsor
- Boehringer Ingelheim
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